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The map label for this gene is apaH

Identifier: 126208238

GI number: 126208238

Start: 869917

End: 870729

Strand: Direct

Name: apaH

Synonym: APL_0760

Alternate gene names: 126208238

Gene position: 869917-870729 (Clockwise)

Preceding gene: 126208237

Following gene: 126208240

Centisome position: 38.25

GC content: 42.68

Gene sequence:

>813_bases
ATGGCGACTTATATTGTTGGCGATTTACACGGCTGTTTTGATGAGTTACAACTGCTGCTCAAACAAGTTAATTACAATCC
GGCACAAGACGAATTGTGGCTGACCGGCGATTTAGTTGCCCGAGGTGCAAAATCGTTGGAATGTTTGCGCTTTGTGAAAG
ATCCGAAAAATAATGCAAAAACTATTTTAGGTAATCACGATCTTCACTTGCTCGCCACTTTACTCGGTGTCAAAAAAGTG
AAGCCTAATGATCAAGTGGATGCGATTTTCGCTGCTGAAGATCGCGCTGATTTGCAAAATTGGCTGAGAAATCAACCGCT
TCTTATTCAACATCCGAAGTATGGCTTCTTATTGACTCACGCCGGTATCAGCCCCGAATGGAACTTAACGGAAACCATCG
CTTGTGCCAGAGAAGCGGAAGCCGTTTTGCAAAGTGGTCATTATGCCGACTACATTGCCCAAATGTACGAAAACACACCG
GATCACTGGTCTGCCGAATGGCAAGGTATCGAACGTTGGCGATATATTATCAACGTATTTACCCGTATGCGTTTTTGCTA
TGCCGACAAGCGGTTGGATTTTGCTTGTAAATTACCTGTTGAAGACGCACCAAACGAATTAAAACCTTGGTTTAAATTAG
ATAATCCGTTATTTCATCAACAAGACATTATTTTCGGTCATTGGGCAAGTTTAATGGGTAAAGCGGATAAACCGAATATC
TACGCCTTAGACACCGGCTGTGCTTGGGGTAACCATCTCACCATGATCCGATGGGAAGATAAACAAATTTTCACCCAAGA
ACGCTTAAAATAA

Upstream 100 bases:

>100_bases
TTTAGTGATCTGCGGTTTGCTTTCTTCATTTATTGCACCGCTGATTTTTCAGTTAGCGGTAAAATGGTTTATGTGATTTT
TTATAACTTGAGAGGATATG

Downstream 100 bases:

>100_bases
AATCAAACGGAATACGGGGTCTTGCTATCCTCCGCATTTTCGATTAGAATTCTTCCCATCTATGCGACTATAGCTCAGTT
GGTTAGAGCACCACCTTGAC

Product: diadenosine tetraphosphatase

Products: NA

Alternate protein names: Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase; Diadenosine tetraphosphatase

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MATYIVGDLHGCFDELQLLLKQVNYNPAQDELWLTGDLVARGAKSLECLRFVKDPKNNAKTILGNHDLHLLATLLGVKKV
KPNDQVDAIFAAEDRADLQNWLRNQPLLIQHPKYGFLLTHAGISPEWNLTETIACAREAEAVLQSGHYADYIAQMYENTP
DHWSAEWQGIERWRYIINVFTRMRFCYADKRLDFACKLPVEDAPNELKPWFKLDNPLFHQQDIIFGHWASLMGKADKPNI
YALDTGCAWGNHLTMIRWEDKQIFTQERLK

Sequences:

