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The map label for this gene is mazG [H]

Identifier: 126208112

GI number: 126208112

Start: 717629

End: 718228

Strand: Reverse

Name: mazG [H]

Synonym: APL_0630

Alternate gene names: 126208112

Gene position: 718228-717629 (Counterclockwise)

Preceding gene: 126208126

Following gene: 126208111

Centisome position: 31.58

GC content: 40.67

Gene sequence:

>600_bases
ATGGCTACTATCAATCAATTTCTTGAAGTCGTTGCAAAATTACGTGATCCCGAAACGGGCTGTCCGTGGGATATAAAACA
AAATTTCGATTCTATGCTCCCCTGCTTATTAGAAGAAACTTACGAAGTCGCAGAAGCCATTCATACTAAAGATAGAGCCT
CTTTGCGCGAAGAATTAGGCGACTTATTATTACAAGTCGTATTTCTTAGTCAATTGACAAAAGAAGAAGGAACTTTTACT
TTTGACGACGTACTAAATGACATTCATCAAAAATTAATTTACAGACATCCTCATGTATTCGGCGATAAAACCGCTTCAAA
CAGTGAAGAAGCTTTAAAAAACTGGGAAGAACAAAAAGCTGCCGAAACTAAACGCCGACAACAGGAGTCCGTTTTAGATG
ATGTGCCTTTCGCTTTACCGGCATTAACTCGAGCAAATAAACTGCAAAAACGTTGCGCTAAAGTCGGGTTCGATTGGGAT
AATCCGCACGCCGTATTGGCTAAAGTCGAAGAAGAATTGCAAGAGGTCAAAGATGAAATGGCGCAATACCCTCAAAGCGC
AAGGGAAATCCGTACAAGAATGCTCTCTGCACGAACTTGA

Upstream 100 bases:

>100_bases
ATTTTAACAATTTTCTGTAGAAAGTGTGAATTTTTAGTTGAATCTCATCACTAACCTGCCAAAATAAGCGAAATATTATA
TAAATTAACCGGAAAAGTTT

Downstream 100 bases:

>100_bases
TTTTATTTGGGATCAAATAAAATCACTATAATGAATTGACAAACCTTGACAAAGTTGTAAATTATCATAACTATGTCAAT
TAGTTACAGTAATAAACATA

Product: pyrophosphatase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MATINQFLEVVAKLRDPETGCPWDIKQNFDSMLPCLLEETYEVAEAIHTKDRASLREELGDLLLQVVFLSQLTKEEGTFT
FDDVLNDIHQKLIYRHPHVFGDKTASNSEEALKNWEEQKAAETKRRQQESVLDDVPFALPALTRANKLQKRCAKVGFDWD
NPHAVLAKVEEELQEVKDEMAQYPQSAREIRTRMLSART

Sequences:

>Translated_199_residues
MATINQFLEVVAKLRDPETGCPWDIKQNFDSMLPCLLEETYEVAEAIHTKDRASLREELGDLLLQVVFLSQLTKEEGTFT
FDDVLNDIHQKLIYRHPHVFGDKTASNSEEALKNWEEQKAAETKRRQQESVLDDVPFALPALTRANKLQKRCAKVGFDWD
NPHAVLAKVEEELQEVKDEMAQYPQSAREIRTRMLSART
>Mature_198_residues
ATINQFLEVVAKLRDPETGCPWDIKQNFDSMLPCLLEETYEVAEAIHTKDRASLREELGDLLLQVVFLSQLTKEEGTFTF
DDVLNDIHQKLIYRHPHVFGDKTASNSEEALKNWEEQKAAETKRRQQESVLDDVPFALPALTRANKLQKRCAKVGFDWDN
PHAVLAKVEEELQEVKDEMAQYPQSAREIRTRMLSART

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=182, Percent_Identity=52.7472527472528, Blast_Score=195, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 22929; Mature: 22798

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATINQFLEVVAKLRDPETGCPWDIKQNFDSMLPCLLEETYEVAEAIHTKDRASLREELG
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLLLQVVFLSQLTKEEGTFTFDDVLNDIHQKLIYRHPHVFGDKTASNSEEALKNWEEQKA
HHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
AETKRRQQESVLDDVPFALPALTRANKLQKRCAKVGFDWDNPHAVLAKVEEELQEVKDEM
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
AQYPQSAREIRTRMLSART
HHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATINQFLEVVAKLRDPETGCPWDIKQNFDSMLPCLLEETYEVAEAIHTKDRASLREELG
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLLLQVVFLSQLTKEEGTFTFDDVLNDIHQKLIYRHPHVFGDKTASNSEEALKNWEEQKA
HHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
AETKRRQQESVLDDVPFALPALTRANKLQKRCAKVGFDWDNPHAVLAKVEEELQEVKDEM
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
AQYPQSAREIRTRMLSART
HHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]