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The map label for this gene is mutL

Identifier: 126172805

GI number: 126172805

Start: 628920

End: 630836

Strand: Direct

Name: mutL

Synonym: Sbal_0556

Alternate gene names: 126172805

Gene position: 628920-630836 (Clockwise)

Preceding gene: 126172804

Following gene: 126172806

Centisome position: 12.27

GC content: 48.2

Gene sequence:

>1917_bases
ATGATGGGCATTCAGATCCTGCCACCGCAATTAGCCAACCAAATTGCGGCGGGGGAAGTGGTTGAGAGACCCGCTTCCGT
AGTCAAAGAATTGGTCGAGAATAGTCTCGACGCAGGAGCGAGCCGAGTCGATATTGAAATCGACAAAGGCGGTAGCAAGC
TGATTAAAATTCGCGATAACGGATCTGGTATACCCAAAGATGAACTCGCGCTGGCCTTATCGCGCCATGCGACCTCAAAG
TTACACACCTTAGACGATCTCGAAGCGATCCTCAGTTTTGGTTTTCGCGGTGAAGCGTTAGCGAGTATCAGCTCAGTCTC
ACGCTTAACCTTAACCTCGCGCACTGCTGATCAAACCGAAGCATGGCAAGCCCATGCTGAAGGTGCCGACATGGCGGTTA
AAGTCATGCCCGCCGCGCATCCTGTTGGTTCTACGATTGAAGTGGTGGATTTATTCTTCAATACGCCAGCTCGCAGACGC
TTTTTAAAGAGCGATAAAACCGAATTTACCCATATCGATGAATGGTTAAAGCGCATTGCATTAGTGCGCGGTGATATCCA
TTTCACACTGACCCATAACGGCAAGATGGTACGCAATTATCGTCCCGCCATGAATGAAGCCCAGTATTTACAACGTTTGA
CCCAAGTGTGTGGCCGTCCATTTGCCGAGCAAGCGCTTAAGATTGAATGCCAGCATGATGATTTACGCCTAAGTGGCTAT
TTGCAGTCACCTTGGTCACCCGTTATCAGCGATACCCATTACTTTTATGTCAACGGACGCCTTATCCGTGACCGCTTAGT
CAATCACGCGGTGCGCCAAGCTTTTGCCCAAAAAGCGGAACTGGAGCAACCCGGCTATGTGTTGATGTTGGATATCGATC
CCCATCAAGTGGATGTTAACGTGCATCCCGCTAAGCATGAGGTGCGATTCCATCAGAGTCGCTATGTGCATGATTATATT
CTGCAAGCATTGCAATCGGCGCTGGAAGAAGCAGGGGAACTCAACTTCGTTCACTCAAGCTCTTTGGATGAAGTTGAAGA
TGTGTTTGTGGATGCCCCGACAAGCGCCACTGAAATCTCAGCCCCTTTTGTACTTGGTGCTGATTCAGCTCAAGTTAATG
TGCCAGCTGATACACTTGAGTCTGCTCAACCGTTAGTTGCCTCTGCCGTTCAAGTAAAATCTGCCGGCGCAGGACGAGAA
GGCACCAGTTTTGGCACTCAAACGAATGCCTTTGGCAGCATGGCCACGCCAAGGGACAATAGTCGCGGCAGTTATTCTGC
TGGTGAATCTCGGCAACGAACTGAATTACCGTCAAAAGCGGCAATTGCAAGTTATGGTGCTTTATTGCAAACACCTTCTT
ACAGTGTAAAAGATCAAGATTATCAGCCATCTTTACCTATGCCTGCTATTTTAGATGGCCAATATTGGGTAATGGCGACG
GCGGATAAACTGAGTCTATTGCCAATAAAATCAGTAGCATTGGCGACGCGCTGCCAAGAGATTGAGGCTAAGCTAGCGAC
CGGATTAATTGGGCAGCCTTTATTGATGCCAGTGTCTGTCGCGGCCGATGCAGATTGGCAGGCTGTGCTCGATGAACATG
ACACGCTGATCCGCCAGTTAGGTTTAGAACTAACAATTCGTTACCAGCAGTTGATTATTAAAAAAGTGCCCCCATATATC
AGAGAGAGCCAGTTAGCAAAAGTGATCCCTGAGTGGTTACAATCGCTGCGTTTTGAAACACCTGCGCCAAGCGCATTGGC
ATTTTGGTTGGCAAAACACAGTTTAACGGGATTCGTTTCGGCACCAGAAATCTGGGCAGCATTTTCGCAGTTAGCTGAAG
AGAAAAAACAGCTTATTGCCAACAAAGCAATATTACTACCTTGGCAATCGTGGCTAGAAGAGCAAGCAAGTGAATAA

Upstream 100 bases:

>100_bases
CGTGTGCATATGTCTAGCATCAAACAAGCGAATGGGATGAAGTCCGATGTAGTGCAGTTAGGGCAAACATTAGTCATACC
CCAGAGTTAAATAGGAAAGC

Downstream 100 bases:

>100_bases
AGAATTACAGCCTAAAGTGATATTTTTGATGGGGCCAACGGCCTCAGGCAAAACTGCTTTAGCATTAGAATTGGCCGAAA
AGCATAACTGTGAAATCATT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MMGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGASRVDIEIDKGGSKLIKIRDNGSGIPKDELALALSRHATSK
LHTLDDLEAILSFGFRGEALASISSVSRLTLTSRTADQTEAWQAHAEGADMAVKVMPAAHPVGSTIEVVDLFFNTPARRR
FLKSDKTEFTHIDEWLKRIALVRGDIHFTLTHNGKMVRNYRPAMNEAQYLQRLTQVCGRPFAEQALKIECQHDDLRLSGY
LQSPWSPVISDTHYFYVNGRLIRDRLVNHAVRQAFAQKAELEQPGYVLMLDIDPHQVDVNVHPAKHEVRFHQSRYVHDYI
LQALQSALEEAGELNFVHSSSLDEVEDVFVDAPTSATEISAPFVLGADSAQVNVPADTLESAQPLVASAVQVKSAGAGRE
GTSFGTQTNAFGSMATPRDNSRGSYSAGESRQRTELPSKAAIASYGALLQTPSYSVKDQDYQPSLPMPAILDGQYWVMAT
ADKLSLLPIKSVALATRCQEIEAKLATGLIGQPLLMPVSVAADADWQAVLDEHDTLIRQLGLELTIRYQQLIIKKVPPYI
RESQLAKVIPEWLQSLRFETPAPSALAFWLAKHSLTGFVSAPEIWAAFSQLAEEKKQLIANKAILLPWQSWLEEQASE

Sequences:

>Translated_638_residues
MMGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGASRVDIEIDKGGSKLIKIRDNGSGIPKDELALALSRHATSK
LHTLDDLEAILSFGFRGEALASISSVSRLTLTSRTADQTEAWQAHAEGADMAVKVMPAAHPVGSTIEVVDLFFNTPARRR
FLKSDKTEFTHIDEWLKRIALVRGDIHFTLTHNGKMVRNYRPAMNEAQYLQRLTQVCGRPFAEQALKIECQHDDLRLSGY
LQSPWSPVISDTHYFYVNGRLIRDRLVNHAVRQAFAQKAELEQPGYVLMLDIDPHQVDVNVHPAKHEVRFHQSRYVHDYI
LQALQSALEEAGELNFVHSSSLDEVEDVFVDAPTSATEISAPFVLGADSAQVNVPADTLESAQPLVASAVQVKSAGAGRE
GTSFGTQTNAFGSMATPRDNSRGSYSAGESRQRTELPSKAAIASYGALLQTPSYSVKDQDYQPSLPMPAILDGQYWVMAT
ADKLSLLPIKSVALATRCQEIEAKLATGLIGQPLLMPVSVAADADWQAVLDEHDTLIRQLGLELTIRYQQLIIKKVPPYI
RESQLAKVIPEWLQSLRFETPAPSALAFWLAKHSLTGFVSAPEIWAAFSQLAEEKKQLIANKAILLPWQSWLEEQASE
>Mature_638_residues
MMGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGASRVDIEIDKGGSKLIKIRDNGSGIPKDELALALSRHATSK
LHTLDDLEAILSFGFRGEALASISSVSRLTLTSRTADQTEAWQAHAEGADMAVKVMPAAHPVGSTIEVVDLFFNTPARRR
FLKSDKTEFTHIDEWLKRIALVRGDIHFTLTHNGKMVRNYRPAMNEAQYLQRLTQVCGRPFAEQALKIECQHDDLRLSGY
LQSPWSPVISDTHYFYVNGRLIRDRLVNHAVRQAFAQKAELEQPGYVLMLDIDPHQVDVNVHPAKHEVRFHQSRYVHDYI
LQALQSALEEAGELNFVHSSSLDEVEDVFVDAPTSATEISAPFVLGADSAQVNVPADTLESAQPLVASAVQVKSAGAGRE
GTSFGTQTNAFGSMATPRDNSRGSYSAGESRQRTELPSKAAIASYGALLQTPSYSVKDQDYQPSLPMPAILDGQYWVMAT
ADKLSLLPIKSVALATRCQEIEAKLATGLIGQPLLMPVSVAADADWQAVLDEHDTLIRQLGLELTIRYQQLIIKKVPPYI
RESQLAKVIPEWLQSLRFETPAPSALAFWLAKHSLTGFVSAPEIWAAFSQLAEEKKQLIANKAILLPWQSWLEEQASE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=328, Percent_Identity=35.0609756097561, Blast_Score=210, Evalue=4e-54,
Organism=Homo sapiens, GI4505911, Length=325, Percent_Identity=27.3846153846154, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI189458898, Length=317, Percent_Identity=27.7602523659306, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI189458896, Length=317, Percent_Identity=27.1293375394322, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI4505913, Length=340, Percent_Identity=26.7647058823529, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI310128478, Length=340, Percent_Identity=26.7647058823529, Blast_Score=126, Evalue=8e-29,
Organism=Homo sapiens, GI263191589, Length=234, Percent_Identity=30.3418803418803, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI91992160, Length=264, Percent_Identity=26.5151515151515, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI91992162, Length=264, Percent_Identity=26.5151515151515, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI310128480, Length=302, Percent_Identity=23.841059602649, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1790612, Length=613, Percent_Identity=47.1451876019576, Blast_Score=491, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=34.7826086956522, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17562796, Length=434, Percent_Identity=24.1935483870968, Blast_Score=123, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=341, Percent_Identity=35.4838709677419, Blast_Score=187, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6324247, Length=350, Percent_Identity=27.1428571428571, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325093, Length=357, Percent_Identity=26.3305322128852, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323063, Length=361, Percent_Identity=25.4847645429363, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17136968, Length=337, Percent_Identity=32.6409495548961, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI17136970, Length=362, Percent_Identity=25.6906077348066, Blast_Score=112, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_SHEB5 (A3D022)

Other databases:

- EMBL:   CP000563
- RefSeq:   YP_001048954.1
- ProteinModelPortal:   A3D022
- STRING:   A3D022
- GeneID:   4844944
- GenomeReviews:   CP000563_GR
- KEGG:   sbl:Sbal_0556
- NMPDR:   fig|325240.3.peg.3195
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FTHIDEW
- PhylomeDB:   A3D022
- ProtClustDB:   PRK00095
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 70305; Mature: 70305

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGASRVDIEIDKGGSKLIKIRDN
CCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECC
GSGIPKDELALALSRHATSKLHTLDDLEAILSFGFRGEALASISSVSRLTLTSRTADQTE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCCHHH
AWQAHAEGADMAVKVMPAAHPVGSTIEVVDLFFNTPARRRFLKSDKTEFTHIDEWLKRIA
HHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHH
LVRGDIHFTLTHNGKMVRNYRPAMNEAQYLQRLTQVCGRPFAEQALKIECQHDDLRLSGY
HHCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHEEEEECCCCEEEEEE
LQSPWSPVISDTHYFYVNGRLIRDRLVNHAVRQAFAQKAELEQPGYVLMLDIDPHQVDVN
ECCCCCCCCCCCEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEE
VHPAKHEVRFHQSRYVHDYILQALQSALEEAGELNFVHSSSLDEVEDVFVDAPTSATEIS
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHCCCCCCCCCCC
APFVLGADSAQVNVPADTLESAQPLVASAVQVKSAGAGREGTSFGTQTNAFGSMATPRDN
CCEEEECCCCEEECCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
SRGSYSAGESRQRTELPSKAAIASYGALLQTPSYSVKDQDYQPSLPMPAILDGQYWVMAT
CCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEEEE
ADKLSLLPIKSVALATRCQEIEAKLATGLIGQPLLMPVSVAADADWQAVLDEHDTLIRQL
CCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEECCCCCHHHHHHHHHHHHHHC
GLELTIRYQQLIIKKVPPYIRESQLAKVIPEWLQSLRFETPAPSALAFWLAKHSLTGFVS
CCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
APEIWAAFSQLAEEKKQLIANKAILLPWQSWLEEQASE
CHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHCCC
>Mature Secondary Structure
MMGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGASRVDIEIDKGGSKLIKIRDN
CCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECC
GSGIPKDELALALSRHATSKLHTLDDLEAILSFGFRGEALASISSVSRLTLTSRTADQTE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCCHHH
AWQAHAEGADMAVKVMPAAHPVGSTIEVVDLFFNTPARRRFLKSDKTEFTHIDEWLKRIA
HHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHH
LVRGDIHFTLTHNGKMVRNYRPAMNEAQYLQRLTQVCGRPFAEQALKIECQHDDLRLSGY
HHCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHEEEEECCCCEEEEEE
LQSPWSPVISDTHYFYVNGRLIRDRLVNHAVRQAFAQKAELEQPGYVLMLDIDPHQVDVN
ECCCCCCCCCCCEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEE
VHPAKHEVRFHQSRYVHDYILQALQSALEEAGELNFVHSSSLDEVEDVFVDAPTSATEIS
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHCCCCCCCCCCC
APFVLGADSAQVNVPADTLESAQPLVASAVQVKSAGAGREGTSFGTQTNAFGSMATPRDN
CCEEEECCCCEEECCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
SRGSYSAGESRQRTELPSKAAIASYGALLQTPSYSVKDQDYQPSLPMPAILDGQYWVMAT
CCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEEEE
ADKLSLLPIKSVALATRCQEIEAKLATGLIGQPLLMPVSVAADADWQAVLDEHDTLIRQL
CCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEECCCCCHHHHHHHHHHHHHHC
GLELTIRYQQLIIKKVPPYIRESQLAKVIPEWLQSLRFETPAPSALAFWLAKHSLTGFVS
CCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
APEIWAAFSQLAEEKKQLIANKAILLPWQSWLEEQASE
CHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA