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The map label for this gene is htrA [H]

Identifier: 125625177

GI number: 125625177

Start: 2361433

End: 2362656

Strand: Direct

Name: htrA [H]

Synonym: llmg_2419

Alternate gene names: 125625177

Gene position: 2361433-2362656 (Clockwise)

Preceding gene: 125625156

Following gene: 125625178

Centisome position: 93.36

GC content: 39.95

Gene sequence:

>1224_bases
ATGGCAAAAGCTAATATAGGAAAATTGCTATTAACCGGTGTTGTGGGTGGAGCTATCGCACTCGGAGGAAGCGCAATTTA
TCAAAGCACTACAAACCAACTAGGAAATGCTAACCGCTCAAATACGACTAGCACAAAGGTTAGTAATGTTTCGGTAAATG
TCAATACCGATGTTACCTCTGCAATTAAAAAAGTTTCAAATTCTGTCGTTTCTGTTATGAATTATCAAAAACAGAATTCA
CAAAGTGATTTTAGTTCAATTTTTGGTGGAAATAGCGGCTCAAGTTCAGCTAATGACGGCTTGCAACTTTCCAGTGAGGG
TTCTGGTGTTATTTACAAAAAATCTGGTGGAGATGCTTACGTGGTCACTAACTATCACGTTATTGCCGGAAATAGTTCCC
TCGATGTTTTACTTTCTGGTGGGCAAAAAGTTAAAGCCACAGTTGTTGGTTATGATGAATACACTGACCTTGCCGTTCTT
AAAATCAGCTCTGACCATGTTAAAGACGTGGCAACTTTCGCTGATTCAAGCAAGTTAACTATTGGTGAACCAGCTATTGC
AGTCGGCTCACCTTTAGGTAGCCAGTTTGCTAATACTGCAACCGAAGGAATTCTGTCTGCAACAAGTCGTCAAGTCACTT
TGACTCAAGAAAATGGTCAAACAACAAGTATCAATGCGATTCAAACGGATGCTGCCATTAACCCTGGTAACTCAGGTGGA
GCCTTGATTAATATTGAAGGTCAAGTGATTGGTATTACTCAAAGTAAAATCACAACGACTGAAGATGGTTCTACCTCTGT
GGAAGGTTTAGGTTTTGCTATCCCATCTAATGATGTGGTAAACATCATTAATAAACTTGAAACTGATGGTAAGATTTCAC
GTCCTGCCTTAGGTATTCGTATGGTTGACCTATCTCAATTATCAACAAATGATAGTTCTCAACTGAAATTACCTAGCAGC
GTAACTGGTGGAGTGGTTGTCTACTCTGTTCAAGCGGGTCTTCCTGCTGCCACAGCTGGTCTGAAAGCTGGCGATGTGAT
AACGAAGGTGGGAGATACCGCCGTTACTTCATCAACAGACTTACAAAGTGCTCTTTACTCACACAATATTAATGATACTG
TGAAAGTCACCTACTACCGTGATGGTAAATCAGCCACAGCAAATGTCAAACTCTCTAAATCAACAAGCGATTTAGAAACA
AATAGTTCATCTTCTTCTAATTAA

Upstream 100 bases:

>100_bases
TTAGTTTGATTTTTGTTACTATTAAGGTATTATTAAGTGAGAGTAGTTATAATTACAATATAGAAATGCTACAAAGAGTA
ATAATTGAAAGGAATTATTT

Downstream 100 bases:

>100_bases
TATATCATTGATAAAAAGTCTTCTTAAAAGAAGGCTTTTTTCATACTAAAGTCTGAAATTTTGTAAAATAATAATTTTCC
ATTTTTCTTTTATTGATTTA

Product: housekeeping protease

Products: NA

Alternate protein names: HtrALl [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQLGNANRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKQNS
QSDFSSIFGGNSGSSSANDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKATVVGYDEYTDLAVL
KISSDHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTSINAIQTDAAINPGNSGG
ALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLETDGKISRPALGIRMVDLSQLSTNDSSQLKLPSS
VTGGVVVYSVQAGLPAATAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSATANVKLSKSTSDLET
NSSSSSN

Sequences:

>Translated_407_residues
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQLGNANRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKQNS
QSDFSSIFGGNSGSSSANDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKATVVGYDEYTDLAVL
KISSDHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTSINAIQTDAAINPGNSGG
ALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLETDGKISRPALGIRMVDLSQLSTNDSSQLKLPSS
VTGGVVVYSVQAGLPAATAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSATANVKLSKSTSDLET
NSSSSSN
>Mature_406_residues
AKANIGKLLLTGVVGGAIALGGSAIYQSTTNQLGNANRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKQNSQ
SDFSSIFGGNSGSSSANDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKATVVGYDEYTDLAVLK
ISSDHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTSINAIQTDAAINPGNSGGA
LINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLETDGKISRPALGIRMVDLSQLSTNDSSQLKLPSSV
TGGVVVYSVQAGLPAATAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSATANVKLSKSTSDLETN
SSSSSN

Specific function: Degrades abnormal exported proteins. Needed for the propeptide processing of a natural pro-protein and for the maturation of a native protein. Responsible for the housekeeping of exported proteins [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=323, Percent_Identity=30.9597523219814, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI24308541, Length=350, Percent_Identity=30.8571428571429, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI7019477, Length=276, Percent_Identity=34.4202898550725, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI4506141, Length=266, Percent_Identity=34.2105263157895, Blast_Score=115, Evalue=5e-26,
Organism=Escherichia coli, GI1789629, Length=340, Percent_Identity=36.1764705882353, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1786356, Length=303, Percent_Identity=37.2937293729373, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1789630, Length=302, Percent_Identity=33.4437086092715, Blast_Score=132, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24646839, Length=277, Percent_Identity=34.6570397111913, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 41541; Mature: 41410

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQLGNANRSNTTSTKVSNVSVNVNTDVTS
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCHHHH
AIKKVSNSVVSVMNYQKQNSQSDFSSIFGGNSGSSSANDGLQLSSEGSGVIYKKSGGDAY
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEECCCCEE
VVTNYHVIAGNSSLDVLLSGGQKVKATVVGYDEYTDLAVLKISSDHVKDVATFADSSKLT
EEEEEEEEECCCCEEEEEECCCEEEEEEEECCCCCCEEEEEECCHHHHHHHHHCCCCCEE
IGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTSINAIQTDAAINPGNSGG
ECCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCC
ALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLETDGKISRPALGIR
EEEEECCEEEEEECCEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCEEE
MVDLSQLSTNDSSQLKLPSSVTGGVVVYSVQAGLPAATAGLKAGDVITKVGDTAVTSSTD
EEEHHHCCCCCCCEEECCCCCCCCEEEEEEECCCCHHHCCCCCCCHHHHCCCCEECCCHH
LQSALYSHNINDTVKVTYYRDGKSATANVKLSKSTSDLETNSSSSSN
HHHHHHHCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKANIGKLLLTGVVGGAIALGGSAIYQSTTNQLGNANRSNTTSTKVSNVSVNVNTDVTS
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCHHHH
AIKKVSNSVVSVMNYQKQNSQSDFSSIFGGNSGSSSANDGLQLSSEGSGVIYKKSGGDAY
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEECCCCEE
VVTNYHVIAGNSSLDVLLSGGQKVKATVVGYDEYTDLAVLKISSDHVKDVATFADSSKLT
EEEEEEEEECCCCEEEEEECCCEEEEEEEECCCCCCEEEEEECCHHHHHHHHHCCCCCEE
IGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTSINAIQTDAAINPGNSGG
ECCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCC
ALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLETDGKISRPALGIR
EEEEECCEEEEEECCEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCEEE
MVDLSQLSTNDSSQLKLPSSVTGGVVVYSVQAGLPAATAGLKAGDVITKVGDTAVTSSTD
EEEHHHCCCCCCCEEECCCCCCCCEEEEEEECCCCHHHCCCCCCCHHHHCCCCEECCCHH
LQSALYSHNINDTVKVTYYRDGKSATANVKLSKSTSDLETNSSSSSN
HHHHHHHCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10712686; 11337471 [H]