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The map label for this gene is cobB [H]

Identifier: 126174721

GI number: 126174721

Start: 2931096

End: 2931827

Strand: Reverse

Name: cobB [H]

Synonym: Sbal_2508

Alternate gene names: 126174721

Gene position: 2931827-2931096 (Counterclockwise)

Preceding gene: 126174723

Following gene: 126174720

Centisome position: 57.18

GC content: 51.09

Gene sequence:

>732_bases
ATGTACCAGCAAATTGTGGTGTTAACCGGCGCAGGGATCTCTGCTGAGTCGGGATTACGCACCTTTCGCGATCAAGATGG
TCTGTGGGAAGAACATCATATTGAAGACGTGGCTACGCCAGAAGGGTATGAACGTGATGCTGAGCTGGTGGAACGCTTTT
ACAATAGTCGTTGGCAGCAATTGCACAGTGGCACAGTTGAGCCCAATGCGGCGCACCTTGCCTTGGCAAAGTTAGAGGCA
GAATTTCAAGGCCAGTTATTGGTGGTGACCCAGAATATTGATGATTTGCATGAGCGTGCGGGTTCACGTCGATTACTGCA
TATGCATGGCGAGCTATCTAAAGGGCGCTGCCCGCGCTCACGTCAGGCCTTTATTCTGCGTGAGCCTTTTGGTGTCGATA
ATTGTTGTACCTGCTGTATTCCTGCCCAGCGTTTACGCCCCCATGTGGTATGGTTTGGCGAAATGCCCTTAGGGATGGAT
CGTATCCACGATGCGCTGGATAACTGCGACTTGTTTATTGCCATTGGCACCTCTGGTACTGTGTATCCTGCCGCGGGCTT
TGTGGATACCGCTAATCATCACGGTGCGCAAACGGTTGAAGTAAATATGATGGCACCCGATAGACACAGTCAGTTTCAAT
ACCATCTGACTGGCAAAGCGGGGGAGTTAGTGCCTCAGTTGGTCGAGACTATTTTAGCGGGCCGAGTGATTGGCAGTGAG
TCGAACACATGA

Upstream 100 bases:

>100_bases
ATTCAAGCATAGTTTTTGTATGGTTATACCAAGGAATAATATTCACGGCCGCCAAAGTCAGTGAGAATAATTCAAATAAA
TAAAATAATAAGGAATCGGC

Downstream 100 bases:

>100_bases
GTGATAAAATCGCGATAATTATGCGTGGTTTACCGGGCAGTGGTAAGTCACATTGGGTTGAAACTTATATCTTTTCTCTT
CCTTTAGAAAAAGCCATTGG

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MYQQIVVLTGAGISAESGLRTFRDQDGLWEEHHIEDVATPEGYERDAELVERFYNSRWQQLHSGTVEPNAAHLALAKLEA
EFQGQLLVVTQNIDDLHERAGSRRLLHMHGELSKGRCPRSRQAFILREPFGVDNCCTCCIPAQRLRPHVVWFGEMPLGMD
RIHDALDNCDLFIAIGTSGTVYPAAGFVDTANHHGAQTVEVNMMAPDRHSQFQYHLTGKAGELVPQLVETILAGRVIGSE
SNT

Sequences:

>Translated_243_residues
MYQQIVVLTGAGISAESGLRTFRDQDGLWEEHHIEDVATPEGYERDAELVERFYNSRWQQLHSGTVEPNAAHLALAKLEA
EFQGQLLVVTQNIDDLHERAGSRRLLHMHGELSKGRCPRSRQAFILREPFGVDNCCTCCIPAQRLRPHVVWFGEMPLGMD
RIHDALDNCDLFIAIGTSGTVYPAAGFVDTANHHGAQTVEVNMMAPDRHSQFQYHLTGKAGELVPQLVETILAGRVIGSE
SNT
>Mature_243_residues
MYQQIVVLTGAGISAESGLRTFRDQDGLWEEHHIEDVATPEGYERDAELVERFYNSRWQQLHSGTVEPNAAHLALAKLEA
EFQGQLLVVTQNIDDLHERAGSRRLLHMHGELSKGRCPRSRQAFILREPFGVDNCCTCCIPAQRLRPHVVWFGEMPLGMD
RIHDALDNCDLFIAIGTSGTVYPAAGFVDTANHHGAQTVEVNMMAPDRHSQFQYHLTGKAGELVPQLVETILAGRVIGSE
SNT

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=236, Percent_Identity=36.4406779661017, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI6912664, Length=254, Percent_Identity=34.251968503937, Blast_Score=147, Evalue=7e-36,
Organism=Homo sapiens, GI13787215, Length=242, Percent_Identity=34.297520661157, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI7657575, Length=247, Percent_Identity=27.5303643724696, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI308199517, Length=236, Percent_Identity=57.2033898305085, Blast_Score=270, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI17541892, Length=197, Percent_Identity=31.9796954314721, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17137536, Length=224, Percent_Identity=29.4642857142857, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571445, Length=119, Percent_Identity=38.655462184874, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27069; Mature: 27069

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQQIVVLTGAGISAESGLRTFRDQDGLWEEHHIEDVATPEGYERDAELVERFYNSRWQQ
CCCEEEEEECCCCCCHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LHSGTVEPNAAHLALAKLEAEFQGQLLVVTQNIDDLHERAGSRRLLHMHGELSKGRCPRS
HHCCCCCCCHHHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCCEEEEECCCCCCCCCCCC
RQAFILREPFGVDNCCTCCIPAQRLRPHVVWFGEMPLGMDRIHDALDNCDLFIAIGTSGT
CCEEEEECCCCCCCCEEECCCHHHCCCEEEEEECCCCCHHHHHHHHCCCEEEEEECCCCC
VYPAAGFVDTANHHGAQTVEVNMMAPDRHSQFQYHLTGKAGELVPQLVETILAGRVIGSE
EEECCCCEECCCCCCCEEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHCEEECCC
SNT
CCC
>Mature Secondary Structure
MYQQIVVLTGAGISAESGLRTFRDQDGLWEEHHIEDVATPEGYERDAELVERFYNSRWQQ
CCCEEEEEECCCCCCHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LHSGTVEPNAAHLALAKLEAEFQGQLLVVTQNIDDLHERAGSRRLLHMHGELSKGRCPRS
HHCCCCCCCHHHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCCEEEEECCCCCCCCCCCC
RQAFILREPFGVDNCCTCCIPAQRLRPHVVWFGEMPLGMDRIHDALDNCDLFIAIGTSGT
CCEEEEECCCCCCCCEEECCCHHHCCCEEEEEECCCCCHHHHHHHHCCCEEEEEECCCCC
VYPAAGFVDTANHHGAQTVEVNMMAPDRHSQFQYHLTGKAGELVPQLVETILAGRVIGSE
EEECCCCEECCCCCCCEEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHCEEECCC
SNT
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]