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The map label for this gene is aceE [H]

Identifier: 126208251

GI number: 126208251

Start: 887432

End: 890086

Strand: Reverse

Name: aceE [H]

Synonym: APL_0773

Alternate gene names: 126208251

Gene position: 890086-887432 (Counterclockwise)

Preceding gene: 126208252

Following gene: 126208250

Centisome position: 39.13

GC content: 42.75

Gene sequence:

>2655_bases
ATGTCAGAGATCGAAAGAGACGTAGATCCATTCGAAACCAAAGAATGGTTAGAGTCATTAGATTCTTTAATCCGTGTAGA
AGGTGTTGAGCGCGCTCAATATATTATTGACCAATTATTAGATCAAGCTCGTACGGAAGGCGTACCTGTTCAATCAGGCG
TTACAACTGCATATGTGAATACTATCCCTGTAAGCGCACAACCTGCATATCCCGGCGATCATAAAATTGAACGTCGTATC
CGTTCTGCAGTACGTTGGAATGCTATTGCAATGGTTTTACGTAGCCAGAAGAAAGATCTCGACTTAGGTGGTCATATTTC
TACTTTCCAATCAGCGGCAACGATGTATGAAGTGTGCTATAACCACTTCTTCAAAGCGGCGACTGAAAAAAACGGCGGTG
ACTTAGTATTTTTCCAAGGTCACGCCGCGCCGGGTATGTATGCTCGTGCTTATGTTGAAGGTCGTTTAACGGAAGAGCAA
TTAGATAACTTCCGTCAAGAAGCGTTTACCGACGGTTTATCTTCATATCCTCACCCGAAATTAATGCCCGAATTTTGGCA
ATTCTCAACCGTATCAATGGGTTTAGGTCCCGTTAATGCGATTTACCAAGCGCGTTTCTTAAAATATCTTGAAAACCGCG
GTTTAAAAGATACCGCTGATCAAAAAGTATATGCGTTCTTAGGCGACGGCGAGATGGATGAAATCGAGTCTAAAGGTGCA
TTAACTTTCGCAGCGCGTGAAAAATTAGATAACTTAATTTTCACAGTAAGCTGTAACTTACAACGTTTAGACGGTCCGGT
AAACGGTAACGGTAAAATCATTCAAGAATTAGAAGGTTTATTTACTGGTGCGGGCTGGGAAGTAATTAAAGTATTATGGG
GCGGTAACTGGGATAAATTATTCGCAAAAGATACCTCTGGTAAATTAGCGCAATTAATGATGGAAGTGGTTGATGGCGAC
TACTTAACCTTCAAATCGAAAGACGGTGCTTATATCCGTGAACACTTCTTCGGTCGTTACCCTGAAACAGCCGCATTAGT
TGCGGATATGACCGATGATGAGATTTGGGATCTTCGCCGTGGTGCGCACGACAGTGAAAAACTTTATGCCGCATATGCGA
AAGCACAAAAATCAGACAAACCGGTTGTGATTTTAGCGCACCAAGTTAAAGGTTATAAAATTCCTGAAGCGGAAAGTAAA
AATACCGCTCACCAATCGAAAAAAATGTCATTAGAAAGCTTAAAAGGCTTCCGTGACTACTTCGAATTACCATTGACGGA
TGAACAAGTAGAAAGCTTAGAGTACATCAAGTTTGCCGAAGGTTCTGAAGAATACAACTACATTCACGGTCACCGTAAAG
CATTAAACGGTTATGTGCCGGCTCGTCGTGCCAAATTCGACGTAGAGTATAAAGTCCCTGCATTAGATGAATTTAAAGCA
TTACTTGCAGAACAACCACGTGGTATTTCAACCACAATGGCGTTTACACGTGCATTAAATATCTTATTAAAAGATAAAAA
TATCGGTAAAACCATCGTTCCGATGATCGTGGACGAAGCGCGTACATTCGGTATGGAAGGTTTATTCCGTCAAGTGGGTA
TTTACAACCCGCACGGTCAAAACTATACCCCTTCAGACCGTGATTTAGTGGCTTACTACCGTGAAGCGAAAGACGGTCAA
GTATTACAAGAAGGTATCAACGAATTAGGTGGTGCGGCATCTTGGGTGGCTGCGGCGACTTCTTACTCCGTAAGTAACCA
ACCGATGATCCCGTTCTTCATCTATTACTCAATGTTCGGTTTCCAACGTGTGGGCGATATGATGTGGTTGGCAGGTGACC
AATTAGCGCGCGGTTTCATGGTCGGCGGTACTTCAGGTCGTACAACGTTAAACGGTGAAGGCTTACAACACGAAGACGGT
CACAGCCATATCCAAGCGGGTATTATTCCTAACTGTGTAACTTATGATCCATCATTTGCGTTTGAAGTAGCGGTAATTAT
GCAAGACGGTATTAACCGTATGTATGGTGAAAAACAAGAAAATGTTTTCTACTATATGACAACATTAAACGAAGTAATGG
AGCAGCCTGCAATGCCTGAAGGTGCAGAAGAGGGTATCCGTAAAGGTTTATATAAATTTGAAACGGTTAAAGGTAAAGGT
AAAGGTAACGTTCAGTTATTAGGCTCAGGTTCTATTATGCGTCACGTTCGTGAAGCAGCACAGATCCTTGCGAATGACTA
CGGCGTAACTTCAGATGTATTCTCAGCTCCGTCATTTAACGAGCTAGCTCGTGAAGGTAACGATGCAGTACGTTGGAACT
TATTACACCCGACAGCAGAACAACGCATTCCTTATGTAGCGCAAGTATTAGCGGACTTACCGACAGTCGCTTCAACCGAC
TATGTAAAACAATATGCGGATCAAATTCGTGCATTCGTACCAAGCAAACACTATCACGTGTTAGGTACGGACGGTTTCGG
TCGTTCGGACAGCCGTGCGAACTTACGTGAGCATTTCGAAGTAGATGCGCGTTATGTTGTTGTTGCAGCATTATCACAAT
TAGCGAAAGAAGGCACGGTAGAAACGAAAGTTGTTGCTGATGCAATCGCTAAATTCGGCTTAAACGTAGATCGTATTAAC
CCGTTATACGCATAA

Upstream 100 bases:

>100_bases
TTATGTCATGCTTGCCAATGGGACGTCTATAATTTCATCAATCGATAAGTTTAAGATACTTAGCTTATCATTCATCATTA
AATCAAAATAAGGAAAACCT

Downstream 100 bases:

>100_bases
GAAAATAGCATTCTCCCCCTTATGGGGGAGAATAATTTATCAAATGAAGGATTACCAAAATGTCAAAACAAATTAATGTG
CCAGACATCGGTTCGGATGA

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 884; Mature: 883

Protein sequence:

>884_residues
MSEIERDVDPFETKEWLESLDSLIRVEGVERAQYIIDQLLDQARTEGVPVQSGVTTAYVNTIPVSAQPAYPGDHKIERRI
RSAVRWNAIAMVLRSQKKDLDLGGHISTFQSAATMYEVCYNHFFKAATEKNGGDLVFFQGHAAPGMYARAYVEGRLTEEQ
LDNFRQEAFTDGLSSYPHPKLMPEFWQFSTVSMGLGPVNAIYQARFLKYLENRGLKDTADQKVYAFLGDGEMDEIESKGA
LTFAAREKLDNLIFTVSCNLQRLDGPVNGNGKIIQELEGLFTGAGWEVIKVLWGGNWDKLFAKDTSGKLAQLMMEVVDGD
YLTFKSKDGAYIREHFFGRYPETAALVADMTDDEIWDLRRGAHDSEKLYAAYAKAQKSDKPVVILAHQVKGYKIPEAESK
NTAHQSKKMSLESLKGFRDYFELPLTDEQVESLEYIKFAEGSEEYNYIHGHRKALNGYVPARRAKFDVEYKVPALDEFKA
LLAEQPRGISTTMAFTRALNILLKDKNIGKTIVPMIVDEARTFGMEGLFRQVGIYNPHGQNYTPSDRDLVAYYREAKDGQ
VLQEGINELGGAASWVAAATSYSVSNQPMIPFFIYYSMFGFQRVGDMMWLAGDQLARGFMVGGTSGRTTLNGEGLQHEDG
HSHIQAGIIPNCVTYDPSFAFEVAVIMQDGINRMYGEKQENVFYYMTTLNEVMEQPAMPEGAEEGIRKGLYKFETVKGKG
KGNVQLLGSGSIMRHVREAAQILANDYGVTSDVFSAPSFNELAREGNDAVRWNLLHPTAEQRIPYVAQVLADLPTVASTD
YVKQYADQIRAFVPSKHYHVLGTDGFGRSDSRANLREHFEVDARYVVVAALSQLAKEGTVETKVVADAIAKFGLNVDRIN
PLYA

Sequences:

>Translated_884_residues
MSEIERDVDPFETKEWLESLDSLIRVEGVERAQYIIDQLLDQARTEGVPVQSGVTTAYVNTIPVSAQPAYPGDHKIERRI
RSAVRWNAIAMVLRSQKKDLDLGGHISTFQSAATMYEVCYNHFFKAATEKNGGDLVFFQGHAAPGMYARAYVEGRLTEEQ
LDNFRQEAFTDGLSSYPHPKLMPEFWQFSTVSMGLGPVNAIYQARFLKYLENRGLKDTADQKVYAFLGDGEMDEIESKGA
LTFAAREKLDNLIFTVSCNLQRLDGPVNGNGKIIQELEGLFTGAGWEVIKVLWGGNWDKLFAKDTSGKLAQLMMEVVDGD
YLTFKSKDGAYIREHFFGRYPETAALVADMTDDEIWDLRRGAHDSEKLYAAYAKAQKSDKPVVILAHQVKGYKIPEAESK
NTAHQSKKMSLESLKGFRDYFELPLTDEQVESLEYIKFAEGSEEYNYIHGHRKALNGYVPARRAKFDVEYKVPALDEFKA
LLAEQPRGISTTMAFTRALNILLKDKNIGKTIVPMIVDEARTFGMEGLFRQVGIYNPHGQNYTPSDRDLVAYYREAKDGQ
VLQEGINELGGAASWVAAATSYSVSNQPMIPFFIYYSMFGFQRVGDMMWLAGDQLARGFMVGGTSGRTTLNGEGLQHEDG
HSHIQAGIIPNCVTYDPSFAFEVAVIMQDGINRMYGEKQENVFYYMTTLNEVMEQPAMPEGAEEGIRKGLYKFETVKGKG
KGNVQLLGSGSIMRHVREAAQILANDYGVTSDVFSAPSFNELAREGNDAVRWNLLHPTAEQRIPYVAQVLADLPTVASTD
YVKQYADQIRAFVPSKHYHVLGTDGFGRSDSRANLREHFEVDARYVVVAALSQLAKEGTVETKVVADAIAKFGLNVDRIN
PLYA
>Mature_883_residues
SEIERDVDPFETKEWLESLDSLIRVEGVERAQYIIDQLLDQARTEGVPVQSGVTTAYVNTIPVSAQPAYPGDHKIERRIR
SAVRWNAIAMVLRSQKKDLDLGGHISTFQSAATMYEVCYNHFFKAATEKNGGDLVFFQGHAAPGMYARAYVEGRLTEEQL
DNFRQEAFTDGLSSYPHPKLMPEFWQFSTVSMGLGPVNAIYQARFLKYLENRGLKDTADQKVYAFLGDGEMDEIESKGAL
TFAAREKLDNLIFTVSCNLQRLDGPVNGNGKIIQELEGLFTGAGWEVIKVLWGGNWDKLFAKDTSGKLAQLMMEVVDGDY
LTFKSKDGAYIREHFFGRYPETAALVADMTDDEIWDLRRGAHDSEKLYAAYAKAQKSDKPVVILAHQVKGYKIPEAESKN
TAHQSKKMSLESLKGFRDYFELPLTDEQVESLEYIKFAEGSEEYNYIHGHRKALNGYVPARRAKFDVEYKVPALDEFKAL
LAEQPRGISTTMAFTRALNILLKDKNIGKTIVPMIVDEARTFGMEGLFRQVGIYNPHGQNYTPSDRDLVAYYREAKDGQV
LQEGINELGGAASWVAAATSYSVSNQPMIPFFIYYSMFGFQRVGDMMWLAGDQLARGFMVGGTSGRTTLNGEGLQHEDGH
SHIQAGIIPNCVTYDPSFAFEVAVIMQDGINRMYGEKQENVFYYMTTLNEVMEQPAMPEGAEEGIRKGLYKFETVKGKGK
GNVQLLGSGSIMRHVREAAQILANDYGVTSDVFSAPSFNELAREGNDAVRWNLLHPTAEQRIPYVAQVLADLPTVASTDY
VKQYADQIRAFVPSKHYHVLGTDGFGRSDSRANLREHFEVDARYVVVAALSQLAKEGTVETKVVADAIAKFGLNVDRINP
LYA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=888, Percent_Identity=67.9054054054054, Blast_Score=1301, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 98920; Mature: 98789

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIERDVDPFETKEWLESLDSLIRVEGVERAQYIIDQLLDQARTEGVPVQSGVTTAYVN
CCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
TIPVSAQPAYPGDHKIERRIRSAVRWNAIAMVLRSQKKDLDLGGHISTFQSAATMYEVCY
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
NHFFKAATEKNGGDLVFFQGHAAPGMYARAYVEGRLTEEQLDNFRQEAFTDGLSSYPHPK
HHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCC
LMPEFWQFSTVSMGLGPVNAIYQARFLKYLENRGLKDTADQKVYAFLGDGEMDEIESKGA
CCHHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHCCCC
LTFAAREKLDNLIFTVSCNLQRLDGPVNGNGKIIQELEGLFTGAGWEVIKVLWGGNWDKL
EEHHHHHHHCCEEEEEEECCEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCHHHE
FAKDTSGKLAQLMMEVVDGDYLTFKSKDGAYIREHFFGRYPETAALVADMTDDEIWDLRR
EECCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCCHHHHEECCCCHHHHHHHC
GAHDSEKLYAAYAKAQKSDKPVVILAHQVKGYKIPEAESKNTAHQSKKMSLESLKGFRDY
CCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FELPLTDEQVESLEYIKFAEGSEEYNYIHGHRKALNGYVPARRAKFDVEYKVPALDEFKA
HCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHH
LLAEQPRGISTTMAFTRALNILLKDKNIGKTIVPMIVDEARTFGMEGLFRQVGIYNPHGQ
HHHCCCCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCC
NYTPSDRDLVAYYREAKDGQVLQEGINELGGAASWVAAATSYSVSNQPMIPFFIYYSMFG
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
FQRVGDMMWLAGDQLARGFMVGGTSGRTTLNGEGLQHEDGHSHIQAGIIPNCVTYDPSFA
HHHHHHHHHHCCHHHHCCEEEECCCCCEEECCCCCCCCCCCCCEECCCCCCCEECCCCHH
FEVAVIMQDGINRMYGEKQENVFYYMTTLNEVMEQPAMPEGAEEGIRKGLYKFETVKGKG
HHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEECCCC
KGNVQLLGSGSIMRHVREAAQILANDYGVTSDVFSAPSFNELAREGNDAVRWNLLHPTAE
CCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHCCCCEEEEEEECCCHH
QRIPYVAQVLADLPTVASTDYVKQYADQIRAFVPSKHYHVLGTDGFGRSDSRANLREHFE
HCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHH
VDARYVVVAALSQLAKEGTVETKVVADAIAKFGLNVDRINPLYA
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure 
SEIERDVDPFETKEWLESLDSLIRVEGVERAQYIIDQLLDQARTEGVPVQSGVTTAYVN
CCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
TIPVSAQPAYPGDHKIERRIRSAVRWNAIAMVLRSQKKDLDLGGHISTFQSAATMYEVCY
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
NHFFKAATEKNGGDLVFFQGHAAPGMYARAYVEGRLTEEQLDNFRQEAFTDGLSSYPHPK
HHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCC
LMPEFWQFSTVSMGLGPVNAIYQARFLKYLENRGLKDTADQKVYAFLGDGEMDEIESKGA
CCHHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHCCCC
LTFAAREKLDNLIFTVSCNLQRLDGPVNGNGKIIQELEGLFTGAGWEVIKVLWGGNWDKL
EEHHHHHHHCCEEEEEEECCEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCHHHE
FAKDTSGKLAQLMMEVVDGDYLTFKSKDGAYIREHFFGRYPETAALVADMTDDEIWDLRR
EECCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCCHHHHEECCCCHHHHHHHC
GAHDSEKLYAAYAKAQKSDKPVVILAHQVKGYKIPEAESKNTAHQSKKMSLESLKGFRDY
CCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FELPLTDEQVESLEYIKFAEGSEEYNYIHGHRKALNGYVPARRAKFDVEYKVPALDEFKA
HCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHH
LLAEQPRGISTTMAFTRALNILLKDKNIGKTIVPMIVDEARTFGMEGLFRQVGIYNPHGQ
HHHCCCCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCC
NYTPSDRDLVAYYREAKDGQVLQEGINELGGAASWVAAATSYSVSNQPMIPFFIYYSMFG
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
FQRVGDMMWLAGDQLARGFMVGGTSGRTTLNGEGLQHEDGHSHIQAGIIPNCVTYDPSFA
HHHHHHHHHHCCHHHHCCEEEECCCCCEEECCCCCCCCCCCCCEECCCCCCCEECCCCHH
FEVAVIMQDGINRMYGEKQENVFYYMTTLNEVMEQPAMPEGAEEGIRKGLYKFETVKGKG
HHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEECCCC
KGNVQLLGSGSIMRHVREAAQILANDYGVTSDVFSAPSFNELAREGNDAVRWNLLHPTAE
CCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHCCCCEEEEEEECCCHH
QRIPYVAQVLADLPTVASTDYVKQYADQIRAFVPSKHYHVLGTDGFGRSDSRANLREHFE
HCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHH
VDARYVVVAALSQLAKEGTVETKVVADAIAKFGLNVDRINPLYA
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]