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The map label for this gene is cpxR [H]

Identifier: 126208111

GI number: 126208111

Start: 716776

End: 717504

Strand: Reverse

Name: cpxR [H]

Synonym: APL_0629

Alternate gene names: 126208111

Gene position: 717504-716776 (Counterclockwise)

Preceding gene: 126208112

Following gene: 126208110

Centisome position: 31.55

GC content: 38.96

Gene sequence:

>729_bases
ATGCCTAGAATTTTACTCGTTGATGACGATATTGAACTGACGGAACTGTTAGCCGAATTACTTTCGCTGGAAGGTTTCGA
GATTCATTGTGTGCATAACGGTCAAGATGCACTTACGGAATTAGAATTACAAAGTTATGATCTTATCCTTTTAGATGTGA
TGATGCCGGTATTAAACGGTATTGAAACCTTAAAACAATTACGTCAAAAACACTCTACGCCGGTATTGATGTTAAGCGCC
AGAGACGATGAAATTGATCGCGTCCTCGGTTTAGAATTAGGCGCAGACGATTATTTACCTAAACCTTTTAACGATCGCGA
ACTAGTTGCTCGTATTAAAGCTATTTTACGTCGTACGACATCCAATATTTTATCAAATCCCGATGTCATTACTTATTCCA
ACCAGTCTCCGGAAAAAAATAGCAAACAACTTTCATTCGGCGGTGTCGAATTGCATCCGGGTCGCCAACAAGCGATTTTT
GAAGGTCGAGATTTAGATCTGACCGGTACGGAATTTGCATTACTCCAAATGTTAATGCGCAATCCGGGGCAAATTCTTTC
TCGTGAATTATTAAGTTTAGAAATTTTAGGCAAACGCCTTACCCCTTACGATCGTGCTATTGATATGCATATTTCTAATC
TTCGTAAAAAATTACCGGAACGAAACGATAACTTGCCTTGGTTTAAAACGTTACGCGGTCGAGGTTATTTACTCGTTACT
GAAAAATAA

Upstream 100 bases:

>100_bases
ACTATAATGAATTGACAAACCTTGACAAAGTTGTAAATTATCATAACTATGTCAATTAGTTACAGTAATAAACATAATTA
AATAAAAATAGGAATTATTT

Downstream 100 bases:

>100_bases
GTCCTTTTCTTTGAAATCCCTCGCTTATCGAGGGATTTTCTTTTTAAATTAAGTGTAAAAATTCATGTCTAAATATATTG
CTTATATCTTAAGTAAGATT

Product: transcriptional regulatory protein CpxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MPRILLVDDDIELTELLAELLSLEGFEIHCVHNGQDALTELELQSYDLILLDVMMPVLNGIETLKQLRQKHSTPVLMLSA
RDDEIDRVLGLELGADDYLPKPFNDRELVARIKAILRRTTSNILSNPDVITYSNQSPEKNSKQLSFGGVELHPGRQQAIF
EGRDLDLTGTEFALLQMLMRNPGQILSRELLSLEILGKRLTPYDRAIDMHISNLRKKLPERNDNLPWFKTLRGRGYLLVT
EK

Sequences:

>Translated_242_residues
MPRILLVDDDIELTELLAELLSLEGFEIHCVHNGQDALTELELQSYDLILLDVMMPVLNGIETLKQLRQKHSTPVLMLSA
RDDEIDRVLGLELGADDYLPKPFNDRELVARIKAILRRTTSNILSNPDVITYSNQSPEKNSKQLSFGGVELHPGRQQAIF
EGRDLDLTGTEFALLQMLMRNPGQILSRELLSLEILGKRLTPYDRAIDMHISNLRKKLPERNDNLPWFKTLRGRGYLLVT
EK
>Mature_241_residues
PRILLVDDDIELTELLAELLSLEGFEIHCVHNGQDALTELELQSYDLILLDVMMPVLNGIETLKQLRQKHSTPVLMLSAR
DDEIDRVLGLELGADDYLPKPFNDRELVARIKAILRRTTSNILSNPDVITYSNQSPEKNSKQLSFGGVELHPGRQQAIFE
GRDLDLTGTEFALLQMLMRNPGQILSRELLSLEILGKRLTPYDRAIDMHISNLRKKLPERNDNLPWFKTLRGRGYLLVTE
K

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=240, Percent_Identity=60.8333333333333, Blast_Score=272, Evalue=2e-74,
Organism=Escherichia coli, GI1789809, Length=240, Percent_Identity=35.8333333333333, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1788394, Length=236, Percent_Identity=36.4406779661017, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1790860, Length=236, Percent_Identity=37.2881355932203, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1786599, Length=242, Percent_Identity=37.1900826446281, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1789402, Length=237, Percent_Identity=35.8649789029536, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1790552, Length=241, Percent_Identity=36.9294605809129, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1790863, Length=236, Percent_Identity=31.7796610169492, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI87082012, Length=242, Percent_Identity=34.297520661157, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1787229, Length=244, Percent_Identity=32.7868852459016, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1786784, Length=238, Percent_Identity=32.3529411764706, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786911, Length=236, Percent_Identity=30.9322033898305, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI145693140, Length=243, Percent_Identity=28.8065843621399, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787375, Length=237, Percent_Identity=26.1603375527426, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=39.2523364485981, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=35.1351351351351, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790437, Length=127, Percent_Identity=36.2204724409449, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27623; Mature: 27492

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRILLVDDDIELTELLAELLSLEGFEIHCVHNGQDALTELELQSYDLILLDVMMPVLNG
CCEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHH
IETLKQLRQKHSTPVLMLSARDDEIDRVLGLELGADDYLPKPFNDRELVARIKAILRRTT
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHHHHH
SNILSNPDVITYSNQSPEKNSKQLSFGGVELHPGRQQAIFEGRDLDLTGTEFALLQMLMR
HHHHCCCCEEEECCCCCCCCCCEEECCCEEECCCCHHHHCCCCCCCCCCHHHHHHHHHHH
NPGQILSRELLSLEILGKRLTPYDRAIDMHISNLRKKLPERNDNLPWFKTLRGRGYLLVT
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEEEEE
EK
CC
>Mature Secondary Structure 
PRILLVDDDIELTELLAELLSLEGFEIHCVHNGQDALTELELQSYDLILLDVMMPVLNG
CEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHH
IETLKQLRQKHSTPVLMLSARDDEIDRVLGLELGADDYLPKPFNDRELVARIKAILRRTT
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHHHHH
SNILSNPDVITYSNQSPEKNSKQLSFGGVELHPGRQQAIFEGRDLDLTGTEFALLQMLMR
HHHHCCCCEEEECCCCCCCCCCEEECCCEEECCCCHHHHCCCCCCCCCCHHHHHHHHHHH
NPGQILSRELLSLEILGKRLTPYDRAIDMHISNLRKKLPERNDNLPWFKTLRGRGYLLVT
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEEEEE
EK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]