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The map label for this gene is mepA [H]

Identifier: 126174387

GI number: 126174387

Start: 2512933

End: 2514573

Strand: Reverse

Name: mepA [H]

Synonym: Sbal_2170

Alternate gene names: 126174387

Gene position: 2514573-2512933 (Counterclockwise)

Preceding gene: 126174388

Following gene: 126174386

Centisome position: 49.04

GC content: 45.89

Gene sequence:

>1641_bases
ATGCCAATAAACTTAGGAGAATTGTTTGTGAAACATGCAACAGCCAACACTTTCAAGCCCGCCAGTATCAATGTTGAACC
TTCTGACATTGTGCCCTTAGCAGCCACCGAAACACCCTCCCACGGGAAATATCACTCAGGCTCTCAGTCAACAGAGTCCT
TAGGTACGTTAGCTATCCCTACTTTGTATTTACGTTTTGCGTTACCCATGGCATTCGCCATGATGCTCAGCGGCAGTTAC
AACTTAGTCGACTCTTATTTTATTTTGAAATACATCGGCGCCGATGCATTGGCTGGGGTAACGATTGCCTTCCCGTTACA
AATGATGATTTTCGCTTTAGCCTGCATGATAGGAAATGGGACTGCGACCTTAGTGAGCCGATTTTTAGGGGCAAACGAGT
TTGATAAGGCGAGTCAAATCGCGAACACCGGTTTCGCGTTAGCCCTAGCTTGTGGCGTGATCGTCACTGTCGTGTCACTC
GCCCAGCTCGATAATCTATTAGCGTTTATTGGGGTAAGCTCAACACTTGCCTTAGCTGCTACAGAGTATCTACAACCCAT
TCTCTGTTTTAGTCTGTTCACCTTTTTGTTATCCCTTAGCGGCGATTTACTCAGAGCACAAGGCAAAGTCGTGGTGATGC
TGCTGGTTATCTTGTTGTCGGCGGTCATGAACATTCTGTTCGATACACTCTTTATTGCCGTTTTGGAGATGGGCGTAAGT
GGTGCGGCTTGGGCAACGGTAGCGGGCCAATGTGTGAGTCTATTTATCGCCGTCGTCTATTTTGTTCCAAATAACCGCTT
TGCCAATAAGCAGGCGCTTCATCGGCAAGCTGCCCAGCCTATTTGTTTTAGAATAGAGCAGATAAAGCTCAACCTCACTG
AGATAAAAGCGATTCTTGGCTTGGGTAGCCCAATACTATTGTCATATCTTGGGATTGCCTGCGTGATCTCATTGGTAAAT
CATATTTTAGTCAGTCATTTAGCCAATGTAGTGCCCAATACGCCAGCGGCGAATGAGGTCGCGTACATGATCAGCGCTTA
TGGTTTGATCGGCCGTTTTAATATCTTTATCGCCCTGCCGCTCATGGCTCTCACCAGTGCAGCACAAACGATCAGTGCCT
ATAACTATGGGGCGATGGCATCTTCTCGGGTGTTAGCGTGTGCTAAATGGGGAATCGTCTTGACCTGCTGTTATCTGAGT
GTAGTGACAATCATATTTATGGGGTTTCCTACCTCAGTATTTGGTGTTTTCACCGATGACCTCGCACTCATTGCCGCCTG
TGTTAAGATTTCGAGTGTGACGTTTATCGCCTTACCTTTGGCGGGGATCACAGGTATTGCGATTGCTGTGTATCAAGGCA
CAAACCGCCCTAAGCTTGCATTGCTATTATCTGGGATAAAAATCTATGGTTTATTACTGCCCCTGCTGGTTCTGTTACCT
CAACTATCCTTCGCAGATATTTCATTTATCACAGGTGCATTAAACATTAATATCATGCGAAACGCTTTGATTGAGTTATG
GATGGCCTTTCCAATTGCGGACATCTTAGCTTGTCTCTTGAGTTTATTGATCATCAGTATTTGGCCTTTCATCCACGTGC
CGCGAGCAAATCGAGTCAGTCATGGAGGTAATGCAAAATGA

Upstream 100 bases:

>100_bases
AGCCTGTCCGCAAAAGATGATATCACTCTGATAAATTAACAGCGTTGCGAATCGATTTCATATCGAACCCACAGCAATCA
AATAAGTTTGGCTTAGCGGA

Downstream 100 bases:

>100_bases
AGTTAGCCAATATGAAAGACTCAAGCGCTATCGCATTAAATGAAACCAAAATTCGCACTAAAAAGCTGTTCAAAGCTTGT
CAGCAGGATGAGCCGTCAGC

Product: multi anti extrusion protein MatE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MPINLGELFVKHATANTFKPASINVEPSDIVPLAATETPSHGKYHSGSQSTESLGTLAIPTLYLRFALPMAFAMMLSGSY
NLVDSYFILKYIGADALAGVTIAFPLQMMIFALACMIGNGTATLVSRFLGANEFDKASQIANTGFALALACGVIVTVVSL
AQLDNLLAFIGVSSTLALAATEYLQPILCFSLFTFLLSLSGDLLRAQGKVVVMLLVILLSAVMNILFDTLFIAVLEMGVS
GAAWATVAGQCVSLFIAVVYFVPNNRFANKQALHRQAAQPICFRIEQIKLNLTEIKAILGLGSPILLSYLGIACVISLVN
HILVSHLANVVPNTPAANEVAYMISAYGLIGRFNIFIALPLMALTSAAQTISAYNYGAMASSRVLACAKWGIVLTCCYLS
VVTIIFMGFPTSVFGVFTDDLALIAACVKISSVTFIALPLAGITGIAIAVYQGTNRPKLALLLSGIKIYGLLLPLLVLLP
QLSFADISFITGALNINIMRNALIELWMAFPIADILACLLSLLIISIWPFIHVPRANRVSHGGNAK

