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The map label for this gene is guaB [H]

Identifier: 126208075

GI number: 126208075

Start: 677056

End: 678519

Strand: Reverse

Name: guaB [H]

Synonym: APL_0593

Alternate gene names: 126208075

Gene position: 678519-677056 (Counterclockwise)

Preceding gene: 126208081

Following gene: 126208074

Centisome position: 29.83

GC content: 44.81

Gene sequence:

>1464_bases
ATGCTACGTATCAAACAAGAAGCCCTCACATTCGATGATGTTCTTCTAGTCCCTGCACACTCTACCGTGCTTCCGAATAC
CGCAGATCTTTCAACTCAACTTACTAAAGATATTCGTCTTAATATCCCGATGCTTTCGGCGGCGATGGATACCGTTACCG
AAACGAAATTAGCCATTTCTTTAGCACAAGAAGGCGGTATCGGTTTTATCCATAAAAATATGTCGATCGAACGCCAAGCG
GATCGTGTGCGTAAAGTGAAGAAATTCGAAAGCGGTATCGTTTCCGAGCCGGTAACGGTTTCTCCGGATCTTACGCTTGC
CGAGCTTGCGGAATTAGTTAAGAAAAACGGTTTTGCCGGCTATCCAGTAGTGGACAGTGAAAATAATTTAATCGGTATTA
TTACCGGACGTGATACACGTTTTGTAAGAGATTTAACTAAAACGGTTGCTAAAGTAATGACGCCTAAAGAACGTTTAGTC
ACGGTAAAAGAAAGTGCTAATCGTGAAGAAATCCTTGAATTAATGCATCAACATCGCGTTGAAAAAGTATTAATGGTTGA
TGATAACTTCAAACTAAAAGGTATGATCACCGTTAAAGACTTCCAAAAAGCGGAGCAAAAACCGAATGCGTGTAAAGATG
AATTCGGTCGTTTACGTGTCGGCGCAGCGGTTGGTGCAGGTCCGGGTAATGAAGAACGTATTGATGCGTTAGTAAAAGCA
GGAGTGGACGTGTTATTAATCGACTCTTCGCACGGTCATTCTGAAGGCGTATTACAACGTGTCCGTGAAACCCGTGCAAA
ATATCCTAACTTACCGATTGTTGCCGGTAATATCGCAACTGCCGAAGGTGCAATCGCATTAGCGGATGCCGGTGCAAGCG
CGGTAAAAGTCGGTATCGGTCCGGGTTCGATCTGTACTACTCGTATCGTGACCGGCGTAGGTGTACCGCAAATTACTGCA
ATTGCAGAAGCGGCGGCGGCATTAGAAGGTCGTGGTATTCCGGTTATTGCTGACGGTGGTATCCGCTACTCCGGCGATAT
TTCAAAAGCAATCGCAGCGGGCGCAAGCTGTGTTATGGTAGGTTCTATGTTTGCCGGTACCGAAGAAGCACCGGGTGAAA
TCGAACTTTACCAAGGTCGTGCATTTAAATCTTACCGTGGTATGGGTTCATTAGGTGCAATGAGCAAAGGTTCTTCAGAT
CGTTATTTCCAATCGGACAACGCGGCAGATAAATTAGTACCGGAAGGTATCGAAGGCCGTATCCCTTACAAAGGTTTCTT
AAAAGAAATCATCCACCAACAAATGGGGGGATTACGTTCTTGTATGGGCTTAACCGGCTCGGCAACCATTGAAGATCTAA
GAACTAAAGCACAATTCGTACGTATCAGCGGTGCAGGTATCAAAGAAAGCCACGTTCACGATGTAACAATTACTAAAGAA
GCACCTAACTATCGTATGGGTTAA

Upstream 100 bases:

>100_bases
GCCAAAATTCAAATTTACAAAAAAAGGAAACCTCTGTATAATCCGCTCGCAATTTTTCCCATACCTATTTTTTTATTTGA
ATCTCAAAGGAACTATTGCA

Downstream 100 bases:

>100_bases
TCTTGACAAGCGGTCGGATTTTGCCAATTTTTTGCAAAATTTGACCGCTTGATTATTCCTTAAATAATTTAGGTCTGAGA
GTATATAAAATGAAAAAGTT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MLRIKQEALTFDDVLLVPAHSTVLPNTADLSTQLTKDIRLNIPMLSAAMDTVTETKLAISLAQEGGIGFIHKNMSIERQA
DRVRKVKKFESGIVSEPVTVSPDLTLAELAELVKKNGFAGYPVVDSENNLIGIITGRDTRFVRDLTKTVAKVMTPKERLV
TVKESANREEILELMHQHRVEKVLMVDDNFKLKGMITVKDFQKAEQKPNACKDEFGRLRVGAAVGAGPGNEERIDALVKA
GVDVLLIDSSHGHSEGVLQRVRETRAKYPNLPIVAGNIATAEGAIALADAGASAVKVGIGPGSICTTRIVTGVGVPQITA
IAEAAAALEGRGIPVIADGGIRYSGDISKAIAAGASCVMVGSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMSKGSSD
RYFQSDNAADKLVPEGIEGRIPYKGFLKEIIHQQMGGLRSCMGLTGSATIEDLRTKAQFVRISGAGIKESHVHDVTITKE
APNYRMG

Sequences:

>Translated_487_residues
MLRIKQEALTFDDVLLVPAHSTVLPNTADLSTQLTKDIRLNIPMLSAAMDTVTETKLAISLAQEGGIGFIHKNMSIERQA
DRVRKVKKFESGIVSEPVTVSPDLTLAELAELVKKNGFAGYPVVDSENNLIGIITGRDTRFVRDLTKTVAKVMTPKERLV
TVKESANREEILELMHQHRVEKVLMVDDNFKLKGMITVKDFQKAEQKPNACKDEFGRLRVGAAVGAGPGNEERIDALVKA
GVDVLLIDSSHGHSEGVLQRVRETRAKYPNLPIVAGNIATAEGAIALADAGASAVKVGIGPGSICTTRIVTGVGVPQITA
IAEAAAALEGRGIPVIADGGIRYSGDISKAIAAGASCVMVGSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMSKGSSD
RYFQSDNAADKLVPEGIEGRIPYKGFLKEIIHQQMGGLRSCMGLTGSATIEDLRTKAQFVRISGAGIKESHVHDVTITKE
APNYRMG
>Mature_487_residues
MLRIKQEALTFDDVLLVPAHSTVLPNTADLSTQLTKDIRLNIPMLSAAMDTVTETKLAISLAQEGGIGFIHKNMSIERQA
DRVRKVKKFESGIVSEPVTVSPDLTLAELAELVKKNGFAGYPVVDSENNLIGIITGRDTRFVRDLTKTVAKVMTPKERLV
TVKESANREEILELMHQHRVEKVLMVDDNFKLKGMITVKDFQKAEQKPNACKDEFGRLRVGAAVGAGPGNEERIDALVKA
GVDVLLIDSSHGHSEGVLQRVRETRAKYPNLPIVAGNIATAEGAIALADAGASAVKVGIGPGSICTTRIVTGVGVPQITA
IAEAAAALEGRGIPVIADGGIRYSGDISKAIAAGASCVMVGSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMSKGSSD
RYFQSDNAADKLVPEGIEGRIPYKGFLKEIIHQQMGGLRSCMGLTGSATIEDLRTKAQFVRISGAGIKESHVHDVTITKE
APNYRMG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=457, Percent_Identity=39.8249452954048, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI34328928, Length=457, Percent_Identity=39.8249452954048, Blast_Score=322, Evalue=5e-88,
Organism=Homo sapiens, GI156616279, Length=457, Percent_Identity=39.8249452954048, Blast_Score=322, Evalue=5e-88,
Organism=Homo sapiens, GI34328930, Length=457, Percent_Identity=39.8249452954048, Blast_Score=322, Evalue=5e-88,
Organism=Homo sapiens, GI66933016, Length=456, Percent_Identity=39.0350877192982, Blast_Score=318, Evalue=9e-87,
Organism=Homo sapiens, GI217035152, Length=451, Percent_Identity=39.9113082039911, Blast_Score=316, Evalue=4e-86,
Organism=Homo sapiens, GI217035148, Length=457, Percent_Identity=38.7308533916849, Blast_Score=308, Evalue=9e-84,
Organism=Homo sapiens, GI217035150, Length=457, Percent_Identity=36.3238512035011, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=37.8048780487805, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=36.0323886639676, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=36.0323886639676, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=36.0323886639676, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=36.0323886639676, Blast_Score=159, Evalue=8e-39,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=81.9301848049281, Blast_Score=761, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=37.5565610859729, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71994385, Length=496, Percent_Identity=36.2903225806452, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI71994389, Length=419, Percent_Identity=38.9021479713604, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=238, Percent_Identity=36.5546218487395, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323585, Length=460, Percent_Identity=38.9130434782609, Blast_Score=315, Evalue=7e-87,
Organism=Saccharomyces cerevisiae, GI6322012, Length=460, Percent_Identity=38.695652173913, Blast_Score=312, Evalue=7e-86,
Organism=Saccharomyces cerevisiae, GI6323464, Length=444, Percent_Identity=40.7657657657658, Blast_Score=308, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=38.7573964497041, Blast_Score=236, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6319353, Length=103, Percent_Identity=45.6310679611651, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=38.7163561076605, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=38.7163561076605, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=39.0022675736961, Blast_Score=276, Evalue=2e-74,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52050; Mature: 52050

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIKQEALTFDDVLLVPAHSTVLPNTADLSTQLTKDIRLNIPMLSAAMDTVTETKLAIS
CCEECCHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHEEE
LAQEGGIGFIHKNMSIERQADRVRKVKKFESGIVSEPVTVSPDLTLAELAELVKKNGFAG
ECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHCCCCC
YPVVDSENNLIGIITGRDTRFVRDLTKTVAKVMTPKERLVTVKESANREEILELMHQHRV
CCEECCCCCEEEEEECCCHHHHHHHHHHHHHHHCCHHHEEEEHHCCCHHHHHHHHHHHCC
EKVLMVDDNFKLKGMITVKDFQKAEQKPNACKDEFGRLRVGAAVGAGPGNEERIDALVKA
CEEEEECCCEEEEEEEEHHHHHHHHCCCCHHHHHHCCEEEEEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRVRETRAKYPNLPIVAGNIATAEGAIALADAGASAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEECCCCCEEEEECC
PGSICTTRIVTGVGVPQITAIAEAAAALEGRGIPVIADGGIRYSGDISKAIAAGASCVMV
CCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEECCCHHHHHHCCCHHEEE
GSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCC
IPYKGFLKEIIHQQMGGLRSCMGLTGSATIEDLRTKAQFVRISGAGIKESHVHDVTITKE
CCHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCCCCCEEEEEEECC
APNYRMG
CCCCCCC
>Mature Secondary Structure
MLRIKQEALTFDDVLLVPAHSTVLPNTADLSTQLTKDIRLNIPMLSAAMDTVTETKLAIS
CCEECCHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHEEE
LAQEGGIGFIHKNMSIERQADRVRKVKKFESGIVSEPVTVSPDLTLAELAELVKKNGFAG
ECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHCCCCC
YPVVDSENNLIGIITGRDTRFVRDLTKTVAKVMTPKERLVTVKESANREEILELMHQHRV
CCEECCCCCEEEEEECCCHHHHHHHHHHHHHHHCCHHHEEEEHHCCCHHHHHHHHHHHCC
EKVLMVDDNFKLKGMITVKDFQKAEQKPNACKDEFGRLRVGAAVGAGPGNEERIDALVKA
CEEEEECCCEEEEEEEEHHHHHHHHCCCCHHHHHHCCEEEEEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRVRETRAKYPNLPIVAGNIATAEGAIALADAGASAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEECCCCCEEEEECC
PGSICTTRIVTGVGVPQITAIAEAAAALEGRGIPVIADGGIRYSGDISKAIAAGASCVMV
CCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEECCCHHHHHHCCCHHEEE
GSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCC
IPYKGFLKEIIHQQMGGLRSCMGLTGSATIEDLRTKAQFVRISGAGIKESHVHDVTITKE
CCHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCCCCCEEEEEEECC
APNYRMG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]