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The map label for this gene is msrAB [H]

Identifier: 126174083

GI number: 126174083

Start: 2157125

End: 2158030

Strand: Direct

Name: msrAB [H]

Synonym: Sbal_1857

Alternate gene names: 126174083

Gene position: 2157125-2158030 (Clockwise)

Preceding gene: 126174080

Following gene: 126174085

Centisome position: 42.07

GC content: 47.02

Gene sequence:

>906_bases
ATGAACAAACTGACTGATTTTGAACGCTATGTTATCGAAGAGAAAGGCACTGAACGCCCCTTTAGTGGTGAGTATTATGA
TCATGATGCCAAGGGTTTGTATTTATGCAAAAAATGCCATGCGCCCTTGTACCGCTCTGAGCATAAATTTAATGCCCATT
GTGGCTGGCCAGCCTTCGATGATGAAATTGCCGGCGCTGTAACGCGCCATGTCGACGCCGATGGCCGCAGAACCGAAATT
GTCTGTAGCCAGTGTGGCGGCCATTTAGGCCATGTTTTTGAAGGTGAGATGCTAACCCCCAATAATATTCGTCACTGTGT
TAACTCCGTTTCTATGGTTTTTAAAGGGATGGATGATGCTGTTGAACCTGCATCGAACAGCTTTGCAACTTTTGGTGCGG
GGTGTTTTTGGTGCGTCGAGGCGATCTTTCAAAGCCTAAAAGGCGTGGTGAATGTGACTTCTGGCTATGCCGGCGGTGAT
GCCCATGATGCCGATTATAAATCGGTTTGCTCGGGCCAAACTGGCCATGCAGAGGTTGTGCATATCGAGTTCAACCCAGA
GGAAATTGATTTTACGACGCTTTTGCAGGTCTTTTTTGAGAGTCATGATCCGACCACGCTCAATCGTCAAGGCAATGATA
AGGGGCCACAATATCGCTCTGTGGTGTTTGCTCATAATGCCGAGCAGATTGAGCAAACCACTGCTATGTTGACTCAGTTA
GCGGCGGCCAAGGTTTTTGATGCGCCGATTGTGACCCAAGTGTCAGCATTTGAGACGTTTTATCCCGCTGAAAACTATCA
CAATGACTATTTTGCTTTACACGGTGAGCAGCCTTATTGTCAGATGGTCGTGCGCCCTAAAGTCGAAAAAGTGAAAGCCT
TGTTTGCACGATTGCAAAAAGCTTAA

Upstream 100 bases:

>100_bases
TTGGATTGGGTCTTATGTGGGCTTTTTATGGATCAGCTCCTTAATCAACTGAATGAAGAGTATCAAAATAGACAACGACG
TGAGTCGAAAGGGCATTAAT

Downstream 100 bases:

>100_bases
GCAATTCAGCGCAGGATGCTAAATACTAAAACGCCACCGATAAAGGTGGCGTTTTTTATAGATTTTTTTAGCATCCAAAA
TGGTAGTTACCGAGGTAACT

Product: bifunctional methionine sulfoxide reductase B/A protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MNKLTDFERYVIEEKGTERPFSGEYYDHDAKGLYLCKKCHAPLYRSEHKFNAHCGWPAFDDEIAGAVTRHVDADGRRTEI
VCSQCGGHLGHVFEGEMLTPNNIRHCVNSVSMVFKGMDDAVEPASNSFATFGAGCFWCVEAIFQSLKGVVNVTSGYAGGD
AHDADYKSVCSGQTGHAEVVHIEFNPEEIDFTTLLQVFFESHDPTTLNRQGNDKGPQYRSVVFAHNAEQIEQTTAMLTQL
AAAKVFDAPIVTQVSAFETFYPAENYHNDYFALHGEQPYCQMVVRPKVEKVKALFARLQKA

Sequences:

>Translated_301_residues
MNKLTDFERYVIEEKGTERPFSGEYYDHDAKGLYLCKKCHAPLYRSEHKFNAHCGWPAFDDEIAGAVTRHVDADGRRTEI
VCSQCGGHLGHVFEGEMLTPNNIRHCVNSVSMVFKGMDDAVEPASNSFATFGAGCFWCVEAIFQSLKGVVNVTSGYAGGD
AHDADYKSVCSGQTGHAEVVHIEFNPEEIDFTTLLQVFFESHDPTTLNRQGNDKGPQYRSVVFAHNAEQIEQTTAMLTQL
AAAKVFDAPIVTQVSAFETFYPAENYHNDYFALHGEQPYCQMVVRPKVEKVKALFARLQKA
>Mature_301_residues
MNKLTDFERYVIEEKGTERPFSGEYYDHDAKGLYLCKKCHAPLYRSEHKFNAHCGWPAFDDEIAGAVTRHVDADGRRTEI
VCSQCGGHLGHVFEGEMLTPNNIRHCVNSVSMVFKGMDDAVEPASNSFATFGAGCFWCVEAIFQSLKGVVNVTSGYAGGD
AHDADYKSVCSGQTGHAEVVHIEFNPEEIDFTTLLQVFFESHDPTTLNRQGNDKGPQYRSVVFAHNAEQIEQTTAMLTQL
AAAKVFDAPIVTQVSAFETFYPAENYHNDYFALHGEQPYCQMVVRPKVEKVKALFARLQKA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=180, Percent_Identity=42.2222222222222, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI208609995, Length=154, Percent_Identity=44.8051948051948, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI117606353, Length=124, Percent_Identity=43.5483870967742, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI301336164, Length=122, Percent_Identity=40.1639344262295, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI301336162, Length=122, Percent_Identity=40.1639344262295, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI73089054, Length=122, Percent_Identity=40.1639344262295, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI37620216, Length=122, Percent_Identity=40.1639344262295, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI208609993, Length=104, Percent_Identity=44.2307692307692, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1790665, Length=175, Percent_Identity=41.1428571428571, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1788077, Length=122, Percent_Identity=36.0655737704918, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17553450, Length=112, Percent_Identity=41.9642857142857, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI115532676, Length=112, Percent_Identity=41.9642857142857, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17533973, Length=143, Percent_Identity=33.5664335664336, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319816, Length=120, Percent_Identity=48.3333333333333, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6320881, Length=158, Percent_Identity=35.4430379746835, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24645799, Length=123, Percent_Identity=45.5284552845528, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45553335, Length=123, Percent_Identity=45.5284552845528, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21356369, Length=123, Percent_Identity=45.5284552845528, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24645801, Length=134, Percent_Identity=41.7910447761194, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24645804, Length=134, Percent_Identity=41.7910447761194, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI221378664, Length=117, Percent_Identity=46.1538461538462, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221378662, Length=124, Percent_Identity=43.5483870967742, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24664627, Length=184, Percent_Identity=30.4347826086957, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24664631, Length=184, Percent_Identity=30.4347826086957, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45553131, Length=147, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.12; =1.8.4.11 [H]

Molecular weight: Translated: 33597; Mature: 33597

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKLTDFERYVIEEKGTERPFSGEYYDHDAKGLYLCKKCHAPLYRSEHKFNAHCGWPAFD
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHCCCCCCCCCCCCCCCC
DEIAGAVTRHVDADGRRTEIVCSQCGGHLGHVFEGEMLTPNNIRHCVNSVSMVFKGMDDA
HHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCHH
VEPASNSFATFGAGCFWCVEAIFQSLKGVVNVTSGYAGGDAHDADYKSVCSGQTGHAEVV
HCCCCCCCHHHCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHCCCCCCEEEE
HIEFNPEEIDFTTLLQVFFESHDPTTLNRQGNDKGPQYRSVVFAHNAEQIEQTTAMLTQL
EEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHH
AAAKVFDAPIVTQVSAFETFYPAENYHNDYFALHGEQPYCQMVVRPKVEKVKALFARLQK
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHEECCCHHHHHHHHHHHHC
A
C
>Mature Secondary Structure
MNKLTDFERYVIEEKGTERPFSGEYYDHDAKGLYLCKKCHAPLYRSEHKFNAHCGWPAFD
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHCCCCCCCCCCCCCCCC
DEIAGAVTRHVDADGRRTEIVCSQCGGHLGHVFEGEMLTPNNIRHCVNSVSMVFKGMDDA
HHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCHH
VEPASNSFATFGAGCFWCVEAIFQSLKGVVNVTSGYAGGDAHDADYKSVCSGQTGHAEVV
HCCCCCCCHHHCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHCCCCCCEEEE
HIEFNPEEIDFTTLLQVFFESHDPTTLNRQGNDKGPQYRSVVFAHNAEQIEQTTAMLTQL
EEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHH
AAAKVFDAPIVTQVSAFETFYPAENYHNDYFALHGEQPYCQMVVRPKVEKVKALFARLQK
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHEECCCHHHHHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]