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The map label for this gene is yeiG [H]

Identifier: 126174631

GI number: 126174631

Start: 2814820

End: 2815662

Strand: Reverse

Name: yeiG [H]

Synonym: Sbal_2418

Alternate gene names: 126174631

Gene position: 2815662-2814820 (Counterclockwise)

Preceding gene: 126174632

Following gene: 126174629

Centisome position: 54.91

GC content: 49.82

Gene sequence:

>843_bases
ATGACCATAGAAAATATCAGTTGTAACAAGAGTTTCGGCGGTTGGCATAAGCAATATCGCCATCAATCTCAGTCGTTAAA
CTGCGAGATGCGCTTTGCGATTTATCTGCCACCTGAAGCGGTGAATAAACCTGTGCCTGTGCTGTATTGGCTCTCAGGCT
TAACCTGCACCGATGAAAACTTTATGCAGAAGGCAGGCGCCCAGCGCATGGCGGCTGAGCTTGGGATGGCGATTGTTGCC
CCTGATACTAGTCCTCGCGGTGATGATGTGCCCGATGCAGCGGACAAAGCCTACGATTTAGGCTTAGGAGCTGGGTTCTA
CCTCAATGCGACCAAGGCACCGTGGAATCGACACTACAAAATGTACGATTACATTGTCCACGAGTTGCCCGCGTTGATTG
AAGCGCATTTTCCGGTGACTACCCAGCGCGCCATCTCTGGCCATTCGATGGGCGGCCATGGTGCTTTGGTGATTGGCCTG
AGTAATCCGCACAGATACAGCTCTATTTCGGCCTTTAGTCCGATTTCGAATCCGAGTAATGCGCCTTGGGGCATTAAAGC
CTTCAGTGAGTATTTAGGTGAGAATCGTGAACACTGGCGCCAGTACGATGCTTGTGAGTTGCTCAAGCTCGCCATTGCCG
AGGTGCCAGTTATGATTGACCAAGGTGAAGCCGATAGCTTTTTAGACACCCAATTGATGCCACAATCGCTAGTGGACATT
GCCAATGCTAAGGGTTATCCCTTAGATGTGCGGATGCAAGCGGGGTACGATCACAGCTACTACTTCATCGCGAGTTTTAT
TGAAGAACACCTTAAGTTCCATAGTTTGTACTTTAAGCCCTGA

Upstream 100 bases:

>100_bases
TCTGTCTGCTGTGTTGCACTGAGCAGATGGCAAACGCTAAGACAAATGCCATGACTAACGCTAAGACAAGCGCTAAAAGA
TTGAGCTTAAAAGGACTTGT

Downstream 100 bases:

>100_bases
ATCGTCGATTCAGCAGTCACGCCGATGAGCTAAAACAAAAATGCCGCAACTCAGTGAGTCGCGGCATTTTTTATAATGCA
GTTTAAGTGATTAGTGGGAG

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MTIENISCNKSFGGWHKQYRHQSQSLNCEMRFAIYLPPEAVNKPVPVLYWLSGLTCTDENFMQKAGAQRMAAELGMAIVA
PDTSPRGDDVPDAADKAYDLGLGAGFYLNATKAPWNRHYKMYDYIVHELPALIEAHFPVTTQRAISGHSMGGHGALVIGL
SNPHRYSSISAFSPISNPSNAPWGIKAFSEYLGENREHWRQYDACELLKLAIAEVPVMIDQGEADSFLDTQLMPQSLVDI
ANAKGYPLDVRMQAGYDHSYYFIASFIEEHLKFHSLYFKP

Sequences:

>Translated_280_residues
MTIENISCNKSFGGWHKQYRHQSQSLNCEMRFAIYLPPEAVNKPVPVLYWLSGLTCTDENFMQKAGAQRMAAELGMAIVA
PDTSPRGDDVPDAADKAYDLGLGAGFYLNATKAPWNRHYKMYDYIVHELPALIEAHFPVTTQRAISGHSMGGHGALVIGL
SNPHRYSSISAFSPISNPSNAPWGIKAFSEYLGENREHWRQYDACELLKLAIAEVPVMIDQGEADSFLDTQLMPQSLVDI
ANAKGYPLDVRMQAGYDHSYYFIASFIEEHLKFHSLYFKP
>Mature_279_residues
TIENISCNKSFGGWHKQYRHQSQSLNCEMRFAIYLPPEAVNKPVPVLYWLSGLTCTDENFMQKAGAQRMAAELGMAIVAP
DTSPRGDDVPDAADKAYDLGLGAGFYLNATKAPWNRHYKMYDYIVHELPALIEAHFPVTTQRAISGHSMGGHGALVIGLS
NPHRYSSISAFSPISNPSNAPWGIKAFSEYLGENREHWRQYDACELLKLAIAEVPVMIDQGEADSFLDTQLMPQSLVDIA
NAKGYPLDVRMQAGYDHSYYFIASFIEEHLKFHSLYFKP

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=281, Percent_Identity=51.2455516014235, Blast_Score=310, Evalue=8e-85,
Organism=Escherichia coli, GI1788477, Length=278, Percent_Identity=57.5539568345324, Blast_Score=337, Evalue=4e-94,
Organism=Escherichia coli, GI1786551, Length=273, Percent_Identity=55.3113553113553, Blast_Score=318, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17510185, Length=279, Percent_Identity=48.0286738351254, Blast_Score=260, Evalue=5e-70,
Organism=Saccharomyces cerevisiae, GI6322393, Length=283, Percent_Identity=43.1095406360424, Blast_Score=229, Evalue=5e-61,
Organism=Drosophila melanogaster, GI45551932, Length=280, Percent_Identity=48.5714285714286, Blast_Score=280, Evalue=6e-76,
Organism=Drosophila melanogaster, GI24648347, Length=280, Percent_Identity=48.5714285714286, Blast_Score=280, Evalue=8e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31372; Mature: 31241

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIENISCNKSFGGWHKQYRHQSQSLNCEMRFAIYLPPEAVNKPVPVLYWLSGLTCTDEN
CCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEECHHHHCCCCCEEEEECCCCCCCHH
FMQKAGAQRMAAELGMAIVAPDTSPRGDDVPDAADKAYDLGLGAGFYLNATKAPWNRHYK
HHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCHHHHHHHCCCCCCEEEECCCCCHHHHHH
MYDYIVHELPALIEAHFPVTTQRAISGHSMGGHGALVIGLSNPHRYSSISAFSPISNPSN
HHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
APWGIKAFSEYLGENREHWRQYDACELLKLAIAEVPVMIDQGEADSFLDTQLMPQSLVDI
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHH
ANAKGYPLDVRMQAGYDHSYYFIASFIEEHLKFHSLYFKP
HCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TIENISCNKSFGGWHKQYRHQSQSLNCEMRFAIYLPPEAVNKPVPVLYWLSGLTCTDEN
CCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEECHHHHCCCCCEEEEECCCCCCCHH
FMQKAGAQRMAAELGMAIVAPDTSPRGDDVPDAADKAYDLGLGAGFYLNATKAPWNRHYK
HHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCHHHHHHHCCCCCCEEEECCCCCHHHHHH
MYDYIVHELPALIEAHFPVTTQRAISGHSMGGHGALVIGLSNPHRYSSISAFSPISNPSN
HHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
APWGIKAFSEYLGENREHWRQYDACELLKLAIAEVPVMIDQGEADSFLDTQLMPQSLVDI
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHH
ANAKGYPLDVRMQAGYDHSYYFIASFIEEHLKFHSLYFKP
HCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA