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The map label for this gene is nhaA [H]

Identifier: 126173427

GI number: 126173427

Start: 1372540

End: 1373709

Strand: Direct

Name: nhaA [H]

Synonym: Sbal_1189

Alternate gene names: 126173427

Gene position: 1372540-1373709 (Clockwise)

Preceding gene: 126173426

Following gene: 126173428

Centisome position: 26.77

GC content: 47.18

Gene sequence:

>1170_bases
ATGGAAAAAGCAATTAGAAATTTTCTGAGCCAAGAATCGGCTGGCGGTATCCTATTATTGGTTGCTGTTGCCTTAGCTAT
GCTGATGGCCAATTCCCCTTTATCTGGACTTTATCAAGGCTTTTTAGGCACTGACGTACAAGTTAAAATTGGCGAGCTCG
ATATTCATAAGCCGTTAATTCTGTGGATCAACGATGGCCTGATGGCCGTATTCTTTTTGCTTATTGGTTTAGAAGTTAAA
CGTGAGTTACTCGAAGGCGCCTTATCGAGTGTCGCTCAAGCCTCTCTGCCTACCTTTGCGGCCATTGGCGGCATGTTAGT
CCCTGCTGGGGTGTACTTGCTGTTTAACTATGGCGATCCGGTCACACAAGCGGGCTGGGCGATTCCTGCCGCGACGGATA
TTGCGTTTGCTTTAGGTATTATGGCGCTGCTTGGGAGCCGCGTTCCCGTTTCACTGAAAGTCTTCTTACTTGCTTTAGCG
ATTATCGATGACTTAGGCGTCATAGTAATTATCGCGCTGTTCTACAGCACCGACCTATCAACCATCAGTTTAGTGATTGC
CAGTTTAGCGATTGCGGGCTTGGTTGGATTAAACCGCAAAGGTGTCACCTCACTTTTACCCTATAGCATCTTAGGATTAA
TCCTTTGGGTCGCCGTACTTAAGTCTGGAGTGCATGCGACTCTGGCTGGCGTCATCATCGCTTTCTGCATTCCATTACGG
GCAAAGGATGGCAGCTCACCTTCAGAAGGCTTAGAGCATAGTTTGCACCCTTGGAGCACCTTCTTCATTCTGCCTGTGTT
CGCTTTCGCCAATGCGGGTGTTTATGTCGGCAATATGAATTTGGAGACGTTAATTTCTCCGGTACCTGTCGGTATTGCAC
TGGGCCTGATGTTAGGCAAGCCCATTGGTGTGATGGTGTTTAGCTATATTGCGGTGAAACTTAAATTGGCTCAGTTACCC
GATGGCGTAGGTTGGAAGCAAATTGCCCCAGTCGCGGCCATGTGCGGTATTGGTTTTACTATGTCTATGTTTATTGCGTC
GTTAGCCTTTGAACATGCAGACCCTATGTACGGTGACTTAGCACGCCTAGGAACCTTAATCGGTTCGATTATGGCGGCGT
TAGTCGGGTATTTCTGGTTATCAAAAGTGTTACCGAATAAAGGAGTATAA

Upstream 100 bases:

>100_bases
AATACCTCGGAATAACCGAGGTGTTAGGTCGAAACTTACGATTATATTTGTTGTTACAATTCGTCTACACTCAATTCATT
ATGATTTTTAGGAGTGCACG

Downstream 100 bases:

>100_bases
CTATGATAAAGTTGAAATTAATGGGAATGGCAACACTCTTATGTCTATCGACAACCGCGACGGCATCGCAAATATCGGCC
TGTAATCAGGATGCGAACTC

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MEKAIRNFLSQESAGGILLLVAVALAMLMANSPLSGLYQGFLGTDVQVKIGELDIHKPLILWINDGLMAVFFLLIGLEVK
RELLEGALSSVAQASLPTFAAIGGMLVPAGVYLLFNYGDPVTQAGWAIPAATDIAFALGIMALLGSRVPVSLKVFLLALA
IIDDLGVIVIIALFYSTDLSTISLVIASLAIAGLVGLNRKGVTSLLPYSILGLILWVAVLKSGVHATLAGVIIAFCIPLR
AKDGSSPSEGLEHSLHPWSTFFILPVFAFANAGVYVGNMNLETLISPVPVGIALGLMLGKPIGVMVFSYIAVKLKLAQLP
DGVGWKQIAPVAAMCGIGFTMSMFIASLAFEHADPMYGDLARLGTLIGSIMAALVGYFWLSKVLPNKGV

Sequences:

>Translated_389_residues
MEKAIRNFLSQESAGGILLLVAVALAMLMANSPLSGLYQGFLGTDVQVKIGELDIHKPLILWINDGLMAVFFLLIGLEVK
RELLEGALSSVAQASLPTFAAIGGMLVPAGVYLLFNYGDPVTQAGWAIPAATDIAFALGIMALLGSRVPVSLKVFLLALA
IIDDLGVIVIIALFYSTDLSTISLVIASLAIAGLVGLNRKGVTSLLPYSILGLILWVAVLKSGVHATLAGVIIAFCIPLR
AKDGSSPSEGLEHSLHPWSTFFILPVFAFANAGVYVGNMNLETLISPVPVGIALGLMLGKPIGVMVFSYIAVKLKLAQLP
DGVGWKQIAPVAAMCGIGFTMSMFIASLAFEHADPMYGDLARLGTLIGSIMAALVGYFWLSKVLPNKGV
>Mature_389_residues
MEKAIRNFLSQESAGGILLLVAVALAMLMANSPLSGLYQGFLGTDVQVKIGELDIHKPLILWINDGLMAVFFLLIGLEVK
RELLEGALSSVAQASLPTFAAIGGMLVPAGVYLLFNYGDPVTQAGWAIPAATDIAFALGIMALLGSRVPVSLKVFLLALA
IIDDLGVIVIIALFYSTDLSTISLVIASLAIAGLVGLNRKGVTSLLPYSILGLILWVAVLKSGVHATLAGVIIAFCIPLR
AKDGSSPSEGLEHSLHPWSTFFILPVFAFANAGVYVGNMNLETLISPVPVGIALGLMLGKPIGVMVFSYIAVKLKLAQLP
DGVGWKQIAPVAAMCGIGFTMSMFIASLAFEHADPMYGDLARLGTLIGSIMAALVGYFWLSKVLPNKGV

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=385, Percent_Identity=58.7012987012987, Blast_Score=416, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 40865; Mature: 40865

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKAIRNFLSQESAGGILLLVAVALAMLMANSPLSGLYQGFLGTDVQVKIGELDIHKPLI
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCEECCCCEE
LWINDGLMAVFFLLIGLEVKRELLEGALSSVAQASLPTFAAIGGMLVPAGVYLLFNYGDP
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCCC
VTQAGWAIPAATDIAFALGIMALLGSRVPVSLKVFLLALAIIDDLGVIVIIALFYSTDLS
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
TISLVIASLAIAGLVGLNRKGVTSLLPYSILGLILWVAVLKSGVHATLAGVIIAFCIPLR
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
AKDGSSPSEGLEHSLHPWSTFFILPVFAFANAGVYVGNMNLETLISPVPVGIALGLMLGK
CCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHCCCHHHHHHHHHHCC
PIGVMVFSYIAVKLKLAQLPDGVGWKQIAPVAAMCGIGFTMSMFIASLAFEHADPMYGDL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ARLGTLIGSIMAALVGYFWLSKVLPNKGV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEKAIRNFLSQESAGGILLLVAVALAMLMANSPLSGLYQGFLGTDVQVKIGELDIHKPLI
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCEECCCCEE
LWINDGLMAVFFLLIGLEVKRELLEGALSSVAQASLPTFAAIGGMLVPAGVYLLFNYGDP
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCCC
VTQAGWAIPAATDIAFALGIMALLGSRVPVSLKVFLLALAIIDDLGVIVIIALFYSTDLS
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
TISLVIASLAIAGLVGLNRKGVTSLLPYSILGLILWVAVLKSGVHATLAGVIIAFCIPLR
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
AKDGSSPSEGLEHSLHPWSTFFILPVFAFANAGVYVGNMNLETLISPVPVGIALGLMLGK
CCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHCCCHHHHHHHHHHCC
PIGVMVFSYIAVKLKLAQLPDGVGWKQIAPVAAMCGIGFTMSMFIASLAFEHADPMYGDL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ARLGTLIGSIMAALVGYFWLSKVLPNKGV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA