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The map label for this gene is lasA [H]

Identifier: 126176426

GI number: 126176426

Start: 4967391

End: 4968683

Strand: Reverse

Name: lasA [H]

Synonym: Sbal_4241

Alternate gene names: 126176426

Gene position: 4968683-4967391 (Counterclockwise)

Preceding gene: 126176427

Following gene: 126176424

Centisome position: 96.9

GC content: 43.77

Gene sequence:

>1293_bases
ATGAATATTTTTAAAATACGTAGTGCGGCATTATGGATAGGCCGCGCGTTAAGTGTCTCAGCGATAATAGCGTTACCATC
GATGGCATCTGACATGCCAACTAGTCAGTATCATATTGATTCAGATGAAATAAAAATGGTAGATATGCCTAGTGTGTTAC
TGCCATTTAATAATCTGATGTTTTTATATGGCGTAGATGCATCGCAGTTTGATTTAGCTGACTTTATTTACGTTAATGCC
CCTGACTTAATTGATAAAGAAGAGGCGATTACGCATTGGGCTGGATATTATAGTATTAACCCCAAAGTCATACTGACTTT
GATGGAAATGCAATCTCAGTTAATTTCGTCTCCGACAGAGGAAGCGCTTAACCGACCTTTGGGAGCCTTATCGGATAAGC
AGGGCTTCGAGGAACAACTTCAAGATGTATTGGCTCAGCTATCACAACGTTTTTATGCCTATGAAGAGTCTCAATTAAAA
GGCCTATACCCGCCAAGTACCGACGCTGTTAATGCGTCGAGTTTCGCATTATTGGCTTTGTTAAACGGTCGTAGGATAGA
GCAGCATGCCGTTATGTCGGGTGAGCACGCTTTGGGATTGGACCCATTTATTGAGCAGTTTAGATTATTATTTGGCAATA
CTGACCGTGAGTTGTTAATGAGTTCCGTTGCTCAAAATCCGCCAGTAGCTGATTCGACTCAGTCGATGCAACAAGTCGTC
CCATTGGCGAATATCACCGCGAGCAGTCTGCCACCCAGTAACATGCTGCAAATGCCTTGGCGACAGGGCTATTCATGGCA
ATCCAATGGTGCCCATTCGCATACTGGGTCTGGCTATCCGCTATCATCAATCGATGTCTCCTACGATTGGCCGCAATGGG
GCAGTCCGACGTATTCGGTTGCTTCCGCACATGGCGGGACTGTCAATGTGTTGTCTCGCTGCCAAGTACGGGTGACAAAT
GCTAATGGTTGGGCGACTAACTATTATCATATGGATCAAATTACAGTGCGTAATGGTCAATATGTAAACCAAAATACCGT
GATGGGCATTTATGCAAATAATAAAAATGCAGCCTTGTGTGAAGGCGGGAGTTCAACTGGGCCCCATTTGCATTTTTCTT
TATTAAAGGATGGCCGCCATGTGTCGTTGCAAGATGTACATTTGGGGCAATATAGAGTCAACATTGGTAGTTACAACTAT
GACAATAACTGTAGTCGTTTCAATCTGTTTGATGTAAGTAACAATCGTACAATGTGCGCTTGGGCGCCGCTGTATAATGC
GGGAAGTCTCTAA

Upstream 100 bases:

>100_bases
ATAGCTATAAAATTAGTCGTGAATATCATTACGTCTAAAGCAAGCTGGCGTTTAAAAATAATATTTAATATGAGTAACTT
ACTAAAGGAATTTGATAAGT

Downstream 100 bases:

>100_bases
TCCATGATAGAAAGCCCCTCAATCGAGGGGCTGATATTATGCGGGGCACAGTTGATCGCTAAGCTAGCTGGACCCTCAAA
TTATTTGGATATCCTCCCAG

Product: peptidase M23B

Products: NA

Alternate protein names: Staphylolytic protease [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MNIFKIRSAALWIGRALSVSAIIALPSMASDMPTSQYHIDSDEIKMVDMPSVLLPFNNLMFLYGVDASQFDLADFIYVNA
PDLIDKEEAITHWAGYYSINPKVILTLMEMQSQLISSPTEEALNRPLGALSDKQGFEEQLQDVLAQLSQRFYAYEESQLK
GLYPPSTDAVNASSFALLALLNGRRIEQHAVMSGEHALGLDPFIEQFRLLFGNTDRELLMSSVAQNPPVADSTQSMQQVV
PLANITASSLPPSNMLQMPWRQGYSWQSNGAHSHTGSGYPLSSIDVSYDWPQWGSPTYSVASAHGGTVNVLSRCQVRVTN
ANGWATNYYHMDQITVRNGQYVNQNTVMGIYANNKNAALCEGGSSTGPHLHFSLLKDGRHVSLQDVHLGQYRVNIGSYNY
DNNCSRFNLFDVSNNRTMCAWAPLYNAGSL

Sequences:

