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The map label for this gene is lpxK

Identifier: 126173915

GI number: 126173915

Start: 1964159

End: 1965178

Strand: Direct

Name: lpxK

Synonym: Sbal_1684

Alternate gene names: 126173915

Gene position: 1964159-1965178 (Clockwise)

Preceding gene: 126173914

Following gene: 126173916

Centisome position: 38.31

GC content: 51.27

Gene sequence:

>1020_bases
ATGCAGGCCTTAGTGAATAAAATTTGGTATCAGGGCCATCCACTGCGCTGGCTCCTGTTACCTTTATCTTGGTTATTCGC
GGTTATCACTTATGTGCGCCGCGCCTTGTTTCGCCTCGGGATAAAATCACAAACGGCAATGCCTGTACCGGTCATTGTTG
TCGGTAATATTACCGTCGGCGGCAGCGGTAAGACGCCAACCGTGATTTATCTGATTGAGCTACTGCGCCAGCATGGGTTT
ACACCCGGTGTGATCAGTCGAGGTTACGGCGTTGATATTCAAGGCGTTAAAACGGTTAACTTAGGTGCGAGTGCAGCAGA
GGTGGGTGATGAACCGGCTATGATAGTGGCGCGCACTCAAGTGCCTATGGTAGTTGGCGCTAAACGCGTCGATGCCGCCA
ATGCACTTATTGCTGAGTTTGGTGTCGATGTCATCATCTGCGACGATGGGCTACAGCACTATGCGCTGGGACGCGATATT
GAGCTGGTGGTGATTGATGGTCAACGCGGTTTAGGTAATGGCTTGCTGTTGCCGGCAGGTCCGCTACGTGAAGGCGCGTG
GCGTCTCGATGCCGTGGATTTTATCGTCAATAATGGTGGCCCAGCAGCAAAAGGGCAGTTCGAAATGCAACTGGCGCCTA
CGGAAGTGAAGCCCGTTAAATGCGATGTGACCTCCGGTGAGTACAGTTTCGATAAATCTCAGCCGCTGGTTGCGATGGCG
GGTATTGGTAACCCTGCGCGTTTTTTTGAATCGCTGCGCGCCCAAGGTTATCAACTGGCGCTATGCCAGGGTTTTGATGA
CCATCAGGCTTACGATAAAACCCTATTACGTGATTTAGCCCAAGACTTGCCACTGTTGATGACAGAAAAAGATGCGGTTA
AATGTCGCGATTTTGCACAAGAGAACTGGTGGTATTTGGCGGTCAATGCCAAGCTATCCCCACAATTTGATGAGCAGCTG
CTCGCACGTCTTCGCGAGGTGGCTGCAGCTAAACAAGGAAACTTCCATGGCATTCGATAA

Upstream 100 bases:

>100_bases
GGTGGATCAGGGACGTATCGTCGAGCGCGGGACGCACCAATCACTATTGGAATTAAATGGCATGTACGCCAAATTGTACC
AAATGCAATTCGGTAGCTAG

Downstream 100 bases:

>100_bases
AAAATTGTTAGATATAGTGGCTTGCCCTGTGTGTAAGGGAAAACTTGAGTACGATAAAACGACGCAGCAGTTGATTTGTA
AGGCAGATAAGCTGGCCTAT

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MQALVNKIWYQGHPLRWLLLPLSWLFAVITYVRRALFRLGIKSQTAMPVPVIVVGNITVGGSGKTPTVIYLIELLRQHGF
TPGVISRGYGVDIQGVKTVNLGASAAEVGDEPAMIVARTQVPMVVGAKRVDAANALIAEFGVDVIICDDGLQHYALGRDI
ELVVIDGQRGLGNGLLLPAGPLREGAWRLDAVDFIVNNGGPAAKGQFEMQLAPTEVKPVKCDVTSGEYSFDKSQPLVAMA
GIGNPARFFESLRAQGYQLALCQGFDDHQAYDKTLLRDLAQDLPLLMTEKDAVKCRDFAQENWWYLAVNAKLSPQFDEQL
LARLREVAAAKQGNFHGIR

Sequences:

