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The map label for this gene is fhs

Identifier: 126172769

GI number: 126172769

Start: 583591

End: 585348

Strand: Direct

Name: fhs

Synonym: Sbal_0520

Alternate gene names: 126172769

Gene position: 583591-585348 (Clockwise)

Preceding gene: 126172767

Following gene: 126172772

Centisome position: 11.38

GC content: 50.91

Gene sequence:

>1758_bases
ATGCTGACAGATATGGATATTTCGAGTCGCGCAAGCCTTAAAAACATCACCGAAATTGGCGCCGACTTAGGCCTGTTACC
CGAAGAGATGATGCTATTTGGTCACACTAAAGCCAAGGTTGAGCTTAGCGTGTTGCAGCGTTTAGCGGGGCAACGCAAAG
GTAAATTGATTATCGTCACCGCAGTTACGCCTACGCCCCACGGCGAAGGTAAAACGGTGACGAGCATTGGCTTAACACAA
TCGTTAAATGCCATAGGCCAAAAGGCCTGTGCTTGTATTCGCCAGCCTAGCATGGGACCTGTGTTTGGGGTGAAAGGCGG
TGCTGCGGGTGGCGGTTATGCTCAAGTGGTGCCCATGCAGGAGATGAACTTACATCTCACGGGTGATATTCATGCCGTCA
GCAGTGCCCACAATTTAGGGGCCGCGGCGATTGCGGCGCGGCTATTCCACGAGACGCGCTTAGGTAAAACAGAATTTGAA
GCGCAATCTGAACAAGCGTTTTTGGATATCGATCCCAACGAGATCCGCTGGCACCGAGTGGTCGATCATAATGATCGCTG
CCTTAGACAAATTCATGTGGGCTTAGGCGATAATAACGGCCCAGAGTACGAATCCAGTTTTGATATTACCGCCGCCTCTG
AGTTGATGGCGATTTTAGCCTTAAGTCATGATTTGGCGGATATGCGGGCGCGGATCGGTCGTTTAGTGCTGGCCTTAAAT
ACCCAAGGGCAAGTGATTACCGCCGAAGACTTAGGTGTCGCTGGCGCGATGACGGCCATCATGGCCGATGCGATAAAACC
GACGTTAATGCAGACCTTAAATGGCTCGCCTTGCCTGATCCACTCGGGACCCTTTGCCAATATTGCCCACGGTAACTCGT
CGATCATTGCCGATGATATCGCCCTCAGGCTGGCGGACTTTGTGGTGACTGAAGGCGGTTTCGGCTCGGATATGGGCTTT
GAAAAGTTCTGTAATATCAAAGTACGTCAATCGGGTCAGGCGCCAGCCGCCGCTGTGTTGGTGACGACTTTAAAAGCGCT
GAAGGCCAATAGTGGCTTGGCAACTGAGGTGGATAGCAATGTATCAAATATCCATGTGCCAAACATCAGTGCGACAAATA
TCAATGCCCCAGATCAGGCTCGACTCGAAGCGGGCTTTGCAAATTTAAACTGGCATATCAACAATGTGGCGCGTTATGGC
ATTCCTGTGGTGGTGGCTATTAACCGTTTCGCCACTGATTCCGATGCTGAGTTGCAATGGCTAATCGAAGCTGTCAACGC
GAGTGCTGCCTTTGGCTGTGAAATTAGCGATGCCTTCATCCAAGGGGAAGCGGGCGCTATCGCCTTAGCACAAACTGTGG
TTCGCGCCGCTGAAACTGAAAGTCAGTTCAAACTGTTATATCCAGATGAAGCGTCATTAGAGGCAAAGTTATCCACCTTA
GCCGAAGTGGGCTATGGCGCTACAGGCGTGAGTCTTTCTATCGAGGCGAAACAGCAGGCGCAGCAACTGACCGCCCTTGG
CTATGGGCATTTGCCTTTGTGTATGGCCAAAACGCCGTTATCCATTAGCCACGACCCTAGCTTAAAGGGTGTTCCTAAGG
ATTTTGTGGTGCCAGTGCGAGAGTTAGTGTTACATGCGGGGGCGGGATTTATAACTGCCTTAGTGGGGAATGTGATGACT
ATGCCAGGCCTTGGGCTTAAGCCGGGTTACTTAAAAATCGATATTGATGCCAAAGGTGAGATAGTCGGTTTAGGCTAA

Upstream 100 bases:

>100_bases
CTTAAAGCCAATCACCTAATATCCGCCCTATTCAATGAGTGTTGTGCTTAGCAACCCCTCATACTAAACCAAAGCGTATC
TGAAAGGGAGAAATCGACGC

Downstream 100 bases:

