Click here to switch to the map view.

The map label for this gene is ppx [H]

Identifier: 126174059

GI number: 126174059

Start: 2126007

End: 2127569

Strand: Reverse

Name: ppx [H]

Synonym: Sbal_1833

Alternate gene names: 126174059

Gene position: 2127569-2126007 (Counterclockwise)

Preceding gene: 126174060

Following gene: 126174058

Centisome position: 41.49

GC content: 49.46

Gene sequence:

>1563_bases
TTGGTAGCCACACATTCGCACACACAGCAACACACATTACTAAAGTCGCAGGCGCCACAAACCAATGCGCCCGCAAATGC
TAAATCGCGCCATTTTGTCGCCATCGATATGGGGTCGAACAGTTTTCATCTGGTCATCGCCCGCGAGCAAGATGGCAGCT
TGCAGATTTTACATAAAGAAAAACAACAGGTTCAGCTCGCCACTGGGCTCAATGCGCAGAATATTCTCGACAATGACGCC
ATAGAACGTGGCCTCAATTGTCTGCGGGATTTTAACCAAAGATTCTCCAATCTAGACCAAGCGCAAGTGCGATTAGTGGC
CACCCACACCCTCAGAATCGCCAAAAACCGCGATCAATTTATCGAGGCCGCGCTCGCCATCATGCCCTATCCGGTGGAAG
TGATTTCAGGCCATGAAGAAGCCCGTTTGATTTATAACGGCATTGCACAAAGCCAAGTGCTTGGAAAAAGTAATTTAGTC
ATCGACATAGGTGGCGGCTCGACCGAAGTCGTGATCGGTAAAAAGAATACCCCAACCCAGTTATCTAGCCTGCGCTGTGG
TTGCGTGAGCTTTAACGAGCGTTTCTTTATCGATGGACTCATCACCCCGACCTCATTTCGTGATGCCCAAAGCGCGGCCG
ATAAACAGTTCGCGTCGCTCTCAAAGGAATATTTCGCGGGCGGCTGGGAGCTGACGTTAGGCAGCTCAGGCACAGTCAAA
GCCATCTGCGAAGCGATTCAAGAAGAACACGGCGATGAAACTATCACGCTGCCACGACTCAAACAGCTCAAAATCAAGTT
GATCAAATGTGGCCATATTAGCCAAATTCAATTTGCCAATGTCGATGATAAACGCATTCCTTTAGTGCCCGCCGGACTTG
CGATTTTAATCAGCTTTTTTAGACGCTTACCAATACAAAAGCTCGAGTTTAGCCCAGGCGCATTGCGTGAAGGCGTACTC
TATGAACTAGCCAAAATTGGCCAGTATCAGGATATTCGCCACCGCACCGTCGACAGTATTGCCCAGCTTTATCATATCGA
TATGGCCCACGCCGCTAAGGTACGCGACACCGCCATGGCCTTGTTTGAACAGGTCGCCGATGAATGGCAATTAAGGCCCC
ATGCACGCTTGCTCGCCTATGGCGCAACCTTACATGAAATCGGGCTACACATTAATTCAAAGTCCCTGCACAAACACGGT
GGTTATATCATCAGCAACAGTGACTTACCCGGGTTTAGTGAAGCCTTGCAGCTTGATTTAGCGCGGCTTATCACCAACCA
CAGAAAAAAGCCCAACGAATTAATGCTCGCCGAACTTGAGCCCAACCATAAGCTCACGTTGAATCGCCTGCTCTGCCTGC
TGAGGCTCGCTGTCTTACTCAACCTTGGCCGTATCGCTAAGACGCTGACCTTAGATCATATTAAAGTGATCCCCGATGGA
CTCATGCTAGTGCTACCGAGCCACAAGCGAAAAATCAGCCTGTTTATGAAGGATTTACAGCGGGAACAGAAGCAAATGCT
CACCCTTGGGATGAACCTGCGGTTAGTGTCTAGTCTGACTTAG

