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The map label for this gene is apxIIB [H]

Identifier: 126208431

GI number: 126208431

Start: 1094981

End: 1095553

Strand: Reverse

Name: apxIIB [H]

Synonym: APL_0955

Alternate gene names: 126208431

Gene position: 1095553-1094981 (Counterclockwise)

Preceding gene: 126208432

Following gene: 126208430

Centisome position: 48.17

GC content: 29.84

Gene sequence:

>573_bases
ATGGAACCCAATAAAAATAAGGATCTTGGTTTAGCTGCACTTAAAATTCTTGCTCAATATCATAATATTTCAGTCAATCC
CGAAGAATTAAAACATAAATTTGATCTAGATGGAAAAGGTTTGTCTTTAACATCATGGTTAATCGCAGCAAAATCATTAG
ATTTAAAAGCAAAGGCTATTAATAAAGCCGTTGAGCGTTTACCTTTTGTTAATTTACCTGCACTTATCTGGAGGGAAGAT
GGAAAACATTTTATCTTAGTAAAGATGGATAAAGATAAAAAACGCTATTTAACCTATAACTTAGAGGATGATGCGCCTAA
AATTTTGGAGGAAAGCGAGTTTACTAATTTATACCAAAATAAAATTATTTTAATGACCTCTAGAGCATCTATTATTGGTC
AACTTGCAAAATTTGATTTTACTTGGTTTATTCCTGCTGTCATTAAATATAGGAAAATTTTTATTGAAACCTTGATCGTT
TCTGTTTTTTTACAAATTTTCCGGTATTATGTAGCAGTTGCACAAAGATTTAATTTAGTGTTTCTGCTACATTTTTTCTT
GCTCTCATTGTAA

Upstream 100 bases:

>100_bases
GTCTCGAATAATATTCAATTAGCTAGAGCCGCTTAATATTCAAATCATAGCAATCCTATGGTGTAAATTATAGGATTGTT
ATTTTTTTAAAGGAGAAGTT

Downstream 100 bases:

>100_bases
TTTAAAGGTAAGAAAAAATGAATGCATTAGAAAAGTTATTAATGGAAGAAATTTCACTCGCAGAACAAGAAAGAAATGAA
TGTGAAGCAAAGATAAAGGG

Product: leukotoxin translocation ATP-binding protein LktB (apxIIB)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MEPNKNKDLGLAALKILAQYHNISVNPEELKHKFDLDGKGLSLTSWLIAAKSLDLKAKAINKAVERLPFVNLPALIWRED
GKHFILVKMDKDKKRYLTYNLEDDAPKILEESEFTNLYQNKIILMTSRASIIGQLAKFDFTWFIPAVIKYRKIFIETLIV
SVFLQIFRYYVAVAQRFNLVFLLHFFLLSL

Sequences:

>Translated_190_residues
MEPNKNKDLGLAALKILAQYHNISVNPEELKHKFDLDGKGLSLTSWLIAAKSLDLKAKAINKAVERLPFVNLPALIWRED
GKHFILVKMDKDKKRYLTYNLEDDAPKILEESEFTNLYQNKIILMTSRASIIGQLAKFDFTWFIPAVIKYRKIFIETLIV
SVFLQIFRYYVAVAQRFNLVFLLHFFLLSL
>Mature_190_residues
MEPNKNKDLGLAALKILAQYHNISVNPEELKHKFDLDGKGLSLTSWLIAAKSLDLKAKAINKAVERLPFVNLPALIWRED
GKHFILVKMDKDKKRYLTYNLEDDAPKILEESEFTNLYQNKIILMTSRASIIGQLAKFDFTWFIPAVIKYRKIFIETLIV
SVFLQIFRYYVAVAQRFNLVFLLHFFLLSL

Specific function: Part of the ABC transporter complex LktBD involved in leukotoxin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable) [H]

COG id: COG2274

COG function: function code V; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 peptidase C39 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593
- InterPro:   IPR010132
- InterPro:   IPR005074 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran; PF03412 Peptidase_C39 [H]

EC number: =3.6.3.43 [H]

Molecular weight: Translated: 22123; Mature: 22123

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: PS50990 PEPTIDASE_C39

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPNKNKDLGLAALKILAQYHNISVNPEELKHKFDLDGKGLSLTSWLIAAKSLDLKAKAI
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHH
NKAVERLPFVNLPALIWREDGKHFILVKMDKDKKRYLTYNLEDDAPKILEESEFTNLYQN
HHHHHHCCCCCCCCEEEECCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHC
KIILMTSRASIIGQLAKFDFTWFIPAVIKYRKIFIETLIVSVFLQIFRYYVAVAQRFNLV
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLLHFFLLSL
HHHHHHHHCC
>Mature Secondary Structure
MEPNKNKDLGLAALKILAQYHNISVNPEELKHKFDLDGKGLSLTSWLIAAKSLDLKAKAI
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHH
NKAVERLPFVNLPALIWREDGKHFILVKMDKDKKRYLTYNLEDDAPKILEESEFTNLYQN
HHHHHHCCCCCCCCEEEECCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHC
KIILMTSRASIIGQLAKFDFTWFIPAVIKYRKIFIETLIVSVFLQIFRYYVAVAQRFNLV
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLLHFFLLSL
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11741868 [H]