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The map label for this gene is clcA [H]

Identifier: 126173400

GI number: 126173400

Start: 1340519

End: 1342243

Strand: Reverse

Name: clcA [H]

Synonym: Sbal_1161

Alternate gene names: 126173400

Gene position: 1342243-1340519 (Counterclockwise)

Preceding gene: 126173404

Following gene: 126173399

Centisome position: 26.18

GC content: 49.1

Gene sequence:

>1725_bases
GTGCAATTAACGATAAATAAAGTCGCTATTCAACATGCCATAGTCACAGCCAAAAAGTATTTAACCAATGAGCTACGTGA
CCATTTATCCCAAGCGAGGATCAGTGCACAACTGTGCATACTGGCACTGCTGTTTGCCATTTTCGCATCCTGCGTGATCT
TACTGTTTCGACTCTTGCTCGTTTGGGCCAATCATTACACCCAAATACAGGCGCTGGATTTTACGGGGAACGTCGCCGAC
TGGCGAGCCCTGTTACCACTTTTAGGCGCAATATTAATTTGGATTGTGGCTAAGCTAGGCTCCAAACGCTATAAACGTAT
GGGAATAGCCTATGTGTTACATAGAGTTAAACTGCACTACGGTAAAATTCCGCTGCAATCTGCCGTAGGGCAATTTTTTC
AAGCACTATTCGCCCTCGGCACCAATTTCTCCGTCGGCCGTGAAGGTCCAGCCATTCATCTGGGTGCTGTCAGTGCCAGT
TTTCTCGCCGAAAAATTCAATCTTCCCGATAACAGTGTGCGCATTATGTGCGCCAGTGGCATTGCCGCAGGGATTGCCGC
GACCTTTAACGCGCCCTTGGCGGCAGTGATTTTTGTACTCGAAGTGATTGTCCGCGAATATAAAGTCCATTACTTCTTCC
CGATTATGCTCTCCGCGATTTGTGGCGCGGTTTCAAGCCAACTGGTGTTTGGTAATGTGCACGAATTTGACCGTATTCAA
GTGATCCACATTCCCTTAGATCACTACCCTATTCTCGCCATCGGCGGCGTGGTATTAGGCTGCGCTGCGGCGCTGTTTAA
TTACTCACTCTTAAAAGTCACCGCGACGGGGCAAAACTGGCCACTCATCTACCGACTATTATTGGCGGGCAGTGTCACCA
CACTAATCGGTCTCGTGTTGCCGCAAGCCCTTGGCACTGGCGATCTCGCCATTAGCGAAGCCATTAGCCAACATCCAAGC
CTGTTGCTGTTAATCGCCCTGTTATTTGCCAAAATCATTGCCACTATTGCGGCGATTGGCTTAGGTATTCCAGGTGGTTT
GATTGGTCCACTCTATGGTATCGGCGCGCTGCTCGGCGCGATTTTGGCGCTGATCAGTGCCATCTTATTCCCGTCCATCG
CCCCTTATGTAGGGCTTTACACTGTGATCGGCATGACAGCCATGATGGGCGTGTGCTTAAGCGCGCCGCTGGCGGCGTTA
GTCGCCCTGCTAGAAATGACCAATGATGCCAGTATCATCCTGCCGGCGATGTTTGTGACTATTCCCGCATTTTTGATTGC
CTATCAAGGCTTTAAGACTAACTCTATTTTCTTTAAACAATTAGAAATCATGGGGCTAGGCTATAAAGTTGCGCCAGTAA
ATTTAGCGCTGCAGAAAAAAGGCGTGCGAGCCTTGATGGATAAACGCTTTGTTATCGTCAATAACAACGATGAATTGTTA
CTCGAAGTGCTTAAACGGGCCGAAGGTCGACCTGTGCTGGTTCGCAATGCCGATGGTGTTATCGAAATGCTCAGCCTTGA
AATGCAATCCTACGATGACAGTACCACGCTATCGCGCCATCCCATGCAAGGCTTAAGCGACAGCACTACGCTCAATGAGG
CCTATTTACTCTTGTCACCCAAGCGCAGCGGTGAGGTGTTTATCTATCAAGATACGCCCGATAACGTGGTCGGAGTGATC
AGTTGGTCGAACCTGCAACAGGAAATTCGCTTAGGCCAAGCCTAA

