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The map label for this gene is hemD [H]

Identifier: 126208483

GI number: 126208483

Start: 1173273

End: 1174037

Strand: Reverse

Name: hemD [H]

Synonym: APL_1009

Alternate gene names: 126208483

Gene position: 1174037-1173273 (Counterclockwise)

Preceding gene: 126208484

Following gene: 126208482

Centisome position: 51.62

GC content: 39.61

Gene sequence:

>765_bases
ATGAATGTGTTAATTACTCGCCCTGATTATCGTGGGCAGGAATTAGTTGAAATGTTGAATCAGTATCAGATTTTTGCGAT
TCATCAGCCGTTATTTACGATTGAAGCCGGGACGGAATTACCTCAGCTTCCGTCGGTTATGTCTCGTCTGAATACGGATG
ATTATGTATTTGCCGTTTCTAAACATGCCATTGATTTTGCTTCGGAAACGCTCGTACAGACAGGTTTTCAGTATCGTTCC
GATTTAAAATATTTTGCGGTGGGAAGACAATCCGCAGCCTATTTTTCGACAAAAACAGCGTATCCTACGTATTATCCGAT
CTCTTCCGAGAATAGTGAGGGATTACTGGAATTACCTGAAATGCAGTGCTTAGAAGGAAAAAATATTCTCGTTTTACGAG
CGGAGAAAGGGCGGGATTTTTTTGCGGAACAAGCGAGTTTACGAGGAGCAAATGTCCAATATTTAGAGTGTTATCGCCGT
CAATATTTAGCAGATAGCATTACGGAAAAAATGAGTTTGTGTAAACGAGCCGGCATTGATAGTATTATTGTAACCAGTAC
GGATATCTTAATCACTTTATATGAACAAACGGCGGAAGACGATCGTCAGTGGTTGATTGAATGTCGTTTAATCGTCGTCA
GCACTCGTATTGCTCAACTGGCGTATAAATTAGGTTGGAGTAGAAATAAGGTTCTACTTTCAGAAAAAGCGGATAATAAT
AGTCTGCTGGAAAGCGTATTGAAATTTATCGACAAATCTAACTAA

Upstream 100 bases:

>100_bases
AAAATGCCGAGCAATTAGGTATTTCCGTGGCCGAACAACTTCTTGCACAAGGTGCGGATAAAATCCTTGCGGAAGTATAT
AAAGACGAATAAGAAATAAA

Downstream 100 bases:

>100_bases
GGTGGAAATATGTCAAAAGATAAACAGAACATTGAACAAACGGAAGATGTTGTTGAAGCGGTTACTGCCGTTGAGCAAGA
AACTAATTCATCTAAGCAGG

Product: putative uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MNVLITRPDYRGQELVEMLNQYQIFAIHQPLFTIEAGTELPQLPSVMSRLNTDDYVFAVSKHAIDFASETLVQTGFQYRS
DLKYFAVGRQSAAYFSTKTAYPTYYPISSENSEGLLELPEMQCLEGKNILVLRAEKGRDFFAEQASLRGANVQYLECYRR
QYLADSITEKMSLCKRAGIDSIIVTSTDILITLYEQTAEDDRQWLIECRLIVVSTRIAQLAYKLGWSRNKVLLSEKADNN
SLLESVLKFIDKSN

Sequences:

>Translated_254_residues
MNVLITRPDYRGQELVEMLNQYQIFAIHQPLFTIEAGTELPQLPSVMSRLNTDDYVFAVSKHAIDFASETLVQTGFQYRS
DLKYFAVGRQSAAYFSTKTAYPTYYPISSENSEGLLELPEMQCLEGKNILVLRAEKGRDFFAEQASLRGANVQYLECYRR
QYLADSITEKMSLCKRAGIDSIIVTSTDILITLYEQTAEDDRQWLIECRLIVVSTRIAQLAYKLGWSRNKVLLSEKADNN
SLLESVLKFIDKSN
>Mature_254_residues
MNVLITRPDYRGQELVEMLNQYQIFAIHQPLFTIEAGTELPQLPSVMSRLNTDDYVFAVSKHAIDFASETLVQTGFQYRS
DLKYFAVGRQSAAYFSTKTAYPTYYPISSENSEGLLELPEMQCLEGKNILVLRAEKGRDFFAEQASLRGANVQYLECYRR
QYLADSITEKMSLCKRAGIDSIIVTSTDILITLYEQTAEDDRQWLIECRLIVVSTRIAQLAYKLGWSRNKVLLSEKADNN
SLLESVLKFIDKSN

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=248, Percent_Identity=38.3064516129032, Blast_Score=166, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 29035; Mature: 29035

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVLITRPDYRGQELVEMLNQYQIFAIHQPLFTIEAGTELPQLPSVMSRLNTDDYVFAVS
CCEEEECCCCCHHHHHHHHHHCEEEEEECCEEEEECCCCCCHHHHHHHHCCCCCEEEEEH
KHAIDFASETLVQTGFQYRSDLKYFAVGRQSAAYFSTKTAYPTYYPISSENSEGLLELPE
HHHHHHHHHHHHHHCHHHHHCCCEEEECCCCHHHEECCCCCCEEECCCCCCCCCCEECCC
MQCLEGKNILVLRAEKGRDFFAEQASLRGANVQYLECYRRQYLADSITEKMSLCKRAGID
HHHCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SIIVTSTDILITLYEQTAEDDRQWLIECRLIVVSTRIAQLAYKLGWSRNKVLLSEKADNN
EEEEECCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
SLLESVLKFIDKSN
HHHHHHHHHHCCCC
>Mature Secondary Structure
MNVLITRPDYRGQELVEMLNQYQIFAIHQPLFTIEAGTELPQLPSVMSRLNTDDYVFAVS
CCEEEECCCCCHHHHHHHHHHCEEEEEECCEEEEECCCCCCHHHHHHHHCCCCCEEEEEH
KHAIDFASETLVQTGFQYRSDLKYFAVGRQSAAYFSTKTAYPTYYPISSENSEGLLELPE
HHHHHHHHHHHHHHCHHHHHCCCEEEECCCCHHHEECCCCCCEEECCCCCCCCCCEECCC
MQCLEGKNILVLRAEKGRDFFAEQASLRGANVQYLECYRRQYLADSITEKMSLCKRAGID
HHHCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SIIVTSTDILITLYEQTAEDDRQWLIECRLIVVSTRIAQLAYKLGWSRNKVLLSEKADNN
EEEEECCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
SLLESVLKFIDKSN
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]