Upstream 100 bases:

>100_bases
AGCGAGAGATCAACGCTGAGCCTGACATAACGCCCGAGTTACAGGCCAAAGCCAGCTAACGCTGGCTTTATATCGCTTTG
ATTGCCTAAGGATAATCCGA

Downstream 100 bases:

>100_bases
CTGTTACGGCGTTAGCTCAGCCGAACGTGGCAGAGGCGAGTGTGGGTTAGCTCTGTGTGAATGATTTTAGCGAAGGATTC
GGTGCTAAAATATTGCCCAG

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MVATHSHTQQHTLLKSQAPQTNAPANAKSRHFVAIDMGSNSFHLVIAREQDGSLQILHKEKQQVQLATGLNAQNILDNDA
IERGLNCLRDFNQRFSNLDQAQVRLVATHTLRIAKNRDQFIEAALAIMPYPVEVISGHEEARLIYNGIAQSQVLGKSNLV
IDIGGGSTEVVIGKKNTPTQLSSLRCGCVSFNERFFIDGLITPTSFRDAQSAADKQFASLSKEYFAGGWELTLGSSGTVK
AICEAIQEEHGDETITLPRLKQLKIKLIKCGHISQIQFANVDDKRIPLVPAGLAILISFFRRLPIQKLEFSPGALREGVL
YELAKIGQYQDIRHRTVDSIAQLYHIDMAHAAKVRDTAMALFEQVADEWQLRPHARLLAYGATLHEIGLHINSKSLHKHG
GYIISNSDLPGFSEALQLDLARLITNHRKKPNELMLAELEPNHKLTLNRLLCLLRLAVLLNLGRIAKTLTLDHIKVIPDG
LMLVLPSHKRKISLFMKDLQREQKQMLTLGMNLRLVSSLT

Sequences:

>Translated_520_residues
MVATHSHTQQHTLLKSQAPQTNAPANAKSRHFVAIDMGSNSFHLVIAREQDGSLQILHKEKQQVQLATGLNAQNILDNDA
IERGLNCLRDFNQRFSNLDQAQVRLVATHTLRIAKNRDQFIEAALAIMPYPVEVISGHEEARLIYNGIAQSQVLGKSNLV
IDIGGGSTEVVIGKKNTPTQLSSLRCGCVSFNERFFIDGLITPTSFRDAQSAADKQFASLSKEYFAGGWELTLGSSGTVK
AICEAIQEEHGDETITLPRLKQLKIKLIKCGHISQIQFANVDDKRIPLVPAGLAILISFFRRLPIQKLEFSPGALREGVL
YELAKIGQYQDIRHRTVDSIAQLYHIDMAHAAKVRDTAMALFEQVADEWQLRPHARLLAYGATLHEIGLHINSKSLHKHG
GYIISNSDLPGFSEALQLDLARLITNHRKKPNELMLAELEPNHKLTLNRLLCLLRLAVLLNLGRIAKTLTLDHIKVIPDG
LMLVLPSHKRKISLFMKDLQREQKQMLTLGMNLRLVSSLT
>Mature_520_residues
MVATHSHTQQHTLLKSQAPQTNAPANAKSRHFVAIDMGSNSFHLVIAREQDGSLQILHKEKQQVQLATGLNAQNILDNDA
IERGLNCLRDFNQRFSNLDQAQVRLVATHTLRIAKNRDQFIEAALAIMPYPVEVISGHEEARLIYNGIAQSQVLGKSNLV
IDIGGGSTEVVIGKKNTPTQLSSLRCGCVSFNERFFIDGLITPTSFRDAQSAADKQFASLSKEYFAGGWELTLGSSGTVK
AICEAIQEEHGDETITLPRLKQLKIKLIKCGHISQIQFANVDDKRIPLVPAGLAILISFFRRLPIQKLEFSPGALREGVL
YELAKIGQYQDIRHRTVDSIAQLYHIDMAHAAKVRDTAMALFEQVADEWQLRPHARLLAYGATLHEIGLHINSKSLHKHG
GYIISNSDLPGFSEALQLDLARLITNHRKKPNELMLAELEPNHKLTLNRLLCLLRLAVLLNLGRIAKTLTLDHIKVIPDG
LMLVLPSHKRKISLFMKDLQREQKQMLTLGMNLRLVSSLT

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=485, Percent_Identity=40.8247422680412, Blast_Score=345, Evalue=5e-96,
Organism=Escherichia coli, GI48994966, Length=439, Percent_Identity=41.4578587699317, Blast_Score=326, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 57982; Mature: 57982

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVATHSHTQQHTLLKSQAPQTNAPANAKSRHFVAIDMGSNSFHLVIAREQDGSLQILHKE
CCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCEEEEECH
KQQVQLATGLNAQNILDNDAIERGLNCLRDFNQRFSNLDQAQVRLVATHTLRIAKNRDQF
HHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEEEEEEECCCHHHH
IEAALAIMPYPVEVISGHEEARLIYNGIAQSQVLGKSNLVIDIGGGSTEVVIGKKNTPTQ
HHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCH
LSSLRCGCVSFNERFFIDGLITPTSFRDAQSAADKQFASLSKEYFAGGWELTLGSSGTVK
HHHCCCCEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHH
AICEAIQEEHGDETITLPRLKQLKIKLIKCGHISQIQFANVDDKRIPLVPAGLAILISFF
HHHHHHHHHCCCCEEECCCHHCCEEEEEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHH
RRLPIQKLEFSPGALREGVLYELAKIGQYQDIRHRTVDSIAQLYHIDMAHAAKVRDTAMA
HHCCCCEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFEQVADEWQLRPHARLLAYGATLHEIGLHINSKSLHKHGGYIISNSDLPGFSEALQLDL
HHHHHHHHHCCCCCHHHHHHCCHHHHHCCCCCCCHHHHCCCEEEECCCCCCHHHHHHHHH
ARLITNHRKKPNELMLAELEPNHKLTLNRLLCLLRLAVLLNLGRIAKTLTLDHIKVIPDG
HHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
LMLVLPSHKRKISLFMKDLQREQKQMLTLGMNLRLVSSLT
EEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCC
>Mature Secondary Structure
MVATHSHTQQHTLLKSQAPQTNAPANAKSRHFVAIDMGSNSFHLVIAREQDGSLQILHKE
CCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCEEEEECH
KQQVQLATGLNAQNILDNDAIERGLNCLRDFNQRFSNLDQAQVRLVATHTLRIAKNRDQF
HHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEEEEEEECCCHHHH
IEAALAIMPYPVEVISGHEEARLIYNGIAQSQVLGKSNLVIDIGGGSTEVVIGKKNTPTQ
HHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCH
LSSLRCGCVSFNERFFIDGLITPTSFRDAQSAADKQFASLSKEYFAGGWELTLGSSGTVK
HHHCCCCEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHH
AICEAIQEEHGDETITLPRLKQLKIKLIKCGHISQIQFANVDDKRIPLVPAGLAILISFF
HHHHHHHHHCCCCEEECCCHHCCEEEEEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHH
RRLPIQKLEFSPGALREGVLYELAKIGQYQDIRHRTVDSIAQLYHIDMAHAAKVRDTAMA
HHCCCCEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFEQVADEWQLRPHARLLAYGATLHEIGLHINSKSLHKHGGYIISNSDLPGFSEALQLDL
HHHHHHHHHCCCCCHHHHHHCCHHHHHCCCCCCCHHHHCCCEEEECCCCCCHHHHHHHHH
ARLITNHRKKPNELMLAELEPNHKLTLNRLLCLLRLAVLLNLGRIAKTLTLDHIKVIPDG
HHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
LMLVLPSHKRKISLFMKDLQREQKQMLTLGMNLRLVSSLT
EEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]