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The map label for this gene is nrdA [H]

Identifier: 126174280

GI number: 126174280

Start: 2386554

End: 2388842

Strand: Reverse

Name: nrdA [H]

Synonym: Sbal_2059

Alternate gene names: 126174280

Gene position: 2388842-2386554 (Counterclockwise)

Preceding gene: 126174281

Following gene: 126174279

Centisome position: 46.59

GC content: 46.57

Gene sequence:

>2289_bases
ATGAATAGCACTATGACAGTCACAAAACGCTGTGGCGATCGTGAAAATATCGATCTCGAAAAAATACACCGCGTAATTAC
TTGGGCAGCCAAGGGATTAAAAAACGTTTCTGTTTCTGAAGTTGAACTTCGCTCGCACCTACAGTTTTTCGATGGCATCC
CAACCGAAGCTATCCATGAAACCATTATCAAAGCGGCGGCGGATTTAATTTCTCCAGAATCACCGGACTATCAATTCCTC
GCCGCCCGTTTAGCGGTGTTTCATTTGCGTAAGAAGGCCTTTGGTCAGTTCGAGCCGCCAGCACTGTATACCCACGTGAC
TAAGTTAGTTGAGCTTGGCAAGTATGATATGCACATTCTGCAGGATTACAGCCGCGAAGAACTCGACGTGATGGATACCT
ATATCGACCATTGGCGCGATATGGACTTTTCTTACGCTGCGGTAAAACAGCTTGAAGGCAAATATTTAGTTCAAAACCGT
GTGACGCACGAAATCTATGAGAGCGCCCAGTTCCTCTACATTTTGGTCGCGGCCTGTTTGTTTGCCCGTTATCCAAAAGA
AACGCGCCTGAAATACGTTAAAGATTTCTATGACGCGGTATCGACCTTTAAGATTTCGCTACCGACGCCAATCATGGCCG
GTGTGCGCACGCCAACGCGTCAGTTCAGCTCTTGCGTACTGATCGAATGTGGTGACAGCTTAGATTCCATCAACGCGACA
GCTTCGTCTATCGTGAAATACGTCAGCCAACGTGCGGGTATCGGTATTAACGCCGGTCGTATTCGCGCCTTAGGTAGCCC
AATCCGTGGTGGTGAAGCCTTCCACACAGGTTGTTTACCTTTCTATAAGTATTTCCAAACCGCAGTGAAGTCTTGTTCTC
AAGGCGGCGTGCGTGGCGGTGCTGCGACCCTGTTCTACCCTATTTGGCACTTAGAAGTCGAATCTCTGCTGGTATTGAAA
AATAACCGCGGCGTCGAAGACAACCGTATCCGTCATTTAGACTACGGTGTGCAGCTGAACAAAGTCATGTATCAACGTCT
GATCAAAGGCGAAAACATCAGCCTGTTTAGCCCATCTGACGTACCTGGCTTATATGATGCTTTCTTTGAAGATCAAAACG
AATTCGAACGTTTATATGTGCAATATGAGCAAGACAGCAGCATTCGTAAGAAAACCATAAAAGCAGTTGAGCTGTTTTCT
CTGATGATGCAAGAGCGTGCCTCAACTGGCCGTATCTACATTCAAAACGTGGATCACTGCAACACTCACAGCCCGTTCGA
TTCAAAAGTCGCACCGATCAGACAGTCTAACCTGTGTCTTGAAATCGCCCTGCCGACTAAACCATTGAACAACATCGATG
ATCCAGAAGGTGAAATCGCGCTTTGTACGCTGTCAGCACTTAACTTAGGTTCTATCAAAGAATTATCTGATATTGAGCCA
TTAGCCGACCTCGCCGTACGCGCACTGGATAACCTGTTGGATTATCAAGATTACCCCATCAAGGCCGCGCAAATTGCCTC
GATGAATCGCCGTACCTTAGGTATAGGCGTGATTAACTTCGCTAACTACTTAGCAAAAAATGGCATGAAGTATTCCGATG
GCAGCGCGAACGAGCTGACCCACAGAACCTTCGAAGCGATTCAGTACTATTTACTGAAAGCCTCAATGAACTTGGCCAAA
GAGCAAGGTGCGTGTCCGTTATTCCACGAGACCACATACTCTCAAGGTATTTTGCCAATCGATACCTACAAACGTGACCT
AGATAAAATTTGTGCAGAACCATTGCACTTAGACTGGGAATCACTGCGTAGCGATATCAAGCAATATGGCCTACGTAACT
CAACGCTGTCGGCATTAATGCCATCAGAAACCTCGTCGCAAATCTCCAATGCGACCAATGGTATCGAGCCACCACGTGGT
CTTATCAGCGTGAAATCGAGCAAAGACGGTCAGCTAAAACAAGTTGTACCTGATTTCGATACGCTGAAAGATAGCTATGA
ATTGCTATGGAAAATGCCAAGCAATGACGGTTACTTACAGCTAGTGGGTATCATGCAGAAGTTCGTTGACCAAGCGATTT
CGGCCAACACTAACTACGATCCTTCACGTTTTGAAGGCCGTAAAGTACCGATGCAAACCCTGCTGAAAGATTTGCTCAAT
GCTTACAAGTTAGGTGTGAAAACGCTTTACTACCATAACACTCGCGATGGTGCGTCGGATTCACACGATGACATCACCAA
TTTAGAGAAAGAAGACGATGGTTGCGCCGGCGGCGCGTGTAAAATCTAG

Upstream 100 bases:

>100_bases
AGTCAGCAGTATTTAAGGGACGGTTATTGATTGTTTTACAAGGATACGTACGGTGAACTTGCTCACCTAAATAGATATAA
GAACCAAGGCCTATCTCCAA

Downstream 100 bases:

>100_bases
TCTTTAACGTTAACGCGGCTCTTACAAATAAAAAGTATAGGGATCCCGATTGAGTGGATCCCTATCCATTGGAAAATAGC
ACCATGGCCTACTCTACCTT

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Protein B1; Ribonucleoside-diphosphate reductase 1 R1 subunit; Ribonucleotide reductase 1 [H]

Number of amino acids: Translated: 762; Mature: 762

Protein sequence:

>762_residues
MNSTMTVTKRCGDRENIDLEKIHRVITWAAKGLKNVSVSEVELRSHLQFFDGIPTEAIHETIIKAAADLISPESPDYQFL
AARLAVFHLRKKAFGQFEPPALYTHVTKLVELGKYDMHILQDYSREELDVMDTYIDHWRDMDFSYAAVKQLEGKYLVQNR
VTHEIYESAQFLYILVAACLFARYPKETRLKYVKDFYDAVSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
ASSIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCLPFYKYFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLVLK
NNRGVEDNRIRHLDYGVQLNKVMYQRLIKGENISLFSPSDVPGLYDAFFEDQNEFERLYVQYEQDSSIRKKTIKAVELFS
LMMQERASTGRIYIQNVDHCNTHSPFDSKVAPIRQSNLCLEIALPTKPLNNIDDPEGEIALCTLSALNLGSIKELSDIEP
LADLAVRALDNLLDYQDYPIKAAQIASMNRRTLGIGVINFANYLAKNGMKYSDGSANELTHRTFEAIQYYLLKASMNLAK
EQGACPLFHETTYSQGILPIDTYKRDLDKICAEPLHLDWESLRSDIKQYGLRNSTLSALMPSETSSQISNATNGIEPPRG
LISVKSSKDGQLKQVVPDFDTLKDSYELLWKMPSNDGYLQLVGIMQKFVDQAISANTNYDPSRFEGRKVPMQTLLKDLLN
AYKLGVKTLYYHNTRDGASDSHDDITNLEKEDDGCAGGACKI

Sequences:

