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The map label for this gene is glk [H]

Identifier: 125625062

GI number: 125625062

Start: 2251002

End: 2251973

Strand: Direct

Name: glk [H]

Synonym: llmg_2299

Alternate gene names: 125625062

Gene position: 2251002-2251973 (Clockwise)

Preceding gene: 125625061

Following gene: 125625063

Centisome position: 88.99

GC content: 40.02

Gene sequence:

>972_bases
ATGACTGCAAGTAAAATTATCGGTATCGACCTTGGCGGAACTTCAATTAAATTTGGGATTTTAACTCTCACTGGTGAAGT
TCAAGATAAATGGTCTATCCCAACAAATATTTTAGAAGATGGAAAACATATCGTTCCTGATATTATCCAATCAATCAACC
ACCGTTTGAACCTTTACAATTTGGATAAATCAGAGTTTCTCGGAATTGGAATGGGAACTCCTGGGTCAGTAAATATTTCT
GAAAGTACTGTTAAAGCCGCTTTCAACTTAAACTGGGCAGACACTCAAGAGGTTGGTAAACCAATTTCTGAGGGTGTTGG
TCTACCTTTCATCTTGGACAATGACGCTAACGTTGCTGCTCTTGGTGAACGTTGGGTTGGGGCTGGTGAAAACAATCCTG
ATGTAGTCTTCATCACTCTTGGAACTGGTGTTGGTGGTGGAATTATCGCCTCAGGAGAGCTAGTTCATGGTATTGCTGGA
GCTGGTGGTGAAATCGGCCACATTTGCGTTGACCCTGATGGTTTTGAATGTACTTGTGGAAACCGCGGATGTTTGGAAAC
AGTAACTTCTGCTACAGGAATCGTTCGCTTAGCTCGTAAATTTGCTGAAGAGTACGAAGGAGATTCTACTATTAAGGCTG
CTATTGACAATGGTGATGAAGTAACTTCTAAAGACATTTTCTTTGCTGCTCAAGAAGGGGACCACTTCAGCTTATCTGTT
GTTGATAAATTTGCTTATTATCTTGGATTTGCCTGTGCAAATTTGGGTTCTACTTTAAACCCTGCTTCAATCGTTATTGG
TGGTGGTGTATCAGCAGCTGGTGAATTCTTGCGTGAAAAAGTTGAAACTTATTTCAATAAATATGCCTTTTCAACTGTTC
GTAACTCAAGTAAAATTAAACTTGCTGTTCTTGGAAATGATGCCGGAATTATCGGCGCTGCAAGTCTTGCTCTTAAATTT
AAAGGAGAATAA

Upstream 100 bases:

>100_bases
TGCTCGCTTGATTTTGTCGCGTGAAGAGAGAATTGAAAAGAAAAAATCTACGACTAATAAAAAATAATGCTTTTTTTATT
GTCAGATTGGAGAAAAAACA

Downstream 100 bases:

>100_bases
TTTTGATTATTATTATCATTGATATCATTCTTGTCTTAGTAATTATCGGAATGTTTGTCTATCCCCGCTGGAATCTTCGT
CGCAATGCAAAACTTGTTGA

Product: glucokinase

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTASKIIGIDLGGTSIKFGILTLTGEVQDKWSIPTNILEDGKHIVPDIIQSINHRLNLYNLDKSEFLGIGMGTPGSVNIS
ESTVKAAFNLNWADTQEVGKPISEGVGLPFILDNDANVAALGERWVGAGENNPDVVFITLGTGVGGGIIASGELVHGIAG
AGGEIGHICVDPDGFECTCGNRGCLETVTSATGIVRLARKFAEEYEGDSTIKAAIDNGDEVTSKDIFFAAQEGDHFSLSV
VDKFAYYLGFACANLGSTLNPASIVIGGGVSAAGEFLREKVETYFNKYAFSTVRNSSKIKLAVLGNDAGIIGAASLALKF
KGE

Sequences:

