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The map label for this gene is hktE [H]

Identifier: 126208462

GI number: 126208462

Start: 1141834

End: 1143360

Strand: Direct

Name: hktE [H]

Synonym: APL_0988

Alternate gene names: 126208462

Gene position: 1141834-1143360 (Clockwise)

Preceding gene: 126208460

Following gene: 126208463

Centisome position: 50.2

GC content: 45.06

Gene sequence:

>1527_bases
ATGTCAAAATGTCCATTTCATCATACCTCATTAACGATGAACAACGGTGCGCCTGTTGTTGATAACCAAAACAGCATGAC
TGCGGGTCCTCGTGGTCCGTTACTTGCTCAAGACTTATGGTTAAACGAAAAATTAGCCAACTTCGTACGTGAAGTGATTC
CTGAGCGTCGTATGCACGCGAAAGGCTCCGGTGCATTCGGTAAATTTACCGTAACGCACGATATTACTCAATATACTAAA
GCGGCAATCTTTAGTGAAGTGGGTAAAGAAACCGAATTATTCGCACGTTTTACTACCGTAGCCGGTGAACGTGGTGCGGC
AGATGCTGAGCGTGATATTCGTGGTTTCGCAGTTAAATTCTATACCGAACAAGGTAACTGGGACTTCGTAGGTAACAATA
CGCCGGTATTCTTCTTACGTGATCCGCGTAAATTCCCGGATTTAAACAAAGCGGTTAAACGTGACCCTCGCACAAATATG
CGTAGTGCGACAAACAACTGGGACTTCTGGACATTATTACCTGAAGCGTTCCACCAAGTAACGATCGTAATGTCAGAGCG
CGGTATCCCTGCTTCATATCGTCATATGCACGGTTACGGTTCACACACATATAGCTTAATCAATGCAAATAACGAACGTT
TCTGGGTAAAATTCCACTTCCGTACCGAACAAGGTATTAAAAACTTAACCAACGAAGAAGCGGCGGCAATCATCGCAAAC
GATCGTGAATCACACCAACGTGATTTATACGAGTCAATCGAAAAAGGCGATTTCCCGAAATGGAAACTTTACATTCAAGT
AATGCCTGAAGCGGAAGCGGAACAAGTGGATTTCCACCCGTTCGATTTAACCAAAATCTGGTCGAAAAAAGATTATCCGT
TAATCGAAGTGGGCGTGATGGAATTAAACCGTAACCCGGCAAATTTCTTTGCCGACGTTGAACAATCCGCATTTGCTCCA
AGCAACTTGGTACCGGGTATCAGCGTATCGCCGGATCGTATGTTACAAGCGCGTTTATTTAACTATGCAGACGCACAACG
TTACCGTTTAGGTGTAAACCACCACCAAATTCCGGTAAACGCACCTCGTTGCCCGGTTCACAGCAATGCGCGTGACGGTC
AAAGTCGTGTAGACGGTAACTACGGTTCAACCTTACATTATGAACCGAACAGCTTCGGCCAATGGCAAGAACAGGCGCAA
TTTGCCGAGCCGCCTCTTAAAATTAACGGCGATGCGGCATTCTGGGATTATCGTCAAGATGACTCGGATTACTTCAGCCA
ACCGCGTGCATTATTTAACTTAATGACGGAGAAAGAAAAACAATCTCTCTTTAAAAATACTGCCGAAGGTATGGGTGATG
CGTTAGATTTCATCAAATATCGTCATATTCGTAACTGCTACTTCTGTGACCCTGCATACGGTGAAGGCGTAGCGAAAGCG
TTAGGAATGACGGTTGCCGATGCAATGGAAGCATACAATACGGATCCGGCAATGGGTCAGCCGGGTTTAATCAAACCTAA
CTTCTAA

Upstream 100 bases:

>100_bases
AATCGTTAATTTGTATCAAATTGATAGTTTTACAAAAAAACTCCAATCAATAACAATAATTCCATAAACAAAATCTATTA
ACCATTAAAGGTAAATTACT

Downstream 100 bases:

>100_bases
TCGGAAGTCACTGAATTAGCAAATGCGGCTGTTTCAAAAACCAACACGAGAAATCGTAAAATAGTCCTCCTACATAATGG
CATTTGCTCTATTAAAGCCC

Product: catalase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSKCPFHHTSLTMNNGAPVVDNQNSMTAGPRGPLLAQDLWLNEKLANFVREVIPERRMHAKGSGAFGKFTVTHDITQYTK
AAIFSEVGKETELFARFTTVAGERGAADAERDIRGFAVKFYTEQGNWDFVGNNTPVFFLRDPRKFPDLNKAVKRDPRTNM
RSATNNWDFWTLLPEAFHQVTIVMSERGIPASYRHMHGYGSHTYSLINANNERFWVKFHFRTEQGIKNLTNEEAAAIIAN
DRESHQRDLYESIEKGDFPKWKLYIQVMPEAEAEQVDFHPFDLTKIWSKKDYPLIEVGVMELNRNPANFFADVEQSAFAP
SNLVPGISVSPDRMLQARLFNYADAQRYRLGVNHHQIPVNAPRCPVHSNARDGQSRVDGNYGSTLHYEPNSFGQWQEQAQ
FAEPPLKINGDAAFWDYRQDDSDYFSQPRALFNLMTEKEKQSLFKNTAEGMGDALDFIKYRHIRNCYFCDPAYGEGVAKA
LGMTVADAMEAYNTDPAMGQPGLIKPNF

Sequences:

>Translated_508_residues
MSKCPFHHTSLTMNNGAPVVDNQNSMTAGPRGPLLAQDLWLNEKLANFVREVIPERRMHAKGSGAFGKFTVTHDITQYTK
AAIFSEVGKETELFARFTTVAGERGAADAERDIRGFAVKFYTEQGNWDFVGNNTPVFFLRDPRKFPDLNKAVKRDPRTNM
RSATNNWDFWTLLPEAFHQVTIVMSERGIPASYRHMHGYGSHTYSLINANNERFWVKFHFRTEQGIKNLTNEEAAAIIAN
DRESHQRDLYESIEKGDFPKWKLYIQVMPEAEAEQVDFHPFDLTKIWSKKDYPLIEVGVMELNRNPANFFADVEQSAFAP
SNLVPGISVSPDRMLQARLFNYADAQRYRLGVNHHQIPVNAPRCPVHSNARDGQSRVDGNYGSTLHYEPNSFGQWQEQAQ
FAEPPLKINGDAAFWDYRQDDSDYFSQPRALFNLMTEKEKQSLFKNTAEGMGDALDFIKYRHIRNCYFCDPAYGEGVAKA
LGMTVADAMEAYNTDPAMGQPGLIKPNF
>Mature_507_residues
SKCPFHHTSLTMNNGAPVVDNQNSMTAGPRGPLLAQDLWLNEKLANFVREVIPERRMHAKGSGAFGKFTVTHDITQYTKA
AIFSEVGKETELFARFTTVAGERGAADAERDIRGFAVKFYTEQGNWDFVGNNTPVFFLRDPRKFPDLNKAVKRDPRTNMR
SATNNWDFWTLLPEAFHQVTIVMSERGIPASYRHMHGYGSHTYSLINANNERFWVKFHFRTEQGIKNLTNEEAAAIIAND
RESHQRDLYESIEKGDFPKWKLYIQVMPEAEAEQVDFHPFDLTKIWSKKDYPLIEVGVMELNRNPANFFADVEQSAFAPS
NLVPGISVSPDRMLQARLFNYADAQRYRLGVNHHQIPVNAPRCPVHSNARDGQSRVDGNYGSTLHYEPNSFGQWQEQAQF
AEPPLKINGDAAFWDYRQDDSDYFSQPRALFNLMTEKEKQSLFKNTAEGMGDALDFIKYRHIRNCYFCDPAYGEGVAKAL
GMTVADAMEAYNTDPAMGQPGLIKPNF

Specific function: Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide [H]

COG id: COG0753

COG function: function code P; Catalase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the catalase family [H]

Homologues:

Organism=Homo sapiens, GI4557014, Length=473, Percent_Identity=50.3171247357294, Blast_Score=482, Evalue=1e-136,
Organism=Escherichia coli, GI48994891, Length=513, Percent_Identity=40.5458089668616, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71998444, Length=473, Percent_Identity=47.9915433403806, Blast_Score=453, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI25151141, Length=473, Percent_Identity=46.0887949260042, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI25147792, Length=473, Percent_Identity=45.877378435518, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6320462, Length=451, Percent_Identity=48.5587583148559, Blast_Score=393, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6321525, Length=362, Percent_Identity=41.9889502762431, Blast_Score=297, Evalue=3e-81,
Organism=Drosophila melanogaster, GI17981717, Length=479, Percent_Identity=47.3903966597077, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI19920968, Length=478, Percent_Identity=44.5606694560669, Blast_Score=414, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002226
- InterPro:   IPR020835
- InterPro:   IPR010582
- InterPro:   IPR018028
- InterPro:   IPR011614 [H]

Pfam domain/function: PF00199 Catalase; PF06628 Catalase-rel [H]

EC number: =1.11.1.6 [H]

Molecular weight: Translated: 57871; Mature: 57740

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00437 CATALASE_1 ; PS00438 CATALASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKCPFHHTSLTMNNGAPVVDNQNSMTAGPRGPLLAQDLWLNEKLANFVREVIPERRMHA
CCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCC
KGSGAFGKFTVTHDITQYTKAAIFSEVGKETELFARFTTVAGERGAADAERDIRGFAVKF
CCCCCCEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHCCCEEEEEE
YTEQGNWDFVGNNTPVFFLRDPRKFPDLNKAVKRDPRTNMRSATNNWDFWTLLPEAFHQV
EEECCCEEEECCCCCEEEEECCCCCCCHHHHHHCCCCCCHHCCCCCCCEEEECHHHHCEE
TIVMSERGIPASYRHMHGYGSHTYSLINANNERFWVKFHFRTEQGIKNLTNEEAAAIIAN
EEEEECCCCCHHHHHHCCCCCCEEEEEECCCCEEEEEEEEECHHHHHHCCCCCCEEEEEC
DRESHQRDLYESIEKGDFPKWKLYIQVMPEAEAEQVDFHPFDLTKIWSKKDYPLIEVGVM
CCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCEEEEEEE
ELNRNPANFFADVEQSAFAPSNLVPGISVSPDRMLQARLFNYADAQRYRLGVNHHQIPVN
EECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHEECCCCCCCCCC
APRCPVHSNARDGQSRVDGNYGSTLHYEPNSFGQWQEQAQFAEPPLKINGDAAFWDYRQD
CCCCCCCCCCCCCHHHCCCCCCCEEEECCCCCCCHHHHHHHCCCCEEECCCEEEECCCCC
DSDYFSQPRALFNLMTEKEKQSLFKNTAEGMGDALDFIKYRHIRNCYFCDPAYGEGVAKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHH
LGMTVADAMEAYNTDPAMGQPGLIKPNF
HHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKCPFHHTSLTMNNGAPVVDNQNSMTAGPRGPLLAQDLWLNEKLANFVREVIPERRMHA
CCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCC
KGSGAFGKFTVTHDITQYTKAAIFSEVGKETELFARFTTVAGERGAADAERDIRGFAVKF
CCCCCCEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHCCCEEEEEE
YTEQGNWDFVGNNTPVFFLRDPRKFPDLNKAVKRDPRTNMRSATNNWDFWTLLPEAFHQV
EEECCCEEEECCCCCEEEEECCCCCCCHHHHHHCCCCCCHHCCCCCCCEEEECHHHHCEE
TIVMSERGIPASYRHMHGYGSHTYSLINANNERFWVKFHFRTEQGIKNLTNEEAAAIIAN
EEEEECCCCCHHHHHHCCCCCCEEEEEECCCCEEEEEEEEECHHHHHHCCCCCCEEEEEC
DRESHQRDLYESIEKGDFPKWKLYIQVMPEAEAEQVDFHPFDLTKIWSKKDYPLIEVGVM
CCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCEEEEEEE
ELNRNPANFFADVEQSAFAPSNLVPGISVSPDRMLQARLFNYADAQRYRLGVNHHQIPVN
EECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHEECCCCCCCCCC
APRCPVHSNARDGQSRVDGNYGSTLHYEPNSFGQWQEQAQFAEPPLKINGDAAFWDYRQD
CCCCCCCCCCCCCHHHCCCCCCCEEEECCCCCCCHHHHHHHCCCCEEECCCEEEECCCCC
DSDYFSQPRALFNLMTEKEKQSLFKNTAEGMGDALDFIKYRHIRNCYFCDPAYGEGVAKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHH
LGMTVADAMEAYNTDPAMGQPGLIKPNF
HHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8188593; 7542800 [H]