>Translated_430_residues
MNIFKIRSAALWIGRALSVSAIIALPSMASDMPTSQYHIDSDEIKMVDMPSVLLPFNNLMFLYGVDASQFDLADFIYVNA
PDLIDKEEAITHWAGYYSINPKVILTLMEMQSQLISSPTEEALNRPLGALSDKQGFEEQLQDVLAQLSQRFYAYEESQLK
GLYPPSTDAVNASSFALLALLNGRRIEQHAVMSGEHALGLDPFIEQFRLLFGNTDRELLMSSVAQNPPVADSTQSMQQVV
PLANITASSLPPSNMLQMPWRQGYSWQSNGAHSHTGSGYPLSSIDVSYDWPQWGSPTYSVASAHGGTVNVLSRCQVRVTN
ANGWATNYYHMDQITVRNGQYVNQNTVMGIYANNKNAALCEGGSSTGPHLHFSLLKDGRHVSLQDVHLGQYRVNIGSYNY
DNNCSRFNLFDVSNNRTMCAWAPLYNAGSL
>Mature_430_residues
MNIFKIRSAALWIGRALSVSAIIALPSMASDMPTSQYHIDSDEIKMVDMPSVLLPFNNLMFLYGVDASQFDLADFIYVNA
PDLIDKEEAITHWAGYYSINPKVILTLMEMQSQLISSPTEEALNRPLGALSDKQGFEEQLQDVLAQLSQRFYAYEESQLK
GLYPPSTDAVNASSFALLALLNGRRIEQHAVMSGEHALGLDPFIEQFRLLFGNTDRELLMSSVAQNPPVADSTQSMQQVV
PLANITASSLPPSNMLQMPWRQGYSWQSNGAHSHTGSGYPLSSIDVSYDWPQWGSPTYSVASAHGGTVNVLSRCQVRVTN
ANGWATNYYHMDQITVRNGQYVNQNTVMGIYANNKNAALCEGGSSTGPHLHFSLLKDGRHVSLQDVHLGQYRVNIGSYNY
DNNCSRFNLFDVSNNRTMCAWAPLYNAGSL

Specific function: Involved in proteolysis and elastolysis. Degradation of elastin is likely to contribute to the pathogenicity of P.aeruginosa [H]

COG id: COG0739

COG function: function code M; Membrane proteins related to metalloendopeptidases

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M23A family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011055
- InterPro:   IPR000841
- InterPro:   IPR016047
- InterPro:   IPR002886 [H]

Pfam domain/function: PF01551 Peptidase_M23 [H]

EC number: NA

Molecular weight: Translated: 47631; Mature: 47631

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIFKIRSAALWIGRALSVSAIIALPSMASDMPTSQYHIDSDEIKMVDMPSVLLPFNNLM
CCEEEEEHHHHHHHHHHHHEEEEECCCHHCCCCCCEEEECCCCEEEEECCHHEECCCCEE
FLYGVDASQFDLADFIYVNAPDLIDKEEAITHWAGYYSINPKVILTLMEMQSQLISSPTE
EEEECCCCCCCCEEEEEECCCCCCCCHHHHHHEEEEEECCHHHHHHHHHHHHHHHCCCHH
EALNRPLGALSDKQGFEEQLQDVLAQLSQRFYAYEESQLKGLYPPSTDAVNASSFALLAL
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCEEEEEE
LNGRRIEQHAVMSGEHALGLDPFIEQFRLLFGNTDRELLMSSVAQNPPVADSTQSMQQVV
CCCCEEHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHH
PLANITASSLPPSNMLQMPWRQGYSWQSNGAHSHTGSGYPLSSIDVSYDWPQWGSPTYSV
CHHCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEE
ASAHGGTVNVLSRCQVRVTNANGWATNYYHMDQITVRNGQYVNQNTVMGIYANNKNAALC
ECCCCCEEEEEEEEEEEEECCCCCEEEEEEEEEEEECCCEEECCCEEEEEEECCCCCEEE
EGGSSTGPHLHFSLLKDGRHVSLQDVHLGQYRVNIGSYNYDNNCSRFNLFDVSNNRTMCA
CCCCCCCCEEEEEEECCCCEEEEEEEEECEEEEEECCCCCCCCCCEEEEEEECCCCEEEE
WAPLYNAGSL
EECCCCCCCC
>Mature Secondary Structure
MNIFKIRSAALWIGRALSVSAIIALPSMASDMPTSQYHIDSDEIKMVDMPSVLLPFNNLM
CCEEEEEHHHHHHHHHHHHEEEEECCCHHCCCCCCEEEECCCCEEEEECCHHEECCCCEE
FLYGVDASQFDLADFIYVNAPDLIDKEEAITHWAGYYSINPKVILTLMEMQSQLISSPTE
EEEECCCCCCCCEEEEEECCCCCCCCHHHHHHEEEEEECCHHHHHHHHHHHHHHHCCCHH
EALNRPLGALSDKQGFEEQLQDVLAQLSQRFYAYEESQLKGLYPPSTDAVNASSFALLAL
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCEEEEEE
LNGRRIEQHAVMSGEHALGLDPFIEQFRLLFGNTDRELLMSSVAQNPPVADSTQSMQQVV
CCCCEEHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHH
PLANITASSLPPSNMLQMPWRQGYSWQSNGAHSHTGSGYPLSSIDVSYDWPQWGSPTYSV
CHHCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEE
ASAHGGTVNVLSRCQVRVTNANGWATNYYHMDQITVRNGQYVNQNTVMGIYANNKNAALC
ECCCCCEEEEEEEEEEEEECCCCCEEEEEEEEEEEECCCEEECCCEEEEEEECCCCCEEE
EGGSSTGPHLHFSLLKDGRHVSLQDVHLGQYRVNIGSYNYDNNCSRFNLFDVSNNRTMCA
CCCCCCCCEEEEEEECCCCEEEEEEEEECEEEEEECCCCCCCCCCEEEEEEECCCCEEEE
WAPLYNAGSL
EECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2836371; 2123032; 8932318; 10984043; 1597429 [H]