>Translated_323_residues
MTASKIIGIDLGGTSIKFGILTLTGEVQDKWSIPTNILEDGKHIVPDIIQSINHRLNLYNLDKSEFLGIGMGTPGSVNIS
ESTVKAAFNLNWADTQEVGKPISEGVGLPFILDNDANVAALGERWVGAGENNPDVVFITLGTGVGGGIIASGELVHGIAG
AGGEIGHICVDPDGFECTCGNRGCLETVTSATGIVRLARKFAEEYEGDSTIKAAIDNGDEVTSKDIFFAAQEGDHFSLSV
VDKFAYYLGFACANLGSTLNPASIVIGGGVSAAGEFLREKVETYFNKYAFSTVRNSSKIKLAVLGNDAGIIGAASLALKF
KGE
>Mature_322_residues
TASKIIGIDLGGTSIKFGILTLTGEVQDKWSIPTNILEDGKHIVPDIIQSINHRLNLYNLDKSEFLGIGMGTPGSVNISE
STVKAAFNLNWADTQEVGKPISEGVGLPFILDNDANVAALGERWVGAGENNPDVVFITLGTGVGGGIIASGELVHGIAGA
GGEIGHICVDPDGFECTCGNRGCLETVTSATGIVRLARKFAEEYEGDSTIKAAIDNGDEVTSKDIFFAAQEGDHFSLSVV
DKFAYYLGFACANLGSTLNPASIVIGGGVSAAGEFLREKVETYFNKYAFSTVRNSSKIKLAVLGNDAGIIGAASLALKFK
GE

Specific function: Acts As A Repressor Of The Nagebacd Operon And Acts Both As An Activator And A Repressor For The Transcription Of The Glmsu Operon. [C]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=274, Percent_Identity=31.021897810219, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI190014632, Length=274, Percent_Identity=31.021897810219, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4885285, Length=274, Percent_Identity=31.021897810219, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI298566325, Length=274, Percent_Identity=31.021897810219, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1786891, Length=310, Percent_Identity=25.8064516129032, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1787878, Length=280, Percent_Identity=25, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787363, Length=323, Percent_Identity=26.9349845201238, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI87081733, Length=319, Percent_Identity=28.5266457680251, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI87082127, Length=184, Percent_Identity=29.8913043478261, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790522, Length=319, Percent_Identity=25.705329153605, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082230, Length=287, Percent_Identity=27.8745644599303, Blast_Score=75, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 33756; Mature: 33625

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASKIIGIDLGGTSIKFGILTLTGEVQDKWSIPTNILEDGKHIVPDIIQSINHRLNLYN
CCCCEEEEEEECCCEEEEEEEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHCCEEEEE
LDKSEFLGIGMGTPGSVNISESTVKAAFNLNWADTQEVGKPISEGVGLPFILDNDANVAA
CCHHHEEEEECCCCCCEEECHHHEEEEEECCCCCHHHHCCHHHHCCCCCEEECCCCCEEE
LGERWVGAGENNPDVVFITLGTGVGGGIIASGELVHGIAGAGGEIGHICVDPDGFECTCG
ECHHHCCCCCCCCCEEEEEECCCCCCCEEECCCEEEEECCCCCCEEEEEECCCCCEEECC
NRGCLETVTSATGIVRLARKFAEEYEGDSTIKAAIDNGDEVTSKDIFFAAQEGDHFSLSV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEHH
VDKFAYYLGFACANLGSTLNPASIVIGGGVSAAGEFLREKVETYFNKYAFSTVRNSSKIK
HHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LAVLGNDAGIIGAASLALKFKGE
EEEEECCCCEEEEEEEEEEECCC
>Mature Secondary Structure 
TASKIIGIDLGGTSIKFGILTLTGEVQDKWSIPTNILEDGKHIVPDIIQSINHRLNLYN
CCCEEEEEEECCCEEEEEEEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHCCEEEEE
LDKSEFLGIGMGTPGSVNISESTVKAAFNLNWADTQEVGKPISEGVGLPFILDNDANVAA
CCHHHEEEEECCCCCCEEECHHHEEEEEECCCCCHHHHCCHHHHCCCCCEEECCCCCEEE
LGERWVGAGENNPDVVFITLGTGVGGGIIASGELVHGIAGAGGEIGHICVDPDGFECTCG
ECHHHCCCCCCCCCEEEEEECCCCCCCEEECCCEEEEECCCCCCEEEEEECCCCCEEECC
NRGCLETVTSATGIVRLARKFAEEYEGDSTIKAAIDNGDEVTSKDIFFAAQEGDHFSLSV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEHH
VDKFAYYLGFACANLGSTLNPASIVIGGGVSAAGEFLREKVETYFNKYAFSTVRNSSKIK
HHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LAVLGNDAGIIGAASLALKFKGE
EEEEECCCCEEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]