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The map label for this gene is lpxB [H]

Identifier: 126173701

GI number: 126173701

Start: 1695967

End: 1697163

Strand: Direct

Name: lpxB [H]

Synonym: Sbal_1463

Alternate gene names: 126173701

Gene position: 1695967-1697163 (Clockwise)

Preceding gene: 126173700

Following gene: 126173702

Centisome position: 33.08

GC content: 50.46

Gene sequence:

>1197_bases
ATGAGACATGATTGGTTTATGAGCAATAAAACTCCATTAGTGTTTGCCATGGTTGCCGGAGAACTCTCGGGCGATATTTT
AGGCGCAGGTTTAATGGCGGCGCTGCAAAAGAAGCACCCCGATGCGCGCTTTGTCGGTATCGGTGGCCCCCGTATGGAAG
CCCTCGGCTTCAGATCCCTGTTTGCGATGGAAGAGCTCGCCGTGATGGGGATTGTAGAAGTGCTATCCCGTTTGCCTCGT
TTATTAACAGTACGTGCCTCCCTGATTAAAGAGATTACCGCGCTTAAGCCCGATTGTTTTATTGGTATCGATGCACCGGA
TTTTAATATTGGCCTCGAGCTTAAACTCAAAGCGCGTGGCATTAAGACGGTCCATTATGTGAGCCCGTCTGTGTGGGCGT
GGCGTCCAAAACGGATATTCAAAATCGCCAAAGCCACTCATATGGTGTTGTCGTTGTTGCCTTTTGAGAAAGCCTTTTAC
GATCAGCATCAGGTGCCTTGTACCTTTGTCGGTCATACCTTGGCCGACGATATTCCCATGCAAAGCGATAAGGCGGCTGC
CCGTGCCTTGCTCGGACTAGATGCTGATGCTGAATACTTAGCGATCCTGCCCGGTTCCCGCGGCGGTGAGTTAAAGCAAC
TGGCCGAGCCGTTTGTGAAAGCAGCTTTATTGATTAGACAAAATTCCCCAGACATACGTTTTGTGACGCCGCTGGTGAAT
CAAAAACGTCGTGACCAATTTGAGCAAGCGCTGAAGGATTTTGCGCCAGATCTTGAAATCCACATGATTGAAGGTCAGTC
GCGTGAAGTGATGACGGCAGCCGATGGGATTTTATTGGCCTCTGGTACAGCGACGTTAGAAGCCATGCTGGTCAAGCGTC
CTATGGTGGTGGCTTATCGCGTGAGCCCGATAACCTATCGCATTGCTAAGCGCATGATGCAGGTGGAGCGTTTCTCGTTA
CCGAATTTGCTTGCAGGAAAAGATCTCGTCCCAGAACTCATTCAAGAAGATTGCACCCCAGAGAAAATTGCGGCGGCAGT
CACCCTTGAGCTCAATCGCGATTTTGCGCCGCTTAAAGCCGAGTTTGAAGCTCTGCACCAAGTATTACGCCGTGATGCGA
GTTTAAAAGCCGCCGAGGCGGTAATGGCGCTGGTTGAGCCTAAACACACTCATGCTAAATTGCAGGAGGCTCATTAG

Upstream 100 bases:

>100_bases
CATTCAACCATCAATGAGCTTAATCATTAATTTACATCAGTATGGCTTGGAATGATGTGTTTTAGCTGTTGTTCGCCCCG
TCATCCAATGTCATTCATTC

Downstream 100 bases:

>100_bases
TGGCAATCTATAAAAGTTTAACCGAAGCCGATTTGCTCGCCTTTTCAACGGGTTTGATTGCCGGAGTGGATGAAGTTGGC
CGCGGCCCCTTAGTCGGCGA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MRHDWFMSNKTPLVFAMVAGELSGDILGAGLMAALQKKHPDARFVGIGGPRMEALGFRSLFAMEELAVMGIVEVLSRLPR
LLTVRASLIKEITALKPDCFIGIDAPDFNIGLELKLKARGIKTVHYVSPSVWAWRPKRIFKIAKATHMVLSLLPFEKAFY
DQHQVPCTFVGHTLADDIPMQSDKAAARALLGLDADAEYLAILPGSRGGELKQLAEPFVKAALLIRQNSPDIRFVTPLVN
QKRRDQFEQALKDFAPDLEIHMIEGQSREVMTAADGILLASGTATLEAMLVKRPMVVAYRVSPITYRIAKRMMQVERFSL
PNLLAGKDLVPELIQEDCTPEKIAAAVTLELNRDFAPLKAEFEALHQVLRRDASLKAAEAVMALVEPKHTHAKLQEAH

Sequences:

>Translated_398_residues
MRHDWFMSNKTPLVFAMVAGELSGDILGAGLMAALQKKHPDARFVGIGGPRMEALGFRSLFAMEELAVMGIVEVLSRLPR
LLTVRASLIKEITALKPDCFIGIDAPDFNIGLELKLKARGIKTVHYVSPSVWAWRPKRIFKIAKATHMVLSLLPFEKAFY
DQHQVPCTFVGHTLADDIPMQSDKAAARALLGLDADAEYLAILPGSRGGELKQLAEPFVKAALLIRQNSPDIRFVTPLVN
QKRRDQFEQALKDFAPDLEIHMIEGQSREVMTAADGILLASGTATLEAMLVKRPMVVAYRVSPITYRIAKRMMQVERFSL
PNLLAGKDLVPELIQEDCTPEKIAAAVTLELNRDFAPLKAEFEALHQVLRRDASLKAAEAVMALVEPKHTHAKLQEAH
>Mature_398_residues
MRHDWFMSNKTPLVFAMVAGELSGDILGAGLMAALQKKHPDARFVGIGGPRMEALGFRSLFAMEELAVMGIVEVLSRLPR
LLTVRASLIKEITALKPDCFIGIDAPDFNIGLELKLKARGIKTVHYVSPSVWAWRPKRIFKIAKATHMVLSLLPFEKAFY
DQHQVPCTFVGHTLADDIPMQSDKAAARALLGLDADAEYLAILPGSRGGELKQLAEPFVKAALLIRQNSPDIRFVTPLVN
QKRRDQFEQALKDFAPDLEIHMIEGQSREVMTAADGILLASGTATLEAMLVKRPMVVAYRVSPITYRIAKRMMQVERFSL
PNLLAGKDLVPELIQEDCTPEKIAAAVTLELNRDFAPLKAEFEALHQVLRRDASLKAAEAVMALVEPKHTHAKLQEAH

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=382, Percent_Identity=57.0680628272251, Blast_Score=439, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 44111; Mature: 44111

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHDWFMSNKTPLVFAMVAGELSGDILGAGLMAALQKKHPDARFVGIGGPRMEALGFRSL
CCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
FAMEELAVMGIVEVLSRLPRLLTVRASLIKEITALKPDCFIGIDAPDFNIGLELKLKARG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCC
IKTVHYVSPSVWAWRPKRIFKIAKATHMVLSLLPFEKAFYDQHQVPCTFVGHTLADDIPM
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHCCCCC
QSDKAAARALLGLDADAEYLAILPGSRGGELKQLAEPFVKAALLIRQNSPDIRFVTPLVN
CCHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECHHHC
QKRRDQFEQALKDFAPDLEIHMIEGQSREVMTAADGILLASGTATLEAMLVKRPMVVAYR
HHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCEEEECCHHHHHHHHHCCCEEEEEE
VSPITYRIAKRMMQVERFSLPNLLAGKDLVPELIQEDCTPEKIAAAVTLELNRDFAPLKA
ECHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHCCCCHHHHEEEEEEEECCCCCHHHH
EFEALHQVLRRDASLKAAEAVMALVEPKHTHAKLQEAH
HHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHCCCC
>Mature Secondary Structure
MRHDWFMSNKTPLVFAMVAGELSGDILGAGLMAALQKKHPDARFVGIGGPRMEALGFRSL
CCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
FAMEELAVMGIVEVLSRLPRLLTVRASLIKEITALKPDCFIGIDAPDFNIGLELKLKARG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCC
IKTVHYVSPSVWAWRPKRIFKIAKATHMVLSLLPFEKAFYDQHQVPCTFVGHTLADDIPM
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHCCCCC
QSDKAAARALLGLDADAEYLAILPGSRGGELKQLAEPFVKAALLIRQNSPDIRFVTPLVN
CCHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECHHHC
QKRRDQFEQALKDFAPDLEIHMIEGQSREVMTAADGILLASGTATLEAMLVKRPMVVAYR
HHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCEEEECCHHHHHHHHHCCCEEEEEE
VSPITYRIAKRMMQVERFSLPNLLAGKDLVPELIQEDCTPEKIAAAVTLELNRDFAPLKA
ECHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHCCCCHHHHEEEEEEEECCCCCHHHH
EFEALHQVLRRDASLKAAEAVMALVEPKHTHAKLQEAH
HHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA