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The map label for this gene is rrmA [H]

Identifier: 126173936

GI number: 126173936

Start: 1984944

End: 1985759

Strand: Direct

Name: rrmA [H]

Synonym: Sbal_1707

Alternate gene names: 126173936

Gene position: 1984944-1985759 (Clockwise)

Preceding gene: 126173935

Following gene: 126173937

Centisome position: 38.71

GC content: 43.75

Gene sequence:

>816_bases
ATGCATTATTTATGTCCCCTGTGTTCCGCGCCGCTGACGTTAACGGATCGAACTTGGGGTTGTCCACAGCAACATAAGTT
TGATATGGCCAAAGAGGGCTATGTCAACTTATTGCCTGTACAGAAGAAAAACTCAAAAGATCCTGGCGATAACAAGCAGA
TGATGTTTGCTCGGCGTGAATTTCTAAACGAAGGCTACTATCAAGATTTGAGTGATAGAGTGAATGCACTCGCGCTCGAT
TTTGGTGCTGAAGCAAAGCAGATCCTCGATATAGGCTGTGGGGAAGGGTACTACAGCCAGCGTTTATTCAATGTGTTGAG
TCAGCACCATGATTGTGATTTACAAGGCATAGATATTTCTAAGTCAGCAATTAAATATGCGGCTAAACGCTACCCCAATT
TAGCATTTTGTGTGGCAAGTGCCTATGAGATGCCCATCGCCTCTCAAAGTGTTGATCTTGCCATTCGCATTTATGCACCT
TCAAAAGTTGAAGAGCTACAACGCATTATGGCTGATGGTGGCATCTTGATCACAGTCTCTCCCGGACCTTCGCATCATTT
CGCCTTGAAGCAACAGATTTATGCCGAGCCTAGATTGCATACCGTATCAGCCGCGCATATTCCCGGATTTGAGTGCCTGC
ATCAGGAACGCTTAATTTCTCAACTTGAACTGACAAAAAGTGAACATATTGCTCATTTTTTAGAAATGACGCCTTACGCT
TGGAAGTTTACCGATGCTCAAAAGCAAGCATTTGCTCTGCAAGGACTGAGTTGTGAATTGGATTTCCAAATTGAAGTGCA
TCGCATTTCAAGATAA

Upstream 100 bases:

>100_bases
TGCTTGCCCCACCTGAACTGATCCAGATGGTTGATCGATTGATGGAAGACGAAGCGTAAACCTTTCTTGCCAAAATTTAG
TTAAATGATAAGAGTCCACT

Downstream 100 bases:

>100_bases
GCGATAAGATTAAGCTATTGAAATAAATTATTTAAAATGTTTAACTGTACTTGCTAAGCAGCATGAACTGAGTGTTCTGC
TAGCCGGTTGCAAAACCGCA

Product: 23S rRNA methyltransferase A

Products: NA

Alternate protein names: 23S rRNA m1G745 methyltransferase; rRNA (guanine-N(1)-)-methyltransferase [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MHYLCPLCSAPLTLTDRTWGCPQQHKFDMAKEGYVNLLPVQKKNSKDPGDNKQMMFARREFLNEGYYQDLSDRVNALALD
FGAEAKQILDIGCGEGYYSQRLFNVLSQHHDCDLQGIDISKSAIKYAAKRYPNLAFCVASAYEMPIASQSVDLAIRIYAP
SKVEELQRIMADGGILITVSPGPSHHFALKQQIYAEPRLHTVSAAHIPGFECLHQERLISQLELTKSEHIAHFLEMTPYA
WKFTDAQKQAFALQGLSCELDFQIEVHRISR

Sequences:

>Translated_271_residues
MHYLCPLCSAPLTLTDRTWGCPQQHKFDMAKEGYVNLLPVQKKNSKDPGDNKQMMFARREFLNEGYYQDLSDRVNALALD
FGAEAKQILDIGCGEGYYSQRLFNVLSQHHDCDLQGIDISKSAIKYAAKRYPNLAFCVASAYEMPIASQSVDLAIRIYAP
SKVEELQRIMADGGILITVSPGPSHHFALKQQIYAEPRLHTVSAAHIPGFECLHQERLISQLELTKSEHIAHFLEMTPYA
WKFTDAQKQAFALQGLSCELDFQIEVHRISR
>Mature_271_residues
MHYLCPLCSAPLTLTDRTWGCPQQHKFDMAKEGYVNLLPVQKKNSKDPGDNKQMMFARREFLNEGYYQDLSDRVNALALD
FGAEAKQILDIGCGEGYYSQRLFNVLSQHHDCDLQGIDISKSAIKYAAKRYPNLAFCVASAYEMPIASQSVDLAIRIYAP
SKVEELQRIMADGGILITVSPGPSHHFALKQQIYAEPRLHTVSAAHIPGFECLHQERLISQLELTKSEHIAHFLEMTPYA
WKFTDAQKQAFALQGLSCELDFQIEVHRISR

Specific function: Specifically methylates the guanosine in position 745 of 23S rRNA [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RlmA family [H]

Homologues:

Organism=Escherichia coli, GI1788125, Length=268, Percent_Identity=46.2686567164179, Blast_Score=236, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216
- InterPro:   IPR016718 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: =2.1.1.187 [H]

Molecular weight: Translated: 30695; Mature: 30695

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYLCPLCSAPLTLTDRTWGCPQQHKFDMAKEGYVNLLPVQKKNSKDPGDNKQMMFARRE
CCCCCCCCCCCCEECCCCCCCCCHHCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHH
FLNEGYYQDLSDRVNALALDFGAEAKQILDIGCGEGYYSQRLFNVLSQHHDCDLQGIDIS
HHHCCHHHHHHHHHHEEEEECCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
KSAIKYAAKRYPNLAFCVASAYEMPIASQSVDLAIRIYAPSKVEELQRIMADGGILITVS
HHHHHHHHHHCCCEEEEEHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCEEEEEC
PGPSHHFALKQQIYAEPRLHTVSAAHIPGFECLHQERLISQLELTKSEHIAHFLEMTPYA
CCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
WKFTDAQKQAFALQGLSCELDFQIEVHRISR
EEECCHHHHHHHHCCCCEEEEEEEEEEECCC
>Mature Secondary Structure
MHYLCPLCSAPLTLTDRTWGCPQQHKFDMAKEGYVNLLPVQKKNSKDPGDNKQMMFARRE
CCCCCCCCCCCCEECCCCCCCCCHHCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHH
FLNEGYYQDLSDRVNALALDFGAEAKQILDIGCGEGYYSQRLFNVLSQHHDCDLQGIDIS
HHHCCHHHHHHHHHHEEEEECCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
KSAIKYAAKRYPNLAFCVASAYEMPIASQSVDLAIRIYAPSKVEELQRIMADGGILITVS
HHHHHHHHHHCCCEEEEEHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCEEEEEC
PGPSHHFALKQQIYAEPRLHTVSAAHIPGFECLHQERLISQLELTKSEHIAHFLEMTPYA
CCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
WKFTDAQKQAFALQGLSCELDFQIEVHRISR
EEECCHHHHHHHHCCCCEEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7984109; 9097040; 9278503; 9440525 [H]