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The map label for this gene is gltT [H]

Identifier: 126173014

GI number: 126173014

Start: 869429

End: 870763

Strand: Direct

Name: gltT [H]

Synonym: Sbal_0768

Alternate gene names: 126173014

Gene position: 869429-870763 (Clockwise)

Preceding gene: 126173013

Following gene: 126173016

Centisome position: 16.96

GC content: 50.79

Gene sequence:

>1335_bases
ATGACAAAACCTAAGTCGTCGGCATTAGGCCGTGTTTGGTCTCGCTGGATGTCAGTGCCGCTGTGGCTGCAAATTGTTAT
TGGTATGGTGCTAGGCATTATTGTCGGCGTCATTTTTGGTGAGCAAGCCACTTGCTTAAAACCGCTGGGCACCTTATTTG
TTAATGCCATAAAGATGCTGATCGTGCCATTGGTGTTTTGCTCGCTGATCGTGGGCGTCACGTCGATGCAAGACACCGGC
AAGATGGGGCGCATCGGCTTTAAATCCTTTGGGTTTTATCTGTTTACCACGGCTATCGCGATCAGTATCGGCCTGCTTGT
TGGTTATGTGCTGCAACCCGGTGCAGGCTTAGGATTAACGCTGGCAGAAGGCGCGACTCAAACCGCCAAAGCTGTGCCTT
CATTAGTCGATACCTTGGTTGATATAGTGCCGACAAATCCGATTGCGGCCATGGCAAGCGGCCAAATTTTGCAAGTCATC
GTATTTGCCATCGCCTTAGGTATCGCGTTAGTGCTGATTGGCGAGCACGGTAAACCTGCGATTAAAGTGTTCGAAAGCCT
CGCCGAAGCCATGTACAAACTGGCCGATATGGTGATGAAACTCGCACCCTACGGCGTCTTTGGGCTAATGGCTTGGGTGG
CGGGAGAGTATGGTATTGATATGCTTTGGCCCCTGATCAAAGTCATCATAGCCGTATACCTTGGCTGTATTATCCACGTG
CTGGGTTTCTATAGTTTTTTGCTGCGCGGATTTGCGAAGTTAAGTCCGCTGCAGTTTTTTAAAGGCATTAGCAACGCCAT
GTTAGTGGCGTTTACCACGTCTAGCTCTGCGGGCACGCTCCCTGCAAGCATGAAGTGCGCGAGTGAAAACCTAGGCGTTC
ATAAGAAGATTTCTAGCTTCGTGTTACCGCTGGGCACTACCATCAATATGGACGGCACTGCGTTATACCAAGGCGTTACT
GTACTGTTTGTGGCGCAGGCGTTTGGCATCGACCTGACTGTCGTCGATTATCTCACCATTATTTTAACCGCGACTTTGGC
TTCTATCGGCACTGCGGGTGTTCCCGGTGCGGGTTTAGTGATGCTGACGTTAGTGCTGACAACTGTAGGGCTGCCTTTAG
AAGGGGTGGCATTGATAGCGGGGATTGACCGTATTTTAGATATGGTGCGCACTGTGGTGAACGTCTCCGGTGACTTAGTG
GCGACGACTGTGATTGCTAAGTCTGAAGATGAGCTGGATATGGCGCATTACAATGCCGACACGGAGCAAAGCGCCGTACT
CGCCGAGCAAAATATCGCCCTTGAAACGGCGGCTGAGAATAGCGCCAAAGTCTAG

Upstream 100 bases:

>100_bases
CCCCTCTGCTAGACTCGGCGATTGCCTCATGTAGACTGAGAAACTAGCGCGCTAGTTTTGGTCTTTGCCCCATCATAGTT
TCGAATTCAAGGTTATGAAT

Downstream 100 bases:

>100_bases
TTGGCTTCTGTTGCTGGCTGTGAAACGAAAAAACCGCCAATGGCGGTTTTTTATGCGGACAAATTTTACTTTGCGGAAGC
TTACTTCACTGGGCTTACTT

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTKPKSSALGRVWSRWMSVPLWLQIVIGMVLGIIVGVIFGEQATCLKPLGTLFVNAIKMLIVPLVFCSLIVGVTSMQDTG
KMGRIGFKSFGFYLFTTAIAISIGLLVGYVLQPGAGLGLTLAEGATQTAKAVPSLVDTLVDIVPTNPIAAMASGQILQVI
VFAIALGIALVLIGEHGKPAIKVFESLAEAMYKLADMVMKLAPYGVFGLMAWVAGEYGIDMLWPLIKVIIAVYLGCIIHV
LGFYSFLLRGFAKLSPLQFFKGISNAMLVAFTTSSSAGTLPASMKCASENLGVHKKISSFVLPLGTTINMDGTALYQGVT
VLFVAQAFGIDLTVVDYLTIILTATLASIGTAGVPGAGLVMLTLVLTTVGLPLEGVALIAGIDRILDMVRTVVNVSGDLV
ATTVIAKSEDELDMAHYNADTEQSAVLAEQNIALETAAENSAKV

Sequences:

>Translated_444_residues
MTKPKSSALGRVWSRWMSVPLWLQIVIGMVLGIIVGVIFGEQATCLKPLGTLFVNAIKMLIVPLVFCSLIVGVTSMQDTG
KMGRIGFKSFGFYLFTTAIAISIGLLVGYVLQPGAGLGLTLAEGATQTAKAVPSLVDTLVDIVPTNPIAAMASGQILQVI
VFAIALGIALVLIGEHGKPAIKVFESLAEAMYKLADMVMKLAPYGVFGLMAWVAGEYGIDMLWPLIKVIIAVYLGCIIHV
LGFYSFLLRGFAKLSPLQFFKGISNAMLVAFTTSSSAGTLPASMKCASENLGVHKKISSFVLPLGTTINMDGTALYQGVT
VLFVAQAFGIDLTVVDYLTIILTATLASIGTAGVPGAGLVMLTLVLTTVGLPLEGVALIAGIDRILDMVRTVVNVSGDLV
ATTVIAKSEDELDMAHYNADTEQSAVLAEQNIALETAAENSAKV
>Mature_443_residues
TKPKSSALGRVWSRWMSVPLWLQIVIGMVLGIIVGVIFGEQATCLKPLGTLFVNAIKMLIVPLVFCSLIVGVTSMQDTGK
MGRIGFKSFGFYLFTTAIAISIGLLVGYVLQPGAGLGLTLAEGATQTAKAVPSLVDTLVDIVPTNPIAAMASGQILQVIV
FAIALGIALVLIGEHGKPAIKVFESLAEAMYKLADMVMKLAPYGVFGLMAWVAGEYGIDMLWPLIKVIIAVYLGCIIHVL
GFYSFLLRGFAKLSPLQFFKGISNAMLVAFTTSSSAGTLPASMKCASENLGVHKKISSFVLPLGTTINMDGTALYQGVTV
LFVAQAFGIDLTVVDYLTIILTATLASIGTAGVPGAGLVMLTLVLTTVGLPLEGVALIAGIDRILDMVRTVVNVSGDLVA
TTVIAKSEDELDMAHYNADTEQSAVLAEQNIALETAAENSAKV

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=450, Percent_Identity=32, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI66773030, Length=509, Percent_Identity=30.4518664047151, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI40254478, Length=501, Percent_Identity=32.5349301397206, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI5032093, Length=389, Percent_Identity=36.2467866323907, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI169790839, Length=475, Percent_Identity=31.1578947368421, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI4827012, Length=321, Percent_Identity=36.1370716510903, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI194239697, Length=301, Percent_Identity=35.8803986710963, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI223468566, Length=292, Percent_Identity=36.3013698630137, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI223468564, Length=283, Percent_Identity=36.7491166077738, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI301601644, Length=191, Percent_Identity=36.6492146596859, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI262359914, Length=383, Percent_Identity=28.1984334203655, Blast_Score=122, Evalue=9e-28,
Organism=Escherichia coli, GI1790514, Length=412, Percent_Identity=37.621359223301, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI1789947, Length=413, Percent_Identity=36.8038740920097, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1788024, Length=437, Percent_Identity=30.4347826086957, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789473, Length=372, Percent_Identity=26.8817204301075, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71996953, Length=484, Percent_Identity=34.504132231405, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71983099, Length=444, Percent_Identity=34.6846846846847, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71983106, Length=444, Percent_Identity=34.6846846846847, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17537407, Length=473, Percent_Identity=30.6553911205074, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI193206505, Length=410, Percent_Identity=32.9268292682927, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI193206654, Length=416, Percent_Identity=31.0096153846154, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17541374, Length=416, Percent_Identity=31.25, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24583025, Length=471, Percent_Identity=29.0870488322718, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17137668, Length=471, Percent_Identity=29.0870488322718, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24583023, Length=471, Percent_Identity=29.0870488322718, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI281360481, Length=471, Percent_Identity=29.5116772823779, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI281360483, Length=471, Percent_Identity=29.5116772823779, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI17137666, Length=471, Percent_Identity=29.5116772823779, Blast_Score=142, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46667; Mature: 46536

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHHHHHHCCCHHEECCCCCCCC
>Mature Secondary Structure 
TKPKSSALGRVWSRWMSVPLWLQIVIGMVLGIIVGVIFGEQATCLKPLGTLFVNAIKML
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
IVPLVFCSLIVGVTSMQDTGKMGRIGFKSFGFYLFTTAIAISIGLLVGYVLQPGAGLGLT
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
LAEGATQTAKAVPSLVDTLVDIVPTNPIAAMASGQILQVIVFAIALGIALVLIGEHGKPA
ECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHH
IKVFESLAEAMYKLADMVMKLAPYGVFGLMAWVAGEYGIDMLWPLIKVIIAVYLGCIIHV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LGFYSFLLRGFAKLSPLQFFKGISNAMLVAFTTSSSAGTLPASMKCASENLGVHKKISSF
HHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHH
VLPLGTTINMDGTALYQGVTVLFVAQAFGIDLTVVDYLTIILTATLASIGTAGVPGAGLV
HHCCCCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
MLTLVLTTVGLPLEGVALIAGIDRILDMVRTVVNVSGDLVATTVIAKSEDELDMAHYNAD
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHCCCC
TEQSAVLAEQNIALETAAENSAKV
CHHHHHHHHCCCHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]