>100_bases
GGTTTAGATTCGAAACTAATATTTCAATGAAAACTCACGCTTAGATGCAAAAGCGTTGCAGAGTCAAAGGGCGAGCTTGC
TGCTACGCCCTTTGACTCTG

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MLTDMDISSRASLKNITEIGADLGLLPEEMMLFGHTKAKVELSVLQRLAGQRKGKLIIVTAVTPTPHGEGKTVTSIGLTQ
SLNAIGQKACACIRQPSMGPVFGVKGGAAGGGYAQVVPMQEMNLHLTGDIHAVSSAHNLGAAAIAARLFHETRLGKTEFE
AQSEQAFLDIDPNEIRWHRVVDHNDRCLRQIHVGLGDNNGPEYESSFDITAASELMAILALSHDLADMRARIGRLVLALN
TQGQVITAEDLGVAGAMTAIMADAIKPTLMQTLNGSPCLIHSGPFANIAHGNSSIIADDIALRLADFVVTEGGFGSDMGF
EKFCNIKVRQSGQAPAAAVLVTTLKALKANSGLATEVDSNVSNIHVPNISATNINAPDQARLEAGFANLNWHINNVARYG
IPVVVAINRFATDSDAELQWLIEAVNASAAFGCEISDAFIQGEAGAIALAQTVVRAAETESQFKLLYPDEASLEAKLSTL
AEVGYGATGVSLSIEAKQQAQQLTALGYGHLPLCMAKTPLSISHDPSLKGVPKDFVVPVRELVLHAGAGFITALVGNVMT
MPGLGLKPGYLKIDIDAKGEIVGLG

Sequences:

>Translated_585_residues
MLTDMDISSRASLKNITEIGADLGLLPEEMMLFGHTKAKVELSVLQRLAGQRKGKLIIVTAVTPTPHGEGKTVTSIGLTQ
SLNAIGQKACACIRQPSMGPVFGVKGGAAGGGYAQVVPMQEMNLHLTGDIHAVSSAHNLGAAAIAARLFHETRLGKTEFE
AQSEQAFLDIDPNEIRWHRVVDHNDRCLRQIHVGLGDNNGPEYESSFDITAASELMAILALSHDLADMRARIGRLVLALN
TQGQVITAEDLGVAGAMTAIMADAIKPTLMQTLNGSPCLIHSGPFANIAHGNSSIIADDIALRLADFVVTEGGFGSDMGF
EKFCNIKVRQSGQAPAAAVLVTTLKALKANSGLATEVDSNVSNIHVPNISATNINAPDQARLEAGFANLNWHINNVARYG
IPVVVAINRFATDSDAELQWLIEAVNASAAFGCEISDAFIQGEAGAIALAQTVVRAAETESQFKLLYPDEASLEAKLSTL
AEVGYGATGVSLSIEAKQQAQQLTALGYGHLPLCMAKTPLSISHDPSLKGVPKDFVVPVRELVLHAGAGFITALVGNVMT
MPGLGLKPGYLKIDIDAKGEIVGLG
>Mature_585_residues
MLTDMDISSRASLKNITEIGADLGLLPEEMMLFGHTKAKVELSVLQRLAGQRKGKLIIVTAVTPTPHGEGKTVTSIGLTQ
SLNAIGQKACACIRQPSMGPVFGVKGGAAGGGYAQVVPMQEMNLHLTGDIHAVSSAHNLGAAAIAARLFHETRLGKTEFE
AQSEQAFLDIDPNEIRWHRVVDHNDRCLRQIHVGLGDNNGPEYESSFDITAASELMAILALSHDLADMRARIGRLVLALN
TQGQVITAEDLGVAGAMTAIMADAIKPTLMQTLNGSPCLIHSGPFANIAHGNSSIIADDIALRLADFVVTEGGFGSDMGF
EKFCNIKVRQSGQAPAAAVLVTTLKALKANSGLATEVDSNVSNIHVPNISATNINAPDQARLEAGFANLNWHINNVARYG
IPVVVAINRFATDSDAELQWLIEAVNASAAFGCEISDAFIQGEAGAIALAQTVVRAAETESQFKLLYPDEASLEAKLSTL
AEVGYGATGVSLSIEAKQQAQQLTALGYGHLPLCMAKTPLSISHDPSLKGVPKDFVVPVRELVLHAGAGFITALVGNVMT
MPGLGLKPGYLKIDIDAKGEIVGLG

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=622, Percent_Identity=47.2668810289389, Blast_Score=507, Evalue=1e-143,
Organism=Homo sapiens, GI36796743, Length=629, Percent_Identity=45.3100158982512, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI310124614, Length=81, Percent_Identity=48.1481481481481, Blast_Score=86, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17568737, Length=626, Percent_Identity=46.9648562300319, Blast_Score=506, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17568739, Length=626, Percent_Identity=46.9648562300319, Blast_Score=506, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6321643, Length=633, Percent_Identity=44.391785150079, Blast_Score=471, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6319558, Length=638, Percent_Identity=43.1034482758621, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI62472483, Length=625, Percent_Identity=43.36, Blast_Score=460, Evalue=1e-129,
Organism=Drosophila melanogaster, GI45551871, Length=625, Percent_Identity=43.36, Blast_Score=460, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24645718, Length=625, Percent_Identity=43.36, Blast_Score=460, Evalue=1e-129,
Organism=Drosophila melanogaster, GI17137370, Length=625, Percent_Identity=43.36, Blast_Score=460, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_SHEB5 (A3CZY6)

