Click here to switch to the map view.

The map label for this gene is lspA

Identifier: 126173299

GI number: 126173299

Start: 1217414

End: 1217929

Strand: Direct

Name: lspA

Synonym: Sbal_1055

Alternate gene names: 126173299

Gene position: 1217414-1217929 (Clockwise)

Preceding gene: 126173298

Following gene: 126173300

Centisome position: 23.74

GC content: 42.64

Gene sequence:

>516_bases
ATGCCATTAACTTGGAAAGACAGTGGCTTACGTTGGTATTGGGTAGCTGTATTGGTGTTTTTCGCCGATCAGCTATCTAA
ACAATGGGTCTTAGCCAATTTTGATTTGCATGAATCGCTGAATTTATTGCCTTTCTTTAATTTCACTTATGTACGTAACT
ACGGGGCCGCCTTTAGTTTTTTAAGTGACGCCGGTGGTTGGCAGCGTTGGTTATTTACGATTGTTGCGGTTGGATTCAGT
ACTCTACTCACAGTGTGGTTGCGTAGGCAATCCGCTTCGTTGTTGAAACTGAATCTGGCTTACACCTTAGTGATTGGTGG
TGCCCTAGGCAATTTGGTCGACAGATTAATGCACGGTTTTGTGGTTGATTTTATCGATTTCTTTTGGGCTAAGAGCCATT
ATCCAGCTTTCAATATCGCCGATTCGGCGATTTGTATTGGTGCTGTGTTGATCATTTGGGATGCATTTTTAAGCGGTAAA
TCTGAAACAGATAGCGCCGAAGGGGTTAAAAAGTGA

Upstream 100 bases:

>100_bases
AGAGGTTGGCACCATCGAGGCCCACCCAACACTCTGTACTCGCTGCGTAACAAACATTGAAGGTGACGGCGAAGTTCGTC
TGTTTGCGTAAAGGATCTGT

Downstream 100 bases:

>100_bases
CTGTGACGCGATCTTTACTATGCCATATGAACATTGTGCTTTCTGATGGTTCAACCGCAGACAGCACTAAAGCTTCGGGT
AAACCAGCTCGATTAAATGT

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MPLTWKDSGLRWYWVAVLVFFADQLSKQWVLANFDLHESLNLLPFFNFTYVRNYGAAFSFLSDAGGWQRWLFTIVAVGFS
TLLTVWLRRQSASLLKLNLAYTLVIGGALGNLVDRLMHGFVVDFIDFFWAKSHYPAFNIADSAICIGAVLIIWDAFLSGK
SETDSAEGVKK

Sequences:

>Translated_171_residues
MPLTWKDSGLRWYWVAVLVFFADQLSKQWVLANFDLHESLNLLPFFNFTYVRNYGAAFSFLSDAGGWQRWLFTIVAVGFS
TLLTVWLRRQSASLLKLNLAYTLVIGGALGNLVDRLMHGFVVDFIDFFWAKSHYPAFNIADSAICIGAVLIIWDAFLSGK
SETDSAEGVKK
>Mature_170_residues
PLTWKDSGLRWYWVAVLVFFADQLSKQWVLANFDLHESLNLLPFFNFTYVRNYGAAFSFLSDAGGWQRWLFTIVAVGFST
LLTVWLRRQSASLLKLNLAYTLVIGGALGNLVDRLMHGFVVDFIDFFWAKSHYPAFNIADSAICIGAVLIIWDAFLSGKS
ETDSAEGVKK

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=164, Percent_Identity=50, Blast_Score=168, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_SHEB2 (B8EFC6)

Other databases:

- EMBL:   CP001252
- RefSeq:   YP_002359141.1
- MEROPS:   A08.001
- GeneID:   7085847
- GenomeReviews:   CP001252_GR
- KEGG:   sbp:Sbal223_3234
- HOGENOM:   HBG724422
- OMA:   VIICDQL
- ProtClustDB:   PRK00376
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 19359; Mature: 19227

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 114-114 ACT_SITE 141-141

Signals:

None

Transmembrane regions:

HASH(0x139a8f88)-; HASH(0x13efcdf0)-; HASH(0x13a830c8)-; HASH(0x11759c24)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTWKDSGLRWYWVAVLVFFADQLSKQWVLANFDLHESLNLLPFFNFTYVRNYGAAFSF
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHCCCCCCCHHHHHHHHHHHHHHH
LSDAGGWQRWLFTIVAVGFSTLLTVWLRRQSASLLKLNLAYTLVIGGALGNLVDRLMHGF
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVDFIDFFWAKSHYPAFNIADSAICIGAVLIIWDAFLSGKSETDSAEGVKK
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
>Mature Secondary Structure 
PLTWKDSGLRWYWVAVLVFFADQLSKQWVLANFDLHESLNLLPFFNFTYVRNYGAAFSF
CCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHCCCCCCCHHHHHHHHHHHHHHH
LSDAGGWQRWLFTIVAVGFSTLLTVWLRRQSASLLKLNLAYTLVIGGALGNLVDRLMHGF
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVDFIDFFWAKSHYPAFNIADSAICIGAVLIIWDAFLSGKSETDSAEGVKK
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA