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The map label for this gene is atoC [H]

Identifier: 126175130

GI number: 126175130

Start: 3442081

End: 3443424

Strand: Reverse

Name: atoC [H]

Synonym: Sbal_2928

Alternate gene names: 126175130

Gene position: 3443424-3442081 (Counterclockwise)

Preceding gene: 126175131

Following gene: 126175129

Centisome position: 67.16

GC content: 46.73

Gene sequence:

>1344_bases
ATGTCTGAAGCAAAGTTATTGCTCGTTGAAGATGATGCCTCATTGCGTGAAGCCTTGTTGGATACCTTAATGTTGGCTCA
GTATGAGTGCATTGATGTTGCCTCCGGTGAAGACGCTATTTTAGCCTTAAAACAACATCAATTTGATTTAGTCATTAGCG
ATGTGCAGATGCAAGGCATTGGTGGGTTGGGATTATTAAACTTCCTACAGCAACATCATCCTAAGTTGCCAGTATTGTTG
ATGACAGCTTATGCCACGATTGGTAGTGCGGTGGATGCCATTAAATTGGGCGCTGTCGATTACTTAGCGAAACCTTTTGC
GCCAGAAGTCTTGCTCAATCAAGTGTCCCGCTATTTGCCGTTAAAACAAAATGTGGATCAGCCAGTTGTTGCCGATGAGA
AGAGTTTAGCTTTATTGGCACTGGCTCAGCGGGTTGCTGCATCCGATGCCTCTGTTATGATCTTAGGTCCAAGCGGCTCG
GGTAAAGAAGTCTTGGCCCGCTATATTCATCAGCACAGTAGCCGTGCGGATCAAGCTTTTGTGGCCATTAACTGTGCAGC
GATTCCTGAGAATATGCTCGAAGCCACTCTTTTTGGTTATGAAAAAGGTGCATTTACTGGCGCCTATCAAGCGTGTCCGG
GGAAATTTGAGCAGGCTCAAGGTGGCACTTTGCTGCTAGATGAAATCTCTGAAATGGATTTAGGCTTACAAGCTAAGTTA
TTGCGGGTATTGCAAGAGCGTGAAGTTGAGCGTTTAGGCGGCCGTAAAACCATTAAGCTCGATGTACGCGTGCTTGCCAC
ATCCAATCGCGACTTAAAAGCCGTGGTAGCCGCCGGTGGATTTAGGGAAGATCTCTACTATCGAATCAACGTGTTCCCCT
TAGCTTGGCCCGCATTAAGTCAACGTCCTGCGGATATTCTGCCTCTTGCGCGTCATTTACTGGTTAAGCATGCCAAGGCA
TTGAATGTCGCCGATGTGCCTGAGTTGGATGAAAATGCACGTCGACGTTTATTGAGTCATCGCTGGCCGGGGAACGTACG
TGAACTCGATAATGTTATACAGCGGGCTTTGATATTAAGAGCCGGTCAAGTGATCACCGCTAATGACATTATTATCGATG
CGCAGGATGTGATTTTAGGCGGCGAAGACCTAGATCAATTTGTTGCCGAGCCAGACGGTTTAGGCGAAGAGCTTAAAGCG
CAGGAGCATGTGATTATTTTAGAAACCCTTAATCAATGCCAAGGAAGCCGCAAACTGGTCGCTGAAAAACTGGGGATAAG
CGCCCGAACCTTAAGATACAAGATGGCAAGAATGCGTGATATGGGCATTCAACTGCCAAATTAG

Upstream 100 bases:

>100_bases
GGACAACTGCAATTAAGTTGCTTACCGAATAAAGGTTGCACTGTGTCTTTAGTCTTCCCACGGGCTAAATCTGCGGTGAT
ATTACCTTTGGAGATTACCC

Downstream 100 bases:

>100_bases
TCTTTAAATTCAAGTTATAATCTTGCGGCCTCAACATGAGTGTGAGGCTGCATTTATTAAAATATACCACCGCAAAAGTG
ACCTGTTTTATCCAGAATCC

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSEAKLLLVEDDASLREALLDTLMLAQYECIDVASGEDAILALKQHQFDLVISDVQMQGIGGLGLLNFLQQHHPKLPVLL
MTAYATIGSAVDAIKLGAVDYLAKPFAPEVLLNQVSRYLPLKQNVDQPVVADEKSLALLALAQRVAASDASVMILGPSGS
GKEVLARYIHQHSSRADQAFVAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
LRVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGGFREDLYYRINVFPLAWPALSQRPADILPLARHLLVKHAKA
LNVADVPELDENARRRLLSHRWPGNVRELDNVIQRALILRAGQVITANDIIIDAQDVILGGEDLDQFVAEPDGLGEELKA
QEHVIILETLNQCQGSRKLVAEKLGISARTLRYKMARMRDMGIQLPN

Sequences:

>Translated_447_residues
MSEAKLLLVEDDASLREALLDTLMLAQYECIDVASGEDAILALKQHQFDLVISDVQMQGIGGLGLLNFLQQHHPKLPVLL
MTAYATIGSAVDAIKLGAVDYLAKPFAPEVLLNQVSRYLPLKQNVDQPVVADEKSLALLALAQRVAASDASVMILGPSGS
GKEVLARYIHQHSSRADQAFVAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
LRVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGGFREDLYYRINVFPLAWPALSQRPADILPLARHLLVKHAKA
LNVADVPELDENARRRLLSHRWPGNVRELDNVIQRALILRAGQVITANDIIIDAQDVILGGEDLDQFVAEPDGLGEELKA
QEHVIILETLNQCQGSRKLVAEKLGISARTLRYKMARMRDMGIQLPN
>Mature_446_residues
SEAKLLLVEDDASLREALLDTLMLAQYECIDVASGEDAILALKQHQFDLVISDVQMQGIGGLGLLNFLQQHHPKLPVLLM
TAYATIGSAVDAIKLGAVDYLAKPFAPEVLLNQVSRYLPLKQNVDQPVVADEKSLALLALAQRVAASDASVMILGPSGSG
KEVLARYIHQHSSRADQAFVAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKLL
RVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGGFREDLYYRINVFPLAWPALSQRPADILPLARHLLVKHAKAL
NVADVPELDENARRRLLSHRWPGNVRELDNVIQRALILRAGQVITANDIIIDAQDVILGGEDLDQFVAEPDGLGEELKAQ
EHVIILETLNQCQGSRKLVAEKLGISARTLRYKMARMRDMGIQLPN

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=448, Percent_Identity=42.8571428571429, Blast_Score=325, Evalue=3e-90,
Organism=Escherichia coli, GI1790437, Length=448, Percent_Identity=38.8392857142857, Blast_Score=285, Evalue=4e-78,
Organism=Escherichia coli, GI1790299, Length=482, Percent_Identity=35.4771784232365, Blast_Score=271, Evalue=8e-74,
Organism=Escherichia coli, GI1788905, Length=375, Percent_Identity=42.1333333333333, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI87082117, Length=307, Percent_Identity=45.928338762215, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1789087, Length=322, Percent_Identity=43.4782608695652, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI1789233, Length=307, Percent_Identity=41.042345276873, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI87081872, Length=303, Percent_Identity=37.6237623762376, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI87082152, Length=231, Percent_Identity=47.6190476190476, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1786524, Length=222, Percent_Identity=45.945945945946, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1787583, Length=320, Percent_Identity=35.625, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789828, Length=239, Percent_Identity=37.2384937238494, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI87081858, Length=228, Percent_Identity=32.0175438596491, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1790552, Length=107, Percent_Identity=35.5140186915888, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49006; Mature: 48875

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAKLLLVEDDASLREALLDTLMLAQYECIDVASGEDAILALKQHQFDLVISDVQMQGI
CCCCEEEEEECCHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEECCCEEEEEEEEEECCC
GGLGLLNFLQQHHPKLPVLLMTAYATIGSAVDAIKLGAVDYLAKPFAPEVLLNQVSRYLP
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
LKQNVDQPVVADEKSLALLALAQRVAASDASVMILGPSGSGKEVLARYIHQHSSRADQAF
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEE
VAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
EEEEEHHCCHHHHHHHHHCCCCCCCCCCHHCCCCCCHHCCCCEEEEHHHHHCCCCHHHHH
LRVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGGFREDLYYRINVFPLAWPALS
HHHHHHHHHHHHCCCEEEEEEEEEEEECCCCEEEEEECCCCCCCEEEEEEEEEEECHHHC
QRPADILPLARHLLVKHAKALNVADVPELDENARRRLLSHRWPGNVRELDNVIQRALILR
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AGQVITANDIIIDAQDVILGGEDLDQFVAEPDGLGEELKAQEHVIILETLNQCQGSRKLV
CCCEEEECCEEEECHHEEECCCHHHHHHCCCCCCCHHHCCCCCEEEEEHHHHCCCHHHHH
AEKLGISARTLRYKMARMRDMGIQLPN
HHHHCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SEAKLLLVEDDASLREALLDTLMLAQYECIDVASGEDAILALKQHQFDLVISDVQMQGI
CCCEEEEEECCHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEECCCEEEEEEEEEECCC
GGLGLLNFLQQHHPKLPVLLMTAYATIGSAVDAIKLGAVDYLAKPFAPEVLLNQVSRYLP
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
LKQNVDQPVVADEKSLALLALAQRVAASDASVMILGPSGSGKEVLARYIHQHSSRADQAF
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEE
VAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
EEEEEHHCCHHHHHHHHHCCCCCCCCCCHHCCCCCCHHCCCCEEEEHHHHHCCCCHHHHH
LRVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGGFREDLYYRINVFPLAWPALS
HHHHHHHHHHHHCCCEEEEEEEEEEEECCCCEEEEEECCCCCCCEEEEEEEEEEECHHHC
QRPADILPLARHLLVKHAKALNVADVPELDENARRRLLSHRWPGNVRELDNVIQRALILR
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AGQVITANDIIIDAQDVILGGEDLDQFVAEPDGLGEELKAQEHVIILETLNQCQGSRKLV
CCCEEEECCEEEECHHEEECCCHHHHHHCCCCCCCHHHCCCCCEEEEEHHHHCCCHHHHH
AEKLGISARTLRYKMARMRDMGIQLPN
HHHHCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]