Other databases:

- EMBL:   CP000563
- RefSeq:   YP_001048918.1
- ProteinModelPortal:   A3CZY6
- SMR:   A3CZY6
- STRING:   A3CZY6
- GeneID:   4843046
- GenomeReviews:   CP000563_GR
- KEGG:   sbl:Sbal_0520
- NMPDR:   fig|325240.3.peg.1655
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   AIKPNIM
- PhylomeDB:   A3CZY6
- ProtClustDB:   PRK13506
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 61594; Mature: 61594

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTDMDISSRASLKNITEIGADLGLLPEEMMLFGHTKAKVELSVLQRLAGQRKGKLIIVT
CCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEHHHHHHHHCCCCCCEEEEE
AVTPTPHGEGKTVTSIGLTQSLNAIGQKACACIRQPSMGPVFGVKGGAAGGGYAQVVPMQ
EECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEHH
EMNLHLTGDIHAVSSAHNLGAAAIAARLFHETRLGKTEFEAQSEQAFLDIDPNEIRWHRV
HCCEEEECCEEEECCCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCEEEECCCCCEEEEEE
VDHNDRCLRQIHVGLGDNNGPEYESSFDITAASELMAILALSHDLADMRARIGRLVLALN
CCCCHHEEHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEE
TQGQVITAEDLGVAGAMTAIMADAIKPTLMQTLNGSPCLIHSGPFANIAHGNSSIIADDI
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCCCEEHHHH
ALRLADFVVTEGGFGSDMGFEKFCNIKVRQSGQAPAAAVLVTTLKALKANSGLATEVDSN
HHHHHHHHEECCCCCCCCCHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCEECCCC
VSNIHVPNISATNINAPDQARLEAGFANLNWHINNVARYGIPVVVAINRFATDSDAELQW
CCEEECCCCCCCCCCCCCHHHHHCCCEEEEEEEECHHHCCCEEEEEEEECCCCCCCHHHH
LIEAVNASAAFGCEISDAFIQGEAGAIALAQTVVRAAETESQFKLLYPDEASLEAKLSTL
HHHHHCCCCEECCCCCHHEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHH
AEVGYGATGVSLSIEAKQQAQQLTALGYGHLPLCMAKTPLSISHDPSLKGVPKDFVVPVR
HHHCCCCCCEEEEEHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHH
ELVLHAGAGFITALVGNVMTMPGLGLKPGYLKIDIDAKGEIVGLG
HHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEECC
>Mature Secondary Structure
MLTDMDISSRASLKNITEIGADLGLLPEEMMLFGHTKAKVELSVLQRLAGQRKGKLIIVT
CCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEHHHHHHHHCCCCCCEEEEE
AVTPTPHGEGKTVTSIGLTQSLNAIGQKACACIRQPSMGPVFGVKGGAAGGGYAQVVPMQ
EECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEHH
EMNLHLTGDIHAVSSAHNLGAAAIAARLFHETRLGKTEFEAQSEQAFLDIDPNEIRWHRV
HCCEEEECCEEEECCCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCEEEECCCCCEEEEEE
VDHNDRCLRQIHVGLGDNNGPEYESSFDITAASELMAILALSHDLADMRARIGRLVLALN
CCCCHHEEHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEE
TQGQVITAEDLGVAGAMTAIMADAIKPTLMQTLNGSPCLIHSGPFANIAHGNSSIIADDI
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCCCEEHHHH
ALRLADFVVTEGGFGSDMGFEKFCNIKVRQSGQAPAAAVLVTTLKALKANSGLATEVDSN
HHHHHHHHEECCCCCCCCCHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCEECCCC
VSNIHVPNISATNINAPDQARLEAGFANLNWHINNVARYGIPVVVAINRFATDSDAELQW
CCEEECCCCCCCCCCCCCHHHHHCCCEEEEEEEECHHHCCCEEEEEEEECCCCCCCHHHH
LIEAVNASAAFGCEISDAFIQGEAGAIALAQTVVRAAETESQFKLLYPDEASLEAKLSTL
HHHHHCCCCEECCCCCHHEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHH
AEVGYGATGVSLSIEAKQQAQQLTALGYGHLPLCMAKTPLSISHDPSLKGVPKDFVVPVR
HHHCCCCCCEEEEEHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHH
ELVLHAGAGFITALVGNVMTMPGLGLKPGYLKIDIDAKGEIVGLG
HHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA