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The map label for this gene is uraA [H]

Identifier: 126174011

GI number: 126174011

Start: 2077130

End: 2078380

Strand: Reverse

Name: uraA [H]

Synonym: Sbal_1784

Alternate gene names: 126174011

Gene position: 2078380-2077130 (Counterclockwise)

Preceding gene: 126174014

Following gene: 126174009

Centisome position: 40.53

GC content: 50.92

Gene sequence:

>1251_bases
ATGAGACGACTCGCAATCCCCCTACAGGGCGCGCAAATGCTGTTTGTGGCCTTCGGTGCTCTAGTGCTAATGCCGCTGCT
GACAGGACTCGACACCAGTGTGGCATTGTTTACCGCAGGTATCGGCACCCTACTGTTCCAATTGATCACTAAACGCCAAG
TGCCTATCTTCCTCGCATCTTCCTTCGCCTTTATTGCCCCCATACTCTATGGCGTGCAAACTTGGGGCATTCCCTCCACC
ATGGGCGGCATTATGGCCGCGGGCGTGGTCTACGTCATGCTCGGCGCCTTGGTCAAAGTGCGCGGCACCGACTTCATCCA
TAGGCTGTTACCGCCTGTGGTAGTGGGTCCTGTGATCATTATCATCGGCCTTGGCTTAGCACCCGTTGCGGTGAATATGG
CCTTAGGTAAAAGTGGCGATGGCAGTTTGACTCTCGTTGACACCAATACTGCGCTATTTATTTCACTAGCATCACTCTGC
ACCACCATAGCAGTGGCGATTTTTGCCAAGGGCTTACTGAGAGTGATGCCAATTTTAGCAGGGATTATAGTGGGTTACGG
CTTAAGCCTTGCCTTTGGCATTGTTGACTTTACCGTGGTCACAGCCGCCAGTTGGATTGCGATTCCTAAATTTGTCGCAC
CCGAATTTAACTGGCATGCCATCGCCTTTATGATCCCAGTCGCAATCGCTCCGGCGGTTGAACACATTGGCGATATTCTG
GCGATATCCAATGTCACAGGTAAAGATTTTATGAAAAAACCGGGACTACACCGCACGCTAACAGGTGATGGTATTGCCAC
GATTGCCGCGGCAGCCTTTGGTGGCCCGCCAAACACCACTTATTCAGAAGTCACGGGGGCAGTGACCTTAACGCGCAATT
TTGATCCGAAAATCATGACTTGGACCGCCATTACTGCCATAACGTTGGCCTTCGTCGGCAAATTAGGTGCGCTGATGCAA
ACCATTCCTGTCCCAGTCATGGGCGGTATTATGTGTTTGTTATTCGGCTCAATTGCAGCCGTTGGTCTCAACACCCTTAT
TCGCAATCATGTGGATTTGTCTGAGCCGCGTAATTTAAGCATTGTCGGTGTCACCTTAGTATTTGGTATCGGCGGCATGG
CATTTGGCATAGGTTCATTCAGTCTGACCGGTATCAGCTTGTGCGGTATTGTCGCAATTACCATGAACTTGTTATTGCCC
GCGACCAAGCCACACGATAAACACAATGAGTCTGATGTCACCCCTCACTAG

Upstream 100 bases:

>100_bases
ACAGTGATCCTAGTCGGCAAAACGGGCGATTTTCTTCTGCTCAAAATCCAACAAACTGATATCATTTGGCGGTTTACCCT
AATATTAACGAGAATAATAA

Downstream 100 bases:

>100_bases
TCGTTGTTTGAGGAATCGCCGTTTTATTGAAGTCTTTGTTGTAATGTTTTTTTAGCGATAGCTCTTTGAAAAACAGCGAC
AAAAAAGCCGCCGTGATATT

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MRRLAIPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITKRQVPIFLASSFAFIAPILYGVQTWGIPST
MGGIMAAGVVYVMLGALVKVRGTDFIHRLLPPVVVGPVIIIIGLGLAPVAVNMALGKSGDGSLTLVDTNTALFISLASLC
TTIAVAIFAKGLLRVMPILAGIIVGYGLSLAFGIVDFTVVTAASWIAIPKFVAPEFNWHAIAFMIPVAIAPAVEHIGDIL
AISNVTGKDFMKKPGLHRTLTGDGIATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPKIMTWTAITAITLAFVGKLGALMQ
TIPVPVMGGIMCLLFGSIAAVGLNTLIRNHVDLSEPRNLSIVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAITMNLLLP
ATKPHDKHNESDVTPH

Sequences:

>Translated_416_residues
MRRLAIPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITKRQVPIFLASSFAFIAPILYGVQTWGIPST
MGGIMAAGVVYVMLGALVKVRGTDFIHRLLPPVVVGPVIIIIGLGLAPVAVNMALGKSGDGSLTLVDTNTALFISLASLC
TTIAVAIFAKGLLRVMPILAGIIVGYGLSLAFGIVDFTVVTAASWIAIPKFVAPEFNWHAIAFMIPVAIAPAVEHIGDIL
AISNVTGKDFMKKPGLHRTLTGDGIATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPKIMTWTAITAITLAFVGKLGALMQ
TIPVPVMGGIMCLLFGSIAAVGLNTLIRNHVDLSEPRNLSIVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAITMNLLLP
ATKPHDKHNESDVTPH
>Mature_416_residues
MRRLAIPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITKRQVPIFLASSFAFIAPILYGVQTWGIPST
MGGIMAAGVVYVMLGALVKVRGTDFIHRLLPPVVVGPVIIIIGLGLAPVAVNMALGKSGDGSLTLVDTNTALFISLASLC
TTIAVAIFAKGLLRVMPILAGIIVGYGLSLAFGIVDFTVVTAASWIAIPKFVAPEFNWHAIAFMIPVAIAPAVEHIGDIL
AISNVTGKDFMKKPGLHRTLTGDGIATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPKIMTWTAITAITLAFVGKLGALMQ
TIPVPVMGGIMCLLFGSIAAVGLNTLIRNHVDLSEPRNLSIVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAITMNLLLP
ATKPHDKHNESDVTPH

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=423, Percent_Identity=24.822695035461, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI44680143, Length=427, Percent_Identity=24.5901639344262, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI44680148, Length=393, Percent_Identity=24.4274809160305, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI40316845, Length=393, Percent_Identity=24.4274809160305, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788843, Length=415, Percent_Identity=38.5542168674699, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI87081818, Length=421, Percent_Identity=38.2422802850356, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87082181, Length=381, Percent_Identity=28.6089238845144, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1790087, Length=373, Percent_Identity=24.9329758713137, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082178, Length=330, Percent_Identity=26.969696969697, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=180, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21356175, Length=392, Percent_Identity=25.2551020408163, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 43279; Mature: 43279

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLAIPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITKRQVPIFLAS
CCEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHH
SFAFIAPILYGVQTWGIPSTMGGIMAAGVVYVMLGALVKVRGTDFIHRLLPPVVVGPVII
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHH
IIGLGLAPVAVNMALGKSGDGSLTLVDTNTALFISLASLCTTIAVAIFAKGLLRVMPILA
HHHCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIIVGYGLSLAFGIVDFTVVTAASWIAIPKFVAPEFNWHAIAFMIPVAIAPAVEHIGDIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AISNVTGKDFMKKPGLHRTLTGDGIATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPKIMT
HCCCCCCHHHHHCCCCCEEECCCCHHHHHHHHCCCCCCCCHHHHCCEEEEEECCCCCEEH
WTAITAITLAFVGKLGALMQTIPVPVMGGIMCLLFGSIAAVGLNTLIRNHVDLSEPRNLS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
IVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAITMNLLLPATKPHDKHNESDVTPH
EEHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRLAIPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITKRQVPIFLAS
CCEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHH
SFAFIAPILYGVQTWGIPSTMGGIMAAGVVYVMLGALVKVRGTDFIHRLLPPVVVGPVII
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHH
IIGLGLAPVAVNMALGKSGDGSLTLVDTNTALFISLASLCTTIAVAIFAKGLLRVMPILA
HHHCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIIVGYGLSLAFGIVDFTVVTAASWIAIPKFVAPEFNWHAIAFMIPVAIAPAVEHIGDIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AISNVTGKDFMKKPGLHRTLTGDGIATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPKIMT
HCCCCCCHHHHHCCCCCEEECCCCHHHHHHHHCCCCCCCCHHHHCCEEEEEECCCCCEEH
WTAITAITLAFVGKLGALMQTIPVPVMGGIMCLLFGSIAAVGLNTLIRNHVDLSEPRNLS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
IVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAITMNLLLPATKPHDKHNESDVTPH
EEHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]