Upstream 100 bases:

>100_bases
TCTAGCCAACGATGATAATTTGGCATTAGGTAACAGCCCCTTATATAAAATACAATCAACTCAAGAACGAGTTCGATACA
ATACAACTCAGGCCAATGCA

Downstream 100 bases:

>100_bases
CGTCAATTTAAAACCTGATATCAATTTAAAATCTGACAGTGATGCAAAACCTAATATCGATGCCAAACCTTGATGCCAAA
CCTAAGGCGGCAGATTAAAA

Product: chloride channel core

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MQLTINKVAIQHAIVTAKKYLTNELRDHLSQARISAQLCILALLFAIFASCVILLFRLLLVWANHYTQIQALDFTGNVAD
WRALLPLLGAILIWIVAKLGSKRYKRMGIAYVLHRVKLHYGKIPLQSAVGQFFQALFALGTNFSVGREGPAIHLGAVSAS
FLAEKFNLPDNSVRIMCASGIAAGIAATFNAPLAAVIFVLEVIVREYKVHYFFPIMLSAICGAVSSQLVFGNVHEFDRIQ
VIHIPLDHYPILAIGGVVLGCAAALFNYSLLKVTATGQNWPLIYRLLLAGSVTTLIGLVLPQALGTGDLAISEAISQHPS
LLLLIALLFAKIIATIAAIGLGIPGGLIGPLYGIGALLGAILALISAILFPSIAPYVGLYTVIGMTAMMGVCLSAPLAAL
VALLEMTNDASIILPAMFVTIPAFLIAYQGFKTNSIFFKQLEIMGLGYKVAPVNLALQKKGVRALMDKRFVIVNNNDELL
LEVLKRAEGRPVLVRNADGVIEMLSLEMQSYDDSTTLSRHPMQGLSDSTTLNEAYLLLSPKRSGEVFIYQDTPDNVVGVI
SWSNLQQEIRLGQA

Sequences:

>Translated_574_residues
MQLTINKVAIQHAIVTAKKYLTNELRDHLSQARISAQLCILALLFAIFASCVILLFRLLLVWANHYTQIQALDFTGNVAD
WRALLPLLGAILIWIVAKLGSKRYKRMGIAYVLHRVKLHYGKIPLQSAVGQFFQALFALGTNFSVGREGPAIHLGAVSAS
FLAEKFNLPDNSVRIMCASGIAAGIAATFNAPLAAVIFVLEVIVREYKVHYFFPIMLSAICGAVSSQLVFGNVHEFDRIQ
VIHIPLDHYPILAIGGVVLGCAAALFNYSLLKVTATGQNWPLIYRLLLAGSVTTLIGLVLPQALGTGDLAISEAISQHPS
LLLLIALLFAKIIATIAAIGLGIPGGLIGPLYGIGALLGAILALISAILFPSIAPYVGLYTVIGMTAMMGVCLSAPLAAL
VALLEMTNDASIILPAMFVTIPAFLIAYQGFKTNSIFFKQLEIMGLGYKVAPVNLALQKKGVRALMDKRFVIVNNNDELL
LEVLKRAEGRPVLVRNADGVIEMLSLEMQSYDDSTTLSRHPMQGLSDSTTLNEAYLLLSPKRSGEVFIYQDTPDNVVGVI
SWSNLQQEIRLGQA
>Mature_574_residues
MQLTINKVAIQHAIVTAKKYLTNELRDHLSQARISAQLCILALLFAIFASCVILLFRLLLVWANHYTQIQALDFTGNVAD
WRALLPLLGAILIWIVAKLGSKRYKRMGIAYVLHRVKLHYGKIPLQSAVGQFFQALFALGTNFSVGREGPAIHLGAVSAS
FLAEKFNLPDNSVRIMCASGIAAGIAATFNAPLAAVIFVLEVIVREYKVHYFFPIMLSAICGAVSSQLVFGNVHEFDRIQ
VIHIPLDHYPILAIGGVVLGCAAALFNYSLLKVTATGQNWPLIYRLLLAGSVTTLIGLVLPQALGTGDLAISEAISQHPS
LLLLIALLFAKIIATIAAIGLGIPGGLIGPLYGIGALLGAILALISAILFPSIAPYVGLYTVIGMTAMMGVCLSAPLAAL
VALLEMTNDASIILPAMFVTIPAFLIAYQGFKTNSIFFKQLEIMGLGYKVAPVNLALQKKGVRALMDKRFVIVNNNDELL
LEVLKRAEGRPVLVRNADGVIEMLSLEMQSYDDSTTLSRHPMQGLSDSTTLNEAYLLLSPKRSGEVFIYQDTPDNVVGVI
SWSNLQQEIRLGQA

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=294, Percent_Identity=28.5714285714286, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87081943, Length=303, Percent_Identity=24.7524752475248, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17532615, Length=361, Percent_Identity=24.9307479224377, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 62074; Mature: 62074

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLTINKVAIQHAIVTAKKYLTNELRDHLSQARISAQLCILALLFAIFASCVILLFRLLL
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWANHYTQIQALDFTGNVADWRALLPLLGAILIWIVAKLGSKRYKRMGIAYVLHRVKLHY
HHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKIPLQSAVGQFFQALFALGTNFSVGREGPAIHLGAVSASFLAEKFNLPDNSVRIMCASG
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCEEEEEECC
IAAGIAATFNAPLAAVIFVLEVIVREYKVHYFFPIMLSAICGAVSSQLVFGNVHEFDRIQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
VIHIPLDHYPILAIGGVVLGCAAALFNYSLLKVTATGQNWPLIYRLLLAGSVTTLIGLVL
EEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
PQALGTGDLAISEAISQHPSLLLLIALLFAKIIATIAAIGLGIPGGLIGPLYGIGALLGA
HHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ILALISAILFPSIAPYVGLYTVIGMTAMMGVCLSAPLAALVALLEMTNDASIILPAMFVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IPAFLIAYQGFKTNSIFFKQLEIMGLGYKVAPVNLALQKKGVRALMDKRFVIVNNNDELL
HHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCEEEECCCHHHH
LEVLKRAEGRPVLVRNADGVIEMLSLEMQSYDDSTTLSRHPMQGLSDSTTLNEAYLLLSP
HHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
KRSGEVFIYQDTPDNVVGVISWSNLQQEIRLGQA
CCCCCEEEEECCCCCEEEEEEHHHHHHHHHCCCC
>Mature Secondary Structure
MQLTINKVAIQHAIVTAKKYLTNELRDHLSQARISAQLCILALLFAIFASCVILLFRLLL
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWANHYTQIQALDFTGNVADWRALLPLLGAILIWIVAKLGSKRYKRMGIAYVLHRVKLHY
HHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKIPLQSAVGQFFQALFALGTNFSVGREGPAIHLGAVSASFLAEKFNLPDNSVRIMCASG
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCEEEEEECC
IAAGIAATFNAPLAAVIFVLEVIVREYKVHYFFPIMLSAICGAVSSQLVFGNVHEFDRIQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
VIHIPLDHYPILAIGGVVLGCAAALFNYSLLKVTATGQNWPLIYRLLLAGSVTTLIGLVL
EEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
PQALGTGDLAISEAISQHPSLLLLIALLFAKIIATIAAIGLGIPGGLIGPLYGIGALLGA
HHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ILALISAILFPSIAPYVGLYTVIGMTAMMGVCLSAPLAALVALLEMTNDASIILPAMFVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IPAFLIAYQGFKTNSIFFKQLEIMGLGYKVAPVNLALQKKGVRALMDKRFVIVNNNDELL
HHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCEEEECCCHHHH
LEVLKRAEGRPVLVRNADGVIEMLSLEMQSYDDSTTLSRHPMQGLSDSTTLNEAYLLLSP
HHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
KRSGEVFIYQDTPDNVVGVISWSNLQQEIRLGQA
CCCCCEEEEECCCCCEEEEEEHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA