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The map label for this gene is glmU [H]

Identifier: 125624848

GI number: 125624848

Start: 2056248

End: 2057624

Strand: Reverse

Name: glmU [H]

Synonym: llmg_2076

Alternate gene names: 125624848

Gene position: 2057624-2056248 (Counterclockwise)

Preceding gene: 125624850

Following gene: 125624847

Centisome position: 81.35

GC content: 38.2

Gene sequence:

>1377_bases
ATGAATAAATTCGCTATTGTCCTAGCGGCTGGTAAAGGAACACGAATGAAATCAGCACTTCCAAAAGTGTTGCATCAAGT
AGCTGGAAAATCAATGCTGGCGCATGTGCTTAAAAGTGTATCCGAAGTGGAGATTGCCAAAAACGTGGTCATCGTTGGAC
ACGAAGCAGACCGTGTAATTGCGACTTTACCTAAGGGAACTCAATTTGTTAAACAGGTAGAACAATTAGGAACAGGACAT
GCTGTACGTATTGCTGCGGATTTGTTGGCTAATGAAGAAGGGGCAACCTTAGTTATCGCTGGTGATACTCCCTTAATTAC
AGGCGAAACATTAGGAGCACTTTTTGATTATCATTTTGCCCAAAAAGCAACAGCAACAATCTTGACTGCTATTGCACCAA
ATCCAACAGGATACGGTCGAATTATTCGGGATGAAAAGGATTCAGTAGAAAAAATTGTTGAGCAAAAAGATGCCAATGCT
TTTGAAAAATCAATTACTGAAATTAACACAGGGACTTATATTTTTGATAATAAATCGCTCTTTAAAGCACTGACGGAAAT
CACAACTGATAATGCGCAAGGTGAATATTATTTAACTGATGTTATTGAAATCTTCAAAAAAGTAGGTCAAACGATAGCTG
CTCATATTCTTGATGATTTTGATGAAAGTTTAGGTGTGAATGACCGTGTGGCTCTTTCACAAGCTGAAGCGACAATGCGT
AAACGTATTAACCATGAACATATGGTTAATGGTGTGACCTTGATTGATCCTGCAACAACTTATATTGACAGTGAAGTAAC
AATTGGGGCAGAAACGGTGATTGAAGCAAATGTAACCATTAAGGGGAACACTTTTATTGGTAAAAATGTTTTGATTACAA
ATGGCAGCCGCATTGAAAATTCGGAAATTCATTCAAATTGTGAGGTTCGTAACTCAACAGTTGAAGAAAGTCGGATGAGT
GTTGGAAGTAATGTTGGACCTTATGCTCATTTACGCCCAGGAACTGTTTTAAGTGAAGAAGTTCATGTTGGAAACTTTGT
TGAAATTAAAGGCTCAACTCTTGGTAAAGGAACCAAGGCCGGACATTTGACTTACATTGGTAATGCAACAGTGGGTGAAA
AAGTGAACTTTGGTGCTGGTACAATTACGGCTAACTTTGATGGTAAAAATAAATTCAATACTGAAATTGATGATTTTGCC
TTTATTGGTTCAAATTCAACCATAATCGCACCTTTGCATATTGGTAAAAATGCCTTGACAGCAGCTGGATCTGTTGTGAC
TGAGGATGTGCCAGATGAAGCAGTTGAAATTGGACGTGGAAAACAAGTGAATAAACTTGGACGTGCGAAAAAAATGCCAC
ATTATCGTGGACAATAA

Upstream 100 bases:

>100_bases
GCTGTGGGCGGGTGAATTAAAAAGATAACGAAAATGGTCAGTGATTATGGTATAATTAGGTAAACATTTTATTTTATTTG
TAACAAAAAAGGAGAAATCT

Downstream 100 bases:

>100_bases
TTTAAGATAATAAGAAAGAGTTTCTCGTGAAGCTCTTTCCTTCGATTTGATGAGAGGGAAATTTTACTTTTTCAAAAGTA
AATTCCATGGAAAGGGTACA

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MNKFAIVLAAGKGTRMKSALPKVLHQVAGKSMLAHVLKSVSEVEIAKNVVIVGHEADRVIATLPKGTQFVKQVEQLGTGH
AVRIAADLLANEEGATLVIAGDTPLITGETLGALFDYHFAQKATATILTAIAPNPTGYGRIIRDEKDSVEKIVEQKDANA
FEKSITEINTGTYIFDNKSLFKALTEITTDNAQGEYYLTDVIEIFKKVGQTIAAHILDDFDESLGVNDRVALSQAEATMR
KRINHEHMVNGVTLIDPATTYIDSEVTIGAETVIEANVTIKGNTFIGKNVLITNGSRIENSEIHSNCEVRNSTVEESRMS
VGSNVGPYAHLRPGTVLSEEVHVGNFVEIKGSTLGKGTKAGHLTYIGNATVGEKVNFGAGTITANFDGKNKFNTEIDDFA
FIGSNSTIIAPLHIGKNALTAAGSVVTEDVPDEAVEIGRGKQVNKLGRAKKMPHYRGQ

Sequences:

>Translated_458_residues
MNKFAIVLAAGKGTRMKSALPKVLHQVAGKSMLAHVLKSVSEVEIAKNVVIVGHEADRVIATLPKGTQFVKQVEQLGTGH
AVRIAADLLANEEGATLVIAGDTPLITGETLGALFDYHFAQKATATILTAIAPNPTGYGRIIRDEKDSVEKIVEQKDANA
FEKSITEINTGTYIFDNKSLFKALTEITTDNAQGEYYLTDVIEIFKKVGQTIAAHILDDFDESLGVNDRVALSQAEATMR
KRINHEHMVNGVTLIDPATTYIDSEVTIGAETVIEANVTIKGNTFIGKNVLITNGSRIENSEIHSNCEVRNSTVEESRMS
VGSNVGPYAHLRPGTVLSEEVHVGNFVEIKGSTLGKGTKAGHLTYIGNATVGEKVNFGAGTITANFDGKNKFNTEIDDFA
FIGSNSTIIAPLHIGKNALTAAGSVVTEDVPDEAVEIGRGKQVNKLGRAKKMPHYRGQ
>Mature_458_residues
MNKFAIVLAAGKGTRMKSALPKVLHQVAGKSMLAHVLKSVSEVEIAKNVVIVGHEADRVIATLPKGTQFVKQVEQLGTGH
AVRIAADLLANEEGATLVIAGDTPLITGETLGALFDYHFAQKATATILTAIAPNPTGYGRIIRDEKDSVEKIVEQKDANA
FEKSITEINTGTYIFDNKSLFKALTEITTDNAQGEYYLTDVIEIFKKVGQTIAAHILDDFDESLGVNDRVALSQAEATMR
KRINHEHMVNGVTLIDPATTYIDSEVTIGAETVIEANVTIKGNTFIGKNVLITNGSRIENSEIHSNCEVRNSTVEESRMS
VGSNVGPYAHLRPGTVLSEEVHVGNFVEIKGSTLGKGTKAGHLTYIGNATVGEKVNFGAGTITANFDGKNKFNTEIDDFA
FIGSNSTIIAPLHIGKNALTAAGSVVTEDVPDEAVEIGRGKQVNKLGRAKKMPHYRGQ

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=447, Percent_Identity=43.8478747203579, Blast_Score=342, Evalue=4e-95,
Organism=Saccharomyces cerevisiae, GI6320148, Length=373, Percent_Identity=24.9329758713137, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355443, Length=372, Percent_Identity=24.4623655913978, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24644084, Length=372, Percent_Identity=24.4623655913978, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 49122; Mature: 49122

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKFAIVLAAGKGTRMKSALPKVLHQVAGKSMLAHVLKSVSEVEIAKNVVIVGHEADRVI
CCCEEEEEECCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCEEEEECCCCCEE
ATLPKGTQFVKQVEQLGTGHAVRIAADLLANEEGATLVIAGDTPLITGETLGALFDYHFA
EECCCCHHHHHHHHHHCCCCEEEEHHHHHCCCCCCEEEEECCCCEECCHHHHHHHHHHHH
QKATATILTAIAPNPTGYGRIIRDEKDSVEKIVEQKDANAFEKSITEINTGTYIFDNKSL
HHHHHHEEEEECCCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCHHH
FKALTEITTDNAQGEYYLTDVIEIFKKVGQTIAAHILDDFDESLGVNDRVALSQAEATMR
HHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
KRINHEHMVNGVTLIDPATTYIDSEVTIGAETVIEANVTIKGNTFIGKNVLITNGSRIEN
HHCCHHHHHCCEEEECCCHHHCCCCEEECCEEEEEEEEEEECCEEECCEEEEECCCCCCC
SEIHSNCEVRNSTVEESRMSVGSNVGPYAHLRPGTVLSEEVHVGNFVEIKGSTLGKGTKA
CHHCCCCCCCCCHHHHHHHHCCCCCCCCCEECCCCEECCCCCCCCEEEECCCCCCCCCCC
GHLTYIGNATVGEKVNFGAGTITANFDGKNKFNTEIDDFAFIGSNSTIIAPLHIGKNALT
CEEEEECCCCCCCEEECCCEEEEEECCCCCCCCCCCCCEEEECCCCEEEEEEECCCCHHH
AAGSVVTEDVPDEAVEIGRGKQVNKLGRAKKMPHYRGQ
HCCCHHCCCCCHHHHHHCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNKFAIVLAAGKGTRMKSALPKVLHQVAGKSMLAHVLKSVSEVEIAKNVVIVGHEADRVI
CCCEEEEEECCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCEEEEECCCCCEE
ATLPKGTQFVKQVEQLGTGHAVRIAADLLANEEGATLVIAGDTPLITGETLGALFDYHFA
EECCCCHHHHHHHHHHCCCCEEEEHHHHHCCCCCCEEEEECCCCEECCHHHHHHHHHHHH
QKATATILTAIAPNPTGYGRIIRDEKDSVEKIVEQKDANAFEKSITEINTGTYIFDNKSL
HHHHHHEEEEECCCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCHHH
FKALTEITTDNAQGEYYLTDVIEIFKKVGQTIAAHILDDFDESLGVNDRVALSQAEATMR
HHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
KRINHEHMVNGVTLIDPATTYIDSEVTIGAETVIEANVTIKGNTFIGKNVLITNGSRIEN
HHCCHHHHHCCEEEECCCHHHCCCCEEECCEEEEEEEEEEECCEEECCEEEEECCCCCCC
SEIHSNCEVRNSTVEESRMSVGSNVGPYAHLRPGTVLSEEVHVGNFVEIKGSTLGKGTKA
CHHCCCCCCCCCHHHHHHHHCCCCCCCCCEECCCCEECCCCCCCCEEEECCCCCCCCCCC
GHLTYIGNATVGEKVNFGAGTITANFDGKNKFNTEIDDFAFIGSNSTIIAPLHIGKNALT
CEEEEECCCCCCCEEECCCEEEEEECCCCCCCCCCCCCEEEECCCCEEEEEEECCCCHHH
AAGSVVTEDVPDEAVEIGRGKQVNKLGRAKKMPHYRGQ
HCCCHHCCCCCHHHHHHCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]