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The map label for this gene is hemN [H]

Identifier: 126208437

GI number: 126208437

Start: 1116207

End: 1117574

Strand: Reverse

Name: hemN [H]

Synonym: APL_0963

Alternate gene names: 126208437

Gene position: 1117574-1116207 (Counterclockwise)

Preceding gene: 126208438

Following gene: 126208436

Centisome position: 49.14

GC content: 40.13

Gene sequence:

>1368_bases
ATGTCAGAAATTATTTGGGATTTAGCCCTTATCCAAAAATATAACCAATCCGGTCCTCGTTATACTTCTTATCCTACCGC
ATTAGAATTTAACGAAAATTACAACGATGACGATTTTAAAGCGGCGGCGGCACGTTATCCGAATCGCCCGTTATCGCTTT
ACGTACATATCCCGTTTTGCCATAAACTATGTTATTTCTGTGCGTGTAATAAAATCATTACCCGTCACCGTCATAAAGTG
GATATTTATTTGGATTATCTTGAAAAAGAAATCAAAACGCGCGCACCGCTGTTCACTAATCGTGTCGTTACTCAAATTCA
CTGGGGCGGTGGTACGCCGACTTATTTGGATGAAGCGCAATCGGCACGCTTAATGAGTATGTTGCGTCAGCATTTTAACG
TCAGTGCAGAAGCGGAAATCAGTATTGAAATGGATCCGCGCGAAATCGAATTAAATATGTTGGATCACCTTAAATCCATC
GGTTTTAACCGTATCAGTATGGGGATTCAGGACTTCAATAAAGAAGTACAAAAATTAGTTAATCGCGAGCAAGACGAAGA
ATTTATTTTTGCTTTGATGAAACGCGCGAAGGAACTCGGTTTCACTTCAACCAATATCGATTTGATTTACGGCTTACCGA
AACAAAATGTCGAAAGTTTTATGTACACGCTTGAACGAGTGATCGAATTGAATCCGGATCGGATGAGTGTGTTTAACTAT
GCGCATTTACCAAGCCGCTTTGCCGCACAAATTAAAATTAAAGACGATATGTTACCGGCTCCGGAAACTAAATTAACCAT
TCTGCAGAAGACTATCGAGTTTTTAGGCGGTAACGGCTATAAATTTATTGGTATGGATCACTTTGCCAAACCGGATGACG
AATTGGCGATTGCTCAGCAACAGGGCGTATTACATCGCAACTTCCAAGGTTATACCACTCAAGAAGAATGCGATTTATTA
GGTATGGGCGTGTCGGCAATCAGCCTACTTGGCGATACCTACGCACAAAACCATAAAGAATTACAACAGTATTATGCCAA
TGTCGAAGAACGCGGTATCGCGTTACATAAAGGTTTGGCGCTTACTCAAGACGATTGTATTCGTCGTGACGTAATCAAAG
CGTTGATTTGCAACTTTAAGTTGGAATTCGACCGCTTACAAGCCGAATATCAAATAGATTTTAAACAGTATTTTGCAGAG
GATTTGGCGTTACTTGAGCCGTTGGCGAAAGACGGTTTATTAGAGATTAACGAAAACGGTATTGTGGTTTCGCCTAGAGG
TCGTCTGCTCATTCGTAATATTTGTTTATGTTTTGACGTATATTCAAGACAATTGGCGAAAAGACAACAATTTTCGAGAA
TTATTTAA

Upstream 100 bases:

>100_bases
TGGAAGAGCAGATTAAAGCGGAGTGCCATCAGTTACTGATTGATATAGCACAGTTAAAACTTACATTATAGTAAGTAATG
CCTATTTTGAAGGAAAGTCA

Downstream 100 bases:

>100_bases
GAGCAAGCGGTCATATTTTCGAACCATTTATAGCTTTCTATTGACAAGGAATCATTATGAAAACACGTTATAGTGTTCTT
TCTGTTGCAATGACGGCAGC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSEIIWDLALIQKYNQSGPRYTSYPTALEFNENYNDDDFKAAAARYPNRPLSLYVHIPFCHKLCYFCACNKIITRHRHKV
DIYLDYLEKEIKTRAPLFTNRVVTQIHWGGGTPTYLDEAQSARLMSMLRQHFNVSAEAEISIEMDPREIELNMLDHLKSI
GFNRISMGIQDFNKEVQKLVNREQDEEFIFALMKRAKELGFTSTNIDLIYGLPKQNVESFMYTLERVIELNPDRMSVFNY
AHLPSRFAAQIKIKDDMLPAPETKLTILQKTIEFLGGNGYKFIGMDHFAKPDDELAIAQQQGVLHRNFQGYTTQEECDLL
GMGVSAISLLGDTYAQNHKELQQYYANVEERGIALHKGLALTQDDCIRRDVIKALICNFKLEFDRLQAEYQIDFKQYFAE
DLALLEPLAKDGLLEINENGIVVSPRGRLLIRNICLCFDVYSRQLAKRQQFSRII

Sequences:

>Translated_455_residues
MSEIIWDLALIQKYNQSGPRYTSYPTALEFNENYNDDDFKAAAARYPNRPLSLYVHIPFCHKLCYFCACNKIITRHRHKV
DIYLDYLEKEIKTRAPLFTNRVVTQIHWGGGTPTYLDEAQSARLMSMLRQHFNVSAEAEISIEMDPREIELNMLDHLKSI
GFNRISMGIQDFNKEVQKLVNREQDEEFIFALMKRAKELGFTSTNIDLIYGLPKQNVESFMYTLERVIELNPDRMSVFNY
AHLPSRFAAQIKIKDDMLPAPETKLTILQKTIEFLGGNGYKFIGMDHFAKPDDELAIAQQQGVLHRNFQGYTTQEECDLL
GMGVSAISLLGDTYAQNHKELQQYYANVEERGIALHKGLALTQDDCIRRDVIKALICNFKLEFDRLQAEYQIDFKQYFAE
DLALLEPLAKDGLLEINENGIVVSPRGRLLIRNICLCFDVYSRQLAKRQQFSRII
>Mature_454_residues
SEIIWDLALIQKYNQSGPRYTSYPTALEFNENYNDDDFKAAAARYPNRPLSLYVHIPFCHKLCYFCACNKIITRHRHKVD
IYLDYLEKEIKTRAPLFTNRVVTQIHWGGGTPTYLDEAQSARLMSMLRQHFNVSAEAEISIEMDPREIELNMLDHLKSIG
FNRISMGIQDFNKEVQKLVNREQDEEFIFALMKRAKELGFTSTNIDLIYGLPKQNVESFMYTLERVIELNPDRMSVFNYA
HLPSRFAAQIKIKDDMLPAPETKLTILQKTIEFLGGNGYKFIGMDHFAKPDDELAIAQQQGVLHRNFQGYTTQEECDLLG
MGVSAISLLGDTYAQNHKELQQYYANVEERGIALHKGLALTQDDCIRRDVIKALICNFKLEFDRLQAEYQIDFKQYFAED
LALLEPLAKDGLLEINENGIVVSPRGRLLIRNICLCFDVYSRQLAKRQQFSRII

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=245, Percent_Identity=25.7142857142857, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI87082341, Length=455, Percent_Identity=70.5494505494506, Blast_Score=695, Evalue=0.0,
Organism=Escherichia coli, GI1789325, Length=242, Percent_Identity=30.5785123966942, Blast_Score=125, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 52689; Mature: 52558

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIIWDLALIQKYNQSGPRYTSYPTALEFNENYNDDDFKAAAARYPNRPLSLYVHIPFC
CCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCEEEEEECHHH
HKLCYFCACNKIITRHRHKVDIYLDYLEKEIKTRAPLFTNRVVTQIHWGGGTPTYLDEAQ
HHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCHHHCCEEEEEECCCCCCHHHHHHH
SARLMSMLRQHFNVSAEAEISIEMDPREIELNMLDHLKSIGFNRISMGIQDFNKEVQKLV
HHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
NREQDEEFIFALMKRAKELGFTSTNIDLIYGLPKQNVESFMYTLERVIELNPDRMSVFNY
CCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
AHLPSRFAAQIKIKDDMLPAPETKLTILQKTIEFLGGNGYKFIGMDHFAKPDDELAIAQQ
HHCCCHHEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHH
QGVLHRNFQGYTTQEECDLLGMGVSAISLLGDTYAQNHKELQQYYANVEERGIALHKGLA
CCHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCEEHHCCCC
LTQDDCIRRDVIKALICNFKLEFDRLQAEYQIDFKQYFAEDLALLEPLAKDGLLEINENG
CCHHHHHHHHHHHHHHHHCCEEHHHHHHHHEECHHHHHHHHHHHHHHHHCCCCEEECCCC
IVVSPRGRLLIRNICLCFDVYSRQLAKRQQFSRII
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEIIWDLALIQKYNQSGPRYTSYPTALEFNENYNDDDFKAAAARYPNRPLSLYVHIPFC
CHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCEEEEEECHHH
HKLCYFCACNKIITRHRHKVDIYLDYLEKEIKTRAPLFTNRVVTQIHWGGGTPTYLDEAQ
HHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCHHHCCEEEEEECCCCCCHHHHHHH
SARLMSMLRQHFNVSAEAEISIEMDPREIELNMLDHLKSIGFNRISMGIQDFNKEVQKLV
HHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
NREQDEEFIFALMKRAKELGFTSTNIDLIYGLPKQNVESFMYTLERVIELNPDRMSVFNY
CCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
AHLPSRFAAQIKIKDDMLPAPETKLTILQKTIEFLGGNGYKFIGMDHFAKPDDELAIAQQ
HHCCCHHEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHH
QGVLHRNFQGYTTQEECDLLGMGVSAISLLGDTYAQNHKELQQYYANVEERGIALHKGLA
CCHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCEEHHCCCC
LTQDDCIRRDVIKALICNFKLEFDRLQAEYQIDFKQYFAEDLALLEPLAKDGLLEINENG
CCHHHHHHHHHHHHHHHHCCEEHHHHHHHHEECHHHHHHHHHHHHHHHHCCCCEEECCCC
IVVSPRGRLLIRNICLCFDVYSRQLAKRQQFSRII
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7768836; 8346018; 9278503 [H]