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The map label for this gene is gppA [H]

Identifier: 126176117

GI number: 126176117

Start: 4620457

End: 4621383

Strand: Reverse

Name: gppA [H]

Synonym: Sbal_3927

Alternate gene names: 126176117

Gene position: 4621383-4620457 (Counterclockwise)

Preceding gene: 126176118

Following gene: 126176106

Centisome position: 90.13

GC content: 48.76

Gene sequence:

>927_bases
ATGCCAACACCCGCTTATGCCGCTATAACATTAGGCTCAAACAGTTTTAATATGCTGATCGCCAAAACTCGTGGTGGTCA
GCCGCATATTATTGCGAAATATAAACGCAAGGTGAGGCTCGCCGAAGGTATAGGCGACGATGGCAACTTAAGCCATGACG
TGATGCAGCGTGGCCTCGACTGTTTGAGTATGTTTGCCCAAATGTTGGTGCAACATAAGATTGAAGCAAATCATGTCGCT
GTGATTGCTACCGCAACCCTTCGCAGTATCAGCAATGCCGATGAGTTTAATCGGCGTGCATTGCCACTCCTTGGTCATCC
AATTGAAATCATCTCAGGCATGCGTGAAGCTGAGCTTATCTATCAAGGCATGGTGGCAACCACCTGTGGTCAAGGCCGTC
GTTTAGTGATAGATATCGGCGGGGCGAGCACTGAGTTTATTATCGGTGATGGGCATCAAGTGTTGTTCAAAACCAGTTTG
CCCTTTGGTAGCGTGACTTATAATCGCCAATTTTTTAGTAGCTTGCCGCTGCAACAGTTAGATTTCGATGATGCCAAGCA
GCAAGTGCTAACCGCATTAGCTGAGCATAGACAAACCCTACGCGATCTCGGTTGGCATTGTGTTGTTGGTGCCTCTGGCG
CGGTGCAATCTGTGGTTGAAGTACTGCTTCACCGTGGCTTATCTGAAACGATAACGCTCGATGTGCTCACTCAGCTGAAG
GCTGAAATTCTCGCACAAGAAGACATTGGCTTAACGGGGATCGCTGGGCTTTGTAGCGAGCGGGCACCGACTTTTGCAGC
GGGTGTCGCTATTTTATTGGCTTTGTTTGAGTTGCTGGGGATAGAGCATTTAGCCTTATCTGGCGGCGCATTACGTGAAG
GTGTTTTAGTGATGCTCGCGCAGCGAATTATTGACGAAGCGAGCTAA

Upstream 100 bases:

>100_bases
CACTCGAAACCTGCGTGATCGTTCTGGGACAAGTCGCCCTGGTGCGCAACGCAGTGGTGCTCGCCCTCCTCGTCATGATA
GGACACGTAGACATTCGTAA

Downstream 100 bases:

>100_bases
GCTTTCTCTGATGGATAAAAACCAAAGGCCGCTATGCGGCCTTTATTGTGTGTACTGCGTCGCTTATTTCAATAAATCGG
CGAGATCTTTTTCTAAGGAA

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MPTPAYAAITLGSNSFNMLIAKTRGGQPHIIAKYKRKVRLAEGIGDDGNLSHDVMQRGLDCLSMFAQMLVQHKIEANHVA
VIATATLRSISNADEFNRRALPLLGHPIEIISGMREAELIYQGMVATTCGQGRRLVIDIGGASTEFIIGDGHQVLFKTSL
PFGSVTYNRQFFSSLPLQQLDFDDAKQQVLTALAEHRQTLRDLGWHCVVGASGAVQSVVEVLLHRGLSETITLDVLTQLK
AEILAQEDIGLTGIAGLCSERAPTFAAGVAILLALFELLGIEHLALSGGALREGVLVMLAQRIIDEAS

Sequences:

>Translated_308_residues
MPTPAYAAITLGSNSFNMLIAKTRGGQPHIIAKYKRKVRLAEGIGDDGNLSHDVMQRGLDCLSMFAQMLVQHKIEANHVA
VIATATLRSISNADEFNRRALPLLGHPIEIISGMREAELIYQGMVATTCGQGRRLVIDIGGASTEFIIGDGHQVLFKTSL
PFGSVTYNRQFFSSLPLQQLDFDDAKQQVLTALAEHRQTLRDLGWHCVVGASGAVQSVVEVLLHRGLSETITLDVLTQLK
AEILAQEDIGLTGIAGLCSERAPTFAAGVAILLALFELLGIEHLALSGGALREGVLVMLAQRIIDEAS
>Mature_307_residues
PTPAYAAITLGSNSFNMLIAKTRGGQPHIIAKYKRKVRLAEGIGDDGNLSHDVMQRGLDCLSMFAQMLVQHKIEANHVAV
IATATLRSISNADEFNRRALPLLGHPIEIISGMREAELIYQGMVATTCGQGRRLVIDIGGASTEFIIGDGHQVLFKTSLP
FGSVTYNRQFFSSLPLQQLDFDDAKQQVLTALAEHRQTLRDLGWHCVVGASGAVQSVVEVLLHRGLSETITLDVLTQLKA
EILAQEDIGLTGIAGLCSERAPTFAAGVAILLALFELLGIEHLALSGGALREGVLVMLAQRIIDEAS

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=291, Percent_Identity=44.3298969072165, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1788848, Length=304, Percent_Identity=39.4736842105263, Blast_Score=206, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 33175; Mature: 33044

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTPAYAAITLGSNSFNMLIAKTRGGQPHIIAKYKRKVRLAEGIGDDGNLSHDVMQRGLD
CCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
CLSMFAQMLVQHKIEANHVAVIATATLRSISNADEFNRRALPLLGHPIEIISGMREAELI
HHHHHHHHHHHHHCCCCCEEEEEHHHHHHHCCHHHHCCCCCCCCCCCHHHHCCCHHHHHH
YQGMVATTCGQGRRLVIDIGGASTEFIIGDGHQVLFKTSLPFGSVTYNRQFFSSLPLQQL
HHHHHHHHCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCCCEEECHHHHHHCCHHHC
DFDDAKQQVLTALAEHRQTLRDLGWHCVVGASGAVQSVVEVLLHRGLSETITLDVLTQLK
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AEILAQEDIGLTGIAGLCSERAPTFAAGVAILLALFELLGIEHLALSGGALREGVLVMLA
HHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHHHHH
QRIIDEAS
HHHHHCCC
>Mature Secondary Structure 
PTPAYAAITLGSNSFNMLIAKTRGGQPHIIAKYKRKVRLAEGIGDDGNLSHDVMQRGLD
CCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
CLSMFAQMLVQHKIEANHVAVIATATLRSISNADEFNRRALPLLGHPIEIISGMREAELI
HHHHHHHHHHHHHCCCCCEEEEEHHHHHHHCCHHHHCCCCCCCCCCCHHHHCCCHHHHHH
YQGMVATTCGQGRRLVIDIGGASTEFIIGDGHQVLFKTSLPFGSVTYNRQFFSSLPLQQL
HHHHHHHHCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCCCEEECHHHHHHCCHHHC
DFDDAKQQVLTALAEHRQTLRDLGWHCVVGASGAVQSVVEVLLHRGLSETITLDVLTQLK
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AEILAQEDIGLTGIAGLCSERAPTFAAGVAILLALFELLGIEHLALSGGALREGVLVMLA
HHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHHHHH
QRIIDEAS
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA