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The map label for this gene is lon [H]

Identifier: 126173840

GI number: 126173840

Start: 1876231

End: 1878585

Strand: Direct

Name: lon [H]

Synonym: Sbal_1606

Alternate gene names: 126173840

Gene position: 1876231-1878585 (Clockwise)

Preceding gene: 126173839

Following gene: 126173841

Centisome position: 36.59

GC content: 47.09

Gene sequence:

>2355_bases
ATGACCCAAGAGCGTGAAGCGCATATCGAACTCCCCGTGCTGCCACTGCGAGATGTGGTGGTCTATCCCCATATGGTAAT
TCCGTTATTTGTCGGACGAGAAAAATCTATTCGATGTCTCGAAACCGCAATGGCGCAGGATAAGCAAATTATTTTAGTGG
CGCAGCGTGATGCCGAACTCGATGAACCATCAAAAGATGACATCTTCGAAGTGGGTACGGTTGCCTCTATTTTACAGTTA
CTTAAGCTGCCAGACGGCACAGTCAAAGTGTTGGTAGAAGGCGGTCGTCGCGCCCGTATTACCCGTTACACCCAAGAAAC
AGAATTCTTTGTGGCTAAGGCTGAGTATCTGGAGTCAGAACCGCTGGAAGACAAAGAAGAAGTGTTAGTGCGCAGTGCTA
TTGGTCAGTTTGAAGGTTATATCAAGCTGAACAAAAAGATCCCGCCAGAAGTCTTGACCTCTTTATCGGGTATCGATGAA
GCGGCGCGTCTGGCAGATACTATGGCTGCACACATGCCACTTAAGCTTGAAGATAAGCAATCTGTGCTTGAGATGATCAA
CGTTGGCGAGCGTCTGGAATATTTAATGGCGATGATGGAATCGGAGATCGACCTATTGCAGGTTGAGAAACGTATCCGTA
CCCGCGTTAAAAAACAGATGGAAAAAAGTCAGCGTGAGTACTATCTGAACGAACAGATGAAAGCCATCCAGAAAGAACTG
GGTGACTTAGACGAAGGCCATGACGAGTTTGAAGCCTTAAATCGTAAGATTGAAGAGGCCAACATGCCCGCCGAGGCGAA
AGAAAAAGCCCTCGCTGAGCTTAATAAGTTACGCATGATGTCGCCAATGTCGGCAGAAGCCACAGTTGTGCGCAGCTATG
TGGATTGGATGACGTCAGTGCCTTGGAGCCAACGCTCTAAAATCAAACGTGATTTAGCAAAAGCCCAAGAAGTGCTCGAT
ACCGATCATTTCGGTCTGGAAAAAGTTAAAGAACGTATCTTGGAATATTTGGCAGTCCAAAGCCGAGTGCGTCAGCTTAA
AGGGCCAATCCTGTGTCTCGTTGGACCTCCAGGTGTGGGTAAAACTTCCTTGGGTCAATCGATCGCTAAGGCGACCGGTC
GTAAGTATGTGCGTGTTGCTTTAGGCGGCGTGCGTGATGAAGCGGAAATCCGTGGTCATCGCCGTACTTATATTGGTTCT
ATGCCAGGTAAAGTCATTCAAAAGATGGCTAAGGTGGGCGTGAAAAACCCATTATTCTTGCTCGATGAAATCGACAAGAT
GAGTTCAGACATGCGCGGCGATCCGGCTTCTGCTTTATTAGAAGTGTTAGATCCTGAGCAAAATGCGACCTTTAACGATC
ATTACCTCGAAGTCGATTACGACTTATCCGATGTGATGTTTGTGGCAACGTCTAACTCTATGGACATTCCTGGTCCACTA
CTGGACCGTATGGAAGTGATCCGTTTGTCGGGTTACACCGAAGACGAGAAGCTGAATATTGCTAAGCAACATTTGCTGAA
TAAGCAAATTGAGCGCAACGGCTTAAAAGCGGCTGAAATTAAAGTAGAGGATAGCGCTATCGTTGGCATTATCCGCTATT
ACACCCGTGAAGCGGGCGTGCGTTCGCTTGAGCGTGAATTGTCTAAGATTTGCCGTAAAGTCGTGAAAATGATTTTGCTC
GATAAATCAGTAAAATCTGTCACTGTGAATCAAGAGAACCTTAAGTCATTCCTTGGCGTGCAGCGCTTCGATTACGGTAA
AGCCGAGTCGAAGAACCAAATCGGTCAAGTGACAGGCTTAGCGTGGACACAAGTAGGCGGTGATCTGCTAACGATTGAAG
CGACATCGGTGCCTGGTAAAGGTAAATTAACTTATACTGGTTCCCTTGGCGACGTGATGCAAGAGTCAATTCAAGCGGCG
ATGACCGTTGTTCGTGCCCGTGCGGAACAATTAGGTATTAATGCGGATTTCTACGAGAAGCGTGATATCCATGTGCATGT
GCCAGAAGGTGCAACGCCAAAAGATGGTCCATCTGCTGGTGCGGCTATGTGTACCGCTTTAGTATCCAGCTTAACGGGTA
ACCCAGTGCGTAGCGACGTGGCCATGACAGGTGAAATAACCTTACGTGGTGAAGTGTTACCTATCGGTGGTTTAAAAGAA
AAACTGCTTGCAGCACACCGCGGCGGCATAAAATTGGTGCTTATTCCAAAAGAAAACGAGCGTGATCTGGAAGAAATTCC
TGCCAATGTGATTGCCGATTTAGAAATTCGTCCCGTGCGTTGGGTCGATGAAGTGTTAAAACTGGCCCTAGAAAGACCAG
TTGAAGGCTTCGAAGTGGTTAAAAACTTGGCATAA

