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The map label for this gene is cpxA [H]

Identifier: 126208109

GI number: 126208109

Start: 715311

End: 716195

Strand: Reverse

Name: cpxA [H]

Synonym: APL_0627

Alternate gene names: 126208109

Gene position: 716195-715311 (Counterclockwise)

Preceding gene: 126208110

Following gene: 126208108

Centisome position: 31.49

GC content: 40.45

Gene sequence:

>885_bases
ATGTTATTGATCGTGCTAGGGGTAAGTATTCCTATTCTATTATGGCTGTCATGGAAAATCTCTCGTCCGGTAAAAGCGCT
TCGTCTGTCGGCCAATGCGGTGGCTACCGGTAACTTTGCTATAAACCCCGCTTTAGAAACGGAAGGCATTAACGAGTTGC
GTGAAGTGGGAAAAAGTTTTAACCAAATGATCACTTCATTACAAGATTTAACCTTACACCAACAACGTTTAGTATCGGAT
ATTTCGCATGAACTGAAAACGCCGCTTGCACGCTTGCATTTGGCAACCGCATTAATTCGTCGCCGTAACGGTGAATCGCC
GGAATTAACTCGGATCGAAAATCAAATCCAAAAATTGGATACCATGGTTCATGATTTATTAGTTCTCTCGCGACAACAAG
TCAATCAGCATTTGACCCGCGAAATTTTCTCTATCAATAAAATTTGGGACGATTTGTTGGAAGATGCGAAATTCGATGCC
GAGCAAAATCATCTTGATTTATTTATTAGTCAGCGAATAACGCATCCTGAAAATTTCTTTATTAACGGTAACCAAAATAT
TTTGGCAAGTGCCATGGAAAATGTTATTCGTAATGCACAAAAATATGCCAAGAAAAGCATTAAGGTTCTGACTTATATTG
ATAATACGGATTTAATTATTGCGATTGATGATGATGGCAAAGGCATTCCCGAAACGGAATATCAACAAATATTCCGTCCT
TTCTATCGTGTCGATGAAGCTCGTGACCGTCAAACCGGCGGTACGGGGCTAGGGCTTGCTATCGTGGCGAATGCGGTTCA
ACAGCATAAAGGTAGCGTACAAGCGATGAAAAGTCCGTTAGGCGGCTTAAGAATTGAAATTAAGTTACCTTTATGGATTG
AATAA

Upstream 100 bases:

>100_bases
TTTAGTAAAATCCAGTAAAAGGGAATATTTCCAATATTTCGCCCAGTCCGTTGATCCTCAAGAAGAACTGTTCAATCAAA
TTTTTGATTCGCCGTGGCTA

Downstream 100 bases:

>100_bases
ATTAGCAAGCGGTTTATTTTGCAAAAAATTAAGCAAAAATGACCGCTTGTTTCTACTCTAATAACCTTTCTTTATATATT
TAAATACATAATCTATTACG

Product: two-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MLLIVLGVSIPILLWLSWKISRPVKALRLSANAVATGNFAINPALETEGINELREVGKSFNQMITSLQDLTLHQQRLVSD
ISHELKTPLARLHLATALIRRRNGESPELTRIENQIQKLDTMVHDLLVLSRQQVNQHLTREIFSINKIWDDLLEDAKFDA
EQNHLDLFISQRITHPENFFINGNQNILASAMENVIRNAQKYAKKSIKVLTYIDNTDLIIAIDDDGKGIPETEYQQIFRP
FYRVDEARDRQTGGTGLGLAIVANAVQQHKGSVQAMKSPLGGLRIEIKLPLWIE

Sequences:

>Translated_294_residues
MLLIVLGVSIPILLWLSWKISRPVKALRLSANAVATGNFAINPALETEGINELREVGKSFNQMITSLQDLTLHQQRLVSD
ISHELKTPLARLHLATALIRRRNGESPELTRIENQIQKLDTMVHDLLVLSRQQVNQHLTREIFSINKIWDDLLEDAKFDA
EQNHLDLFISQRITHPENFFINGNQNILASAMENVIRNAQKYAKKSIKVLTYIDNTDLIIAIDDDGKGIPETEYQQIFRP
FYRVDEARDRQTGGTGLGLAIVANAVQQHKGSVQAMKSPLGGLRIEIKLPLWIE
>Mature_294_residues
MLLIVLGVSIPILLWLSWKISRPVKALRLSANAVATGNFAINPALETEGINELREVGKSFNQMITSLQDLTLHQQRLVSD
ISHELKTPLARLHLATALIRRRNGESPELTRIENQIQKLDTMVHDLLVLSRQQVNQHLTREIFSINKIWDDLLEDAKFDA
EQNHLDLFISQRITHPENFFINGNQNILASAMENVIRNAQKYAKKSIKVLTYIDNTDLIIAIDDDGKGIPETEYQQIFRP
FYRVDEARDRQTGGTGLGLAIVANAVQQHKGSVQAMKSPLGGLRIEIKLPLWIE

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=290, Percent_Identity=50, Blast_Score=275, Evalue=2e-75,
Organism=Escherichia coli, GI1787894, Length=300, Percent_Identity=28, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1789808, Length=293, Percent_Identity=28.6689419795222, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=27.8388278388278, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787374, Length=285, Percent_Identity=28.0701754385965, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1786783, Length=253, Percent_Identity=28.4584980237154, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786600, Length=252, Percent_Identity=26.1904761904762, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1790551, Length=281, Percent_Identity=27.0462633451957, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790861, Length=293, Percent_Identity=24.2320819112628, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI87082128, Length=300, Percent_Identity=23.3333333333333, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=24.5833333333333, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=26.6968325791855, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=26.1261261261261, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1789149, Length=219, Percent_Identity=26.9406392694064, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87081816, Length=340, Percent_Identity=22.0588235294118, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788279, Length=234, Percent_Identity=25.6410256410256, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788549, Length=221, Percent_Identity=24.4343891402715, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 33293; Mature: 33293

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIVLGVSIPILLWLSWKISRPVKALRLSANAVATGNFAINPALETEGINELREVGKSF
CEEEEEHHHHHHHHHHHHHHCCCHHHHHCCCCEEEECCEEECCCCCCCCHHHHHHHHHHH
NQMITSLQDLTLHQQRLVSDISHELKTPLARLHLATALIRRRNGESPELTRIENQIQKLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
TMVHDLLVLSRQQVNQHLTREIFSINKIWDDLLEDAKFDAEQNHLDLFISQRITHPENFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEE
INGNQNILASAMENVIRNAQKYAKKSIKVLTYIDNTDLIIAIDDDGKGIPETEYQQIFRP
EECCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHH
FYRVDEARDRQTGGTGLGLAIVANAVQQHKGSVQAMKSPLGGLRIEIKLPLWIE
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCEEEC
>Mature Secondary Structure
MLLIVLGVSIPILLWLSWKISRPVKALRLSANAVATGNFAINPALETEGINELREVGKSF
CEEEEEHHHHHHHHHHHHHHCCCHHHHHCCCCEEEECCEEECCCCCCCCHHHHHHHHHHH
NQMITSLQDLTLHQQRLVSDISHELKTPLARLHLATALIRRRNGESPELTRIENQIQKLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
TMVHDLLVLSRQQVNQHLTREIFSINKIWDDLLEDAKFDAEQNHLDLFISQRITHPENFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEE
INGNQNILASAMENVIRNAQKYAKKSIKVLTYIDNTDLIIAIDDDGKGIPETEYQQIFRP
EECCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHH
FYRVDEARDRQTGGTGLGLAIVANAVQQHKGSVQAMKSPLGGLRIEIKLPLWIE
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]