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The map label for this gene is tyrA [H]

Identifier: 126173453

GI number: 126173453

Start: 1395253

End: 1396404

Strand: Direct

Name: tyrA [H]

Synonym: Sbal_1215

Alternate gene names: 126173453

Gene position: 1395253-1396404 (Clockwise)

Preceding gene: 126173452

Following gene: 126173454

Centisome position: 27.21

GC content: 48.7

Gene sequence:

>1152_bases
ATGGACTCAGGTATGAATGAAAAAACAACGGCCGAATTAGAACATCTTCGCGGCCTGATTGATGGTGTCGATCAGCAATT
ACTGCATTTACTGCGTAAGCGCTTGGATCTCGTGGCGCAAGTGGGCACAGTGAAACACGGCGCCGGTTTACCGATCTATG
CACCGCAGCGTGAAGCCGCCATGCTCGCTAAACGCCGCGAAGAAGCGAAAAACATGGGGATTGCGCCGCAATTAATTGAG
GATATTTTACGCCGCTTGATGCGCGAGTCTTATCTCAATGAAAAAGATGTTGGCTTTAAGCAAGTTAAAAAAGATCTCGG
CTCAGTGGTGATTGTCGGCGGTAAGGGGCAACTCGGTGGATTGTTTTCACAAATGCTGACCTTATCTGGCTACCAAGTGA
ATCTGCTCGATAAAGACGATTGGCAGCAAGCAGATAGCCTATTTGCCGATGCGGGCATGGTGTTAGTGACAGTGCCGATA
GCGATTACTTGCGAGCTTATTCGCGAAAAGCTGACCCAATTACCAGCCGACTGTATTCTGGCGGATTTGACCTCCATCAA
GACAGAGCCAGTTAAAGCCATGCTTGAGGCGCATTCTGGTCCTGTCGTCGGTTTCCATCCTATGTTTGGTCCCGATGTGG
GCAGTTTGGCGAAACAAGTTGTGGTGGTGTGCCACGGTCGCTCGCCGGAAAAATACCAATGGTTACTCGAGCAGATTGCC
ATTTGGGGCGCGCGGATTGTCGAAGCAGAGCCCGAACGTCACGACAGTGCAATGCAATTAGTGCAGGCGATGCGCCACTT
CTCGACCTTTGTGTATGGTTTGAATCTGTGCAAGGAAGAGGCAGATATTGATACTTTACTGCAATTTAGCTCGCCGATTT
ATCGCTTAGAATTGGCTATGGTAGGGCGCTTATTCGCCCAAAGCCCAGAGCTTTACGCCGATATTATTTTTGCCCAGCAA
GATAGCCAGCATGCTATTGGTGATTACTTAGATAACTACCGTGAAGCGTTAGAGCTGCTAAAACGCGGCGACAGGAACGA
GTTTATTAAGCAGTTCCAAAGCGTCGCTAAATGGTTTGGGGATTTTGCCCCTCAATTCCAACGCGAAAGCCGCATTATGC
TGCAATCGGTAAATGATATGAAAACCAATTAA

Upstream 100 bases:

>100_bases
AGAAACTATTTTACGTGACGGCGCGGTGAAGTTATCTTCAATACTCCCGGCACGCTTCGATATGCTTAAAGTAGCTAACG
CTTAAATTGGCTACAGCTTA

Downstream 100 bases:

>100_bases
TAAATAATAAGTTACTCTTTAAAACGCCCATCAATGATGGGCGTTTTTTTATGGATTTATGGCAGTTTTTATTACCTTTA
TTAGTGATTGCTTAAGGTGA

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MDSGMNEKTTAELEHLRGLIDGVDQQLLHLLRKRLDLVAQVGTVKHGAGLPIYAPQREAAMLAKRREEAKNMGIAPQLIE
DILRRLMRESYLNEKDVGFKQVKKDLGSVVIVGGKGQLGGLFSQMLTLSGYQVNLLDKDDWQQADSLFADAGMVLVTVPI
AITCELIREKLTQLPADCILADLTSIKTEPVKAMLEAHSGPVVGFHPMFGPDVGSLAKQVVVVCHGRSPEKYQWLLEQIA
IWGARIVEAEPERHDSAMQLVQAMRHFSTFVYGLNLCKEEADIDTLLQFSSPIYRLELAMVGRLFAQSPELYADIIFAQQ
DSQHAIGDYLDNYREALELLKRGDRNEFIKQFQSVAKWFGDFAPQFQRESRIMLQSVNDMKTN

Sequences:

>Translated_383_residues
MDSGMNEKTTAELEHLRGLIDGVDQQLLHLLRKRLDLVAQVGTVKHGAGLPIYAPQREAAMLAKRREEAKNMGIAPQLIE
DILRRLMRESYLNEKDVGFKQVKKDLGSVVIVGGKGQLGGLFSQMLTLSGYQVNLLDKDDWQQADSLFADAGMVLVTVPI
AITCELIREKLTQLPADCILADLTSIKTEPVKAMLEAHSGPVVGFHPMFGPDVGSLAKQVVVVCHGRSPEKYQWLLEQIA
IWGARIVEAEPERHDSAMQLVQAMRHFSTFVYGLNLCKEEADIDTLLQFSSPIYRLELAMVGRLFAQSPELYADIIFAQQ
DSQHAIGDYLDNYREALELLKRGDRNEFIKQFQSVAKWFGDFAPQFQRESRIMLQSVNDMKTN
>Mature_383_residues
MDSGMNEKTTAELEHLRGLIDGVDQQLLHLLRKRLDLVAQVGTVKHGAGLPIYAPQREAAMLAKRREEAKNMGIAPQLIE
DILRRLMRESYLNEKDVGFKQVKKDLGSVVIVGGKGQLGGLFSQMLTLSGYQVNLLDKDDWQQADSLFADAGMVLVTVPI
AITCELIREKLTQLPADCILADLTSIKTEPVKAMLEAHSGPVVGFHPMFGPDVGSLAKQVVVVCHGRSPEKYQWLLEQIA
IWGARIVEAEPERHDSAMQLVQAMRHFSTFVYGLNLCKEEADIDTLLQFSSPIYRLELAMVGRLFAQSPELYADIIFAQQ
DSQHAIGDYLDNYREALELLKRGDRNEFIKQFQSVAKWFGDFAPQFQRESRIMLQSVNDMKTN

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=372, Percent_Identity=58.3333333333333, Blast_Score=442, Evalue=1e-125,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 43029; Mature: 43029

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00933 FGGY_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSGMNEKTTAELEHLRGLIDGVDQQLLHLLRKRLDLVAQVGTVKHGAGLPIYAPQREAA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
MLAKRREEAKNMGIAPQLIEDILRRLMRESYLNEKDVGFKQVKKDLGSVVIVGGKGQLGG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCEEEECCCCCHHH
LFSQMLTLSGYQVNLLDKDDWQQADSLFADAGMVLVTVPIAITCELIREKLTQLPADCIL
HHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHCCHHHHH
ADLTSIKTEPVKAMLEAHSGPVVGFHPMFGPDVGSLAKQVVVVCHGRSPEKYQWLLEQIA
HHHHHHCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
IWGARIVEAEPERHDSAMQLVQAMRHFSTFVYGLNLCKEEADIDTLLQFSSPIYRLELAM
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VGRLFAQSPELYADIIFAQQDSQHAIGDYLDNYREALELLKRGDRNEFIKQFQSVAKWFG
HHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
DFAPQFQRESRIMLQSVNDMKTN
HHCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDSGMNEKTTAELEHLRGLIDGVDQQLLHLLRKRLDLVAQVGTVKHGAGLPIYAPQREAA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
MLAKRREEAKNMGIAPQLIEDILRRLMRESYLNEKDVGFKQVKKDLGSVVIVGGKGQLGG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCEEEECCCCCHHH
LFSQMLTLSGYQVNLLDKDDWQQADSLFADAGMVLVTVPIAITCELIREKLTQLPADCIL
HHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHCCHHHHH
ADLTSIKTEPVKAMLEAHSGPVVGFHPMFGPDVGSLAKQVVVVCHGRSPEKYQWLLEQIA
HHHHHHCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
IWGARIVEAEPERHDSAMQLVQAMRHFSTFVYGLNLCKEEADIDTLLQFSSPIYRLELAM
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VGRLFAQSPELYADIIFAQQDSQHAIGDYLDNYREALELLKRGDRNEFIKQFQSVAKWFG
HHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
DFAPQFQRESRIMLQSVNDMKTN
HHCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]