Upstream 100 bases:

>100_bases
GAGTCCAATGGACTCCTTTTTTCGTATTAGCCATTGAAACTCAATAAAGCGTCCCAATATACTCCAGTATTAATCCATTT
CACCAAAACGGAATCGAACT

Downstream 100 bases:

>100_bases
CGCAAGAAATTGCGCTATCACGTTAAAAAAAATGAAAAAAGGGGCTTAACAAAGCGTAGACCTGTGGTAGCCTAGGTCTG
TGGAGAGCCAGCTGCTCCAA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 784; Mature: 783

Protein sequence:

>784_residues
MTQEREAHIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIILVAQRDAELDEPSKDDIFEVGTVASILQL
LKLPDGTVKVLVEGGRRARITRYTQETEFFVAKAEYLESEPLEDKEEVLVRSAIGQFEGYIKLNKKIPPEVLTSLSGIDE
AARLADTMAAHMPLKLEDKQSVLEMINVGERLEYLMAMMESEIDLLQVEKRIRTRVKKQMEKSQREYYLNEQMKAIQKEL
GDLDEGHDEFEALNRKIEEANMPAEAKEKALAELNKLRMMSPMSAEATVVRSYVDWMTSVPWSQRSKIKRDLAKAQEVLD
TDHFGLEKVKERILEYLAVQSRVRQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGS
MPGKVIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMDIPGPL
LDRMEVIRLSGYTEDEKLNIAKQHLLNKQIERNGLKAAEIKVEDSAIVGIIRYYTREAGVRSLERELSKICRKVVKMILL
DKSVKSVTVNQENLKSFLGVQRFDYGKAESKNQIGQVTGLAWTQVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQAA
MTVVRARAEQLGINADFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLKE
KLLAAHRGGIKLVLIPKENERDLEEIPANVIADLEIRPVRWVDEVLKLALERPVEGFEVVKNLA

Sequences:

>Translated_784_residues
MTQEREAHIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIILVAQRDAELDEPSKDDIFEVGTVASILQL
LKLPDGTVKVLVEGGRRARITRYTQETEFFVAKAEYLESEPLEDKEEVLVRSAIGQFEGYIKLNKKIPPEVLTSLSGIDE
AARLADTMAAHMPLKLEDKQSVLEMINVGERLEYLMAMMESEIDLLQVEKRIRTRVKKQMEKSQREYYLNEQMKAIQKEL
GDLDEGHDEFEALNRKIEEANMPAEAKEKALAELNKLRMMSPMSAEATVVRSYVDWMTSVPWSQRSKIKRDLAKAQEVLD
TDHFGLEKVKERILEYLAVQSRVRQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGS
MPGKVIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMDIPGPL
LDRMEVIRLSGYTEDEKLNIAKQHLLNKQIERNGLKAAEIKVEDSAIVGIIRYYTREAGVRSLERELSKICRKVVKMILL
DKSVKSVTVNQENLKSFLGVQRFDYGKAESKNQIGQVTGLAWTQVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQAA
MTVVRARAEQLGINADFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLKE
KLLAAHRGGIKLVLIPKENERDLEEIPANVIADLEIRPVRWVDEVLKLALERPVEGFEVVKNLA
>Mature_783_residues
TQEREAHIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIILVAQRDAELDEPSKDDIFEVGTVASILQLL
KLPDGTVKVLVEGGRRARITRYTQETEFFVAKAEYLESEPLEDKEEVLVRSAIGQFEGYIKLNKKIPPEVLTSLSGIDEA
ARLADTMAAHMPLKLEDKQSVLEMINVGERLEYLMAMMESEIDLLQVEKRIRTRVKKQMEKSQREYYLNEQMKAIQKELG
DLDEGHDEFEALNRKIEEANMPAEAKEKALAELNKLRMMSPMSAEATVVRSYVDWMTSVPWSQRSKIKRDLAKAQEVLDT
DHFGLEKVKERILEYLAVQSRVRQLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGSM
PGKVIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMDIPGPLL
DRMEVIRLSGYTEDEKLNIAKQHLLNKQIERNGLKAAEIKVEDSAIVGIIRYYTREAGVRSLERELSKICRKVVKMILLD
KSVKSVTVNQENLKSFLGVQRFDYGKAESKNQIGQVTGLAWTQVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQAAM
TVVRARAEQLGINADFYEKRDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLKEK
LLAAHRGGIKLVLIPKENERDLEEIPANVIADLEIRPVRWVDEVLKLALERPVEGFEVVKNLA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=775, Percent_Identity=38.9677419354839, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI21396489, Length=830, Percent_Identity=36.6265060240964, Blast_Score=509, Evalue=1e-144,
Organism=Escherichia coli, GI1786643, Length=781, Percent_Identity=80.7938540332907, Blast_Score=1281, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=653, Percent_Identity=41.5007656967841, Blast_Score=500, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17556486, Length=796, Percent_Identity=34.1708542713568, Blast_Score=438, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319449, Length=723, Percent_Identity=38.4508990318119, Blast_Score=495, Evalue=1e-140,
Organism=Drosophila melanogaster, GI221513036, Length=629, Percent_Identity=44.1971383147854, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24666867, Length=620, Percent_Identity=44.5161290322581, Blast_Score=521, Evalue=1e-148,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87530; Mature: 87399

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQEREAHIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIILVAQRDAEL
CCCCCCCCEECCCCCHHHHHHCCHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCC
DEPSKDDIFEVGTVASILQLLKLPDGTVKVLVEGGRRARITRYTQETEFFVAKAEYLESE
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHCCC
PLEDKEEVLVRSAIGQFEGYIKLNKKIPPEVLTSLSGIDEAARLADTMAAHMPLKLEDKQ
CCCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCEECHHH
SVLEMINVGERLEYLMAMMESEIDLLQVEKRIRTRVKKQMEKSQREYYLNEQMKAIQKEL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDLDEGHDEFEALNRKIEEANMPAEAKEKALAELNKLRMMSPMSAEATVVRSYVDWMTSV
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
PWSQRSKIKRDLAKAQEVLDTDHFGLEKVKERILEYLAVQSRVRQLKGPILCLVGPPGVG
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
KTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGSMPGKVIQKMAKVGVKNPLFL
HHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHHH
LDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMDIPGPL
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCHH
LDRMEVIRLSGYTEDEKLNIAKQHLLNKQIERNGLKAAEIKVEDSAIVGIIRYYTREAGV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHH
RSLERELSKICRKVVKMILLDKSVKSVTVNQENLKSFLGVQRFDYGKAESKNQIGQVTGL
HHHHHHHHHHHHHHHHHHHHCCCHHHEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHCC
AWTQVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQAAMTVVRARAEQLGINADFYEK
HHHHCCCCEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLKE
CCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECEEEECCCHHH
KLLAAHRGGIKLVLIPKENERDLEEIPANVIADLEIRPVRWVDEVLKLALERPVEGFEVV
HHHHHHCCCEEEEEECCCCCCCHHHCCHHHEECCCCCCHHHHHHHHHHHHHCCCHHHHHH
KNLA
HHCC
>Mature Secondary Structure 
TQEREAHIELPVLPLRDVVVYPHMVIPLFVGREKSIRCLETAMAQDKQIILVAQRDAEL
CCCCCCCEECCCCCHHHHHHCCHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCC
DEPSKDDIFEVGTVASILQLLKLPDGTVKVLVEGGRRARITRYTQETEFFVAKAEYLESE
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHCCC
PLEDKEEVLVRSAIGQFEGYIKLNKKIPPEVLTSLSGIDEAARLADTMAAHMPLKLEDKQ
CCCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCEECHHH
SVLEMINVGERLEYLMAMMESEIDLLQVEKRIRTRVKKQMEKSQREYYLNEQMKAIQKEL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDLDEGHDEFEALNRKIEEANMPAEAKEKALAELNKLRMMSPMSAEATVVRSYVDWMTSV
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
PWSQRSKIKRDLAKAQEVLDTDHFGLEKVKERILEYLAVQSRVRQLKGPILCLVGPPGVG
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
KTSLGQSIAKATGRKYVRVALGGVRDEAEIRGHRRTYIGSMPGKVIQKMAKVGVKNPLFL
HHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHHH
LDEIDKMSSDMRGDPASALLEVLDPEQNATFNDHYLEVDYDLSDVMFVATSNSMDIPGPL
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCHH
LDRMEVIRLSGYTEDEKLNIAKQHLLNKQIERNGLKAAEIKVEDSAIVGIIRYYTREAGV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHH
RSLERELSKICRKVVKMILLDKSVKSVTVNQENLKSFLGVQRFDYGKAESKNQIGQVTGL
HHHHHHHHHHHHHHHHHHHHCCCHHHEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHCC
AWTQVGGDLLTIEATSVPGKGKLTYTGSLGDVMQESIQAAMTVVRARAEQLGINADFYEK
HHHHCCCCEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RDIHVHVPEGATPKDGPSAGAAMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLKE
CCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECEEEECCCHHH
KLLAAHRGGIKLVLIPKENERDLEEIPANVIADLEIRPVRWVDEVLKLALERPVEGFEVV
HHHHHHCCCEEEEEECCCCCCCHHHCCHHHEECCCCCCHHHHHHHHHHHHHCCCHHHHHH
KNLA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]