>Translated_762_residues
MNSTMTVTKRCGDRENIDLEKIHRVITWAAKGLKNVSVSEVELRSHLQFFDGIPTEAIHETIIKAAADLISPESPDYQFL
AARLAVFHLRKKAFGQFEPPALYTHVTKLVELGKYDMHILQDYSREELDVMDTYIDHWRDMDFSYAAVKQLEGKYLVQNR
VTHEIYESAQFLYILVAACLFARYPKETRLKYVKDFYDAVSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
ASSIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCLPFYKYFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLVLK
NNRGVEDNRIRHLDYGVQLNKVMYQRLIKGENISLFSPSDVPGLYDAFFEDQNEFERLYVQYEQDSSIRKKTIKAVELFS
LMMQERASTGRIYIQNVDHCNTHSPFDSKVAPIRQSNLCLEIALPTKPLNNIDDPEGEIALCTLSALNLGSIKELSDIEP
LADLAVRALDNLLDYQDYPIKAAQIASMNRRTLGIGVINFANYLAKNGMKYSDGSANELTHRTFEAIQYYLLKASMNLAK
EQGACPLFHETTYSQGILPIDTYKRDLDKICAEPLHLDWESLRSDIKQYGLRNSTLSALMPSETSSQISNATNGIEPPRG
LISVKSSKDGQLKQVVPDFDTLKDSYELLWKMPSNDGYLQLVGIMQKFVDQAISANTNYDPSRFEGRKVPMQTLLKDLLN
AYKLGVKTLYYHNTRDGASDSHDDITNLEKEDDGCAGGACKI
>Mature_762_residues
MNSTMTVTKRCGDRENIDLEKIHRVITWAAKGLKNVSVSEVELRSHLQFFDGIPTEAIHETIIKAAADLISPESPDYQFL
AARLAVFHLRKKAFGQFEPPALYTHVTKLVELGKYDMHILQDYSREELDVMDTYIDHWRDMDFSYAAVKQLEGKYLVQNR
VTHEIYESAQFLYILVAACLFARYPKETRLKYVKDFYDAVSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
ASSIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCLPFYKYFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLVLK
NNRGVEDNRIRHLDYGVQLNKVMYQRLIKGENISLFSPSDVPGLYDAFFEDQNEFERLYVQYEQDSSIRKKTIKAVELFS
LMMQERASTGRIYIQNVDHCNTHSPFDSKVAPIRQSNLCLEIALPTKPLNNIDDPEGEIALCTLSALNLGSIKELSDIEP
LADLAVRALDNLLDYQDYPIKAAQIASMNRRTLGIGVINFANYLAKNGMKYSDGSANELTHRTFEAIQYYLLKASMNLAK
EQGACPLFHETTYSQGILPIDTYKRDLDKICAEPLHLDWESLRSDIKQYGLRNSTLSALMPSETSSQISNATNGIEPPRG
LISVKSSKDGQLKQVVPDFDTLKDSYELLWKMPSNDGYLQLVGIMQKFVDQAISANTNYDPSRFEGRKVPMQTLLKDLLN
AYKLGVKTLYYHNTRDGASDSHDDITNLEKEDDGCAGGACKI

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=786, Percent_Identity=27.6081424936387, Blast_Score=238, Evalue=1e-62,
Organism=Escherichia coli, GI2367133, Length=762, Percent_Identity=79.9212598425197, Blast_Score=1293, Evalue=0.0,
Organism=Escherichia coli, GI1789030, Length=684, Percent_Identity=24.8538011695906, Blast_Score=166, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17555242, Length=699, Percent_Identity=28.4692417739628, Blast_Score=232, Evalue=6e-61,
Organism=Saccharomyces cerevisiae, GI6322123, Length=672, Percent_Identity=28.2738095238095, Blast_Score=241, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6320914, Length=815, Percent_Identity=26.6257668711656, Blast_Score=239, Evalue=1e-63,
Organism=Drosophila melanogaster, GI17352481, Length=692, Percent_Identity=29.6242774566474, Blast_Score=239, Evalue=6e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 85775; Mature: 85775