>Translated_270_residues
MATYIVGDLHGCFDELQLLLKQVNYNPAQDELWLTGDLVARGAKSLECLRFVKDPKNNAKTILGNHDLHLLATLLGVKKV
KPNDQVDAIFAAEDRADLQNWLRNQPLLIQHPKYGFLLTHAGISPEWNLTETIACAREAEAVLQSGHYADYIAQMYENTP
DHWSAEWQGIERWRYIINVFTRMRFCYADKRLDFACKLPVEDAPNELKPWFKLDNPLFHQQDIIFGHWASLMGKADKPNI
YALDTGCAWGNHLTMIRWEDKQIFTQERLK
>Mature_269_residues
ATYIVGDLHGCFDELQLLLKQVNYNPAQDELWLTGDLVARGAKSLECLRFVKDPKNNAKTILGNHDLHLLATLLGVKKVK
PNDQVDAIFAAEDRADLQNWLRNQPLLIQHPKYGFLLTHAGISPEWNLTETIACAREAEAVLQSGHYADYIAQMYENTPD
HWSAEWQGIERWRYIINVFTRMRFCYADKRLDFACKLPVEDAPNELKPWFKLDNPLFHQQDIIFGHWASLMGKADKPNIY
ALDTGCAWGNHLTMIRWEDKQIFTQERLK

Specific function: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Ap4A hydrolase family

Homologues:

Organism=Escherichia coli, GI1786234, Length=266, Percent_Identity=50.7518796992481, Blast_Score=292, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APAH_ACTP2 (A3N0C2)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053463.1
- ProteinModelPortal:   A3N0C2
- SMR:   A3N0C2
- STRING:   A3N0C2
- GeneID:   4849814
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0760
- eggNOG:   COG0639
- HOGENOM:   HBG724457
- OMA:   LVFGHWA
- PhylomeDB:   A3N0C2
- ProtClustDB:   PRK00166
- BioCyc:   APLE416269:APL_0760-MONOMER
- HAMAP:   MF_00199
- InterPro:   IPR004617
- InterPro:   IPR004843
- InterPro:   IPR006186
- PANTHER:   PTHR11668
- PIRSF:   PIRSF000903
- TIGRFAMs:   TIGR00668

Pfam domain/function: PF00149 Metallophos

EC number: =3.6.1.41

Molecular weight: Translated: 31224; Mature: 31093

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATYIVGDLHGCFDELQLLLKQVNYNPAQDELWLTGDLVARGAKSLECLRFVKDPKNNAK
CCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHCCHHHHHHHHHHHCCCCCCC
TILGNHDLHLLATLLGVKKVKPNDQVDAIFAAEDRADLQNWLRNQPLLIQHPKYGFLLTH
EEECCCCHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHCCCCEEEECCCCCEEEEE
AGISPEWNLTETIACAREAEAVLQSGHYADYIAQMYENTPDHWSAEWQGIERWRYIINVF
CCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
TRMRFCYADKRLDFACKLPVEDAPNELKPWFKLDNPLFHQQDIIFGHWASLMGKADKPNI
HHHHHHHHCCCCCEEEECCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHCCCCCCCCE
YALDTGCAWGNHLTMIRWEDKQIFTQERLK
EEEECCCCCCCCEEEEEECCHHHHHHHHCC
>Mature Secondary Structure 
ATYIVGDLHGCFDELQLLLKQVNYNPAQDELWLTGDLVARGAKSLECLRFVKDPKNNAK
CEEEEEHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHCCHHHHHHHHHHHCCCCCCC
TILGNHDLHLLATLLGVKKVKPNDQVDAIFAAEDRADLQNWLRNQPLLIQHPKYGFLLTH
EEECCCCHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHCCCCEEEECCCCCEEEEE
AGISPEWNLTETIACAREAEAVLQSGHYADYIAQMYENTPDHWSAEWQGIERWRYIINVF
CCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
TRMRFCYADKRLDFACKLPVEDAPNELKPWFKLDNPLFHQQDIIFGHWASLMGKADKPNI
HHHHHHHHCCCCCEEEECCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHCCCCCCCCE
YALDTGCAWGNHLTMIRWEDKQIFTQERLK
EEEECCCCCCCCEEEEEECCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA