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The map label for this gene is mro [H]

Identifier: 126175923

GI number: 126175923

Start: 4364694

End: 4365728

Strand: Direct

Name: mro [H]

Synonym: Sbal_3729

Alternate gene names: 126175923

Gene position: 4364694-4365728 (Clockwise)

Preceding gene: 126175922

Following gene: 126175926

Centisome position: 85.13

GC content: 51.01

Gene sequence:

>1035_bases
ATGGTACGTTTCAGTGTTTTGGATCCTTGGACCGATCCCCGCGGCGGCGAAATCGAACGGGTTCGGATCGACAATGGCAT
ACTCGCATTAGAAGTCATCAGCTTAGGCGGAATTATCCGCGCTCTGTGGACCCCAGATAAACACGGCGAACGTGCCAATA
TCGTCCTTGGTTGCGACAGCGCCGAAGACTACCTGACGCAATCGGCTCACTTAGGCGCCATTGCTGGCCGCTTTGCAAAT
CGCATCGCTAACGGCAAAATGCACTTTCAAGGCCAAGATTATCAACTTGATGTCAACCAAGCGACTAACTGTTTGCACGG
CGGCCGTGAAGGGTTTAACCGTAAAAACTGGCACTTAGGCCAACTGCCCGATGGTGTGCGCTTGACCTTAATGAGTCCAG
ACGGCGACATGGGTTTCCCCGGTAATTGCACGGTTCAGCTGGATTACCGCCTCGCAGGTAATAATCTCTATGTGGAAATT
TTGGCCTCGGTGGATAAAGCCTGTCCCGTGAGCTTAACCCAGCACAGTTATTTCAACCTCGATGGTTCAGAGACCAATCA
CGAGCATTTGATGCAAATCGATGCCAAGCGTTATCTCACCATGAATGATGTCAGTGTTCCCACTGGGATTGCCGAGACTA
CAGGATCAATTTTCGACTTGAGTCAGCCGATACGCTTAGGCGACAAACTGCATGCAGCAGAATTAGCGAGCACGCGCGGT
TATGATCACTGTTATATGATGAATGACTCCGACGGTTCACTCGCCCGCTTTGGCTGTTTAAGCAGCCCAGTGAGTGGCCG
CGCTATGACGGTTTATACCAATCAACCGAGCGTGCAGCTCTACTGCGCTAACTTTTTAGATGGCACTGTGGGTCGCAATC
AACAGGTATTGAATCAACATCATGGCGTGTGTTTAGAGCCGCAGATGCTGCCAGACTCACCGAATCAAGGCGAGCGCTTT
GGTGATGATGTTTGGTTAGTGCCAGGCAAGGTTTATCACCACATCAGCCGATATCAGTTCGATGCCGATGCGTAA

Upstream 100 bases:

>100_bases
ATTCATCGCTGATGTTTATGGTGTTGATGGCAAATAATAGGGTTAACATACTCATTTAACACAATAAGCAGTGAGCATAT
TCAACACAGAGGGAAGCTAA

Downstream 100 bases:

>100_bases
CATTAGCTATAAATTAGCGGTATATTAACGGGTAAATCGAGTCGCGATAAAATAGCGATGAATTGAGGTTAACGCACGGT
TTCGCGGAAGGAAATAAAGC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MVRFSVLDPWTDPRGGEIERVRIDNGILALEVISLGGIIRALWTPDKHGERANIVLGCDSAEDYLTQSAHLGAIAGRFAN
RIANGKMHFQGQDYQLDVNQATNCLHGGREGFNRKNWHLGQLPDGVRLTLMSPDGDMGFPGNCTVQLDYRLAGNNLYVEI
LASVDKACPVSLTQHSYFNLDGSETNHEHLMQIDAKRYLTMNDVSVPTGIAETTGSIFDLSQPIRLGDKLHAAELASTRG
YDHCYMMNDSDGSLARFGCLSSPVSGRAMTVYTNQPSVQLYCANFLDGTVGRNQQVLNQHHGVCLEPQMLPDSPNQGERF
GDDVWLVPGKVYHHISRYQFDADA

Sequences:

>Translated_344_residues
MVRFSVLDPWTDPRGGEIERVRIDNGILALEVISLGGIIRALWTPDKHGERANIVLGCDSAEDYLTQSAHLGAIAGRFAN
RIANGKMHFQGQDYQLDVNQATNCLHGGREGFNRKNWHLGQLPDGVRLTLMSPDGDMGFPGNCTVQLDYRLAGNNLYVEI
LASVDKACPVSLTQHSYFNLDGSETNHEHLMQIDAKRYLTMNDVSVPTGIAETTGSIFDLSQPIRLGDKLHAAELASTRG
YDHCYMMNDSDGSLARFGCLSSPVSGRAMTVYTNQPSVQLYCANFLDGTVGRNQQVLNQHHGVCLEPQMLPDSPNQGERF
GDDVWLVPGKVYHHISRYQFDADA
>Mature_344_residues
MVRFSVLDPWTDPRGGEIERVRIDNGILALEVISLGGIIRALWTPDKHGERANIVLGCDSAEDYLTQSAHLGAIAGRFAN
RIANGKMHFQGQDYQLDVNQATNCLHGGREGFNRKNWHLGQLPDGVRLTLMSPDGDMGFPGNCTVQLDYRLAGNNLYVEI
LASVDKACPVSLTQHSYFNLDGSETNHEHLMQIDAKRYLTMNDVSVPTGIAETTGSIFDLSQPIRLGDKLHAAELASTRG
YDHCYMMNDSDGSLARFGCLSSPVSGRAMTVYTNQPSVQLYCANFLDGTVGRNQQVLNQHHGVCLEPQMLPDSPNQGERF
GDDVWLVPGKVYHHISRYQFDADA

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=332, Percent_Identity=40.0602409638554, Blast_Score=234, Evalue=7e-62,
Organism=Escherichia coli, GI1786971, Length=325, Percent_Identity=36, Blast_Score=201, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17557428, Length=316, Percent_Identity=29.4303797468354, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI115533334, Length=316, Percent_Identity=29.4303797468354, Blast_Score=146, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319493, Length=313, Percent_Identity=28.7539936102236, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322004, Length=359, Percent_Identity=26.7409470752089, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324399, Length=319, Percent_Identity=26.3322884012539, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24659048, Length=353, Percent_Identity=34.5609065155807, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24668278, Length=327, Percent_Identity=32.4159021406728, Blast_Score=174, Evalue=6e-44,
Organism=Drosophila melanogaster, GI24583720, Length=327, Percent_Identity=31.1926605504587, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24641876, Length=334, Percent_Identity=29.3413173652695, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24668282, Length=350, Percent_Identity=28.5714285714286, Blast_Score=137, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 37996; Mature: 37996

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRFSVLDPWTDPRGGEIERVRIDNGILALEVISLGGIIRALWTPDKHGERANIVLGCDS
CEEEEEECCCCCCCCCEEEEEEECCCEEEEEEEHHCCEEEEEECCCCCCCEEEEEEECCC
AEDYLTQSAHLGAIAGRFANRIANGKMHFQGQDYQLDVNQATNCLHGGREGFNRKNWHLG
HHHHHHHCHHHHHHHHHHHHHHCCCEEEECCCCEEEEHHHHHHHHHCCCCCCCCCCCCCC
QLPDGVRLTLMSPDGDMGFPGNCTVQLDYRLAGNNLYVEILASVDKACPVSLTQHSYFNL
CCCCCCEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEEECCCCCCCCEEECCEEEEC
DGSETNHEHLMQIDAKRYLTMNDVSVPTGIAETTGSIFDLSQPIRLGDKLHAAELASTRG
CCCCCCCHHHEEECHHHEEEECCCCCCCCHHHHCCCEEECCCCHHCCCHHHHHHHHHCCC
YDHCYMMNDSDGSLARFGCLSSPVSGRAMTVYTNQPSVQLYCANFLDGTVGRNQQVLNQH
CCEEEEEECCCCCEEEEECCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHC
HGVCLEPQMLPDSPNQGERFGDDVWLVPGKVYHHISRYQFDADA
CCEEECCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHEEECCCC
>Mature Secondary Structure
MVRFSVLDPWTDPRGGEIERVRIDNGILALEVISLGGIIRALWTPDKHGERANIVLGCDS
CEEEEEECCCCCCCCCEEEEEEECCCEEEEEEEHHCCEEEEEECCCCCCCEEEEEEECCC
AEDYLTQSAHLGAIAGRFANRIANGKMHFQGQDYQLDVNQATNCLHGGREGFNRKNWHLG
HHHHHHHCHHHHHHHHHHHHHHCCCEEEECCCCEEEEHHHHHHHHHCCCCCCCCCCCCCC
QLPDGVRLTLMSPDGDMGFPGNCTVQLDYRLAGNNLYVEILASVDKACPVSLTQHSYFNL
CCCCCCEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEEECCCCCCCCEEECCEEEEC
DGSETNHEHLMQIDAKRYLTMNDVSVPTGIAETTGSIFDLSQPIRLGDKLHAAELASTRG
CCCCCCCHHHEEECHHHEEEECCCCCCCCHHHHCCCEEECCCCHHCCCHHHHHHHHHCCC
YDHCYMMNDSDGSLARFGCLSSPVSGRAMTVYTNQPSVQLYCANFLDGTVGRNQQVLNQH
CCEEEEEECCCCCEEEEECCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHC
HGVCLEPQMLPDSPNQGERFGDDVWLVPGKVYHHISRYQFDADA
CCEEECCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]