>Translated_339_residues
MQALVNKIWYQGHPLRWLLLPLSWLFAVITYVRRALFRLGIKSQTAMPVPVIVVGNITVGGSGKTPTVIYLIELLRQHGF
TPGVISRGYGVDIQGVKTVNLGASAAEVGDEPAMIVARTQVPMVVGAKRVDAANALIAEFGVDVIICDDGLQHYALGRDI
ELVVIDGQRGLGNGLLLPAGPLREGAWRLDAVDFIVNNGGPAAKGQFEMQLAPTEVKPVKCDVTSGEYSFDKSQPLVAMA
GIGNPARFFESLRAQGYQLALCQGFDDHQAYDKTLLRDLAQDLPLLMTEKDAVKCRDFAQENWWYLAVNAKLSPQFDEQL
LARLREVAAAKQGNFHGIR
>Mature_339_residues
MQALVNKIWYQGHPLRWLLLPLSWLFAVITYVRRALFRLGIKSQTAMPVPVIVVGNITVGGSGKTPTVIYLIELLRQHGF
TPGVISRGYGVDIQGVKTVNLGASAAEVGDEPAMIVARTQVPMVVGAKRVDAANALIAEFGVDVIICDDGLQHYALGRDI
ELVVIDGQRGLGNGLLLPAGPLREGAWRLDAVDFIVNNGGPAAKGQFEMQLAPTEVKPVKCDVTSGEYSFDKSQPLVAMA
GIGNPARFFESLRAQGYQLALCQGFDDHQAYDKTLLRDLAQDLPLLMTEKDAVKCRDFAQENWWYLAVNAKLSPQFDEQL
LARLREVAAAKQGNFHGIR

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=333, Percent_Identity=45.045045045045, Blast_Score=273, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_SHEB5 (A3D382)

Other databases:

- EMBL:   CP000563
- RefSeq:   YP_001050064.1
- STRING:   A3D382
- GeneID:   4841780
- GenomeReviews:   CP000563_GR
- KEGG:   sbl:Sbal_1684
- NMPDR:   fig|325240.3.peg.3726
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- PhylomeDB:   A3D382
- ProtClustDB:   PRK00652
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 37022; Mature: 37022

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQALVNKIWYQGHPLRWLLLPLSWLFAVITYVRRALFRLGIKSQTAMPVPVIVVGNITVG
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEC
GSGKTPTVIYLIELLRQHGFTPGVISRGYGVDIQGVKTVNLGASAAEVGDEPAMIVARTQ
CCCCCCHHHHHHHHHHHCCCCCCHHCCCCCCCCCCEEEEECCCCHHHCCCCCEEEEEECC
VPMVVGAKRVDAANALIAEFGVDVIICDDGLQHYALGRDIELVVIDGQRGLGNGLLLPAG
CCEEECCCHHHHHHHHHHHHCCEEEEECCCCHHHHCCCCEEEEEEECCCCCCCCEECCCC
PLREGAWRLDAVDFIVNNGGPAAKGQFEMQLAPTEVKPVKCDVTSGEYSFDKSQPLVAMA
CCCCCCEEEEEEEEEEECCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEEEE
GIGNPARFFESLRAQGYQLALCQGFDDHQAYDKTLLRDLAQDLPLLMTEKDAVKCRDFAQ
CCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHCC
ENWWYLAVNAKLSPQFDEQLLARLREVAAAKQGNFHGIR
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQALVNKIWYQGHPLRWLLLPLSWLFAVITYVRRALFRLGIKSQTAMPVPVIVVGNITVG
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEC
GSGKTPTVIYLIELLRQHGFTPGVISRGYGVDIQGVKTVNLGASAAEVGDEPAMIVARTQ
CCCCCCHHHHHHHHHHHCCCCCCHHCCCCCCCCCCEEEEECCCCHHHCCCCCEEEEEECC
VPMVVGAKRVDAANALIAEFGVDVIICDDGLQHYALGRDIELVVIDGQRGLGNGLLLPAG
CCEEECCCHHHHHHHHHHHHCCEEEEECCCCHHHHCCCCEEEEEEECCCCCCCCEECCCC
PLREGAWRLDAVDFIVNNGGPAAKGQFEMQLAPTEVKPVKCDVTSGEYSFDKSQPLVAMA
CCCCCCEEEEEEEEEEECCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEEEE
GIGNPARFFESLRAQGYQLALCQGFDDHQAYDKTLLRDLAQDLPLLMTEKDAVKCRDFAQ
CCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHCC
ENWWYLAVNAKLSPQFDEQLLARLREVAAAKQGNFHGIR
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA