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The map label for this gene is hemX [H]

Identifier: 126208482

GI number: 126208482

Start: 1171923

End: 1173263

Strand: Reverse

Name: hemX [H]

Synonym: APL_1008

Alternate gene names: 126208482

Gene position: 1173263-1171923 (Counterclockwise)

Preceding gene: 126208483

Following gene: 126208481

Centisome position: 51.58

GC content: 39.67

Gene sequence:

>1341_bases
ATGTCAAAAGATAAACAGAACATTGAACAAACGGAAGATGTTGTTGAAGCGGTTACTGCCGTTGAGCAAGAAACTAATTC
ATCTAAGCAGGAATTTGTAGAAAATTCAGAAAAAGAGACCGCTCCTCAAGCAGATAAAGAGGATACGAAAGTGGAACAAA
AGGCTGAAGAAAAAACGGTCGTCGTTCAAAAATCCGGCGGCAAAGGCATTGCTCTGTTGGCATTATTAGTTGCGATTGCA
GTCGGCGGTGCGGGTCATTATTTGGCAAATCAGAAATTTACCGATGTAGAGCAACAAATCGCAAAACTGGCAGGGCAACA
ACCTGTTTCTTCTCCTCAAATAGAAATCCCGAATTTTGATGCGGAAAAAGCGCAAATTGCAGAACTGGGTTCTTCATATC
AGAAAGCGTTGGAACGTATCGGCCAATTAGAACAAGAGCAATCGAATTACCTGAATCAAATTAACGGCTTGAAAACACAA
TTGCAAAAAGTAAGCGGCGTGCCTCAATCTGAATCGGTTGTTTGGAAATTATCCGATGCGGATTTTTTACTCAACAACGC
ATTACGCAAATTGGTTTTGGATAACGATATCGATACGGCTAAGAGCTTATTATCGGAAGCGGATAGCGTATTGTCACAAG
TTTCCAATACGGAAGTTGCAAATGTACGCAGTGCGATTAAAAGTGATTTGAGCCAGTTGGCAAATGTGAATAACGTAGAT
CAGAATAGTTTGATGCAACGTTTAACCGCACTGGCAAATCGTTTGGATGATTTACCGATGATCGCTAATGAAGCTATTGA
AGATACCGTAATGGAAAGCGGAGAAGTAAGCGATTCGATTGAAGATTGGCAAAAAAATATTGAAAAAAGCGCAAGTTCTT
TCTTAGATCATTTTATTCGTGTAAGCGATCGTAATAAAGCGGATGAAAAAGCGTTTGTCGCACCGAATCAGGAAGTTTAT
TTACGTGAGAATATTCGTTTACGTTTACAGATTGCTATTCTTGCTATCCCGCGTCAGCAAAATGAATTGTATAAGCAGTC
GTTAGATGCGGTCGGTACTTGGATTAGAAGTTATTTTGAAACGCAAAACGAAAGTGTGAAAAGTTTCTTGAAAGAATTGG
ATGATTTAAGCGAACAATCTATTTATATTGATGCGCCTGATCGTCTTAAAAGTATTGAATTATTGGAACATCTCTTAAAT
AAAGCGCCTCAAACGGTAGAAAAAATTGAAATTAAAGCGGAAAAAGAATTAGCTCAACCGGCTACCGAAACAAAAGAGGA
GCCGGTACCGCAACAACCCGTTCAGCCCCAAACTGAACAACCGTCTTCAGTTGCACAGTAA

Upstream 100 bases:

>100_bases
TTGGAGTAGAAATAAGGTTCTACTTTCAGAAAAAGCGGATAATAATAGTCTGCTGGAAAGCGTATTGAAATTTATCGACA
AATCTAACTAAGGTGGAAAT

Downstream 100 bases:

>100_bases
GGAGGATAGCGATGTTTAGAGTGCTTTTTTTAATGCTTTTATTACTGGCGAGTTTAATTTTCGGCCCTTATCTTTCCGGT
AATCAAGGTTACGTTCGTAT

Product: putative uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen-III methylase; ORF X [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSKDKQNIEQTEDVVEAVTAVEQETNSSKQEFVENSEKETAPQADKEDTKVEQKAEEKTVVVQKSGGKGIALLALLVAIA
VGGAGHYLANQKFTDVEQQIAKLAGQQPVSSPQIEIPNFDAEKAQIAELGSSYQKALERIGQLEQEQSNYLNQINGLKTQ
LQKVSGVPQSESVVWKLSDADFLLNNALRKLVLDNDIDTAKSLLSEADSVLSQVSNTEVANVRSAIKSDLSQLANVNNVD
QNSLMQRLTALANRLDDLPMIANEAIEDTVMESGEVSDSIEDWQKNIEKSASSFLDHFIRVSDRNKADEKAFVAPNQEVY
LRENIRLRLQIAILAIPRQQNELYKQSLDAVGTWIRSYFETQNESVKSFLKELDDLSEQSIYIDAPDRLKSIELLEHLLN
KAPQTVEKIEIKAEKELAQPATETKEEPVPQQPVQPQTEQPSSVAQ

Sequences:

>Translated_446_residues
MSKDKQNIEQTEDVVEAVTAVEQETNSSKQEFVENSEKETAPQADKEDTKVEQKAEEKTVVVQKSGGKGIALLALLVAIA
VGGAGHYLANQKFTDVEQQIAKLAGQQPVSSPQIEIPNFDAEKAQIAELGSSYQKALERIGQLEQEQSNYLNQINGLKTQ
LQKVSGVPQSESVVWKLSDADFLLNNALRKLVLDNDIDTAKSLLSEADSVLSQVSNTEVANVRSAIKSDLSQLANVNNVD
QNSLMQRLTALANRLDDLPMIANEAIEDTVMESGEVSDSIEDWQKNIEKSASSFLDHFIRVSDRNKADEKAFVAPNQEVY
LRENIRLRLQIAILAIPRQQNELYKQSLDAVGTWIRSYFETQNESVKSFLKELDDLSEQSIYIDAPDRLKSIELLEHLLN
KAPQTVEKIEIKAEKELAQPATETKEEPVPQQPVQPQTEQPSSVAQ
>Mature_445_residues
SKDKQNIEQTEDVVEAVTAVEQETNSSKQEFVENSEKETAPQADKEDTKVEQKAEEKTVVVQKSGGKGIALLALLVAIAV
GGAGHYLANQKFTDVEQQIAKLAGQQPVSSPQIEIPNFDAEKAQIAELGSSYQKALERIGQLEQEQSNYLNQINGLKTQL
QKVSGVPQSESVVWKLSDADFLLNNALRKLVLDNDIDTAKSLLSEADSVLSQVSNTEVANVRSAIKSDLSQLANVNNVDQ
NSLMQRLTALANRLDDLPMIANEAIEDTVMESGEVSDSIEDWQKNIEKSASSFLDHFIRVSDRNKADEKAFVAPNQEVYL
RENIRLRLQIAILAIPRQQNELYKQSLDAVGTWIRSYFETQNESVKSFLKELDDLSEQSIYIDAPDRLKSIELLEHLLNK
APQTVEKIEIKAEKELAQPATETKEEPVPQQPVQPQTEQPSSVAQ

Specific function: Siroheme and cobalamin biosynthesis. [C]

COG id: COG2959

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790235, Length=331, Percent_Identity=36.2537764350453, Blast_Score=200, Evalue=1e-52,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007470 [H]

Pfam domain/function: PF04375 HemX [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 49581; Mature: 49450

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKDKQNIEQTEDVVEAVTAVEQETNSSKQEFVENSEKETAPQADKEDTKVEQKAEEKTV
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHCEE
VVQKSGGKGIALLALLVAIAVGGAGHYLANQKFTDVEQQIAKLAGQQPVSSPQIEIPNFD
EEECCCCCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCC
AEKAQIAELGSSYQKALERIGQLEQEQSNYLNQINGLKTQLQKVSGVPQSESVVWKLSDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCH
DFLLNNALRKLVLDNDIDTAKSLLSEADSVLSQVSNTEVANVRSAIKSDLSQLANVNNVD
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
QNSLMQRLTALANRLDDLPMIANEAIEDTVMESGEVSDSIEDWQKNIEKSASSFLDHFIR
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VSDRNKADEKAFVAPNQEVYLRENIRLRLQIAILAIPRQQNELYKQSLDAVGTWIRSYFE
HCCCCCCCCCCEECCCCCEEEECCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
TQNESVKSFLKELDDLSEQSIYIDAPDRLKSIELLEHLLNKAPQTVEKIEIKAEKELAQP
CCCHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
ATETKEEPVPQQPVQPQTEQPSSVAQ
CHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKDKQNIEQTEDVVEAVTAVEQETNSSKQEFVENSEKETAPQADKEDTKVEQKAEEKTV
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHCEE
VVQKSGGKGIALLALLVAIAVGGAGHYLANQKFTDVEQQIAKLAGQQPVSSPQIEIPNFD
EEECCCCCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCC
AEKAQIAELGSSYQKALERIGQLEQEQSNYLNQINGLKTQLQKVSGVPQSESVVWKLSDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCH
DFLLNNALRKLVLDNDIDTAKSLLSEADSVLSQVSNTEVANVRSAIKSDLSQLANVNNVD
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
QNSLMQRLTALANRLDDLPMIANEAIEDTVMESGEVSDSIEDWQKNIEKSASSFLDHFIR
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VSDRNKADEKAFVAPNQEVYLRENIRLRLQIAILAIPRQQNELYKQSLDAVGTWIRSYFE
HCCCCCCCCCCEECCCCCEEEECCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
TQNESVKSFLKELDDLSEQSIYIDAPDRLKSIELLEHLLNKAPQTVEKIEIKAEKELAQP
CCCHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
ATETKEEPVPQQPVQPQTEQPSSVAQ
CHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062586; 3054815; 1379743; 9278503; 9298646 [H]