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The map label for this gene is atoC [H]

Identifier: 126175536

GI number: 126175536

Start: 3902452

End: 3903933

Strand: Reverse

Name: atoC [H]

Synonym: Sbal_3338

Alternate gene names: 126175536

Gene position: 3903933-3902452 (Counterclockwise)

Preceding gene: 126175537

Following gene: 126175535

Centisome position: 76.14

GC content: 50.61

Gene sequence:

>1482_bases
ATGGATACTATCCTCATCGTCGACGACAATCATGCTATCTGCCAAGCCCTAGGTTTGATGCTAGAACTCAATGATTATCG
GGTGCTGACTTGCCATAGCCCAGAGGACGCCCTTGGATTATTGGCGACGCAAGATGTGGATTTAGTGATCCAAGATATGA
ACTTTACTCGGGATACCACGTCGGGTGAGGAAGGCAAGCAGCTGTTTTATGCCCTGCGTGAACGCCAAGGCGATCTGCCG
ATCATTTTGATGACGGCGTGGACCCAACTCGAAACCGCAGTTGAATTAGTGAAAGCGGGCGCCGCCGATTATATGGGTAA
ACCTTGGGATGACGCTAAGGTACTCAATAGCATCACCAATCTGATTGCGCTTTATAAACTCTCCCGTGCTAACCATCGTC
TCGAGCGGGTGAATCATCAACGCCAAGTGGCGATCGCCGATGCGGATCTTTGCGGAATAGTCTTTGGTAGCGGCGCGATG
CAGCGTTGTATTGATTTAGCCTTGCAACTGGCGCGCTCCGATGTGTCGGTCTTAATCACTGGCCCCAATGGCGCGGGTAA
AGACAAGCTTGCCGATATTCTCCATGCTAATTCTCCCTTAAAAAACAAACCCTTTATCAAGGTCAATGTCGGCGCCTTGC
CGATGGATTTATTAGAGGCAGAGTTGTTTGGTGCCGAGGCGGGGGCTTTTACGGGCGCGACTAAAGCCCGTATTGGTCGC
TTTGAAGCGGCCGACGGCGGCACGTTGTTTTTAGATGAAATCGGTAACTTGCCGTTATCTGGCCAAGTGAAATTACTGCG
GGTGCTGCAAACCGGTGAATTTGAACGCTTAGGAAGCCATAAAACCCAAAAAGTGAAAGTGCGGGTGATCAGTGCGACCA
ATGCGGATCTGGCCCAAGATATTGCCGAAGGGCGTTTTCGTGAAGATTTGTTTTACCGCTTAAATGTTATCGAACTGGCG
CTATCGCCGCTGAATCAACGTACCGACGATATCTTACCTTTAGTGCAGCATTTTATCGGCAGCAATTTTAGCTTGAGTAA
ACCGGCATTGCAGGCGTTATTGCACCATCGCTGGCCGGGAAATGTACGCGAGCTTGAAAATGCCTGTAAGCGAGCGGTAT
TGTTGGCGCAAAGTCATGTGCTGACTGAAGCTGATTTTGGTTTGGCCCCTGTCGTGAGTGCCGTAAGAGCTGCTACTTCC
CATATTTCGGCAACTTCTGAGCCTCGACGCTTTGATCAGCGACAATCTGATCCTCAGCCCGTTTATGCGTCTGCTTCCAT
TCCCACTCATGCCACTTTTTCTGATAGCTCTGCCCGCGACCAAACACAGTCGGCTAATGAGGCGATAGAAGTGAGTCGCG
AAGATATCGAAGCGGCGCTAAAACAGCACCATGGCGTGATTGCTCGGGTCGCCAAAGCGCTTGGGCTCAGTCGTCAGGCG
CTGTATCGGCGCATGGATAAGTTTGGTTTAGATAAGTCATAG

Upstream 100 bases:

>100_bases
GTACGATAAAAGCCCGATAAAAGTGCGATAACAATAGGATGTTATTGCACTTTTTGTTACTTTACGGTTAATAGTTTTAT
ATAGGACAACACTCATACTT

Downstream 100 bases:

>100_bases
GCCACAGATGCTAGGCCACAGAAAGGCTATCGATTAAGGAATGTGAGTGTTAATTCGAACTAAACTGATCATTTATTCAA
TGGCTTGCTGCGCCTTTGGC

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MDTILIVDDNHAICQALGLMLELNDYRVLTCHSPEDALGLLATQDVDLVIQDMNFTRDTTSGEEGKQLFYALRERQGDLP
IILMTAWTQLETAVELVKAGAADYMGKPWDDAKVLNSITNLIALYKLSRANHRLERVNHQRQVAIADADLCGIVFGSGAM
QRCIDLALQLARSDVSVLITGPNGAGKDKLADILHANSPLKNKPFIKVNVGALPMDLLEAELFGAEAGAFTGATKARIGR
FEAADGGTLFLDEIGNLPLSGQVKLLRVLQTGEFERLGSHKTQKVKVRVISATNADLAQDIAEGRFREDLFYRLNVIELA
LSPLNQRTDDILPLVQHFIGSNFSLSKPALQALLHHRWPGNVRELENACKRAVLLAQSHVLTEADFGLAPVVSAVRAATS
HISATSEPRRFDQRQSDPQPVYASASIPTHATFSDSSARDQTQSANEAIEVSREDIEAALKQHHGVIARVAKALGLSRQA
LYRRMDKFGLDKS

Sequences:

>Translated_493_residues
MDTILIVDDNHAICQALGLMLELNDYRVLTCHSPEDALGLLATQDVDLVIQDMNFTRDTTSGEEGKQLFYALRERQGDLP
IILMTAWTQLETAVELVKAGAADYMGKPWDDAKVLNSITNLIALYKLSRANHRLERVNHQRQVAIADADLCGIVFGSGAM
QRCIDLALQLARSDVSVLITGPNGAGKDKLADILHANSPLKNKPFIKVNVGALPMDLLEAELFGAEAGAFTGATKARIGR
FEAADGGTLFLDEIGNLPLSGQVKLLRVLQTGEFERLGSHKTQKVKVRVISATNADLAQDIAEGRFREDLFYRLNVIELA
LSPLNQRTDDILPLVQHFIGSNFSLSKPALQALLHHRWPGNVRELENACKRAVLLAQSHVLTEADFGLAPVVSAVRAATS
HISATSEPRRFDQRQSDPQPVYASASIPTHATFSDSSARDQTQSANEAIEVSREDIEAALKQHHGVIARVAKALGLSRQA
LYRRMDKFGLDKS
>Mature_493_residues
MDTILIVDDNHAICQALGLMLELNDYRVLTCHSPEDALGLLATQDVDLVIQDMNFTRDTTSGEEGKQLFYALRERQGDLP
IILMTAWTQLETAVELVKAGAADYMGKPWDDAKVLNSITNLIALYKLSRANHRLERVNHQRQVAIADADLCGIVFGSGAM
QRCIDLALQLARSDVSVLITGPNGAGKDKLADILHANSPLKNKPFIKVNVGALPMDLLEAELFGAEAGAFTGATKARIGR
FEAADGGTLFLDEIGNLPLSGQVKLLRVLQTGEFERLGSHKTQKVKVRVISATNADLAQDIAEGRFREDLFYRLNVIELA
LSPLNQRTDDILPLVQHFIGSNFSLSKPALQALLHHRWPGNVRELENACKRAVLLAQSHVLTEADFGLAPVVSAVRAATS
HISATSEPRRFDQRQSDPQPVYASASIPTHATFSDSSARDQTQSANEAIEVSREDIEAALKQHHGVIARVAKALGLSRQA
LYRRMDKFGLDKS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=501, Percent_Identity=37.125748502994, Blast_Score=276, Evalue=3e-75,
Organism=Escherichia coli, GI1790299, Length=498, Percent_Identity=35.3413654618474, Blast_Score=271, Evalue=7e-74,
Organism=Escherichia coli, GI1790437, Length=494, Percent_Identity=35.4251012145749, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1788905, Length=389, Percent_Identity=40.3598971722365, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI87082117, Length=386, Percent_Identity=38.60103626943, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1789087, Length=394, Percent_Identity=38.0710659898477, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI87082152, Length=355, Percent_Identity=37.4647887323944, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1786524, Length=240, Percent_Identity=47.5, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1789233, Length=341, Percent_Identity=37.2434017595308, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI87081872, Length=214, Percent_Identity=47.196261682243, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1787583, Length=244, Percent_Identity=39.7540983606557, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1789828, Length=273, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI87081858, Length=339, Percent_Identity=30.0884955752212, Blast_Score=116, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53949; Mature: 53949

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTILIVDDNHAICQALGLMLELNDYRVLTCHSPEDALGLLATQDVDLVIQDMNFTRDTT
CCEEEEEECCHHHHHHHHHHEEECCEEEEEECCCCHHHHHHEECCCEEEEECCCCCCCCC
SGEEGKQLFYALRERQGDLPIILMTAWTQLETAVELVKAGAADYMGKPWDDAKVLNSITN
CCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHH
LIALYKLSRANHRLERVNHQRQVAIADADLCGIVFGSGAMQRCIDLALQLARSDVSVLIT
HHHHHHHHHHHHHHHHHCCHHEEEEECCCCHHHEECCHHHHHHHHHHHHHHCCCCEEEEE
GPNGAGKDKLADILHANSPLKNKPFIKVNVGALPMDLLEAELFGAEAGAFTGATKARIGR
CCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHCCC
FEAADGGTLFLDEIGNLPLSGQVKLLRVLQTGEFERLGSHKTQKVKVRVISATNADLAQD
EECCCCCEEEHHHHCCCCCCCCHHHHHHHHCCCHHHHCCCCCEEEEEEEEECCCHHHHHH
IAEGRFREDLFYRLNVIELALSPLNQRTDDILPLVQHFIGSNFSLSKPALQALLHHRWPG
HHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCC
NVRELENACKRAVLLAQSHVLTEADFGLAPVVSAVRAATSHISATSEPRRFDQRQSDPQP
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCC
VYASASIPTHATFSDSSARDQTQSANEAIEVSREDIEAALKQHHGVIARVAKALGLSRQA
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHH
LYRRMDKFGLDKS
HHHHHHHHCCCCC
>Mature Secondary Structure
MDTILIVDDNHAICQALGLMLELNDYRVLTCHSPEDALGLLATQDVDLVIQDMNFTRDTT
CCEEEEEECCHHHHHHHHHHEEECCEEEEEECCCCHHHHHHEECCCEEEEECCCCCCCCC
SGEEGKQLFYALRERQGDLPIILMTAWTQLETAVELVKAGAADYMGKPWDDAKVLNSITN
CCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHH
LIALYKLSRANHRLERVNHQRQVAIADADLCGIVFGSGAMQRCIDLALQLARSDVSVLIT
HHHHHHHHHHHHHHHHHCCHHEEEEECCCCHHHEECCHHHHHHHHHHHHHHCCCCEEEEE
GPNGAGKDKLADILHANSPLKNKPFIKVNVGALPMDLLEAELFGAEAGAFTGATKARIGR
CCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHCCC
FEAADGGTLFLDEIGNLPLSGQVKLLRVLQTGEFERLGSHKTQKVKVRVISATNADLAQD
EECCCCCEEEHHHHCCCCCCCCHHHHHHHHCCCHHHHCCCCCEEEEEEEEECCCHHHHHH
IAEGRFREDLFYRLNVIELALSPLNQRTDDILPLVQHFIGSNFSLSKPALQALLHHRWPG
HHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCC
NVRELENACKRAVLLAQSHVLTEADFGLAPVVSAVRAATSHISATSEPRRFDQRQSDPQP
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCC
VYASASIPTHATFSDSSARDQTQSANEAIEVSREDIEAALKQHHGVIARVAKALGLSRQA
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHH
LYRRMDKFGLDKS
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]