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The map label for this gene is ezrA [H]

Identifier: 125625186

GI number: 125625186

Start: 2377538

End: 2379268

Strand: Reverse

Name: ezrA [H]

Synonym: llmg_2428

Alternate gene names: 125625186

Gene position: 2379268-2377538 (Counterclockwise)

Preceding gene: 125625187

Following gene: 125625185

Centisome position: 94.06

GC content: 36.11

Gene sequence:

>1731_bases
ATGTCAAGTACTGTAATTATCCTCATTGTTGTCCTATTAGTTATTCTCGTTGCTTTTTACGCTTTTGCAATTTTGATGCG
AAAGAAAACGGAGGATCGTATTTTAGCCTTAGAAGAGCGAAAAGAGTCGCTTTTCGATTTACCCGTTCAAGAAGAGATTG
ATTCTGTGAAGAAAATGCACCTTGTAGGGCAATCACAGACAATTTTCCGCGAATGGAATCAAAAATGGCTTGATTTATCA
TCAAATTCTTTTGCTGACTTAGAAGAGCACATTTTTGAAGCCGAACAGCTCAACGATTCTTTCCACTTTTTCCGCGCTCG
CGAATCTGTCGCAGATAGCGAAGCCCAAATTGAAATGATGGAAGGAGATGTTGAAGGAATTCGCCAAGGGGTTGCCCAAC
TTGTTGAGCAAGAAAAACGAAATTCAAACAAGATTCAAGAATCTCTTGATTTGTATGATAATTTGCGTAGCGATATCGCA
GATAATGCAGATTTGTATGGGACAGTTATTACTGAGCTCGAAAAACATCTTGCTAATATTGAAACAGAGTTTTCTCAATT
TGTAACGTTGAACTCAACTGGTGACCCAATTGAGGCAGCCGAAGTTTTAGAAACGGCAGAAGAACATACAATTGCATTGC
GTGCGATTACCGAACAAATCCCATCATTCATTAAAACAATTGAAAAAGATGTGCCTAAACGTCTTGAAGAATTACAAGAA
GCAAGTGACAAATTCATTGCCGAAGATTATATTCTCCCAGAGAATGTTAATCTTAAAGAGAGAATGGATGATTTACAACA
TCATCTTGAAGAAAGTAGCTCACTTTTGGAGCAATTTGAACTTGATCGAGTTGAAGCAGAACTTGATTTGATTCAAGAAC
GAGTGGAAGAACTTTATTCTATCTTTGAGAGAGAATACAGTGCACGTCGAAATGTCGAAAAACGTTCATCGGTTCTTAAA
GAATATATTGAACATATTAGAGTGAATAACAAAAATCTTCTTCTTGAAATTGATCATGTGACTCAAGCTTATATCCTTTC
GGGAAATGAAAAAGGTTATGTGAGAGGATATCAAGAACATTTAGAGTCATTGGATGCAGATGTTGATGAAATCATCGCCA
ACATTGAAGCTAAAGCGATTCCTTATTCAAGCCTTTCACGTCGCGTGAACTCTGTTGTCAATGCTTTAGAAGATATTGAA
AAAAATCAAATCAAAATTAGCGAGACTCTTTCAGGACTCAGAGATGAAGAAAGAGCAGCACAAGAAATTGCAGAACGTTT
TGATTCTGAACTTCGTACTATCAAACGTTATGTTGAAAAATGTAATTTGCCAGGACTTCCTAAAGATTATCTTGATTTAT
TCTTTATGACTGGAGATCGAGTGCAAAATCTTTTCAAAGAGTTGGGACGTGTAAGAATTAATATTGATACAATTAACCAT
CTTGTTGATGTGAGTACCGAAGATATGCATGTTTTGAAAGAAGCAACAACTAATTTGACAGACCATGCAGTATTAGCAGA
ACAACTTATTCAATATGCTAATCGTTATAAAGCGTCTAATGAACAAGTTGCACAAGGCATCTCAAGAGCACTTCAACTTT
TTGAAAACAGTCGCGATTATGATGGTTCATTCGATGAAATTTCTAAGACTTTAGAAATAGTTGAACCTGGTGCCGCTTCA
AGAATTTCCGGAGTTTATTTCAAAAATAAACCTACACCAGATTATTTATAA

Upstream 100 bases:

>100_bases
ATGCTATAATTATATTTGAGATTTTCTATTTAATTAAAATCTATTAACCTTAGTAAACAAATATATTTTCAAGTAATAAA
ATCATTTTATGGAGTAAAGC

Downstream 100 bases:

>100_bases
AAAAGTAAGGATTAATTTCCTTGCTTTTTTTTATTTTGTTTCAAAAAATAGTTTGATAATTTTAGAATTTTCTGTATAAT
GGTGTTAGGTAAAACAAATA

Product: septation ring formation regulator EzrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 575

Protein sequence:

>576_residues
MSSTVIILIVVLLVILVAFYAFAILMRKKTEDRILALEERKESLFDLPVQEEIDSVKKMHLVGQSQTIFREWNQKWLDLS
SNSFADLEEHIFEAEQLNDSFHFFRARESVADSEAQIEMMEGDVEGIRQGVAQLVEQEKRNSNKIQESLDLYDNLRSDIA
DNADLYGTVITELEKHLANIETEFSQFVTLNSTGDPIEAAEVLETAEEHTIALRAITEQIPSFIKTIEKDVPKRLEELQE
ASDKFIAEDYILPENVNLKERMDDLQHHLEESSSLLEQFELDRVEAELDLIQERVEELYSIFEREYSARRNVEKRSSVLK
EYIEHIRVNNKNLLLEIDHVTQAYILSGNEKGYVRGYQEHLESLDADVDEIIANIEAKAIPYSSLSRRVNSVVNALEDIE
KNQIKISETLSGLRDEERAAQEIAERFDSELRTIKRYVEKCNLPGLPKDYLDLFFMTGDRVQNLFKELGRVRINIDTINH
LVDVSTEDMHVLKEATTNLTDHAVLAEQLIQYANRYKASNEQVAQGISRALQLFENSRDYDGSFDEISKTLEIVEPGAAS
RISGVYFKNKPTPDYL

Sequences:

>Translated_576_residues
MSSTVIILIVVLLVILVAFYAFAILMRKKTEDRILALEERKESLFDLPVQEEIDSVKKMHLVGQSQTIFREWNQKWLDLS
SNSFADLEEHIFEAEQLNDSFHFFRARESVADSEAQIEMMEGDVEGIRQGVAQLVEQEKRNSNKIQESLDLYDNLRSDIA
DNADLYGTVITELEKHLANIETEFSQFVTLNSTGDPIEAAEVLETAEEHTIALRAITEQIPSFIKTIEKDVPKRLEELQE
ASDKFIAEDYILPENVNLKERMDDLQHHLEESSSLLEQFELDRVEAELDLIQERVEELYSIFEREYSARRNVEKRSSVLK
EYIEHIRVNNKNLLLEIDHVTQAYILSGNEKGYVRGYQEHLESLDADVDEIIANIEAKAIPYSSLSRRVNSVVNALEDIE
KNQIKISETLSGLRDEERAAQEIAERFDSELRTIKRYVEKCNLPGLPKDYLDLFFMTGDRVQNLFKELGRVRINIDTINH
LVDVSTEDMHVLKEATTNLTDHAVLAEQLIQYANRYKASNEQVAQGISRALQLFENSRDYDGSFDEISKTLEIVEPGAAS
RISGVYFKNKPTPDYL
>Mature_575_residues
SSTVIILIVVLLVILVAFYAFAILMRKKTEDRILALEERKESLFDLPVQEEIDSVKKMHLVGQSQTIFREWNQKWLDLSS
NSFADLEEHIFEAEQLNDSFHFFRARESVADSEAQIEMMEGDVEGIRQGVAQLVEQEKRNSNKIQESLDLYDNLRSDIAD
NADLYGTVITELEKHLANIETEFSQFVTLNSTGDPIEAAEVLETAEEHTIALRAITEQIPSFIKTIEKDVPKRLEELQEA
SDKFIAEDYILPENVNLKERMDDLQHHLEESSSLLEQFELDRVEAELDLIQERVEELYSIFEREYSARRNVEKRSSVLKE
YIEHIRVNNKNLLLEIDHVTQAYILSGNEKGYVRGYQEHLESLDADVDEIIANIEAKAIPYSSLSRRVNSVVNALEDIEK
NQIKISETLSGLRDEERAAQEIAERFDSELRTIKRYVEKCNLPGLPKDYLDLFFMTGDRVQNLFKELGRVRINIDTINHL
VDVSTEDMHVLKEATTNLTDHAVLAEQLIQYANRYKASNEQVAQGISRALQLFENSRDYDGSFDEISKTLEIVEPGAASR
ISGVYFKNKPTPDYL

Specific function: Negative regulator of ftsZ ring formation; modulates the frequency and position of ftsZ ring formation. Inhibits ftsZ ring formation at polar sites. Interacts either with ftsZ or with one of its binding partners to promote depolymerization [H]

COG id: COG4477

COG function: function code D; Negative regulator of septation ring formation

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein. Note=Colocalized with ftsZ to the nascent septal site [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ezrA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010379 [H]

Pfam domain/function: PF06160 EzrA [H]

EC number: NA

Molecular weight: Translated: 66306; Mature: 66175

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTVIILIVVLLVILVAFYAFAILMRKKTEDRILALEERKESLFDLPVQEEIDSVKKMH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LVGQSQTIFREWNQKWLDLSSNSFADLEEHIFEAEQLNDSFHFFRARESVADSEAQIEMM
HCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHH
EGDVEGIRQGVAQLVEQEKRNSNKIQESLDLYDNLRSDIADNADLYGTVITELEKHLANI
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ETEFSQFVTLNSTGDPIEAAEVLETAEEHTIALRAITEQIPSFIKTIEKDVPKRLEELQE
HHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASDKFIAEDYILPENVNLKERMDDLQHHLEESSSLLEQFELDRVEAELDLIQERVEELYS
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFEREYSARRNVEKRSSVLKEYIEHIRVNNKNLLLEIDHVTQAYILSGNEKGYVRGYQEH
HHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHEEHHCCCCCCCHHHHHHHH
LESLDADVDEIIANIEAKAIPYSSLSRRVNSVVNALEDIEKNQIKISETLSGLRDEERAA
HHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHCCCHHHHHH
QEIAERFDSELRTIKRYVEKCNLPGLPKDYLDLFFMTGDRVQNLFKELGRVRINIDTINH
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCEEEEHHHHHH
LVDVSTEDMHVLKEATTNLTDHAVLAEQLIQYANRYKASNEQVAQGISRALQLFENSRDY
HHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
DGSFDEISKTLEIVEPGAASRISGVYFKNKPTPDYL
CCCHHHHHHHHHHHCCCCHHHHCCCEECCCCCCCCC
>Mature Secondary Structure 
SSTVIILIVVLLVILVAFYAFAILMRKKTEDRILALEERKESLFDLPVQEEIDSVKKMH
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LVGQSQTIFREWNQKWLDLSSNSFADLEEHIFEAEQLNDSFHFFRARESVADSEAQIEMM
HCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHH
EGDVEGIRQGVAQLVEQEKRNSNKIQESLDLYDNLRSDIADNADLYGTVITELEKHLANI
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ETEFSQFVTLNSTGDPIEAAEVLETAEEHTIALRAITEQIPSFIKTIEKDVPKRLEELQE
HHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASDKFIAEDYILPENVNLKERMDDLQHHLEESSSLLEQFELDRVEAELDLIQERVEELYS
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFEREYSARRNVEKRSSVLKEYIEHIRVNNKNLLLEIDHVTQAYILSGNEKGYVRGYQEH
HHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHEEHHCCCCCCCHHHHHHHH
LESLDADVDEIIANIEAKAIPYSSLSRRVNSVVNALEDIEKNQIKISETLSGLRDEERAA
HHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHCCCHHHHHH
QEIAERFDSELRTIKRYVEKCNLPGLPKDYLDLFFMTGDRVQNLFKELGRVRINIDTINH
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCEEEEHHHHHH
LVDVSTEDMHVLKEATTNLTDHAVLAEQLIQYANRYKASNEQVAQGISRALQLFENSRDY
HHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
DGSFDEISKTLEIVEPGAASRISGVYFKNKPTPDYL
CCCHHHHHHHHHHHCCCCHHHHCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]