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The map label for this gene is moeB [H]

Identifier: 126176409

GI number: 126176409

Start: 4951550

End: 4952317

Strand: Direct

Name: moeB [H]

Synonym: Sbal_4224

Alternate gene names: 126176409

Gene position: 4951550-4952317 (Clockwise)

Preceding gene: 126176408

Following gene: 126176410

Centisome position: 96.57

GC content: 49.35

Gene sequence:

>768_bases
ATGAATGTGCCTGACGATATTCTCAGCGACAGCGAACTCTTAAGATACAGCCGTCAGATCTCCATCAAAGCCATGGATAT
CGACGGCCAAGAACACCTAAAACAAGCGAAAGTGTTGATGATAGGTGCAGGCGGATTAGGCTGCGCCGCTAGCCAATACC
TCACAGTTGCAGGGATTGGCGAGCTGACCTTGGTCGATTTTGATCACGTTGAACTCTCTAACCTGCAGCGCCAAGTGCTG
CATCAAGATGCCAATGTCGGCCAGCCAAAAGTCGAATCGGCCAAACAGAGCCTGAGTCAGCTCAATCCCTTTATTAAGAT
CAACATTATCAATGCAGTATTAGATGATCATGAGATTGACGCCCTTGTCGCCAATCACAATCTAGTGCTCGACTGCACCG
ATAATGTCAGTGTGCGCGAACAACTCAACCTCAGCTGTTTTAAGCATAAAGTGCCCTTAGTGTCCGCGGCGGCAATTCGG
ATGGAAGGCATGGTCACTGTGTTCGATTATCACAGCGAAACACCTTGTTATCATTGCTTTAGCGCCCTATTTGGCGAGCA
ACAACTCAGCTGCGTCGAGTCGGGCATCCTAGCCCCTGTGGTCGGCATGATAGGTTGCTTGCAGGCGGTTGAAGCCATCA
AGGTCATTACTGGTATGGGTAAAACCTTAGCGGGCCGCATTTTGATGATCGATGCGATGACGATGGAGTTTCGTGAGATG
AAACTATCGAAACACGCCAACTGCAGTGTCTGTGGTACTCAGGCTTAA

Upstream 100 bases:

>100_bases
AACTGTTTCGTTTTATTGGAACAATTCCAAGGGGATACTGCCGCTGGCACCCAAGTGACAGTCGAGCCCTTTAACAGCGT
GCTTTGCTAGGAAAATCTCC

Downstream 100 bases:

>100_bases
GATATTCTCGCTTGACAAACGGCTTTACTTGCCTTAACTTAGCTCGACGCTGGTGAGGCTAAACGACCAGTTAACATAAG
GAAATCACAAGGAAAACATA

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MNVPDDILSDSELLRYSRQISIKAMDIDGQEHLKQAKVLMIGAGGLGCAASQYLTVAGIGELTLVDFDHVELSNLQRQVL
HQDANVGQPKVESAKQSLSQLNPFIKINIINAVLDDHEIDALVANHNLVLDCTDNVSVREQLNLSCFKHKVPLVSAAAIR
MEGMVTVFDYHSETPCYHCFSALFGEQQLSCVESGILAPVVGMIGCLQAVEAIKVITGMGKTLAGRILMIDAMTMEFREM
KLSKHANCSVCGTQA

Sequences:

>Translated_255_residues
MNVPDDILSDSELLRYSRQISIKAMDIDGQEHLKQAKVLMIGAGGLGCAASQYLTVAGIGELTLVDFDHVELSNLQRQVL
HQDANVGQPKVESAKQSLSQLNPFIKINIINAVLDDHEIDALVANHNLVLDCTDNVSVREQLNLSCFKHKVPLVSAAAIR
MEGMVTVFDYHSETPCYHCFSALFGEQQLSCVESGILAPVVGMIGCLQAVEAIKVITGMGKTLAGRILMIDAMTMEFREM
KLSKHANCSVCGTQA
>Mature_255_residues
MNVPDDILSDSELLRYSRQISIKAMDIDGQEHLKQAKVLMIGAGGLGCAASQYLTVAGIGELTLVDFDHVELSNLQRQVL
HQDANVGQPKVESAKQSLSQLNPFIKINIINAVLDDHEIDALVANHNLVLDCTDNVSVREQLNLSCFKHKVPLVSAAAIR
MEGMVTVFDYHSETPCYHCFSALFGEQQLSCVESGILAPVVGMIGCLQAVEAIKVITGMGKTLAGRILMIDAMTMEFREM
KLSKHANCSVCGTQA

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=254, Percent_Identity=41.3385826771654, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4885649, Length=153, Percent_Identity=32.6797385620915, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI23510338, Length=180, Percent_Identity=29.4444444444444, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI23510340, Length=180, Percent_Identity=29.4444444444444, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI38045948, Length=185, Percent_Identity=30.2702702702703, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1787048, Length=245, Percent_Identity=63.265306122449, Blast_Score=338, Evalue=3e-94,
Organism=Escherichia coli, GI87082356, Length=245, Percent_Identity=39.1836734693878, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI1789177, Length=153, Percent_Identity=28.7581699346405, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17540406, Length=248, Percent_Identity=38.3064516129032, Blast_Score=192, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI193203301, Length=150, Percent_Identity=30, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI86565433, Length=170, Percent_Identity=27.0588235294118, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI86565431, Length=170, Percent_Identity=27.0588235294118, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=255, Percent_Identity=34.9019607843137, Blast_Score=156, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6322639, Length=165, Percent_Identity=29.0909090909091, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325438, Length=158, Percent_Identity=27.8481012658228, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320598, Length=153, Percent_Identity=24.1830065359477, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24582879, Length=251, Percent_Identity=43.0278884462151, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24660640, Length=152, Percent_Identity=32.8947368421053, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28573937, Length=161, Percent_Identity=27.3291925465839, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI20129973, Length=166, Percent_Identity=28.3132530120482, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 27729; Mature: 27729

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVPDDILSDSELLRYSRQISIKAMDIDGQEHLKQAKVLMIGAGGLGCAASQYLTVAGIG
CCCCHHHCCHHHHHHHHHHEEEEEEECCCHHHHHHCEEEEEECCCCCCHHHCEEEEECCC
ELTLVDFDHVELSNLQRQVLHQDANVGQPKVESAKQSLSQLNPFIKINIINAVLDDHEID
CEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEEEEHHHCCCCCE
ALVANHNLVLDCTDNVSVREQLNLSCFKHKVPLVSAAAIRMEGMVTVFDYHSETPCYHCF
EEEECCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEECCCCCHHHHHH
SALFGEQQLSCVESGILAPVVGMIGCLQAVEAIKVITGMGKTLAGRILMIDAMTMEFREM
HHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCEEEEEEHHHHHHHHH
KLSKHANCSVCGTQA
HHHCCCCCCCCCCCC
>Mature Secondary Structure
MNVPDDILSDSELLRYSRQISIKAMDIDGQEHLKQAKVLMIGAGGLGCAASQYLTVAGIG
CCCCHHHCCHHHHHHHHHHEEEEEEECCCHHHHHHCEEEEEECCCCCCHHHCEEEEECCC
ELTLVDFDHVELSNLQRQVLHQDANVGQPKVESAKQSLSQLNPFIKINIINAVLDDHEID
CEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEEEEHHHCCCCCE
ALVANHNLVLDCTDNVSVREQLNLSCFKHKVPLVSAAAIRMEGMVTVFDYHSETPCYHCF
EEEECCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEECCCCCHHHHHH
SALFGEQQLSCVESGILAPVVGMIGCLQAVEAIKVITGMGKTLAGRILMIDAMTMEFREM
HHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCEEEEEEHHHHHHHHH
KLSKHANCSVCGTQA
HHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]