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The map label for this gene is pepP [H]

Identifier: 126208143

GI number: 126208143

Start: 757061

End: 758347

Strand: Reverse

Name: pepP [H]

Synonym: APL_0663

Alternate gene names: 126208143

Gene position: 758347-757061 (Counterclockwise)

Preceding gene: 126208144

Following gene: 126208138

Centisome position: 33.34

GC content: 43.2

Gene sequence:

>1287_bases
ATGGATCTTGCCTATTTAGCTGAATTGCCGAGAGAAGAATTTGTTGAGCGTAGAAATCGTGTGTTTGAGCAAATGCAGGA
TAATTCTGCGTTGGTGGTGTTTACCGAAACTGAGAAACGCCGTAATAGCGATTGCGATTATTTGTTCCGACCTGATAGTT
ATTTCTGGTATTTAACCGGTTTTGCCGAGCCGAAATCGGCGTTGTTGCTGATTAAAAAAGACGGCAAAAATGAGAGCGTG
ATTTTTGTGCGTAAAAAAGATCCGCTAATGGAAACGTGGAACGGCCGCCGTTTGGGGATTGAAAAAGCGCCTGAAACTTT
GAATGTGGATTCAGCATTTGCTATTGAGGACATTTCTCGTGTTTTTGCAGAAAAAACGCAAAATCTGACCACTTGTTATT
ATGCCAAAGGCTTACAGGAATGGGGCGATAGTGTGGTGGCGGAGCAGTTTGCTGACGTGATTGACTGGCAGTCGATATTG
TCGGAAATGCGGTTGATTAAATCAACGGCAGAAATTGCGTTGATTCAACAAGCCTGCCATATTTCAGCGTTGGCACATAT
TCGTGCGATGAAGCAAACCCGCCCAAATCGTTATGAATTAGAAATTGAGGGCGAAATTCAGCACGAATTTACTCGTTTTG
GGGCAAGATTCCCGGCTTATAATTCGATTGTAGCAAGCGGTGAAAATGCCTGTATTTTGCACTACAATGAAAATGATCAG
GTACTAAAAGACGGTGATTTATTGCTGATTGATGCCGGGGCGGAATTTGCTCACTATGCCGGCGATATTACTCGAACCTT
CCCGATTAACGGTAAATTTTCTGAACCGCAACGAGAGATTTATCAGCTCGTGTTGGACGCAATGAAAGAAGCGGCTAAAT
GGTTAATACCACAAAGCTCGATCAAAATTGCCAATGAAAAAGTAGTGCAGGTGCTGACTGAAGGCTTGGTTCGTTTAGGC
ATTTTACAGGGCGAAGTAGAGCAGTTAATCGCTGAGAAAGCCTATCGTCAATTTTATATGCACGGTTTAGGGCATTGGCT
GGGGCTAGATGTTCACGATGTGGGCAATTATGGTACGGAGCGAGATCGACCGCTTGAAATCGGTATGGTACTAACCCTTG
AGCCAGGGCTATACATTTCAAGTGAGGCGAACGTGCCGGATCAATATAAAGGCATTGGTGTGCGTATTGAGGATAATTTA
TTAATTACCGAATATGGTAATAAAAATCTGACAAGCGGCTGCCCGAAAGAAATTGCTGATATTGAAGCAATTATGAATGT
TCAATAG

Upstream 100 bases:

>100_bases
ACTGACTTTTTCTTTTTTATGTGGTGGCTTTGTGAAATTTGCGAGAAATCAGACCGCTTGCTTGTGTTAGAATAAATAGA
CATTTGAAGAGGAGAATCGT

Downstream 100 bases:

>100_bases
ATAGGAAAGATTCAATAACCACAGAACGCACGGAATACACAGAAATTTTTCGTATAATGTAAAAACTGTGGTTTTTTATT
ACCTAAAGCTATACATAAAA

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MDLAYLAELPREEFVERRNRVFEQMQDNSALVVFTETEKRRNSDCDYLFRPDSYFWYLTGFAEPKSALLLIKKDGKNESV
IFVRKKDPLMETWNGRRLGIEKAPETLNVDSAFAIEDISRVFAEKTQNLTTCYYAKGLQEWGDSVVAEQFADVIDWQSIL
SEMRLIKSTAEIALIQQACHISALAHIRAMKQTRPNRYELEIEGEIQHEFTRFGARFPAYNSIVASGENACILHYNENDQ
VLKDGDLLLIDAGAEFAHYAGDITRTFPINGKFSEPQREIYQLVLDAMKEAAKWLIPQSSIKIANEKVVQVLTEGLVRLG
ILQGEVEQLIAEKAYRQFYMHGLGHWLGLDVHDVGNYGTERDRPLEIGMVLTLEPGLYISSEANVPDQYKGIGVRIEDNL
LITEYGNKNLTSGCPKEIADIEAIMNVQ

Sequences:

>Translated_428_residues
MDLAYLAELPREEFVERRNRVFEQMQDNSALVVFTETEKRRNSDCDYLFRPDSYFWYLTGFAEPKSALLLIKKDGKNESV
IFVRKKDPLMETWNGRRLGIEKAPETLNVDSAFAIEDISRVFAEKTQNLTTCYYAKGLQEWGDSVVAEQFADVIDWQSIL
SEMRLIKSTAEIALIQQACHISALAHIRAMKQTRPNRYELEIEGEIQHEFTRFGARFPAYNSIVASGENACILHYNENDQ
VLKDGDLLLIDAGAEFAHYAGDITRTFPINGKFSEPQREIYQLVLDAMKEAAKWLIPQSSIKIANEKVVQVLTEGLVRLG
ILQGEVEQLIAEKAYRQFYMHGLGHWLGLDVHDVGNYGTERDRPLEIGMVLTLEPGLYISSEANVPDQYKGIGVRIEDNL
LITEYGNKNLTSGCPKEIADIEAIMNVQ
>Mature_428_residues
MDLAYLAELPREEFVERRNRVFEQMQDNSALVVFTETEKRRNSDCDYLFRPDSYFWYLTGFAEPKSALLLIKKDGKNESV
IFVRKKDPLMETWNGRRLGIEKAPETLNVDSAFAIEDISRVFAEKTQNLTTCYYAKGLQEWGDSVVAEQFADVIDWQSIL
SEMRLIKSTAEIALIQQACHISALAHIRAMKQTRPNRYELEIEGEIQHEFTRFGARFPAYNSIVASGENACILHYNENDQ
VLKDGDLLLIDAGAEFAHYAGDITRTFPINGKFSEPQREIYQLVLDAMKEAAKWLIPQSSIKIANEKVVQVLTEGLVRLG
ILQGEVEQLIAEKAYRQFYMHGLGHWLGLDVHDVGNYGTERDRPLEIGMVLTLEPGLYISSEANVPDQYKGIGVRIEDNL
LITEYGNKNLTSGCPKEIADIEAIMNVQ

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=442, Percent_Identity=31.9004524886878, Blast_Score=242, Evalue=5e-64,
Organism=Homo sapiens, GI149589008, Length=468, Percent_Identity=30.982905982906, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI260593663, Length=459, Percent_Identity=29.8474945533769, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI260593665, Length=299, Percent_Identity=34.7826086956522, Blast_Score=162, Evalue=4e-40,
Organism=Escherichia coli, GI1789275, Length=435, Percent_Identity=50.3448275862069, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI1788728, Length=278, Percent_Identity=28.4172661870504, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790282, Length=300, Percent_Identity=28.3333333333333, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17508215, Length=474, Percent_Identity=32.7004219409283, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71989583, Length=358, Percent_Identity=23.463687150838, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320922, Length=439, Percent_Identity=30.751708428246, Blast_Score=199, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6321118, Length=422, Percent_Identity=31.9905213270142, Blast_Score=192, Evalue=7e-50,
Organism=Drosophila melanogaster, GI21357079, Length=459, Percent_Identity=34.640522875817, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI19920384, Length=418, Percent_Identity=33.4928229665072, Blast_Score=216, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 48718; Mature: 48718

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLAYLAELPREEFVERRNRVFEQMQDNSALVVFTETEKRRNSDCDYLFRPDSYFWYLTG
CCHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCCEEECCCCEEEEEEE
FAEPKSALLLIKKDGKNESVIFVRKKDPLMETWNGRRLGIEKAPETLNVDSAFAIEDISR
CCCCCCEEEEEEECCCCCCEEEEECCCCHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHH
VFAEKTQNLTTCYYAKGLQEWGDSVVAEQFADVIDWQSILSEMRLIKSTAEIALIQQACH
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISALAHIRAMKQTRPNRYELEIEGEIQHEFTRFGARFPAYNSIVASGENACILHYNENDQ
HHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCHHHEECCCCEEEEEECCCCC
VLKDGDLLLIDAGAEFAHYAGDITRTFPINGKFSEPQREIYQLVLDAMKEAAKWLIPQSS
EEECCCEEEEECCCHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
IKIANEKVVQVLTEGLVRLGILQGEVEQLIAEKAYRQFYMHGLGHWLGLDVHDVGNYGTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCC
RDRPLEIGMVLTLEPGLYISSEANVPDQYKGIGVRIEDNLLITEYGNKNLTSGCPKEIAD
CCCCEEEEEEEEECCCEEEECCCCCCHHHCCEEEEEECCEEEEECCCCCCCCCCCHHHHH
IEAIMNVQ
HHHHHCCC
>Mature Secondary Structure
MDLAYLAELPREEFVERRNRVFEQMQDNSALVVFTETEKRRNSDCDYLFRPDSYFWYLTG
CCHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCCEEECCCCEEEEEEE
FAEPKSALLLIKKDGKNESVIFVRKKDPLMETWNGRRLGIEKAPETLNVDSAFAIEDISR
CCCCCCEEEEEEECCCCCCEEEEECCCCHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHH
VFAEKTQNLTTCYYAKGLQEWGDSVVAEQFADVIDWQSILSEMRLIKSTAEIALIQQACH
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISALAHIRAMKQTRPNRYELEIEGEIQHEFTRFGARFPAYNSIVASGENACILHYNENDQ
HHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCHHHEECCCCEEEEEECCCCC
VLKDGDLLLIDAGAEFAHYAGDITRTFPINGKFSEPQREIYQLVLDAMKEAAKWLIPQSS
EEECCCEEEEECCCHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
IKIANEKVVQVLTEGLVRLGILQGEVEQLIAEKAYRQFYMHGLGHWLGLDVHDVGNYGTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCC
RDRPLEIGMVLTLEPGLYISSEANVPDQYKGIGVRIEDNLLITEYGNKNLTSGCPKEIAD
CCCCEEEEEEEEECCCEEEECCCCCCHHHCCEEEEEECCEEEEECCCCCCCCCCCHHHHH
IEAIMNVQ
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]