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The map label for this gene is fkpA [H]

Identifier: 126173134

GI number: 126173134

Start: 1014082

End: 1014855

Strand: Direct

Name: fkpA [H]

Synonym: Sbal_0889

Alternate gene names: 126173134

Gene position: 1014082-1014855 (Clockwise)

Preceding gene: 126173126

Following gene: 126173135

Centisome position: 19.78

GC content: 42.51

Gene sequence:

>774_bases
ATGAAATCGATTTATAAATTATCGTTAGTTGCATTGGCTGTTATTGGCCTATCTGCTTGTAATCAAGAAGAAAAAGCAGC
TACTGCGAGTACAAGTGTTGAATTAACGACAGAAGCTCAAAAAGAAGCTTACAGTGTAGGCGCTTCAATCGGTCGTTACA
TGTCTGGCCATATCAAAGAGCAAGAAGAATTAGGCCTACCAGTTGATCGCACTCTGATCGTCACTGGTTTCACTAATGGT
CTGAATGACCAATTAAAATTAACCGAAGAAGAAATGCAAACCATTCTTCAAGGTCTAGATAAAAAGTTAAACGATAAACG
TCAGGAACAAGCGACTGCGATTTCTGCTAAGAACATCGAAGACGGTAAAAAATTCCTTGAAGAAAATAAGGCTAAGTCTG
GCGTAGTGACAACTGAGTCTGGCTTACAATATGAAGTATTAACACCAGGTACTGGCGAAAAACCTGCCGCAGAAGACACT
GTAGAAGTGGATTATGTTGGTACGTTAATCGACGGTACTGAGTTCGACAGTTCATACAAACGTGGTCAAACGGCTAAGTT
CCCACTGAACCGCGTGATCCCAGGTTGGACCGAAGGCGTGCAATTAATGCCTGTTGGCGCTAAGTACAAGTTTGTTATTC
CTGCAAACTTAGCCTACGGCGAGCGTGACACTGGTACTATTCCACCAAACTCCACACTGGTTTTTGAAGTTGAATTGAAA
TCAGTTGAGAAAGCGTCTGCAACGCCAGCCGCTGAACCAGCAGCTAAAAAGTAA

Upstream 100 bases:

>100_bases
GTTAACCCATAAAGAATCTAGTTGGTATAACCGAGGTAACTAGTATAAAGTTGTCTCGCTTAGGTTATTGTAACCGCTTG
AGGATGCTGAGGAAGCTTTA

Downstream 100 bases:

>100_bases
TGAATTAACTGCCGCGTTTAATACGCAGTAAGTGAAATACCGCTCCTAAATGGGCGGTATTTTTTTGTCTGTAAAAATCA
CATTATTGTTTTAATGCTTA

Product: peptidylprolyl isomerase FKBP-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MKSIYKLSLVALAVIGLSACNQEEKAATASTSVELTTEAQKEAYSVGASIGRYMSGHIKEQEELGLPVDRTLIVTGFTNG
LNDQLKLTEEEMQTILQGLDKKLNDKRQEQATAISAKNIEDGKKFLEENKAKSGVVTTESGLQYEVLTPGTGEKPAAEDT
VEVDYVGTLIDGTEFDSSYKRGQTAKFPLNRVIPGWTEGVQLMPVGAKYKFVIPANLAYGERDTGTIPPNSTLVFEVELK
SVEKASATPAAEPAAKK

Sequences:

>Translated_257_residues
MKSIYKLSLVALAVIGLSACNQEEKAATASTSVELTTEAQKEAYSVGASIGRYMSGHIKEQEELGLPVDRTLIVTGFTNG
LNDQLKLTEEEMQTILQGLDKKLNDKRQEQATAISAKNIEDGKKFLEENKAKSGVVTTESGLQYEVLTPGTGEKPAAEDT
VEVDYVGTLIDGTEFDSSYKRGQTAKFPLNRVIPGWTEGVQLMPVGAKYKFVIPANLAYGERDTGTIPPNSTLVFEVELK
SVEKASATPAAEPAAKK
>Mature_257_residues
MKSIYKLSLVALAVIGLSACNQEEKAATASTSVELTTEAQKEAYSVGASIGRYMSGHIKEQEELGLPVDRTLIVTGFTNG
LNDQLKLTEEEMQTILQGLDKKLNDKRQEQATAISAKNIEDGKKFLEENKAKSGVVTTESGLQYEVLTPGTGEKPAAEDT
VEVDYVGTLIDGTEFDSSYKRGQTAKFPLNRVIPGWTEGVQLMPVGAKYKFVIPANLAYGERDTGTIPPNSTLVFEVELK
SVEKASATPAAEPAAKK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=45.7943925233645, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=45.7943925233645, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI206725530, Length=91, Percent_Identity=47.2527472527472, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI17149844, Length=91, Percent_Identity=47.2527472527472, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI17149842, Length=91, Percent_Identity=47.2527472527472, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=39.2523364485981, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI192448443, Length=96, Percent_Identity=39.5833333333333, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI33469985, Length=90, Percent_Identity=40, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4503729, Length=94, Percent_Identity=44.6808510638298, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1789745, Length=258, Percent_Identity=41.4728682170543, Blast_Score=184, Evalue=4e-48,
Organism=Escherichia coli, GI87082390, Length=213, Percent_Identity=43.1924882629108, Blast_Score=154, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17540882, Length=95, Percent_Identity=43.1578947368421, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=45.2830188679245, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561782, Length=91, Percent_Identity=48.3516483516484, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320727, Length=92, Percent_Identity=53.2608695652174, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324194, Length=109, Percent_Identity=42.2018348623853, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323566, Length=123, Percent_Identity=38.2113821138211, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323482, Length=119, Percent_Identity=38.655462184874, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=46.7289719626168, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI281363946, Length=124, Percent_Identity=40.3225806451613, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17352457, Length=124, Percent_Identity=40.3225806451613, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24583150, Length=108, Percent_Identity=38.8888888888889, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356629, Length=94, Percent_Identity=46.8085106382979, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24647110, Length=97, Percent_Identity=43.298969072165, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 27723; Mature: 27723

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIYKLSLVALAVIGLSACNQEEKAATASTSVELTTEAQKEAYSVGASIGRYMSGHIKE
CCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCC
QEELGLPVDRTLIVTGFTNGLNDQLKLTEEEMQTILQGLDKKLNDKRQEQATAISAKNIE
HHHCCCCCCCEEEEEECCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DGKKFLEENKAKSGVVTTESGLQYEVLTPGTGEKPAAEDTVEVDYVGTLIDGTEFDSSYK
HHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCEEEEEEEEEECCCCCCCHHH
RGQTAKFPLNRVIPGWTEGVQLMPVGAKYKFVIPANLAYGERDTGTIPPNSTLVFEVELK
CCCCCCCCHHHCCCCCCCCEEEEECCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEC
SVEKASATPAAEPAAKK
CCHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKSIYKLSLVALAVIGLSACNQEEKAATASTSVELTTEAQKEAYSVGASIGRYMSGHIKE
CCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCC
QEELGLPVDRTLIVTGFTNGLNDQLKLTEEEMQTILQGLDKKLNDKRQEQATAISAKNIE
HHHCCCCCCCEEEEEECCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DGKKFLEENKAKSGVVTTESGLQYEVLTPGTGEKPAAEDTVEVDYVGTLIDGTEFDSSYK
HHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCEEEEEEEEEECCCCCCCHHH
RGQTAKFPLNRVIPGWTEGVQLMPVGAKYKFVIPANLAYGERDTGTIPPNSTLVFEVELK
CCCCCCCCHHHCCCCCCCCEEEEECCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEC
SVEKASATPAAEPAAKK
CCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]