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSTMTVTKRCGDRENIDLEKIHRVITWAAKGLKNVSVSEVELRSHLQFFDGIPTEAIHE
CCCCEEHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHH
TIIKAAADLISPESPDYQFLAARLAVFHLRKKAFGQFEPPALYTHVTKLVELGKYDMHIL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHH
QDYSREELDVMDTYIDHWRDMDFSYAAVKQLEGKYLVQNRVTHEIYESAQFLYILVAACL
HHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FARYPKETRLKYVKDFYDAVSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
HHHCCHHHHHHHHHHHHHHHHEEEEECCCHHHHCCCCCHHHHCCEEEEEECCCHHHHHHH
ASSIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCLPFYKYFQTAVKSCSQGGVRGG
HHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
AATLFYPIWHLEVESLLVLKNNRGVEDNRIRHLDYGVQLNKVMYQRLIKGENISLFSPSD
CHHEEHHHHHEEEEEEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEECCCC
VPGLYDAFFEDQNEFERLYVQYEQDSSIRKKTIKAVELFSLMMQERASTGRIYIQNVDHC
CCHHHHHHHCCHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
NTHSPFDSKVAPIRQSNLCLEIALPTKPLNNIDDPEGEIALCTLSALNLGSIKELSDIEP
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCH
LADLAVRALDNLLDYQDYPIKAAQIASMNRRTLGIGVINFANYLAKNGMKYSDGSANELT
HHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCCCCCHHHH
HRTFEAIQYYLLKASMNLAKEQGACPLFHETTYSQGILPIDTYKRDLDKICAEPLHLDWE
HHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCEEHHHHHHHHHHHHCCCCCCCHH
SLRSDIKQYGLRNSTLSALMPSETSSQISNATNGIEPPRGLISVKSSKDGQLKQVVPDFD
HHHHHHHHHCCCCCHHHHHCCCCHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHCCCHH
TLKDSYELLWKMPSNDGYLQLVGIMQKFVDQAISANTNYDPSRFEGRKVPMQTLLKDLLN
HHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCHHHHHHHHHH
AYKLGVKTLYYHNTRDGASDSHDDITNLEKEDDGCAGGACKI
HHHHHHHHEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNSTMTVTKRCGDRENIDLEKIHRVITWAAKGLKNVSVSEVELRSHLQFFDGIPTEAIHE
CCCCEEHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHH
TIIKAAADLISPESPDYQFLAARLAVFHLRKKAFGQFEPPALYTHVTKLVELGKYDMHIL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHH
QDYSREELDVMDTYIDHWRDMDFSYAAVKQLEGKYLVQNRVTHEIYESAQFLYILVAACL
HHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FARYPKETRLKYVKDFYDAVSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
HHHCCHHHHHHHHHHHHHHHHEEEEECCCHHHHCCCCCHHHHCCEEEEEECCCHHHHHHH
ASSIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCLPFYKYFQTAVKSCSQGGVRGG
HHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
AATLFYPIWHLEVESLLVLKNNRGVEDNRIRHLDYGVQLNKVMYQRLIKGENISLFSPSD
CHHEEHHHHHEEEEEEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEECCCC
VPGLYDAFFEDQNEFERLYVQYEQDSSIRKKTIKAVELFSLMMQERASTGRIYIQNVDHC
CCHHHHHHHCCHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
NTHSPFDSKVAPIRQSNLCLEIALPTKPLNNIDDPEGEIALCTLSALNLGSIKELSDIEP
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCH
LADLAVRALDNLLDYQDYPIKAAQIASMNRRTLGIGVINFANYLAKNGMKYSDGSANELT
HHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCCCCCHHHH
HRTFEAIQYYLLKASMNLAKEQGACPLFHETTYSQGILPIDTYKRDLDKICAEPLHLDWE
HHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCEEHHHHHHHHHHHHCCCCCCCHH
SLRSDIKQYGLRNSTLSALMPSETSSQISNATNGIEPPRGLISVKSSKDGQLKQVVPDFD
HHHHHHHHHCCCCCHHHHHCCCCHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHCCCHH
TLKDSYELLWKMPSNDGYLQLVGIMQKFVDQAISANTNYDPSRFEGRKVPMQTLLKDLLN
HHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCHHHHHHHHHH
AYKLGVKTLYYHNTRDGASDSHDDITNLEKEDDGCAGGACKI
HHHHHHHHEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6087316; 3287341; 9205837; 9278503; 3894026; 2663852; 8702814; 8052308; 9309223; 10493864 [H]