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The map label for this gene is hemC [H]

Identifier: 126208484

GI number: 126208484

Start: 1174046

End: 1174975

Strand: Reverse

Name: hemC [H]

Synonym: APL_1010

Alternate gene names: 126208484

Gene position: 1174975-1174046 (Counterclockwise)

Preceding gene: 126208486

Following gene: 126208483

Centisome position: 51.66

GC content: 44.41

Gene sequence:

>930_bases
ATGAAAGATACCTTACGTATTGCGACTCGCCAAAGTCCTCTTGCATTGTGGCAAGCAAATTTTGTAAAAGACGAATTAGA
AAAACGTTTTCCGGAACTTTCTGTCGAATTAGTGACGATGGTTACTAAAGGCGATGTGATTTTAGATACCCCGTTAGCTA
AAATCGGCGGAAAAGGGCTGTTTGTAAAAGAATTGGAATTGGCGCTTTTAGAAAACCGTGCGGATATTGCTGTGCATTCA
ATGAAAGACGTGCCGATGACCTTTCCGGAAGGTTTAGGTTTGGCGGTAATTTGCGAGCGAGAAGATCCGCGTGATGCGTT
CGTTTCAAATAAATATCAAAATTTAGACGAATTACCTGCCGGAGCCGTTGTGGGGACATCCAGCTTACGTCGTCAGTGTC
AATTGATGGCAAAATATCCGCATTTGGAAGTGAAATCTTTGCGTGGTAACGTTGGCACTCGTTTATCAAAATTGGATAAC
GGCGAATATGATGCGATTATTTTAGCGTCTGCCGGATTAATTCGTTTAGGAATGCCTGAGCGCATTCGTAGCTTTATTTC
GGTCGAACAATCTTTGCCGGCGGCAGGGCAAGGTGCGGTAGGAATTGAAACTCGAGTAAATGACGAGCGAGTGTTAAATT
ATCTTGCGACATTAAATCATAATCCGACCGCTTGTTGTGTCATCGCGGAGCGTGCGATGAATACCCGTTTGCAAGGCGGA
TGCCAAGTGCCGATTGGTGGTTTTGCAACCTTAAACGGAAATGAAATAACGTTAAACGCCTTGGTCGGTGCGCTGGACGG
TTCGAACATTATTCGAGCATCAGGAGTAGCGGATAGAGAAAATGCCGAGCAATTAGGTATTTCCGTGGCCGAACAACTTC
TTGCACAAGGTGCGGATAAAATCCTTGCGGAAGTATATAAAGACGAATAA

Upstream 100 bases:

>100_bases
GCATAATGTATTAACTTTACACAGAAATTTTGGCAGTTACAGGTAATTAATGGTAGGATAAGAACATTTATATAAGTACA
ACAAAATGATGAATTTACCT

Downstream 100 bases:

>100_bases
GAAATAAAATGAATGTGTTAATTACTCGCCCTGATTATCGTGGGCAGGAATTAGTTGAAATGTTGAATCAGTATCAGATT
TTTGCGATTCATCAGCCGTT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKDTLRIATRQSPLALWQANFVKDELEKRFPELSVELVTMVTKGDVILDTPLAKIGGKGLFVKELELALLENRADIAVHS
MKDVPMTFPEGLGLAVICEREDPRDAFVSNKYQNLDELPAGAVVGTSSLRRQCQLMAKYPHLEVKSLRGNVGTRLSKLDN
GEYDAIILASAGLIRLGMPERIRSFISVEQSLPAAGQGAVGIETRVNDERVLNYLATLNHNPTACCVIAERAMNTRLQGG
CQVPIGGFATLNGNEITLNALVGALDGSNIIRASGVADRENAEQLGISVAEQLLAQGADKILAEVYKDE

Sequences:

>Translated_309_residues
MKDTLRIATRQSPLALWQANFVKDELEKRFPELSVELVTMVTKGDVILDTPLAKIGGKGLFVKELELALLENRADIAVHS
MKDVPMTFPEGLGLAVICEREDPRDAFVSNKYQNLDELPAGAVVGTSSLRRQCQLMAKYPHLEVKSLRGNVGTRLSKLDN
GEYDAIILASAGLIRLGMPERIRSFISVEQSLPAAGQGAVGIETRVNDERVLNYLATLNHNPTACCVIAERAMNTRLQGG
CQVPIGGFATLNGNEITLNALVGALDGSNIIRASGVADRENAEQLGISVAEQLLAQGADKILAEVYKDE
>Mature_309_residues
MKDTLRIATRQSPLALWQANFVKDELEKRFPELSVELVTMVTKGDVILDTPLAKIGGKGLFVKELELALLENRADIAVHS
MKDVPMTFPEGLGLAVICEREDPRDAFVSNKYQNLDELPAGAVVGTSSLRRQCQLMAKYPHLEVKSLRGNVGTRLSKLDN
GEYDAIILASAGLIRLGMPERIRSFISVEQSLPAAGQGAVGIETRVNDERVLNYLATLNHNPTACCVIAERAMNTRLQGG
CQVPIGGFATLNGNEITLNALVGALDGSNIIRASGVADRENAEQLGISVAEQLLAQGADKILAEVYKDE

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=331, Percent_Identity=41.6918429003021, Blast_Score=237, Evalue=8e-63,
Organism=Homo sapiens, GI20149500, Length=331, Percent_Identity=41.6918429003021, Blast_Score=237, Evalue=1e-62,
Organism=Escherichia coli, GI48994974, Length=306, Percent_Identity=70.9150326797386, Blast_Score=427, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319996, Length=322, Percent_Identity=40.9937888198758, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI20130425, Length=282, Percent_Identity=42.1985815602837, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33436; Mature: 33436

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDTLRIATRQSPLALWQANFVKDELEKRFPELSVELVTMVTKGDVILDTPLAKIGGKGL
CCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEECCHHHHCCCCE
FVKELELALLENRADIAVHSMKDVPMTFPEGLGLAVICEREDPRDAFVSNKYQNLDELPA
EHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHCCHHCCHHHCCC
GAVVGTSSLRRQCQLMAKYPHLEVKSLRGNVGTRLSKLDNGEYDAIILASAGLIRLGMPE
CCEECCHHHHHHHHHHHHCCCCEEHHHCCCHHHHHHHCCCCCCCEEEEECCCEEECCCHH
RIRSFISVEQSLPAAGQGAVGIETRVNDERVLNYLATLNHNPTACCVIAERAMNTRLQGG
HHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHCCC
CQVPIGGFATLNGNEITLNALVGALDGSNIIRASGVADRENAEQLGISVAEQLLAQGADK
CCCCCCCEEEECCCEEEEEHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCHHH
ILAEVYKDE
HHHHHHCCC
>Mature Secondary Structure
MKDTLRIATRQSPLALWQANFVKDELEKRFPELSVELVTMVTKGDVILDTPLAKIGGKGL
CCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEECCHHHHCCCCE
FVKELELALLENRADIAVHSMKDVPMTFPEGLGLAVICEREDPRDAFVSNKYQNLDELPA
EHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHCCHHCCHHHCCC
GAVVGTSSLRRQCQLMAKYPHLEVKSLRGNVGTRLSKLDNGEYDAIILASAGLIRLGMPE
CCEECCHHHHHHHHHHHHCCCCEEHHHCCCHHHHHHHCCCCCCCEEEEECCCEEECCCHH
RIRSFISVEQSLPAAGQGAVGIETRVNDERVLNYLATLNHNPTACCVIAERAMNTRLQGG
HHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHCCC
CQVPIGGFATLNGNEITLNALVGALDGSNIIRASGVADRENAEQLGISVAEQLLAQGADK
CCCCCCCEEEECCCEEEEEHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCHHH
ILAEVYKDE
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA