Click here to switch to the map view.

The map label for this gene is wzb [C]

Identifier: 126174080

GI number: 126174080

Start: 2154133

End: 2154615

Strand: Direct

Name: wzb [C]

Synonym: Sbal_1854

Alternate gene names: 126174080

Gene position: 2154133-2154615 (Clockwise)

Preceding gene: 126174078

Following gene: 126174083

Centisome position: 42.01

GC content: 50.31

Gene sequence:

>483_bases
ATGAAAGAGGCGAGAGTGCAACGAATATTAATGGTGTGTATGGGCAATATCTGCCGCTCACCGACGGCGGAAGCTGTGTG
CCGCTGTAAGGTTGCGGATCGCAGGCTTAATATTGAGGTGGATTCTGCAGGCACTATTGGTTATCACCAAGGGGATACGC
CTGACCGCCGTGCTATGGCGGCGGGGAAAAAGCGGGGTTTTAGTTTCGATGGAATACGGGCACGGCAGGTTGTGGATGCC
GACTTTGAACACTTTGATTTAATTTTGGCGGCGGATAAGGCCAATTTAGCGGATTTGCGTAGCCGTTGTCCGCTCGAGTA
TCAGTACAAGTTACAGTTAATGCTCTCTTATGCGGATACGCAAGTCACAGAAGTGCCGGACCCTTACTATGGTGGCGAGC
AGGGCTTTGAGTTGGTGTTGGATTTATTAGAGCAGAGTATGGATGCCTTGCTTGATAGGTTGACCTCTGGTCCACAAAAG
TAG

Upstream 100 bases:

>100_bases
CACTCCTATGTCGCCTTAATTTGACAACTCAGGCACAAAGCACATTTAATCAATTAATCATGACGATGGATAAGCTTTGA
CTGTTGAAGGATTGAATGAA

Downstream 100 bases:

>100_bases
TTGCGCGTGACAGTGTTTGTTAACGCTATTATTTAGGCGAATAAAAAAGCCAGCATATTCAATATGCTGGCTTAAATTTT
AAATTTGATGAATTAGCCTA

Product: protein tyrosine phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MKEARVQRILMVCMGNICRSPTAEAVCRCKVADRRLNIEVDSAGTIGYHQGDTPDRRAMAAGKKRGFSFDGIRARQVVDA
DFEHFDLILAADKANLADLRSRCPLEYQYKLQLMLSYADTQVTEVPDPYYGGEQGFELVLDLLEQSMDALLDRLTSGPQK

Sequences:

>Translated_160_residues
MKEARVQRILMVCMGNICRSPTAEAVCRCKVADRRLNIEVDSAGTIGYHQGDTPDRRAMAAGKKRGFSFDGIRARQVVDA
DFEHFDLILAADKANLADLRSRCPLEYQYKLQLMLSYADTQVTEVPDPYYGGEQGFELVLDLLEQSMDALLDRLTSGPQK
>Mature_160_residues
MKEARVQRILMVCMGNICRSPTAEAVCRCKVADRRLNIEVDSAGTIGYHQGDTPDRRAMAAGKKRGFSFDGIRARQVVDA
DFEHFDLILAADKANLADLRSRCPLEYQYKLQLMLSYADTQVTEVPDPYYGGEQGFELVLDLLEQSMDALLDRLTSGPQK

Specific function: Dephosphorylates Wzc. Required For The Extracellular Polysaccharide Colanic Acid Synthesis. Probably Involved In The Export Of Colanic Acid From The Cell To Medium. [C]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI4757714, Length=157, Percent_Identity=39.4904458598726, Blast_Score=104, Evalue=3e-23,
Organism=Homo sapiens, GI6005988, Length=157, Percent_Identity=36.3057324840764, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI96304457, Length=85, Percent_Identity=44.7058823529412, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788375, Length=138, Percent_Identity=34.0579710144928, Blast_Score=70, Evalue=6e-14,
Organism=Escherichia coli, GI87081812, Length=155, Percent_Identity=30.9677419354839, Blast_Score=68, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6325330, Length=136, Percent_Identity=32.3529411764706, Blast_Score=83, Evalue=2e-17,
Organism=Drosophila melanogaster, GI78706770, Length=142, Percent_Identity=40.8450704225352, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI78706772, Length=142, Percent_Identity=40.8450704225352, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI78706766, Length=139, Percent_Identity=36.6906474820144, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI78706768, Length=139, Percent_Identity=36.6906474820144, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI78706764, Length=131, Percent_Identity=35.8778625954198, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI78711846, Length=137, Percent_Identity=36.4963503649635, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 17936; Mature: 17936

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEARVQRILMVCMGNICRSPTAEAVCRCKVADRRLNIEVDSAGTIGYHQGDTPDRRAMA
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHH
AGKKRGFSFDGIRARQVVDADFEHFDLILAADKANLADLRSRCPLEYQYKLQLMLSYADT
HHHHCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHCCCCCHHHHHEEEHHHCC
QVTEVPDPYYGGEQGFELVLDLLEQSMDALLDRLTSGPQK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKEARVQRILMVCMGNICRSPTAEAVCRCKVADRRLNIEVDSAGTIGYHQGDTPDRRAMA
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHH
AGKKRGFSFDGIRARQVVDADFEHFDLILAADKANLADLRSRCPLEYQYKLQLMLSYADT
HHHHCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHCCCCCHHHHHEEEHHHCC
QVTEVPDPYYGGEQGFELVLDLLEQSMDALLDRLTSGPQK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]