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The map label for this gene is truC [H]

Identifier: 126208338

GI number: 126208338

Start: 1002696

End: 1003439

Strand: Direct

Name: truC [H]

Synonym: APL_0862

Alternate gene names: 126208338

Gene position: 1002696-1003439 (Clockwise)

Preceding gene: 126208337

Following gene: 126208339

Centisome position: 44.08

GC content: 41.8

Gene sequence:

>744_bases
ATGGAACTTGAGATTTTATATCGTGATGATGAACTGATTGCGATTAATAAACCGGCGGGAATGTTAGTTCACCGATCATG
GCTAGATAAACACGAAACGCAATTTGCGATGCAAACATTACGTGATCAAATCGGTCAGCACGTCTTCCCGATTCATCGCT
TAGATCGCCCGACTTCCGGTGTGTTATTGTTTGCGCTAAATAGTGAGATGGCTCGCCTAATGAGCGAACAATTTGAACAA
CACCAACTGAAGAAAGGCTATTTAGCGGTGGTACGAGGTTATCTACTCGACAAAGGCGAGATCGATTATCCGCTAAAAGT
CATTTTAGACAAAATTGCCGATAAGTTTTCGCAGCCGAAAGAAGCGCAGCAAGCGGTCACTTTTTACCAAAATCTTGCAA
GTGTCGAAATGCTTTATCCGGCAGGCAAACACCAAACGGCACGTTACAGTTTGGTTGAATTATTACCGAAAACCGGACGT
AAACACCAATTGCGCCGCCATATGAAGCATCTATTTCATCCGATTATGGGCGATACGAAATATGGTGACTTGCACCAGAA
TCGTACTTTAACCGAAAAAACCGGTTGCGACCGATTAATGCTACATTCGCATTTTTTGAAATTTACGCACCCGAAAACGG
CGCAAAAAATCGAAATTTTTGCACCGCTTGATAAACAATGGCAAAATCTGTTTGCTACTTTTAACTGGAACTTTCCTACA
TTTTTTCAATCTGAACCAAACTAA

Upstream 100 bases:

>100_bases
TTCGATTACGCCTTACTTGGAAGAAGCCCTAAAAGACGAAAGCTATTTAAAAGCAATTCATCAGCCGGTGTTATTGATTG
AATTATTATTAAAGGACTAA

Downstream 100 bases:

>100_bases
TATGGATAACGCATTACTGTCTTTAACGCACGAGCAGCAACAAGCTGCTGTGGAACAAATTCAAGAACTGATGGCGCAAG
GCGTAAGTAGCGGCGAAGCG

Product: tRNA pseudouridine synthase C

Products: NA

Alternate protein names: tRNA pseudouridylate synthase C; tRNA-uridine isomerase C [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MELEILYRDDELIAINKPAGMLVHRSWLDKHETQFAMQTLRDQIGQHVFPIHRLDRPTSGVLLFALNSEMARLMSEQFEQ
HQLKKGYLAVVRGYLLDKGEIDYPLKVILDKIADKFSQPKEAQQAVTFYQNLASVEMLYPAGKHQTARYSLVELLPKTGR
KHQLRRHMKHLFHPIMGDTKYGDLHQNRTLTEKTGCDRLMLHSHFLKFTHPKTAQKIEIFAPLDKQWQNLFATFNWNFPT
FFQSEPN

Sequences:

>Translated_247_residues
MELEILYRDDELIAINKPAGMLVHRSWLDKHETQFAMQTLRDQIGQHVFPIHRLDRPTSGVLLFALNSEMARLMSEQFEQ
HQLKKGYLAVVRGYLLDKGEIDYPLKVILDKIADKFSQPKEAQQAVTFYQNLASVEMLYPAGKHQTARYSLVELLPKTGR
KHQLRRHMKHLFHPIMGDTKYGDLHQNRTLTEKTGCDRLMLHSHFLKFTHPKTAQKIEIFAPLDKQWQNLFATFNWNFPT
FFQSEPN
>Mature_247_residues
MELEILYRDDELIAINKPAGMLVHRSWLDKHETQFAMQTLRDQIGQHVFPIHRLDRPTSGVLLFALNSEMARLMSEQFEQ
HQLKKGYLAVVRGYLLDKGEIDYPLKVILDKIADKFSQPKEAQQAVTFYQNLASVEMLYPAGKHQTARYSLVELLPKTGR
KHQLRRHMKHLFHPIMGDTKYGDLHQNRTLTEKTGCDRLMLHSHFLKFTHPKTAQKIEIFAPLDKQWQNLFATFNWNFPT
FFQSEPN

Specific function: Responsible for synthesis of pseudouridine from uracil- 65 in transfer RNAs [H]

COG id: COG0564

COG function: function code J; Pseudouridylate synthases, 23S RNA-specific

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pseudouridine synthase rluA family [H]

Homologues:

Organism=Homo sapiens, GI221316667, Length=185, Percent_Identity=36.2162162162162, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI23308689, Length=183, Percent_Identity=28.4153005464481, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI221316663, Length=204, Percent_Identity=33.8235294117647, Blast_Score=78, Evalue=7e-15,
Organism=Escherichia coli, GI1789155, Length=235, Percent_Identity=59.1489361702128, Blast_Score=285, Evalue=1e-78,
Organism=Escherichia coli, GI1787327, Length=230, Percent_Identity=36.5217391304348, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786244, Length=223, Percent_Identity=33.1838565022422, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1788946, Length=258, Percent_Identity=25.968992248062, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17534965, Length=189, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324506, Length=185, Percent_Identity=29.1891891891892, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320168, Length=185, Percent_Identity=30.2702702702703, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6321608, Length=191, Percent_Identity=29.3193717277487, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24583449, Length=188, Percent_Identity=32.4468085106383, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24583447, Length=188, Percent_Identity=32.4468085106383, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24583445, Length=188, Percent_Identity=32.4468085106383, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19921090, Length=180, Percent_Identity=31.1111111111111, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR006224
- InterPro:   IPR006145 [H]

Pfam domain/function: PF00849 PseudoU_synth_2 [H]

EC number: NA

Molecular weight: Translated: 28986; Mature: 28986

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS01129 PSI_RLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELEILYRDDELIAINKPAGMLVHRSWLDKHETQFAMQTLRDQIGQHVFPIHRLDRPTSG
CCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCC
VLLFALNSEMARLMSEQFEQHQLKKGYLAVVRGYLLDKGEIDYPLKVILDKIADKFSQPK
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCH
EAQQAVTFYQNLASVEMLYPAGKHQTARYSLVELLPKTGRKHQLRRHMKHLFHPIMGDTK
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
YGDLHQNRTLTEKTGCDRLMLHSHFLKFTHPKTAQKIEIFAPLDKQWQNLFATFNWNFPT
CCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHEEEECCCCCC
FFQSEPN
CCCCCCC
>Mature Secondary Structure
MELEILYRDDELIAINKPAGMLVHRSWLDKHETQFAMQTLRDQIGQHVFPIHRLDRPTSG
CCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCC
VLLFALNSEMARLMSEQFEQHQLKKGYLAVVRGYLLDKGEIDYPLKVILDKIADKFSQPK
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCH
EAQQAVTFYQNLASVEMLYPAGKHQTARYSLVELLPKTGRKHQLRRHMKHLFHPIMGDTK
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
YGDLHQNRTLTEKTGCDRLMLHSHFLKFTHPKTAQKIEIFAPLDKQWQNLFATFNWNFPT
CCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHEEEECCCCCC
FFQSEPN
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA