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The map label for this gene is frr

Identifier: 126208052

GI number: 126208052

Start: 643158

End: 643715

Strand: Direct

Name: frr

Synonym: APL_0570

Alternate gene names: 126208052

Gene position: 643158-643715 (Clockwise)

Preceding gene: 126208051

Following gene: 126208054

Centisome position: 28.28

GC content: 39.43

Gene sequence:

>558_bases
ATGATCAATGAAATTAAAAAAGATACGCAAGATCGTATGGAAAAGAGCTTAGAAGCGTTAAAAAGCCATATTTCTAAAAT
TCGTACCGGTCGTGCGCAACCAAGTCTTTTAGACGGTATCCAAGTAGAATACTACGGTTCTGCAACACCGCTTCGCCAAT
TAGCAAACGTAGTGGCGGAAGATGCGCGTACATTAGCGGTAAACGTATTTGACCGTTCTTTAATCAGTGCGGTAGAAAAA
GCGATTTTAACTTCCGATTTAGGTTTAAACCCTTCATCAGCCGGTGCAACCATCCGTGTTCCGCTTCCGCCATTAACGGA
AGAACGTCGTCGTGATTTAATCAAAATCGTAAAAGGCGAAGGCGAACAAGGTAAAATTGCAATCCGTAACGTACGTCGTG
ATGCAAACGATCAAATCAAAGCGTTATTAAAAGACAAAGAAATCAGTGAAGACGAAGAGCGTAAAGCACAAGATGAAATC
CAAAAAATCACTGATGGTTATGTGAAAAAAGTAGATGAAGTATTAGCGGCAAAAGAAAAAGAATTATTAGATTTCTAA

Upstream 100 bases:

>100_bases
TGTTCGGTAAGCGAGAAATTTGGTGTTAGGGCTATGAAAACGAAAGGGATTTAGGTAGAATTGATAAGATTATTGACTCA
AATATTGAAAGGAACAACAA

Downstream 100 bases:

>100_bases
TCTTTGCTGAATGAAGAAAAAGGCACGTGTTTACGTGCCTTTATTTTTGCAAAAAAATTGTAAAATTTGACCGCTTGTTA
GCAAGCAATACCCCAACAAT

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MINEIKKDTQDRMEKSLEALKSHISKIRTGRAQPSLLDGIQVEYYGSATPLRQLANVVAEDARTLAVNVFDRSLISAVEK
AILTSDLGLNPSSAGATIRVPLPPLTEERRRDLIKIVKGEGEQGKIAIRNVRRDANDQIKALLKDKEISEDEERKAQDEI
QKITDGYVKKVDEVLAAKEKELLDF

Sequences:

>Translated_185_residues
MINEIKKDTQDRMEKSLEALKSHISKIRTGRAQPSLLDGIQVEYYGSATPLRQLANVVAEDARTLAVNVFDRSLISAVEK
AILTSDLGLNPSSAGATIRVPLPPLTEERRRDLIKIVKGEGEQGKIAIRNVRRDANDQIKALLKDKEISEDEERKAQDEI
QKITDGYVKKVDEVLAAKEKELLDF
>Mature_185_residues
MINEIKKDTQDRMEKSLEALKSHISKIRTGRAQPSLLDGIQVEYYGSATPLRQLANVVAEDARTLAVNVFDRSLISAVEK
AILTSDLGLNPSSAGATIRVPLPPLTEERRRDLIKIVKGEGEQGKIAIRNVRRDANDQIKALLKDKEISEDEERKAQDEI
QKITDGYVKKVDEVLAAKEKELLDF

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family

Homologues:

Organism=Homo sapiens, GI20270317, Length=179, Percent_Identity=32.9608938547486, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI291042689, Length=150, Percent_Identity=34, Blast_Score=70, Evalue=9e-13,
Organism=Escherichia coli, GI1786368, Length=185, Percent_Identity=68.6486486486486, Blast_Score=272, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24661488, Length=174, Percent_Identity=32.183908045977, Blast_Score=84, Evalue=5e-17,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): RRF_ACTP2 (A3MZT6)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053277.1
- ProteinModelPortal:   A3MZT6
- SMR:   A3MZT6
- STRING:   A3MZT6
- GeneID:   4850072
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0570
- eggNOG:   COG0233
- HOGENOM:   HBG533975
- OMA:   YYGAETP
- PhylomeDB:   A3MZT6
- ProtClustDB:   PRK00083
- BioCyc:   APLE416269:APL_0570-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00040
- InterPro:   IPR002661
- InterPro:   IPR015998
- PANTHER:   PTHR20982
- PANTHER:   PTHR20982:SF3
- TIGRFAMs:   TIGR00496

Pfam domain/function: PF01765 RRF; SSF55194 Ribosome_recyc_fac

EC number: NA

Molecular weight: Translated: 20677; Mature: 20677

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINEIKKDTQDRMEKSLEALKSHISKIRTGRAQPSLLDGIQVEYYGSATPLRQLANVVAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEECCCHHHHHHHHHHHH
DARTLAVNVFDRSLISAVEKAILTSDLGLNPSSAGATIRVPLPPLTEERRRDLIKIVKGE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCC
GEQGKIAIRNVRRDANDQIKALLKDKEISEDEERKAQDEIQKITDGYVKKVDEVLAAKEK
CCCCCHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLDF
HHCCC
>Mature Secondary Structure
MINEIKKDTQDRMEKSLEALKSHISKIRTGRAQPSLLDGIQVEYYGSATPLRQLANVVAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEECCCHHHHHHHHHHHH
DARTLAVNVFDRSLISAVEKAILTSDLGLNPSSAGATIRVPLPPLTEERRRDLIKIVKGE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCC
GEQGKIAIRNVRRDANDQIKALLKDKEISEDEERKAQDEIQKITDGYVKKVDEVLAAKEK
CCCCCHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLDF
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA