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The map label for this gene is f1pep1 [H]

Identifier: 126173970

GI number: 126173970

Start: 2025720

End: 2027903

Strand: Direct

Name: f1pep1 [H]

Synonym: Sbal_1741

Alternate gene names: 126173970

Gene position: 2025720-2027903 (Clockwise)

Preceding gene: 126173969

Following gene: 126173971

Centisome position: 39.51

GC content: 44.73

Gene sequence:

>2184_bases
ATGGCATTAAGATTTCGCCTTGCAAAGCAAGGTTTGTTAGTGGCCACATTGGGAATGGCACTCGGTGCCTGCCAAAGTGG
CAATGCACCTGAACAAAATTCGACTGAGCAGGCAAGCGCAAATAAATTGGTTTACCCTGTGACTCAAAAAGATGATCTCG
TCGAAACCATTCACGGTGTTACCGTGGCGGACCCTTACCGCCACTTAGAAGCCAATACGCCAGAAACGGAAGCTTGGGTA
AAAGAACAACAAGCCTTCGGTCAAGCCTATTTAGCCAAGATCCCCAATAAACAAGCTGTGGTCGATCGCATCACAGAACT
GTGGAATTACGAAAAAGTCTCGGCCCCATTTGAGAATGGCGACAATCAATTTTACTACCGTAATGATGGCCTGCAGGCGC
AATCTGTTTTGTATGTCAAAGGGTTAGATGGTGTTGAAAAGCCAGTTCTCGATCCAAACAAACTGTCAGCGGATGGTACT
GTGGCGCTATCAGGTGTTGCAGTGAGTAATGACGGTAAAATTTTAGCCTATGGTGTGTCAAATTCGGGCTCAGATTGGCA
GCAATGGCAGTTTGTTGATATCGCAACCGGTAAGAAACTTGCCGATGAATTGAAATGGATTAAATTTTCTAGCGCAGTGT
GGGATAAAGAAAACCAAGGTGTGTTTTATGCTCGCTATGATGCCCCTGCGGGTGGAGATGTCTTAGCCGACGTCAATTTC
AATCAAAAAGTGTATTACCATAAATTAGGCACAGATCAGCGCCAAGATTTATTGATTTACGAGCGCCCACAGAATAAAGA
TTGGGGCTTTGGCATAGAGGTATCCGAGAAAGGCGAATACTTATTACTGTCGATTTCTCAAGGCACGGATAAGCGTAATC
GTTTCTTCTATAAATCCTTATTTGAGCCTAAATCGCAAGTGGTGGAATTAATCCTCAACTTAGAAGCTGAATATGAGTTT
CTCGGTAATGATGGTTCAGTGTTTTATTTTAAAACCGACTTAGATGCGCCTAACGGTAAAGTGATTGCGATTGATACCCG
CAATAGCGATAAATCCCAATGGCAAACCATTATTCCTGAGTCTACAGATCCGATAAATAACGTCGCCATAATTAATGACC
ATTTAGTGGTGAGTTATTTACACGATGTATTAGGTCAATTATCGATTTACAGCATGGGTGGGCAGAAACGCCAAGACGTG
GCATTACCTGGTCAAGGCAATGTGGCTGGGCCTTTTGGCAAAGCAAGCAAAGACTATTTCTATTATGTGTTTAATAGTTA
TATTCAACCTGAGACCACCTATAAGTTTGACTTTAAAACCGCTGAATCAAGCGTAATTGCCAAACCTAAAGTATCGTTTA
ATCCCGATGACTATGTTTCTGAGCAAGTGTTTTATCGCAGCAAAGACGGCACGCGTGTGCCTATGATGCTGTCCTATAAA
AAAGGCTTAGTGAAGAACGCTCAAAACCCAACATTACTGTATGCCTATGGTGGCTTTGCCATTTCGATGACACCACGCTT
TAGTCCGGCCAACATTGCTTGGTTAGATATGGGCGGTATTTACGCTGTGCCGAGTTTACGTGGCGGCGCTGAATACGGCG
AAAGCTGGCATCAAGCGGGAATGTTCGATAAAAAGCAAAATGTGTTTGATGACTATTTTGCCGCCGCTGAATATCTAGTG
AATGAGAAATACACTAATAGCACTAAGTTAGGAGCCTATGGCCGCAGTAATGGTGGTCTGTTGATGGGCGCTGCGGTAAC
TCAACGCCCTGAACTCTTTGCTGCGGTATTACCTGCTGTGGGCGTTCTGGATATGCTGCGCTTCCATAAGTTCACTATCG
GTTGGGCTTGGACGAGTGAATATGGCAGTGCCGATAAAGCAGATCAATTCCCAGCGCTATTGGCTTATTCGCCTTATCAC
AATGTGAAAGCGCAAGCTTATCCAGCGACTATGGTGATGACTGCCGATCATGATGATCGCGTCGTGCCGTTACACAGTTT
CAAGTTCGCAGCCATGTTGCAGGATAAGCAGCAGGGCACTGAACCTGTGATCATGCGTATCGAGTCCAATGCGGGTCACG
GAGCCGGTAAACCAACGGCGATGAAGATTGATGAATTTGCCGATATCTACAGTTTCTTGTGGCAGAGTTTTGGCTTAACA
CTGCCACAAACTATCGCAAAATAA

Upstream 100 bases:

>100_bases
ATCTTCTTATTAAGTTACGGCATTGCCATGATTTTTTTTGCTTGTATAGTACTTGCTGAAAAGGCCTTAAGCCCGAAACC
ACAAGAAGGACGATAACAAG

Downstream 100 bases:

>100_bases
CTAACTATGTTAATAAAATGGGGTCATTTGACCCCATTGTCTTTTACAATTGCCCCTATTCATCTGAAACCCGCGCTATT
CCTATCTATATCTTCGTCGG

Product: prolyl oligopeptidase

Products: NA

Alternate protein names: Post-proline cleaving enzyme; Proline-specific endopeptidase; PE; PSE [H]

Number of amino acids: Translated: 727; Mature: 726

Protein sequence:

>727_residues
MALRFRLAKQGLLVATLGMALGACQSGNAPEQNSTEQASANKLVYPVTQKDDLVETIHGVTVADPYRHLEANTPETEAWV
KEQQAFGQAYLAKIPNKQAVVDRITELWNYEKVSAPFENGDNQFYYRNDGLQAQSVLYVKGLDGVEKPVLDPNKLSADGT
VALSGVAVSNDGKILAYGVSNSGSDWQQWQFVDIATGKKLADELKWIKFSSAVWDKENQGVFYARYDAPAGGDVLADVNF
NQKVYYHKLGTDQRQDLLIYERPQNKDWGFGIEVSEKGEYLLLSISQGTDKRNRFFYKSLFEPKSQVVELILNLEAEYEF
LGNDGSVFYFKTDLDAPNGKVIAIDTRNSDKSQWQTIIPESTDPINNVAIINDHLVVSYLHDVLGQLSIYSMGGQKRQDV
ALPGQGNVAGPFGKASKDYFYYVFNSYIQPETTYKFDFKTAESSVIAKPKVSFNPDDYVSEQVFYRSKDGTRVPMMLSYK
KGLVKNAQNPTLLYAYGGFAISMTPRFSPANIAWLDMGGIYAVPSLRGGAEYGESWHQAGMFDKKQNVFDDYFAAAEYLV
NEKYTNSTKLGAYGRSNGGLLMGAAVTQRPELFAAVLPAVGVLDMLRFHKFTIGWAWTSEYGSADKADQFPALLAYSPYH
NVKAQAYPATMVMTADHDDRVVPLHSFKFAAMLQDKQQGTEPVIMRIESNAGHGAGKPTAMKIDEFADIYSFLWQSFGLT
LPQTIAK

Sequences:

>Translated_727_residues
MALRFRLAKQGLLVATLGMALGACQSGNAPEQNSTEQASANKLVYPVTQKDDLVETIHGVTVADPYRHLEANTPETEAWV
KEQQAFGQAYLAKIPNKQAVVDRITELWNYEKVSAPFENGDNQFYYRNDGLQAQSVLYVKGLDGVEKPVLDPNKLSADGT
VALSGVAVSNDGKILAYGVSNSGSDWQQWQFVDIATGKKLADELKWIKFSSAVWDKENQGVFYARYDAPAGGDVLADVNF
NQKVYYHKLGTDQRQDLLIYERPQNKDWGFGIEVSEKGEYLLLSISQGTDKRNRFFYKSLFEPKSQVVELILNLEAEYEF
LGNDGSVFYFKTDLDAPNGKVIAIDTRNSDKSQWQTIIPESTDPINNVAIINDHLVVSYLHDVLGQLSIYSMGGQKRQDV
ALPGQGNVAGPFGKASKDYFYYVFNSYIQPETTYKFDFKTAESSVIAKPKVSFNPDDYVSEQVFYRSKDGTRVPMMLSYK
KGLVKNAQNPTLLYAYGGFAISMTPRFSPANIAWLDMGGIYAVPSLRGGAEYGESWHQAGMFDKKQNVFDDYFAAAEYLV
NEKYTNSTKLGAYGRSNGGLLMGAAVTQRPELFAAVLPAVGVLDMLRFHKFTIGWAWTSEYGSADKADQFPALLAYSPYH
NVKAQAYPATMVMTADHDDRVVPLHSFKFAAMLQDKQQGTEPVIMRIESNAGHGAGKPTAMKIDEFADIYSFLWQSFGLT
LPQTIAK
>Mature_726_residues
ALRFRLAKQGLLVATLGMALGACQSGNAPEQNSTEQASANKLVYPVTQKDDLVETIHGVTVADPYRHLEANTPETEAWVK
EQQAFGQAYLAKIPNKQAVVDRITELWNYEKVSAPFENGDNQFYYRNDGLQAQSVLYVKGLDGVEKPVLDPNKLSADGTV
ALSGVAVSNDGKILAYGVSNSGSDWQQWQFVDIATGKKLADELKWIKFSSAVWDKENQGVFYARYDAPAGGDVLADVNFN
QKVYYHKLGTDQRQDLLIYERPQNKDWGFGIEVSEKGEYLLLSISQGTDKRNRFFYKSLFEPKSQVVELILNLEAEYEFL
GNDGSVFYFKTDLDAPNGKVIAIDTRNSDKSQWQTIIPESTDPINNVAIINDHLVVSYLHDVLGQLSIYSMGGQKRQDVA
LPGQGNVAGPFGKASKDYFYYVFNSYIQPETTYKFDFKTAESSVIAKPKVSFNPDDYVSEQVFYRSKDGTRVPMMLSYKK
GLVKNAQNPTLLYAYGGFAISMTPRFSPANIAWLDMGGIYAVPSLRGGAEYGESWHQAGMFDKKQNVFDDYFAAAEYLVN
EKYTNSTKLGAYGRSNGGLLMGAAVTQRPELFAAVLPAVGVLDMLRFHKFTIGWAWTSEYGSADKADQFPALLAYSPYHN
VKAQAYPATMVMTADHDDRVVPLHSFKFAAMLQDKQQGTEPVIMRIESNAGHGAGKPTAMKIDEFADIYSFLWQSFGLTL
PQTIAK

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=708, Percent_Identity=41.5254237288136, Blast_Score=550, Evalue=1e-156,
Organism=Homo sapiens, GI108860686, Length=200, Percent_Identity=29.5, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI284172420, Length=200, Percent_Identity=29.5, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI284172413, Length=200, Percent_Identity=29.5, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI70778815, Length=200, Percent_Identity=29.5, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI284172438, Length=200, Percent_Identity=29.5, Blast_Score=94, Evalue=7e-19,
Organism=Homo sapiens, GI284172431, Length=200, Percent_Identity=29.5, Blast_Score=94, Evalue=7e-19,
Organism=Homo sapiens, GI108860692, Length=198, Percent_Identity=29.2929292929293, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1788150, Length=695, Percent_Identity=26.9064748201439, Blast_Score=212, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24583414, Length=712, Percent_Identity=42.6966292134831, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI221510989, Length=720, Percent_Identity=39.8611111111111, Blast_Score=508, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 80895; Mature: 80764

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALRFRLAKQGLLVATLGMALGACQSGNAPEQNSTEQASANKLVYPVTQKDDLVETIHGV
CCEEEEHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCEEEECCCCHHHHHHHCCC
TVADPYRHLEANTPETEAWVKEQQAFGQAYLAKIPNKQAVVDRITELWNYEKVSAPFENG
EEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCC
DNQFYYRNDGLQAQSVLYVKGLDGVEKPVLDPNKLSADGTVALSGVAVSNDGKILAYGVS
CCEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCEEEEEECC
NSGSDWQQWQFVDIATGKKLADELKWIKFSSAVWDKENQGVFYARYDAPAGGDVLADVNF
CCCCCCCEEEEEEECCCHHHHHHHHHEEECHHHCCCCCCCEEEEEECCCCCCCEEEECCC
NQKVYYHKLGTDQRQDLLIYERPQNKDWGFGIEVSEKGEYLLLSISQGTDKRNRFFYKSL
CCEEEEEECCCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHH
FEPKSQVVELILNLEAEYEFLGNDGSVFYFKTDLDAPNGKVIAIDTRNSDKSQWQTIIPE
CCCHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCEEEEEECCCCCHHHHHEECCC
STDPINNVAIINDHLVVSYLHDVLGQLSIYSMGGQKRQDVALPGQGNVAGPFGKASKDYF
CCCCCCCEEEEECHHHHHHHHHHHHCEEEEECCCCCCCCEECCCCCCCCCCCCCCCCCEE
YYVFNSYIQPETTYKFDFKTAESSVIAKPKVSFNPDDYVSEQVFYRSKDGTRVPMMLSYK
EEEEECCCCCCCEEEEEEECCCCCEEECCCCCCCCCHHHCCHHEEECCCCCCCCEEEECH
KGLVKNAQNPTLLYAYGGFAISMTPRFSPANIAWLDMGGIYAVPSLRGGAEYGESWHQAG
HHHHCCCCCCEEEEEECCEEEEECCCCCCCCEEEEECCCEEECCCCCCCHHHHHHHHHCC
MFDKKQNVFDDYFAAAEYLVNEKYTNSTKLGAYGRSNGGLLMGAAVTQRPELFAAVLPAV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHCCCHHHHHHHHHHH
GVLDMLRFHKFTIGWAWTSEYGSADKADQFPALLAYSPYHNVKAQAYPATMVMTADHDDR
HHHHHHHHHEEEEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCEECCEEEEEEECCCCC
VVPLHSFKFAAMLQDKQQGTEPVIMRIESNAGHGAGKPTAMKIDEFADIYSFLWQSFGLT
EEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCC
LPQTIAK
CHHHHCC
>Mature Secondary Structure 
ALRFRLAKQGLLVATLGMALGACQSGNAPEQNSTEQASANKLVYPVTQKDDLVETIHGV
CEEEEHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCEEEECCCCHHHHHHHCCC
TVADPYRHLEANTPETEAWVKEQQAFGQAYLAKIPNKQAVVDRITELWNYEKVSAPFENG
EEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCC
DNQFYYRNDGLQAQSVLYVKGLDGVEKPVLDPNKLSADGTVALSGVAVSNDGKILAYGVS
CCEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCEEEEEECC
NSGSDWQQWQFVDIATGKKLADELKWIKFSSAVWDKENQGVFYARYDAPAGGDVLADVNF
CCCCCCCEEEEEEECCCHHHHHHHHHEEECHHHCCCCCCCEEEEEECCCCCCCEEEECCC
NQKVYYHKLGTDQRQDLLIYERPQNKDWGFGIEVSEKGEYLLLSISQGTDKRNRFFYKSL
CCEEEEEECCCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHH
FEPKSQVVELILNLEAEYEFLGNDGSVFYFKTDLDAPNGKVIAIDTRNSDKSQWQTIIPE
CCCHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCEEEEEECCCCCHHHHHEECCC
STDPINNVAIINDHLVVSYLHDVLGQLSIYSMGGQKRQDVALPGQGNVAGPFGKASKDYF
CCCCCCCEEEEECHHHHHHHHHHHHCEEEEECCCCCCCCEECCCCCCCCCCCCCCCCCEE
YYVFNSYIQPETTYKFDFKTAESSVIAKPKVSFNPDDYVSEQVFYRSKDGTRVPMMLSYK
EEEEECCCCCCCEEEEEEECCCCCEEECCCCCCCCCHHHCCHHEEECCCCCCCCEEEECH
KGLVKNAQNPTLLYAYGGFAISMTPRFSPANIAWLDMGGIYAVPSLRGGAEYGESWHQAG
HHHHCCCCCCEEEEEECCEEEEECCCCCCCCEEEEECCCEEECCCCCCCHHHHHHHHHCC
MFDKKQNVFDDYFAAAEYLVNEKYTNSTKLGAYGRSNGGLLMGAAVTQRPELFAAVLPAV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHCCCHHHHHHHHHHH
GVLDMLRFHKFTIGWAWTSEYGSADKADQFPALLAYSPYHNVKAQAYPATMVMTADHDDR
HHHHHHHHHEEEEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCEECCEEEEEEECCCCC
VVPLHSFKFAAMLQDKQQGTEPVIMRIESNAGHGAGKPTAMKIDEFADIYSFLWQSFGLT
EEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCC
LPQTIAK
CHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1840588; 7764331 [H]