Click here to switch to the map view.

The map label for this gene is hpt [H]

Identifier: 126172969

GI number: 126172969

Start: 814271

End: 814801

Strand: Direct

Name: hpt [H]

Synonym: Sbal_0721

Alternate gene names: 126172969

Gene position: 814271-814801 (Clockwise)

Preceding gene: 126172968

Following gene: 126172970

Centisome position: 15.88

GC content: 46.33

Gene sequence:

>531_bases
ATGAAACACACCACCGAAGTGATGATCTCTGCGGAAGAGATAAGCCAGAAATTGGATCAAATGGCCGAGCTAATCAATGC
CCATTATGCCCACAGCGAACGTCTGCTGATGGTAGGCTTGTTAAAAGGCTCAGTGGTCTTTATGGCTGACCTGTGTCGCC
GAATTAAAGGCCATGTTGAAATCGATTTTATGTCGGTTTCCAGTTATGGCAATGCTATGACCAGCTCACGGGATGTGAAA
GTGCTGAAAGATGTGCAATCAGATATCGCCGGTCGCGATGTATTGATTGTGGAAGACTTGATTGACTCAGGTAACACCTT
AAGCAAAGTGCGCGAGATGCTGTTACTGCGCGAGCCTAAGAGCCTTGCACTGTGCACCCTGCTGGATAAACCTGAACGTC
GTGAAGTGGATGTGAAGGTCGATTTTATCGGTTTCACTATCCCTGATGAGTTTATCGTGGGTTATGGTATTGATTATGCA
GAGCAATATCGCAATCTACCTTACATCGCGAAAGTCGTGCCACTCGATTAA

Upstream 100 bases:

>100_bases
GTCGCTCGAATTCTCGATCATTTGGGCGTTGACCATGCATTAACGAGTCGCTGGGGTTATGACAAACAGTCTAACCGCGA
CCTCGACAATTGAGACTTAT

Downstream 100 bases:

>100_bases
GTGTCCGATACCGTTTAAAACTCCCGCAACAGGCGGGAGTTTTGCTTTTTACGGTTATATAAAAAATAGTATAAATAATT
GAACCATTAAAGATTGGTTT

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MKHTTEVMISAEEISQKLDQMAELINAHYAHSERLLMVGLLKGSVVFMADLCRRIKGHVEIDFMSVSSYGNAMTSSRDVK
VLKDVQSDIAGRDVLIVEDLIDSGNTLSKVREMLLLREPKSLALCTLLDKPERREVDVKVDFIGFTIPDEFIVGYGIDYA
EQYRNLPYIAKVVPLD

Sequences:

>Translated_176_residues
MKHTTEVMISAEEISQKLDQMAELINAHYAHSERLLMVGLLKGSVVFMADLCRRIKGHVEIDFMSVSSYGNAMTSSRDVK
VLKDVQSDIAGRDVLIVEDLIDSGNTLSKVREMLLLREPKSLALCTLLDKPERREVDVKVDFIGFTIPDEFIVGYGIDYA
EQYRNLPYIAKVVPLD
>Mature_176_residues
MKHTTEVMISAEEISQKLDQMAELINAHYAHSERLLMVGLLKGSVVFMADLCRRIKGHVEIDFMSVSSYGNAMTSSRDVK
VLKDVQSDIAGRDVLIVEDLIDSGNTLSKVREMLLLREPKSLALCTLLDKPERREVDVKVDFIGFTIPDEFIVGYGIDYA
EQYRNLPYIAKVVPLD

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=174, Percent_Identity=35.0574712643678, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI9910262, Length=173, Percent_Identity=29.4797687861272, Blast_Score=81, Evalue=5e-16,
Organism=Escherichia coli, GI87081689, Length=177, Percent_Identity=63.8418079096045, Blast_Score=238, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17510817, Length=176, Percent_Identity=31.25, Blast_Score=83, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19850; Mature: 19850

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHTTEVMISAEEISQKLDQMAELINAHYAHSERLLMVGLLKGSVVFMADLCRRIKGHVE
CCCHHHHEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHCCCEE
IDFMSVSSYGNAMTSSRDVKVLKDVQSDIAGRDVLIVEDLIDSGNTLSKVREMLLLREPK
EEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCC
SLALCTLLDKPERREVDVKVDFIGFTIPDEFIVGYGIDYAEQYRNLPYIAKVVPLD
HHEEEEECCCCCCCEEEEEEEEEEEECCCHHHEECCCCHHHHHCCCCCEEEEECCC
>Mature Secondary Structure
MKHTTEVMISAEEISQKLDQMAELINAHYAHSERLLMVGLLKGSVVFMADLCRRIKGHVE
CCCHHHHEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHCCCEE
IDFMSVSSYGNAMTSSRDVKVLKDVQSDIAGRDVLIVEDLIDSGNTLSKVREMLLLREPK
EEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCC
SLALCTLLDKPERREVDVKVDFIGFTIPDEFIVGYGIDYAEQYRNLPYIAKVVPLD
HHEEEEECCCCCCCEEEEEEEEEEEECCCHHHEECCCCHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]