Sequences:

>Translated_546_residues
MPINLGELFVKHATANTFKPASINVEPSDIVPLAATETPSHGKYHSGSQSTESLGTLAIPTLYLRFALPMAFAMMLSGSY
NLVDSYFILKYIGADALAGVTIAFPLQMMIFALACMIGNGTATLVSRFLGANEFDKASQIANTGFALALACGVIVTVVSL
AQLDNLLAFIGVSSTLALAATEYLQPILCFSLFTFLLSLSGDLLRAQGKVVVMLLVILLSAVMNILFDTLFIAVLEMGVS
GAAWATVAGQCVSLFIAVVYFVPNNRFANKQALHRQAAQPICFRIEQIKLNLTEIKAILGLGSPILLSYLGIACVISLVN
HILVSHLANVVPNTPAANEVAYMISAYGLIGRFNIFIALPLMALTSAAQTISAYNYGAMASSRVLACAKWGIVLTCCYLS
VVTIIFMGFPTSVFGVFTDDLALIAACVKISSVTFIALPLAGITGIAIAVYQGTNRPKLALLLSGIKIYGLLLPLLVLLP
QLSFADISFITGALNINIMRNALIELWMAFPIADILACLLSLLIISIWPFIHVPRANRVSHGGNAK
>Mature_545_residues
PINLGELFVKHATANTFKPASINVEPSDIVPLAATETPSHGKYHSGSQSTESLGTLAIPTLYLRFALPMAFAMMLSGSYN
LVDSYFILKYIGADALAGVTIAFPLQMMIFALACMIGNGTATLVSRFLGANEFDKASQIANTGFALALACGVIVTVVSLA
QLDNLLAFIGVSSTLALAATEYLQPILCFSLFTFLLSLSGDLLRAQGKVVVMLLVILLSAVMNILFDTLFIAVLEMGVSG
AAWATVAGQCVSLFIAVVYFVPNNRFANKQALHRQAAQPICFRIEQIKLNLTEIKAILGLGSPILLSYLGIACVISLVNH
ILVSHLANVVPNTPAANEVAYMISAYGLIGRFNIFIALPLMALTSAAQTISAYNYGAMASSRVLACAKWGIVLTCCYLSV
VTIIFMGFPTSVFGVFTDDLALIAACVKISSVTFIALPLAGITGIAIAVYQGTNRPKLALLLSGIKIYGLLLPLLVLLPQ
LSFADISFITGALNINIMRNALIELWMAFPIADILACLLSLLIISIWPFIHVPRANRVSHGGNAK

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 58139; Mature: 58008

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPINLGELFVKHATANTFKPASINVEPSDIVPLAATETPSHGKYHSGSQSTESLGTLAIP
CCCCHHHHHHHHHCCCCCCCCEECCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
TLYLRFALPMAFAMMLSGSYNLVDSYFILKYIGADALAGVTIAFPLQMMIFALACMIGNG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
TATLVSRFLGANEFDKASQIANTGFALALACGVIVTVVSLAQLDNLLAFIGVSSTLALAA
HHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEYLQPILCFSLFTFLLSLSGDLLRAQGKVVVMLLVILLSAVMNILFDTLFIAVLEMGVS
HHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GAAWATVAGQCVSLFIAVVYFVPNNRFANKQALHRQAAQPICFRIEQIKLNLTEIKAILG
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LGSPILLSYLGIACVISLVNHILVSHLANVVPNTPAANEVAYMISAYGLIGRFNIFIALP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LMALTSAAQTISAYNYGAMASSRVLACAKWGIVLTCCYLSVVTIIFMGFPTSVFGVFTDD
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LALIAACVKISSVTFIALPLAGITGIAIAVYQGTNRPKLALLLSGIKIYGLLLPLLVLLP
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHC
QLSFADISFITGALNINIMRNALIELWMAFPIADILACLLSLLIISIWPFIHVPRANRVS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
HGGNAK
CCCCCC
>Mature Secondary Structure 
PINLGELFVKHATANTFKPASINVEPSDIVPLAATETPSHGKYHSGSQSTESLGTLAIP
CCCHHHHHHHHHCCCCCCCCEECCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
TLYLRFALPMAFAMMLSGSYNLVDSYFILKYIGADALAGVTIAFPLQMMIFALACMIGNG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
TATLVSRFLGANEFDKASQIANTGFALALACGVIVTVVSLAQLDNLLAFIGVSSTLALAA
HHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEYLQPILCFSLFTFLLSLSGDLLRAQGKVVVMLLVILLSAVMNILFDTLFIAVLEMGVS
HHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GAAWATVAGQCVSLFIAVVYFVPNNRFANKQALHRQAAQPICFRIEQIKLNLTEIKAILG
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LGSPILLSYLGIACVISLVNHILVSHLANVVPNTPAANEVAYMISAYGLIGRFNIFIALP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LMALTSAAQTISAYNYGAMASSRVLACAKWGIVLTCCYLSVVTIIFMGFPTSVFGVFTDD
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LALIAACVKISSVTFIALPLAGITGIAIAVYQGTNRPKLALLLSGIKIYGLLLPLLVLLP
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHC
QLSFADISFITGALNINIMRNALIELWMAFPIADILACLLSLLIISIWPFIHVPRANRVS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
HGGNAK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA