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The map label for this gene is uppS [H]

Identifier: 125625173

GI number: 125625173

Start: 2358350

End: 2359084

Strand: Reverse

Name: uppS [H]

Synonym: llmg_2415

Alternate gene names: 125625173

Gene position: 2359084-2358350 (Counterclockwise)

Preceding gene: 125625174

Following gene: 125625172

Centisome position: 93.26

GC content: 39.05

Gene sequence:

>735_bases
ATGTTTAATAACTTAAAAAATAAAGAACAAGAAGAATTGCTTCCAGAGCATATCGGGATTATCATGGATGGTAATGGACG
ATGGGCCAAAAAGAAGGGGAAACCACGAATTTTTGGTCATAAAGCAGGAATGGATTCGCTAAAAGATGTTGCCGTTCATG
GTGCAAGACGGGGAATTAAAGTGATGACTGTTTATGCTTTTTCTACCGAAAATTGGACAAGACCAGTAGATGAAGTAAAA
TTCATTATGAGCTTACCGATTGACTTTTACAGCAAATATGTTCCAGTTTTAAAAGAAGAAAATATTCAAATCCGTATGAT
TGGTGAACGAGCAGGAATGCCAAAAGCAACCTTAGACTCTATTGATCGTGCGGCTCGAGAAACTTCTGAAAATACTGGAA
TGATTTTGAATTTTGCGATGAATTATGGTGGACGTCGTGATATTATCTTAGCCATTCAAGAACTTGCTAAGAGTGGACAG
GACTTAAGTACACTGACCGAAGAAGATTTATCAAAACATCTACAAACCGCTGTTTTGCCTGAAAATCTTCGGGATCCCGA
TTTGATTATCAGAACATCAGGTGAACAACGGATGTCTAATTTCTTGACTTGGCAGTCAGCTTATAGTGAATTATATTTTG
CGCAAACCGCTTGGCCCGACTTTGATGAAGCGGAATTGGACAAAGCGATTGCTGCGTTCCAAAAGCGTGACCGCAGATAT
GGAGGAGTCAAATAA

Upstream 100 bases:

>100_bases
TTTCAGAAAGCTCTTATCTCAATAGAACTTTAATAACCAAAGAGTATATTGGTGAGTTTATGAAATACAATTTTTGCATA
AAATTCCCATGTGAGGTACT

Downstream 100 bases:

>100_bases
TGATGCAACGAATTATCACAGGAGTGGTTGCAGGAGGGATTTTTCTAGCCCTTTTGCTCTTGGGAGGTGCTTACTTCCAA
ATTTTAGTCGCATTGCTTGT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MFNNLKNKEQEELLPEHIGIIMDGNGRWAKKKGKPRIFGHKAGMDSLKDVAVHGARRGIKVMTVYAFSTENWTRPVDEVK
FIMSLPIDFYSKYVPVLKEENIQIRMIGERAGMPKATLDSIDRAARETSENTGMILNFAMNYGGRRDIILAIQELAKSGQ
DLSTLTEEDLSKHLQTAVLPENLRDPDLIIRTSGEQRMSNFLTWQSAYSELYFAQTAWPDFDEAELDKAIAAFQKRDRRY
GGVK

Sequences:

>Translated_244_residues
MFNNLKNKEQEELLPEHIGIIMDGNGRWAKKKGKPRIFGHKAGMDSLKDVAVHGARRGIKVMTVYAFSTENWTRPVDEVK
FIMSLPIDFYSKYVPVLKEENIQIRMIGERAGMPKATLDSIDRAARETSENTGMILNFAMNYGGRRDIILAIQELAKSGQ
DLSTLTEEDLSKHLQTAVLPENLRDPDLIIRTSGEQRMSNFLTWQSAYSELYFAQTAWPDFDEAELDKAIAAFQKRDRRY
GGVK
>Mature_244_residues
MFNNLKNKEQEELLPEHIGIIMDGNGRWAKKKGKPRIFGHKAGMDSLKDVAVHGARRGIKVMTVYAFSTENWTRPVDEVK
FIMSLPIDFYSKYVPVLKEENIQIRMIGERAGMPKATLDSIDRAARETSENTGMILNFAMNYGGRRDIILAIQELAKSGQ
DLSTLTEEDLSKHLQTAVLPENLRDPDLIIRTSGEQRMSNFLTWQSAYSELYFAQTAWPDFDEAELDKAIAAFQKRDRRY
GGVK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=228, Percent_Identity=35.5263157894737, Blast_Score=127, Evalue=6e-30,
Organism=Homo sapiens, GI45580738, Length=228, Percent_Identity=35.5263157894737, Blast_Score=127, Evalue=6e-30,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=44.2982456140351, Blast_Score=207, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI71993029, Length=227, Percent_Identity=32.5991189427313, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319474, Length=214, Percent_Identity=32.7102803738318, Blast_Score=108, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6323748, Length=214, Percent_Identity=28.5046728971963, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI18857969, Length=230, Percent_Identity=33.0434782608696, Blast_Score=125, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27805; Mature: 27805

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNNLKNKEQEELLPEHIGIIMDGNGRWAKKKGKPRIFGHKAGMDSLKDVAVHGARRGIK
CCCCCCCCHHHHHHHHHCCEEECCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCEE
VMTVYAFSTENWTRPVDEVKFIMSLPIDFYSKYVPVLKEENIQIRMIGERAGMPKATLDS
EEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHCCHHCCCCEEEEEEECCCCCCHHHHHH
IDRAARETSENTGMILNFAMNYGGRRDIILAIQELAKSGQDLSTLTEEDLSKHLQTAVLP
HHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
ENLRDPDLIIRTSGEQRMSNFLTWQSAYSELYFAQTAWPDFDEAELDKAIAAFQKRDRRY
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
GGVK
CCCC
>Mature Secondary Structure
MFNNLKNKEQEELLPEHIGIIMDGNGRWAKKKGKPRIFGHKAGMDSLKDVAVHGARRGIK
CCCCCCCCHHHHHHHHHCCEEECCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCEE
VMTVYAFSTENWTRPVDEVKFIMSLPIDFYSKYVPVLKEENIQIRMIGERAGMPKATLDS
EEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHCCHHCCCCEEEEEEECCCCCCHHHHHH
IDRAARETSENTGMILNFAMNYGGRRDIILAIQELAKSGQDLSTLTEEDLSKHLQTAVLP
HHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
ENLRDPDLIIRTSGEQRMSNFLTWQSAYSELYFAQTAWPDFDEAELDKAIAAFQKRDRRY
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
GGVK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]