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The map label for this gene is epsD [H]

Identifier: 126176391

GI number: 126176391

Start: 4925514

End: 4927631

Strand: Reverse

Name: epsD [H]

Synonym: Sbal_4206

Alternate gene names: 126176391

Gene position: 4927631-4925514 (Counterclockwise)

Preceding gene: 126176392

Following gene: 126176390

Centisome position: 96.1

GC content: 47.36

Gene sequence:

>2118_bases
ATGAATAACAAAAGGATTCGACGCAAGCTGATTGCAGGGATTGTTGCGGGTGCAGCCATGTTCTCCTCCCAATTCGCTTG
GTCTGAACAGTATGCGGCCAACTTTAAGGGCACGGATATTCAAGAGTTTATCAACATAGTTGGTAAAAACTTGAACAAGA
CCATCATAGTCGACCCGACGATCCGCGGTAAAATCAACGTTCGCAGTTATGATCTGCTGAACGATGAACAGTATTACCAG
TTTTTCCTCAACGTCTTACAAGTCTACGGTTATGCCATCGTCGAGATGGAGAATAACGTCATCAAAGTCATCAAAGACAA
AGACGCCAAAACTGCAGCAATCCGAGTGGCTAATGATGCCGAACCTGGGATAGGCGATGAGATGGTCACGCGTATCGTGG
CGCTGTATAACACTGAGGCCAAACAATTAGCTCCGCTGTTACGCCAATTAAATGATAACGCGGGTGGCGGTAACGTAGTG
AACTACGATCCCTCCAACGTCTTGATGCTGTCTGGCCGTGCCGCTGTGGTGAACAAGTTAGTTGAAATCGTTCGCCGCGT
AGATAAACAGGGCGACACCTCAGTACAAGTGGTGCCGTTAGAGTTCGCTTCCGCCGGTGAAATGGTACGAATTATCGATA
CCCTTTATCGCGCCACGGCTAACCAATCTCAAATGCCAGGCCAAGCGCCGAAAGTGGTTGCTGACGAACGTATCAACGCT
GTGGTTGTTAGCGGCGACGAAAAGAGCCGCCAACGTGTGGTTGAGCTTATTCATCGTCTTGATGCCGAGCAAGCCAGCAC
AGGCAACACTAAGGTGCGTTACTTACGTTATGCCAAAGCAGAAGATTTAGTTGAAGTGCTGACAGGTTTTGCTCAAAAGC
TAGAGGGCGATAAAGATCCAAGCGCTCAAGCTGCAGGTGGCAAACGCCGTAATGAAATCAATATTATGGCCCATGCCGAG
ACCAACGCTTTAGTGATCAGTGCCGAACCCGATCAAATGCGGACTATCGAGAGCGTGATTAATCAGCTCGATATTCGCCG
TGCTCAAGTGTTAGTCGAAGCGATCATTGTCGAAGTTGCTGAAGGCGATAACGTTGGCTTCGGCGTGCAATGGGCGTCTA
AAGCGGGTGGTGGGACTCAGTTTAATAACTTAGGCCCAACCATTGGTGAAGTCGGTGCGGGTGTTTGGGCGGCTCAGACT
GAGAAAGCTTCTCAAACCTGTACAGGTTCAGGTGATAATAAGACCTGTACAGATAACCCAGATAAGCGCGGTGATGTGAC
ACTACTTGCCCAAGCTTTAGGCAAAGTAAACGGTATGGCTTGGGGCGTGGCCATGGGCGACTTTGGTGCCTTAATTCAAG
CCGTGTCGAGTGACACTAACTCAAACGTACTGGCGACACCGTCAATTACCACTTTAGATAACCAAGAAGCGTCTTTCATC
GTCGGTGATGAAGTGCCTATTCTGACGGGCTCTACCGCCAGTTCGAGCAACAGTAACCCATTCCAAACCGTTGAACGTAA
GGAGGTTGGGGTTAAGCTGAAAGTGGTGCCGCAGATCAACGAAGGTAATGCGGTTAAGCTGACGATTGAACAGGAAGTGT
CAGGGGTTAACGGTAACACAGGGGTGGATATTTCCTTTGCTACTCGCCGTTTAACCACCACTGTTATGGCTGACTCAGGT
CAAATCGTGGTTCTGGGTGGCTTGATCAACGAAGAAGTACAAGAAAGCATACAGAAAGTACCGTTCTTGGGTGATATCCC
CATCATTGGCCACTTGTTTAAATCTTCTTCGAGCAAAAAGACCAAGAAAAACCTGATGATCTTCATCAAGCCAACCATTA
TCCGTGATGGCATCACAATGGAAGGAATTGCTGGTCGTAAATATAACTATTTCAGAGCATTACAACTTGAGCAGCAAGAA
CGTGGCGTTAACTTAATGCCAAATACTAAAGTGCCTGTGTTGGAAGAATGGAATCAATCAGAGTATTTACCGCCAGAAGT
TAACGCGATTTTAGAGCGTTATAAAGAAGGCAAAGGTTTAGATACCCAGATGCGCAAAACGGATCCGACCTTAAAGTCAC
TGGAAGAAAACAAGAATAAAGATAAAACCAATGAGTGA

Upstream 100 bases:

>100_bases
CGAGTTAACCGAAGTATCAATTATGGTTGAACGGGAAGGACAATTGGTTGAAATCATGTTTAGTTTGCCGCAATAACACG
CGTTAGAGGAAAGAAAAAGA

Downstream 100 bases:

>100_bases
AATACAATTATCCCAAGTCGATGACCTCAGCCAAGTCTCCAATGAGCTAGGTCTGGAAGCTGAAGGTGATGAGGTGTTTC
GTTCGAGCAGTAAAGAGCGT

Product: general secretion pathway protein D

Products: NA

Alternate protein names: Cholera toxin secretion protein epsD [H]

Number of amino acids: Translated: 705; Mature: 705

Protein sequence:

>705_residues
MNNKRIRRKLIAGIVAGAAMFSSQFAWSEQYAANFKGTDIQEFINIVGKNLNKTIIVDPTIRGKINVRSYDLLNDEQYYQ
FFLNVLQVYGYAIVEMENNVIKVIKDKDAKTAAIRVANDAEPGIGDEMVTRIVALYNTEAKQLAPLLRQLNDNAGGGNVV
NYDPSNVLMLSGRAAVVNKLVEIVRRVDKQGDTSVQVVPLEFASAGEMVRIIDTLYRATANQSQMPGQAPKVVADERINA
VVVSGDEKSRQRVVELIHRLDAEQASTGNTKVRYLRYAKAEDLVEVLTGFAQKLEGDKDPSAQAAGGKRRNEINIMAHAE
TNALVISAEPDQMRTIESVINQLDIRRAQVLVEAIIVEVAEGDNVGFGVQWASKAGGGTQFNNLGPTIGEVGAGVWAAQT
EKASQTCTGSGDNKTCTDNPDKRGDVTLLAQALGKVNGMAWGVAMGDFGALIQAVSSDTNSNVLATPSITTLDNQEASFI
VGDEVPILTGSTASSSNSNPFQTVERKEVGVKLKVVPQINEGNAVKLTIEQEVSGVNGNTGVDISFATRRLTTTVMADSG
QIVVLGGLINEEVQESIQKVPFLGDIPIIGHLFKSSSSKKTKKNLMIFIKPTIIRDGITMEGIAGRKYNYFRALQLEQQE
RGVNLMPNTKVPVLEEWNQSEYLPPEVNAILERYKEGKGLDTQMRKTDPTLKSLEENKNKDKTNE

Sequences:

>Translated_705_residues
MNNKRIRRKLIAGIVAGAAMFSSQFAWSEQYAANFKGTDIQEFINIVGKNLNKTIIVDPTIRGKINVRSYDLLNDEQYYQ
FFLNVLQVYGYAIVEMENNVIKVIKDKDAKTAAIRVANDAEPGIGDEMVTRIVALYNTEAKQLAPLLRQLNDNAGGGNVV
NYDPSNVLMLSGRAAVVNKLVEIVRRVDKQGDTSVQVVPLEFASAGEMVRIIDTLYRATANQSQMPGQAPKVVADERINA
VVVSGDEKSRQRVVELIHRLDAEQASTGNTKVRYLRYAKAEDLVEVLTGFAQKLEGDKDPSAQAAGGKRRNEINIMAHAE
TNALVISAEPDQMRTIESVINQLDIRRAQVLVEAIIVEVAEGDNVGFGVQWASKAGGGTQFNNLGPTIGEVGAGVWAAQT
EKASQTCTGSGDNKTCTDNPDKRGDVTLLAQALGKVNGMAWGVAMGDFGALIQAVSSDTNSNVLATPSITTLDNQEASFI
VGDEVPILTGSTASSSNSNPFQTVERKEVGVKLKVVPQINEGNAVKLTIEQEVSGVNGNTGVDISFATRRLTTTVMADSG
QIVVLGGLINEEVQESIQKVPFLGDIPIIGHLFKSSSSKKTKKNLMIFIKPTIIRDGITMEGIAGRKYNYFRALQLEQQE
RGVNLMPNTKVPVLEEWNQSEYLPPEVNAILERYKEGKGLDTQMRKTDPTLKSLEENKNKDKTNE
>Mature_705_residues
MNNKRIRRKLIAGIVAGAAMFSSQFAWSEQYAANFKGTDIQEFINIVGKNLNKTIIVDPTIRGKINVRSYDLLNDEQYYQ
FFLNVLQVYGYAIVEMENNVIKVIKDKDAKTAAIRVANDAEPGIGDEMVTRIVALYNTEAKQLAPLLRQLNDNAGGGNVV
NYDPSNVLMLSGRAAVVNKLVEIVRRVDKQGDTSVQVVPLEFASAGEMVRIIDTLYRATANQSQMPGQAPKVVADERINA
VVVSGDEKSRQRVVELIHRLDAEQASTGNTKVRYLRYAKAEDLVEVLTGFAQKLEGDKDPSAQAAGGKRRNEINIMAHAE
TNALVISAEPDQMRTIESVINQLDIRRAQVLVEAIIVEVAEGDNVGFGVQWASKAGGGTQFNNLGPTIGEVGAGVWAAQT
EKASQTCTGSGDNKTCTDNPDKRGDVTLLAQALGKVNGMAWGVAMGDFGALIQAVSSDTNSNVLATPSITTLDNQEASFI
VGDEVPILTGSTASSSNSNPFQTVERKEVGVKLKVVPQINEGNAVKLTIEQEVSGVNGNTGVDISFATRRLTTTVMADSG
QIVVLGGLINEEVQESIQKVPFLGDIPIIGHLFKSSSSKKTKKNLMIFIKPTIIRDGITMEGIAGRKYNYFRALQLEQQE
RGVNLMPNTKVPVLEEWNQSEYLPPEVNAILERYKEGKGLDTQMRKTDPTLKSLEENKNKDKTNE

Specific function: Required for secretion of cholera toxin through the outer membrane [H]

COG id: COG1450

COG function: function code NU; Type II secretory pathway, component PulD

Gene ontology:

Cell location: Cell outer membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP D family [H]

Homologues:

Organism=Escherichia coli, GI87082242, Length=666, Percent_Identity=43.993993993994, Blast_Score=546, Evalue=1e-156,
Organism=Escherichia coli, GI1789793, Length=302, Percent_Identity=24.8344370860927, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001775
- InterPro:   IPR005644
- InterPro:   IPR004846
- InterPro:   IPR013356
- InterPro:   IPR004845
- InterPro:   IPR001814 [H]

Pfam domain/function: PF00263 Secretin; PF03958 Secretin_N [H]

EC number: NA

Molecular weight: Translated: 76820; Mature: 76820

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKRIRRKLIAGIVAGAAMFSSQFAWSEQYAANFKGTDIQEFINIVGKNLNKTIIVDPT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHCCCCCCEEEECCC
IRGKINVRSYDLLNDEQYYQFFLNVLQVYGYAIVEMENNVIKVIKDKDAKTAAIRVANDA
CCCEEEEEEEECCCCHHHHHHHHHHHHHHCEEEEEECCCEEEEEECCCCCEEEEEEECCC
EPGIGDEMVTRIVALYNTEAKQLAPLLRQLNDNAGGGNVVNYDPSNVLMLSGRAAVVNKL
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCCCEEEECCCHHHHHHH
VEIVRRVDKQGDTSVQVVPLEFASAGEMVRIIDTLYRATANQSQMPGQAPKVVADERINA
HHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCE
VVVSGDEKSRQRVVELIHRLDAEQASTGNTKVRYLRYAKAEDLVEVLTGFAQKLEGDKDP
EEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCC
SAQAAGGKRRNEINIMAHAETNALVISAEPDQMRTIESVINQLDIRRAQVLVEAIIVEVA
CCCCCCCCCCCEEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EGDNVGFGVQWASKAGGGTQFNNLGPTIGEVGAGVWAAQTEKASQTCTGSGDNKTCTDNP
CCCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCEECCCHHCCCCCCCCCCCCCCCCCC
DKRGDVTLLAQALGKVNGMAWGVAMGDFGALIQAVSSDTNSNVLATPSITTLDNQEASFI
CCCCCHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCCCCEEECCCEEECCCCCCEEE
VGDEVPILTGSTASSSNSNPFQTVERKEVGVKLKVVPQINEGNAVKLTIEQEVSGVNGNT
ECCCCEEEECCCCCCCCCCCHHHHHHHHCCEEEEEEEEECCCCEEEEEEECCCCCCCCCC
GVDISFATRRLTTTVMADSGQIVVLGGLINEEVQESIQKVPFLGDIPIIGHLFKSSSSKK
CEEEEEHHHEEEEEEEECCCCEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCC
TKKNLMIFIKPTIIRDGITMEGIAGRKYNYFRALQLEQQERGVNLMPNTKVPVLEEWNQS
CCCCEEEEEEEEEEECCCEECCCCCCCCCEEEEEEEHHHHCCCCCCCCCCCCHHHCCCCC
EYLPPEVNAILERYKEGKGLDTQMRKTDPTLKSLEENKNKDKTNE
CCCCHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNNKRIRRKLIAGIVAGAAMFSSQFAWSEQYAANFKGTDIQEFINIVGKNLNKTIIVDPT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHCCCCCCEEEECCC
IRGKINVRSYDLLNDEQYYQFFLNVLQVYGYAIVEMENNVIKVIKDKDAKTAAIRVANDA
CCCEEEEEEEECCCCHHHHHHHHHHHHHHCEEEEEECCCEEEEEECCCCCEEEEEEECCC
EPGIGDEMVTRIVALYNTEAKQLAPLLRQLNDNAGGGNVVNYDPSNVLMLSGRAAVVNKL
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCCCEEEECCCHHHHHHH
VEIVRRVDKQGDTSVQVVPLEFASAGEMVRIIDTLYRATANQSQMPGQAPKVVADERINA
HHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCE
VVVSGDEKSRQRVVELIHRLDAEQASTGNTKVRYLRYAKAEDLVEVLTGFAQKLEGDKDP
EEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCC
SAQAAGGKRRNEINIMAHAETNALVISAEPDQMRTIESVINQLDIRRAQVLVEAIIVEVA
CCCCCCCCCCCEEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EGDNVGFGVQWASKAGGGTQFNNLGPTIGEVGAGVWAAQTEKASQTCTGSGDNKTCTDNP
CCCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCEECCCHHCCCCCCCCCCCCCCCCCC
DKRGDVTLLAQALGKVNGMAWGVAMGDFGALIQAVSSDTNSNVLATPSITTLDNQEASFI
CCCCCHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCCCCEEECCCEEECCCCCCEEE
VGDEVPILTGSTASSSNSNPFQTVERKEVGVKLKVVPQINEGNAVKLTIEQEVSGVNGNT
ECCCCEEEECCCCCCCCCCCHHHHHHHHCCEEEEEEEEECCCCEEEEEEECCCCCCCCCC
GVDISFATRRLTTTVMADSGQIVVLGGLINEEVQESIQKVPFLGDIPIIGHLFKSSSSKK
CEEEEEHHHEEEEEEEECCCCEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCC
TKKNLMIFIKPTIIRDGITMEGIAGRKYNYFRALQLEQQERGVNLMPNTKVPVLEEWNQS
CCCCEEEEEEEEEEECCCEECCCCCCCCCEEEEEEEHHHHCCCCCCCCCCCCHHHCCCCC
EYLPPEVNAILERYKEGKGLDTQMRKTDPTLKSLEENKNKDKTNE
CCCCHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]