Click here to switch to the map view.

The map label for this gene is tyrP [H]

Identifier: 126173142

GI number: 126173142

Start: 1024957

End: 1026132

Strand: Direct

Name: tyrP [H]

Synonym: Sbal_0897

Alternate gene names: 126173142

Gene position: 1024957-1026132 (Clockwise)

Preceding gene: 126173141

Following gene: 126173143

Centisome position: 19.99

GC content: 48.38

Gene sequence:

>1176_bases
ATGTTAGGCTCGATCGCCATCGTTGCCGGGACGGCCATTGGCGCAGGTATGTTAGCCTTACCTTTAGCTACCGCGGCTTT
AGGTATTATTCCGGCGTTAGTGTTACTCGTTGTTATTTGGGGCGTATCTGCCTATACCTCATTACTGATGCTCGAAATTA
ACTTACGCACTGGCGTGGGTGATAATCTGCATGTCATTACGGGTAAATTGCTGGGTAAAAAAGGTCAAATAATTCAAGGC
GCTTCTTTCTTAAGTTTATTATTTGCCTTGACCGCCGCTTATCTCACCGGTGGGTCATCGCTATTAGTGCTTAAAGCTAA
GAACATGTTTGATATCGTGCTCGATAATCAAGTCGCGGTATTGTTGTTTACCCTAGTGCTCGGCGGATTTGCGGCGCTCG
GAGTGGCTTGGGTCGATAAAGTGTCCCGCTTCCTGTTTTCGTTAATGATTTTACTGCTGGTGGTTGTGGTGTTATTTCTC
CTGCCTGAAGTCAGTATTGCCAGCATGGCAACGGGCGCGATTGCCGAGTCGATGACCAGCAGTTGGATGGCGGCGATTCC
AGTAGTGTTTACTTCTTTTGGTTTCCACGTTTGTATTGCCACTTTAGTGCGTTATCTGGATGGTGATGCAGTTTCACTGC
GCAAGGTATTGTTAATCGGTTCGACGATTCCACTGGCTTGTTATGTGCTTTGGTTGTTGGTGACCTTAGGCACAGTCGGT
GGCTATGAAGTCAGTGGTTTTGAAGGTTCATTACCGTCACTAGTGACAGCATTGCAGGATATTGCCCATACGCCTTGGAT
CAGCAAATGTATTTCGTTATTCGCCGATTTAGCCCTAGTGACCTCATTCCTCGGGGTGACCTTAAGCCTGTATGACTTTG
TCGCCGAATTAACCCGCGCTAAAGAGACGTTTGCCGGCCGTATACAGACCTGGTTGTTAACTTTCACTCCGCCAGTATTA
TGTGCTCTGTATCTGCCAGAAGGCTTTGTGGCGGTACTGGGATTCGCAGCCGTGCCATTGGTGGTGATGATCATCTTCTT
GCCAATCGTGATGGCATTGCGTCAACGCCAAACACAACCGGGCGGTTATCAAGTGTCGGGTGGTTCTGCAGGCTTAGTGA
TGGCAGGTTTGTTAGGCGCTGTGATTGTGGGCGCGCAGCTATTTGTTGCAATCTAA

Upstream 100 bases:

>100_bases
TTGCTTATTTCGATTTAAGACGCAAGGCTTTATCGGTTCAAATCTTACTCAAATAAAATAATAATTAATCATTGAACAGG
ACTATTGTGTGAATTCAAAA

Downstream 100 bases:

>100_bases
CGGCTTGATATTTAATTCGCGGCTAGCGTCAGCATTGTAGTGAACGCCGCGGGGTAACTTTGATGGAATGTATTTGCTTT
GTAAGCGAATTTTTTCTGAG

Product: aromatic amino acid permease

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MLGSIAIVAGTAIGAGMLALPLATAALGIIPALVLLVVIWGVSAYTSLLMLEINLRTGVGDNLHVITGKLLGKKGQIIQG
ASFLSLLFALTAAYLTGGSSLLVLKAKNMFDIVLDNQVAVLLFTLVLGGFAALGVAWVDKVSRFLFSLMILLLVVVVLFL
LPEVSIASMATGAIAESMTSSWMAAIPVVFTSFGFHVCIATLVRYLDGDAVSLRKVLLIGSTIPLACYVLWLLVTLGTVG
GYEVSGFEGSLPSLVTALQDIAHTPWISKCISLFADLALVTSFLGVTLSLYDFVAELTRAKETFAGRIQTWLLTFTPPVL
CALYLPEGFVAVLGFAAVPLVVMIIFLPIVMALRQRQTQPGGYQVSGGSAGLVMAGLLGAVIVGAQLFVAI

Sequences:

>Translated_391_residues
MLGSIAIVAGTAIGAGMLALPLATAALGIIPALVLLVVIWGVSAYTSLLMLEINLRTGVGDNLHVITGKLLGKKGQIIQG
ASFLSLLFALTAAYLTGGSSLLVLKAKNMFDIVLDNQVAVLLFTLVLGGFAALGVAWVDKVSRFLFSLMILLLVVVVLFL
LPEVSIASMATGAIAESMTSSWMAAIPVVFTSFGFHVCIATLVRYLDGDAVSLRKVLLIGSTIPLACYVLWLLVTLGTVG
GYEVSGFEGSLPSLVTALQDIAHTPWISKCISLFADLALVTSFLGVTLSLYDFVAELTRAKETFAGRIQTWLLTFTPPVL
CALYLPEGFVAVLGFAAVPLVVMIIFLPIVMALRQRQTQPGGYQVSGGSAGLVMAGLLGAVIVGAQLFVAI
>Mature_391_residues
MLGSIAIVAGTAIGAGMLALPLATAALGIIPALVLLVVIWGVSAYTSLLMLEINLRTGVGDNLHVITGKLLGKKGQIIQG
ASFLSLLFALTAAYLTGGSSLLVLKAKNMFDIVLDNQVAVLLFTLVLGGFAALGVAWVDKVSRFLFSLMILLLVVVVLFL
LPEVSIASMATGAIAESMTSSWMAAIPVVFTSFGFHVCIATLVRYLDGDAVSLRKVLLIGSTIPLACYVLWLLVTLGTVG
GYEVSGFEGSLPSLVTALQDIAHTPWISKCISLFADLALVTSFLGVTLSLYDFVAELTRAKETFAGRIQTWLLTFTPPVL
CALYLPEGFVAVLGFAAVPLVVMIIFLPIVMALRQRQTQPGGYQVSGGSAGLVMAGLLGAVIVGAQLFVAI

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=393, Percent_Identity=40.9669211195929, Blast_Score=274, Evalue=8e-75,
Organism=Escherichia coli, GI1790145, Length=372, Percent_Identity=28.7634408602151, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1789552, Length=361, Percent_Identity=28.5318559556787, Blast_Score=139, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 40966; Mature: 40966

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGSIAIVAGTAIGAGMLALPLATAALGIIPALVLLVVIWGVSAYTSLLMLEINLRTGVG
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
DNLHVITGKLLGKKGQIIQGASFLSLLFALTAAYLTGGSSLLVLKAKNMFDIVLDNQVAV
CCEEEEEHHHHCCCCCEECCHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEHHCCCHHHH
LLFTLVLGGFAALGVAWVDKVSRFLFSLMILLLVVVVLFLLPEVSIASMATGAIAESMTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SWMAAIPVVFTSFGFHVCIATLVRYLDGDAVSLRKVLLIGSTIPLACYVLWLLVTLGTVG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
GYEVSGFEGSLPSLVTALQDIAHTPWISKCISLFADLALVTSFLGVTLSLYDFVAELTRA
CEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KETFAGRIQTWLLTFTPPVLCALYLPEGFVAVLGFAAVPLVVMIIFLPIVMALRQRQTQP
HHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GGYQVSGGSAGLVMAGLLGAVIVGAQLFVAI
CCEEECCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLGSIAIVAGTAIGAGMLALPLATAALGIIPALVLLVVIWGVSAYTSLLMLEINLRTGVG
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
DNLHVITGKLLGKKGQIIQGASFLSLLFALTAAYLTGGSSLLVLKAKNMFDIVLDNQVAV
CCEEEEEHHHHCCCCCEECCHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEHHCCCHHHH
LLFTLVLGGFAALGVAWVDKVSRFLFSLMILLLVVVVLFLLPEVSIASMATGAIAESMTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SWMAAIPVVFTSFGFHVCIATLVRYLDGDAVSLRKVLLIGSTIPLACYVLWLLVTLGTVG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
GYEVSGFEGSLPSLVTALQDIAHTPWISKCISLFADLALVTSFLGVTLSLYDFVAELTRA
CEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KETFAGRIQTWLLTFTPPVLCALYLPEGFVAVLGFAAVPLVVMIIFLPIVMALRQRQTQP
HHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GGYQVSGGSAGLVMAGLLGAVIVGAQLFVAI
CCEEECCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]